教育背景 博士 1996.9-2000.6 山东大学 微生物学 硕士 1985.9-1988.6 山东大学 微生物学 本科 1981.9-1985.9 山东大学 微生物学 工作经历 2001-今 教授，博士生导师, 山东大学 微生物技术国家重点实验室&国家糖工程技术研究中心 1996-2000 副教授, 山东大学 微生物技术国家重点实验室 1998-1995 助教及讲师, 山东大学微生物系 2003 美国Wayne State Univ访问学者 1997-1998 日本京都大学（Kyoto Univ）UNESCO微生物学高级研修

主要集中在生物催化与生物合成方面，现今重点开展酶催化的糖基化作用研，也同时关注真菌的尼古丁代谢及光合细菌的类胡萝卜素合成研究。

1.Peng Liu, Huaqin Zhang, Yuying Wang, Xiaodi Chen, Lan Jin, Li Xu*,Min Xiao*. Screening and characterization of an α-L-fucosidase fromBacteroides fragilisNCTC9343 for synthesis of fucosyl-N-acetylglucosamine disaccharides. Appl Microbiol Appl Microbiol Biotechnol. 2020,104:7827-7840 2.Yinping Li, Weiying Hong, Henan Zhang, Tian Tian Zhang, Zhiyong Chen, Shiling Yuan, Peng Peng*,Min Xiao*,Li Xu*. Photothermally triggered cytosolic drug delivery of glucose functionalized polydopamine nanoparticles in response to tumor microenvironment for the GLUT1-targeting chemo-phototherapy. J Control Release. 2020, 317: 232-245. 3.Xiaodi Chen, Lan Jin, Xukai Jiang, Longcheng Guo, Guofeng Gu , Li Xu 1, Lili Lu, Fengshan Wang,Min Xiao*. Converting a β-N-acetylhexosaminidase into two trans-β-N-acetylhexosaminidases by domain-targeted mutagenesis. Appl Microbiol Biotechnol. 2020, 104(2): 661-673. 4.Li Xu, Xiaohong Liu , Yinping Li , Zhenhao Yin, Lan Jin, Lili Lu, Jingyao Qu,Min Xiao*. Enzymatic rhamnosylation of anticancer drugs by anα-L-rhamnosidase fromAlternariasp. L1 for cancer-targeting and enzyme-activated prodrug therapy. Appl Microbiol Biotechnol. 2019, 103(19): 7997-8008 5.Ke Wang, Tingting Qi, Longcheng Guo, Zhongxuan Ma, Guofeng Gu,Min Xiao*, Lili Lu*. Enzymatic Glucosylation of Salidroside from Starch by α-Amylase. J Agric Food Chem. 2019, 67, 2012-2019 6.Tiantian Zhang, Yinping Li, Weiying Hong, Zhiyong Chen, Peng Peng, Shiling Yuan, Jingyao Qu,Min Xiao*, Li Xu*. Glucose oxidase and polydopamine functionalized iron oxide nanoparticles: combination of the photothermal effect and reactive oxygen species generation for dual-modality selective cancer therapy. J Mater Chem B. 2019, 7:2190-2200. 7.Chunjuan He, Yougui Huang, Peng Liu, Jianhuan Wei, Yirui Yang, Li Xu*,Min Xiao*. Transcriptome analysis of genes and metabolic pathways associated with nicotine degradation inAspergillus oryzae112822. BMC genomics. 2019, 20: 86. doi:10.1186/s12864-019-5446-2 8.Longcheng Guo, Xiaodi Chen, Li Xu,Min Xiao*,Lili Lu*. Enzymatic Synthesis of 6’α-Sialyllactose, a Dominant Sialylated Human Milk Oligosaccharide, by a Novel exo-α-Sialidase fromBacteroides fragilisNCTC9343. Appl Environ Microbiol. 2018, 84(13):e00071-18 9.Chunjuan He, Yirui Yang, Renfei Zhao, Jingyao Qu, Lan Jin, Lili Lu, Li Xu*,Min Xiao*.Rational designed mutagenesis of levansucrase fromBacillus licheniformis8-37-0-1 for product specificity study. Appl Microbiol Biotechnol. 2018, 102(7):3217-3228 10.Tingting Qi, Guofeng Gu, Li Xu,Min Xiao*, Lili Lu*. Efficient synthesis of tyrosol galactosides by theβ-galactosidase fromEnterobacter cloacaeB5. Appl Microbiol Biotechnol. 2017, 101(12):4995-5003. 11. Xiaodi Chen, Li Xu, Lan Jin, Bin Sun, Guofeng Gu, Lili Lu*,Min Xiao*.Efficient and regioselective synthesis of β-GalNAc/GlcNAc-lactose by a bifunctional transglycosylating β-N-acetylhexosaminidase from Bifidobacterium bifidum. Appl Environ Microbiol. 2016, 82(18):5642-5652. 12. Li Xu, Xiaohong Liu, Zhenhao Yin, Qian Liu, Lili Lu,Min Xiao*.Site-directed mutagenesis of α-L-rhamnosidase from Alternaria sp. L1 to enhance synthesis yield of reverse hydrolysis based on rational design. Appl Microbiol Biotechnol. 2016, 100(24):10385-10394. 13. Wei Gong，Li Xu，Guofeng Gu，Lili Lu，Min Xiao*. Efficient and regioselective synthesis of globotriose by a novel α-galactosidase from Bacteroides fragilis. Appl Microbiol Biotechnol 2016,100: 6693–6702. 14. Lijuan Xu, Tingting Qi, Li Xu, Lili Lu*,Min Xiao*. Recent progress in the enzymatic glycosylation of phenolic compounds. Journal of Carbohydrate Chemistry. 2016, 35(1):1-23. 15. Jie Zhang, Lili Lu, Li Lu, Yang Zhao, Liping Kang, Xu Pang, Jingyuan Liu, Tengchuan Jiang,Min Xiao*,Baiping Ma*. Galactosylation of steroidal saponins by β-galactosidase from Lactobacillus bulgaricus L3. Glycoconj J. Glycoconj J. 2016, 33(1):53-62. 16. Shuquan Fan, Huaqin Zhang, Xiaodi Chen, Lili Lu, Li Xu,Min Xiao*. Cloning, characterization, and production of three α-L-fucosidases from Clostridium perfringens ATCC 13124. J Basic Microbiol. 2015, 55(4), 347-357. 17. Lili Lu, Qian Liu, Lan Jan, Zhenghao Yin, Li Xu,Min Xiao*. Enzymatic synthesis of rhamnose containing chemicals by reverse hydrolysis. PLoS One. 2015, 10(10):e0140531. 18. Lili Lu, Yuchuan Guo, Lijuan Xu, Tingting Qi, Lan Jin, Li Xu,Min Xiao*. Galactosylation of caffeic acid by an engineered β-galactosidase. Drug Discoveries & Therapeutics. 2015; 9(2):123-128. 19. Lili Lu, Lijuan Xu, Yuchuan Guo, Dayu Zhang, Tingting Qi, Lan Jin, Guofeng Gu, Li Xu,Min Xiao*. Glycosylation of Phenolic Compounds by the Site-Mutated β-Galactosidase from Lactobacillus bulgaricus L3. PLoS ONE. 2015, 10(3): e0121445. 20. Lili Zhang, Lili Lu, Shuquan Fan, Lan Jin, Guofeng Gu, Li Xu,Min Xiao*. One-step synthesis of α-Gal epitope and globotriose derivatives by an engineered α-galactosidase. RSC Advances, 2015, 5, 22361 – 22364.