教育经历 2000/09-2008/01，北京大学，蛋白质工程及植物基因工程国家重点实验室，博士 1996/09-2000/06，山东大学，生物科学系，学士 科研与学术工作经历 2012/06-今，山东大学，国家糖工程技术研究中心，讲师 2009/08-2012/05，美国堪萨斯大学，化学系，生物化学博士后 2008/04-2009/04，加拿大滑铁卢大学，化学系，生物分析化学博士后

肿瘤靶向诊疗，蛋白质工程，酶分子结构与功能 糖分子作为靶向分子，结合生物基纳米材料，构建疾病微环境的响应释药载体，用于疾病的诊断治疗 利用蛋白质工程技术，以原核、真核各种表达体系为平台，表达并研究具有重要生理功能的蛋白质，以获得蛋白类药物及重要工具酶 通过酶的定点突变和定向进化技术，获得特殊功能的糖苷酶，用于合成生物活性糖苷类化合物，并研究糖苷化合物的生理功能。

(1) Zan Cui, Chenyu Shi, Ran An, Yinping Li, Yan Tang, Xueting Cao, Xukai Jiang, Chang-Cheng Liu*, Min Xiao* and Li Xu*, In silico-guided rational design of chemical modification of inulin as adjuvant for cancer immunotherapy, ACS Nano 2025, 19, 2099-2116 (2) Ran An, Chenyu Shi, Yan Tang, Zan Cui, Yinping Li, Zhiyong Chen, Min Xiao, Li Xu*, Chitosan/rutin multifunctional hydrogel with tunable adhesion, anti-inflammatory and antibacterial properties for skin wound healing, Carbohydrate Polymers, 2024, 343,122492 (3) Jiasheng Shi, Henan Zhang, Qian Wang, Zhengyu Duan, Li Xu*, Fenghao Guo, Yunfeng Xie*, Zhiyong Chen*; Biomimetic rigid cryogels with aligned micro-sized tubular structures prepared by conventional redox-induced cryopolymerization in a freezer, Chemical Engineering Journal, 2022, 427, 131903 (4) Weiying Hong, Chang-Cheng Liu, Henan Zhang, Zhiyong Chen, Min Xiao*, and Li Xu*; Cancer cell preferential penetration and pH-responsive drug delivery of oligorutin, Biomacromolecules, 2021, DOI:10.1021/acs.biomac.1c00268 (5) Yinping Li#; Weiying Hong#; Henan Zhang#; Tian Tian Zhang; Zhiyong Chen; Shiling Yuan; Peng Peng*; Min Xiao*; Li Xu*; Photothermally triggered cytosolic drug delivery of glucose functionalized polydopamine nanoparticles in response to tumor microenvironment for the GLUT1-targeting chemo-phototherapy, Journal of Controlled Release, 2020, 317: 232-245. (6) Tiantian Zhang#; Yinping Li#; Weiying Hong; Zhiyong Chen; Peng Peng; Shiling Yuan; Jingyao Qu; Min Xiao*; Li Xu*; Glucose oxidase and polydopamine functionalized iron oxide nanoparticles: combination of the photothermal effect and reactive oxygen species generation for dual-modality selective cancer therapy, Journal of Materials Chemistry B, 2019, 7: 2190-2200.