教育经历 1998-9 — 2004-1复旦大学遗传学理学博士学位 1995-9 — 1998-7烟台大学生物化学理学学士 工作经历 2009-05-至今山东大学 2005-10 — 2009-04斯坦福大学 2005-01 — 2005-09哈佛大学医学院 2004-01 — 2004-12国家人类基因组南方研究中心

听觉转导与耳聋发生 毛细胞静纤毛发育与维持

1. Nana Li , Shuang Liu , Dange Zhao , Haibo Du , Yuehui Xi , Xiaoxi Wei , Qingling Liu , Ulrich Müller , Qing Lu , Wei Xiong and Zhigang Xu. Disruption of Cdh23 exon 68 splicing leads to progressive hearing loss in mice by affecting tip-link stability. Proc Natl Acad Sci U S A, 121, e2309656121, 2024. 2. Ying Guan , Hai-Bo Du , Zhao Yang , Yu-Zhu Wang , Rui Ren , Wen-Wen Liu , Chao Zhang , Jia-Hai Zhang , Wen-Tao An , Na-Na Li , Xiao-Xue Zeng , Jie Li , Yi-Xiao Sun , Yan-Fei Wang , Fan Yang , Jun Yang , Wei Xiong , Xiao Yu , Ren-Jie Chai , Xiao-Ming Tu , Jin-Peng Sun and Zhi-Gang Xu. Deafness-associated ADGRV1 mutation impairs USH2A stability through improper phosphorylation of WHRN and WDSUB1 recruitment. Advanced Science, 10, e2205993, 2023. 3. Xiaoying Wang , Shuang Liu , Qi Cheng , Chengli Qu , Rui Ren , Haibo Du , Nana Li , Keji Yan , Yanfei Wang , Wei Xiong and Zhigang Xu. CIB2 and CIB3 regulate stereocilia maintenance and mechanoelectrical transduction in mouse vestibular hair cells. Journal of Neuroscience, 43, 3219-3231, 2023. 4. Rui Ren , Haiyue Xing , Xiaoying Wang , Haibo Du , Yanfei Wang and Zhigang Xu. Loss of TMCC2 activates endoplasm reticulum stress and causes auditory hair cell death. Human Molecular Genetics, 32, 1622-1633, 2023. 5. Huang Wang , Haibo Du , Rui Ren , Tingting Du , Lin Lin , Zhe Feng , Dange Zhao , Xiaoxi Wei , Xiaoyan Zhai , Hongyang Wang , Tingting Dong , Jin-Peng Sun , Hao Wu , Zhigang Xu and Qing Lu. Temporal and spatial assembly of inner ear hair cell ankle link condensate through phase separation. Nature Communications, 14, 1657, 2023. 6. Xiaoyan Zhai , Haibo Du , Yuxin Shen , Xiujuan Zhang , Zhengjun Chen , Yanfei Wang and Zhigang Xu. FCHSD2 is required for stereocilia maintenance in mouse cochlear hair cells. Journal of Cell Science, 135, jcs259912, 2022. 7. Haibo Du , Linzhi Zou , Rui Ren , Nana Li , Jie Li , Yanfei Wang , Jinpeng Sun , Jun Yang , Wei Xiong and Zhigang Xu. Lack of PDZD7 long isoform disrupts ankle-link complex and causes hearing loss in mice. FASEB Journal, 34, 1136, 2020. 8. Xiao-Ning Cheng , Ming Shao , Ji-Tong Li , Yan-Fei Wang , Jing Qi , Zhi-Gang Xu and De-Li Shi. Leucine repeat adaptor protein 1 interacts with Dishevelled to regulate gastrulation cell movements in zebrafish. Nature Communications, 8, 1353, 2017. 9. Qiao-Xia Hu , Jun-Hong Dong , Hai-Bo Du , Dao-Lai Zhang , Hong-Ze Ren , Ming-Liang Ma , Yuan Cai , Tong-Chao Zhao , Xiao-Lei Yin , Xiao Yu , Tian Xue , Zhi-Gang Xu and Jin-Peng Sun. Constitutive Gαi coupling activity of very large G protein-coupled receptor 1 (VLGR1) and its regulation by PDZD7 protein. Journal of Biological Chemistry, 289, 24215-24225, 2014.