教育背景 2009/10-2011/10，德国明斯特大学，分子微生物技术研究所，联合培养博士 2006/09-2012/07，山东大学，微生物技术国家重点实验室，博士 2002/09-2006/07，山东大学，国家生命科学和技术基地班，学士 工作经历 2019/09- 至今， 山东大学“齐鲁青年学者”，微生物技术国家重点实验室，教授（破格） 2018/09 –2019.08， 山东大学，微生物技术国家重点实验室，副教授 2012/07- 2018.09，山东大学，微生物技术国家重点实验室，讲师 2012/07- 2014/07，山东大学，化学与化工学院，博士后

主要定位在环境微生物与合成生物学技术开发上开展研究。在环境微生物方向，目前主要在研究异养细菌硫氧化，其中涉及途径的挖掘、关键基因的功能分析、元素硫介导的细胞间通讯及其对细胞生理的影响、及H2S生物处理等；在生物技术方向上，主要是建立或改进微生物遗传操作的方法，并且对发现的新机理进行深入探究。

1.Tianqi Wang, Xiaoju Li, Honglei Liu, Huaiwei Liu,Yongzhen Xia*, Luying Xun*，Microorganisms uptake zero-valent sulfur via membrane lipid dissolution of octasulfur and intracellular solubilization as persulfide，Sci Total Environ，2024 Apr 20:922:170504. (5 year IF=9.8，一区) 2.Tianqi Wang, Guomei Zhong, Honglei Liu, Huaiwei Liu,Yongzhen Xia*, Luying Xun*, A common mechanism for rapid transfer of zero-valent sulfur between microbial cells, Sci Total Environ. 2023 Sep 15;891:164461. (5 year IF=9.8，一区) 3.Mingxue Ran, Qingbin Li, Yufeng Xin, Shaohua Ma, Rui Zhao, Min Wang, Luying Xun*,Yongzhen Xia*, Rhodaneses minimize the accumulation of cellular sulfane sulfur to avoid disulfide stress during sulfide oxidation in bacteria, Redox Biology, 2022 Jul; 53: 102345. (5 year IF=11.271，一区) 4.Rui Zhao, Zimai Li, Yuqing Sun, Wei Ge, Mingyu Wang, Huaiwei Liu, Luying Xun,Yongzhen Xia*，EngineeredEscherichia coliNissle 1917 with urate oxidase and an oxygen-recycling system for hyperuricemia treatment，Gut Microbes，2022 Jan-Dec; 14(1):2070391. (5 year IF=11.724，一区) 5.Ran Mingxue, Wang Tianqi, Shao Ming, Chen Zhigang, Liu Huaiwei,Xia Yongzhen*, Xun Luying*，Sensitive Method for Reliable Quantification of Sulfane Sulfur in Biological Samples, Anal Chem. 2019, 17;91(18):11981-11986 (5 year IF=7.528，一区) 6.Xia Yongzhen, Li Kai, Li Jingjing, Wang Tianqi, Gu Lichuan*, Xun Luying*. T5 exonuclease-dependent assembly offers a low-cost method for efficient cloning and site-directed mutagenesis, Nucleic Acids Res., 2019, 47(3):e15 (5 year IF=17.21,一区) 7.Yongzhen Xia, Chuanjuan Lü, Ningke Hou,Yufeng Xin,Jihua Liu, Honglei Liu*, Luying Xun*, Sulfide production and oxidation by heterotrophic bacteria under aerobic conditions. ISME J., 2017, Dec;11(12):2754-2766. (5 year IF=13.214，一区Top) 8.Chao Tang#; Jingjing Tang#; Yuemeng Shen; Menghui Liu; Honglei Liu; Huaiwei Liu; LuyingXun*;Yongzhen Xia*; A sulfide-sensor and a sulfane sulfur-sensor collectively regulate sulfur-oxidation for feather degradation byBacillus licheniformis, Communications Biology, 2023, 6(1): 167-167. (IF=6.548，二区) 二区代表性论文： 9.Guanhua Xuan, Luying Xun,Yongzhen Xia*, MarR family proteins sense sulfane sulfur in bacteria, mLife, 2024 (online). 10.Yuqing Yang, Menghui Liu, Tianqi Wang, Qian Wang, Huaiwei Liu, Luying Xun,Yongzhen Xia*; An Optimized Transformation Protocol forEscherichia coliBW3KD with Supreme DNA Assembly Efficiency; Microbiol Spectr. 2022 Dec 21;10(6):e0249722. (IF=3.7，二区) 11.Qiaoli Yu, Mingxue Ran, Yuping Xin, Huaiwei Liu, Honglei Liu,Yongzhen Xia*, Luying Xun*; The Rhodanese PspE Converts Thiosulfate to Cellular Sulfane Sulfur inEscherichia coli; Antioxidants (Basel). 2023 May 20;12(5):1127. (IF=7.0，二区) 12.Huangwei Xu#, Guanhua Xuan#, Huaiwei Liu, Honglei Liu,Yongzhen Xia*, Luying Xun*, Sulfane Sulfur Is an Intrinsic Signal for the Organic Peroxide Sensor OhrR ofPseudomonas aeruginosa, Antioxidants (Basel),2022 Aug 26;11(9):1667. (5 year IF=7.886,二区Top) 13.Qiaoli Yu, Mingxue Ran, Yuqing Yang, Huaiwei Liu, Luying Xun*,Yongzhen Xia*, Optimization of a Method for Detecting Intracellular Sulfane Sulfur Levels and Evaluation of Reagents That Affect the Levels inEscherichia coli, 2022 Jul; 11(7): 1292., Antioxidants (Basel). (5 year IF=7.886,二区Top) 14.Tianqi Wang, Yuqing Yang, Menghui Liu, Honglei Liu, Huaiwei Liu,Yongzhen Xia*, Luying Xun*,Elemental Sulfur Inhibits Yeast Growth via Producing Toxic Sulfide and Causing Disulfide Stress, Antioxidants (Basel)., 2022 Mar 17;11(3):576. (5 year IF=7.886,二区Top) 15.Yuqing Yang, Qiaoli Yu, Min Wang, Rui Zhao, Huaiwei Liu, Luying Xun,Yongzhen Xia*,Escherichia coliBW25113 Competent Cells Prepared Using a Simple Chemical Method Have Unmatched Transformation and Cloning Efficiencies, Front Microbiol., 2022 Mar 24;13:838698. (5 year IF=6.843,二区Top) 16.Tianqi Wang, Mingxue Ran, Xiaoju Li, Yequn Liu, Yufeng Xin, Honglei Liu, Huaiwei Liu,Yongzhen Xia*, Luying Xun*, The Pathway of Sulfide Oxidation to Octasulfur Globules in the Cytoplasm of Aerobic Bacteria, Appl Environ Microbiol., 2022 Feb 8;88(3): e0194121. (5 year IF=5.632,二区Top) 17.Huangwei Xu, Guanhua Xuan, Huaiwei Liu,Yongzhen Xia*, Luying Xun*,Sulfane Sulfur Is a Strong Inducer of the Multiple Antibiotic Resistance Regulator MarR inEscherichia coli, Antioxidants (Basel)., 2021 Nov 6;10(11):1778. (5 year IF=7.886,二区Top) 18.Guanhua Xuan, Chuanjuan Lv, Huangwei Xu, Kai Li, Huaiwei Liu,Yongzhen Xia*, Luying Xun*, Sulfane Sulfur Regulates LasR-Mediated Quorum Sensing and Virulence inPseudomonas aeruginosaPAO1,Antioxidants (Basel)., 2021 Sep 21;10(9):1498. (5 year IF=7.886,二区Top) 19.Yuqing Yang, Tianqi Wang, Qiaoli Yu, Huaiwei Liu, Luying Xun,Yongzhen Xia*, The pathway of recombining short homologous ends inEscherichia colirevealed by the genetic study, Mol Microbiol., 2021 Jun;115(6):1309-1322. (5 year IF=4.157,二区) 20.Yufeng Xin, Rui Gao, Feifei Cui, Chuanjuan Lü, Honglei Liu, Huaiwei Liu,Yongzhen Xia*, Luying Xun*, The Heterotrophic BacteriumCupriavidus pinatubonensisJMP134 Oxidizes Sulfide to Sulfate with Thiosulfate as a Key Intermediate,Appl Environ Microbiol., 2020 Oct 28;86(22):e01835-20. (5 year IF=5.632,二区Top) 21.Guanhua Xuan, Chuanjuan Lü, Huangwei Xu, Zhigang Chen, Kai Li, Honglei Liu, Huaiwei Liu,Yongzhen Xia*, Luying Xun*, Sulfane Sulfur is an intrinsic signal activating MexR-regulated antibiotic resistance inPseudomonas aeruginosa, Mol Microbiol., 2020 Dec;114(6):1038-1048. (5 year IF=4.157,二区) 22.Liu Huaiwei, Fan Kaili, Li Huanjie, Wang Qingda, Yang Yunyun, Li Kai,Xia Yongzhen*, Luying Xun*，Synthetic Gene Circuits EnableEscherichia coliTo Use Endogenous H2S as a Signaling Molecule for Quorum Sensing, ACS Synth Biol. 2019, 20;8(9):2113-2120.(5 year IF=5.373，二区Top) 23.Kai Li, Yufeng Xin, Guanhua Xuan, Rui Zhao, Huaiwei Liu,Yongzhen Xia*, Luying Xun*.Escherichia coliuses different enzymes to produce H2S and reactive sulfane sulfur from L-cysteine, Front Microbiol., 2019 Feb 20;10:298. (5 year IF=6.843,二区Top)