王海钠
副教授
个人简介
1995.9-1999.7山东医科大学药学院,学士 2000.9-2003.6山东大学药学院药物分析学专业,硕士 2003.7-2006.7山东大学药学院药物分析教研室,助教 2006.9-2011.12浙江大学药学院药物分析学专业,医学博士 2006.8-2013.8山东大学药学院药物分析教研室,讲师 2013.9-2014.9美国国立卫生研究院国家癌症研究所访问学者 2013.9-至今山东大学药学院药物分析教研室,副教授
研究领域
手性药物分析与立体选择性代谢 药物质量控制与药代动力学研究 药物代谢组学与代谢调控
近期论文
1. Meng R, Zhang XL,Wang HN*, Zhang DL, Zhao X.Different Induction Effects of Praziquantel Racemate and Enantiomers on the Enzyme CYP3A4 Mediated by Pregnane X Receptor and Its Variants. Current Drug Metabolism, 2021, 22(3):232-239. 2. Zhang XL, Meng R,Wang HN*, Xing J*. Differential effects of components in Artemisia annua extract on the induction of drug-metabolizing enzyme expression mediated by nuclear receptors. Planta Medica, 2020, 86(12):867-875. 3. Dong S, Ji J, Hu L,Wang HN*. Dihydromyricetin alleviates acetaminophen-induced liver injury via the regulation of transformation, lipid homeostasis, cell death and regeneration, Life Sciences, 2019, 227:20-29. 4.Meng R, Zhang D, Ji J, Hu L, Sun D*,Wang HN*,Enantioselective plasma pharmacokinetic study of a novel anti-Sichistosomiasis agent P96 in rat by liquid chromatography-tandem mass spectrometry, Current Pharmaceutical Analysis, 2019, 15(4):388-398. 5. Dong S, Ji J, Zhang B, Hu L, Cui X,Wang HN*. Protective effects and possible molecular mechanism of Hovenia dulcis Thunb. extract on acetaminophen-induced hepatotoxicity, Pharmazie, 2018, 73(11): 666-670. 6. Zhao M, Meng R, Lu Y, Hu L, Na Sun, Nie L*,Wang HN*, A useful quantitative model for determination of enantiomeric composition of racemate praziquantel by ultraviolet spectroscopy combined with partial least squares and its application to praziquantel tablets, Journal of Innovative Optical Health Sciences, 2018, 11(3) 7.Wang HN, Fang ZZ, Meng R, et al. Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthylisothiocyanate-induced liver injury and bile acid cycle disruption, Toxicology, 2017,386:133-142. 8. Cao J,Wang HN*.Ticagrelor Affects the Glucuronidation of Propofol, Latin American Journal of Pharmacy, 2016, 35(6):1464-1468. 9.Wang HN, Fang ZZ, Zheng Y, et al. Metabolic profiling of praziquantel enantiomers.Biochemical Pharmacology, 2014, 90(2):166-178.