个人简介
教育背景 博士 起止时间:2001/9 - 2008/1;毕业院校:中国科学院昆明植物研究所;专业:植物学 学士 起止时间:1997/9 - 2001/7;毕业院校:安徽大学;专业:生物学 工作经历 2016/9 -至今 山东大学 副教授 2010/6–2016.8 山东大学 讲师 2008/3 - 2010/3 厦门大学 博士后
研究领域
1.放线菌与“不可培养”微生物中新天然产物的理性挖掘与生物合成研究2.基于生物合成/合成生物学的天然产物结构改造3.天然产物活性与功能研究
近期论文
1. Shi, P.; Li, Y.; Zhu, J.; Shen, Y.*;Wang, H.*, Targeted Discovery of the Polyene Macrolide Hexacosalactone A from Streptomyces by Reporter-Guided Selection of Fermentation Media. J Nat Prod 2021, 84 (7), 1924-1929. 2. Zhu, J.; Liu, M.; Deng, J.; Chen, W.; Zhu, D.; Duan, J.; Li, Y.;Wang, H.*; Shen, Y.*, The coupled reaction catalyzed by EchB and EchC lead to the formation of the common 2',3',5'-trihydroxy-benzene core in echosides biosynthesis. Biochem Biophys Res Commun 2021, 559, 62-69. 3. Wei, F.#; Wang, Z.#; Lu, C.; Li, Y.; Zhu, J.;Wang, H.*; Shen, Y., Targeted Discovery of Pentaketide Ansamycin Aminoansamycins A-G. Organic letters 2019, 21 (19), 7818-7822. 4. Song, R.; Shi, H.; Zhu, J.;Wang, H.*; Shen, Y.*, A Single-Component Flavoenzyme Catalyzed Regioselective Halogenation of Pyrone in the Biosynthesis of Venemycins. ACS Chem Biol 2019, 14 (12), 2533-2537. 5. Li, Y.;Wang, H.; Liu, Y.; Jiao, Y.; Li, S.; Shen, Y.*; Du, L.*, Biosynthesis of the Polycyclic System in the Antifungal HSAF and Analogues from Lysobacter enzymogenes. Angewandte Chemie-International Edition 2018, 57 (21), 6221-6225. 6. Shi, G.#; Shi, N.#; Li, Y.; Chen, W.; Deng, J.; Liu, C.; Zhu, J.;Wang, H.*; Shen, Y.*, d-Alanylation in the Assembly of Ansatrienin Side Chain Is Catalyzed by a Modular NRPS. ACS Chemical Biology 2016, 11 (4), 876-881. 7. Liu, C.; Zhu, J.; Li, Y.; Zhang, J.; Lu, C.;Wang, H.*; Shen, Y.*, In Vitro Reconstitution of a PKS Pathway for the Biosynthesis of Galbonolides in Streptomyces sp. LZ35. Chembiochem 2015. 8. Li, S.; Li, Y.; Lu, C.; Zhang, J.; Zhu, J.;Wang, H.*; Shen, Y.*, Activating a Cryptic Ansamycin Biosynthetic Gene Cluster to Produce Three New Naphthalenic Octaketide Ansamycins with n-Pentyl and n-Butyl Side Chains. Organic letters 2015, 17 (15), 3706-9. 9.Wang, H.; Chen, Y.; Ge, L.; Fang, T.; Meng, J.; Liu, Z.; Fang, X.; Ni, S.; Lin, C.; Wu, Y.; Wang, M.; Shi, N.; He, H.; Hong, K.; Shen, Y.*, PCR screening reveals considerable unexploited biosynthetic potential of ansamycins and a mysterious family of AHBA-containing natural products in actinomycetes. J Appl Microbiol 2013, 115 (1), 77-85. 10. Lu, C.; Li, Y.; Deng, J.; Li, S.; Shen, Y.;Wang, H.*; Shen, Y.*, Hygrocins C-G, cytotoxic naphthoquinone ansamycins from gdmAI-disrupted Streptomyces sp. LZ35. J Nat Prod 2013, 76 (12), 2175-2179. 11. Wang, H.; Geng, Z.; Zeng, Y.*; Shen, Y.*, Enriching plant microbiota for a metagenomic library construction. Environ Microbiol 2008, 10 (10), 2684-2691.