学习经历 1978年10月～1982年7月：山东医学院药学系，获医学学士学位； 1983年8月～1986年7月：山东医科大学药学系，获生物药物学理学硕士学位； 1995年10月～1996年10月：英国伦敦大学Imperial College化学系，访问学者； 1998年3月~2001年3月：华东理工大学生物工程学院，获生物化工工学博士学位。 工作经历 1982年7月～1983年7月：化工部勘探公司化肥厂职工医院(河南太康)，药师； 1986年7月～1988年10月：山东医科大学药学院生化制药教研室，助教； 1988年10月～1994年11月：山东医科大学药学院生化制药教研室，讲师，秘书； 1994年12月～1998年12月：山东医科大学药学院生化制药教研室，副教授，秘书； 1999年1月～2000年7月：山东医科大学药学院生化制药教研室，教授，教研室主任； 2000年8月～2004年3月：山东大学药学院生化与生物技术药物研究所所长，制药工程系主任； 2004年4月～2007年12月：山东大学药学院院长助理，生化与生物技术药物研究所所长，制药工程系主任； 2007年5月～今：山东大学国家糖工程技术研究中心副主任； 2007年12月～2016年6月：山东大学药学院院长； 2009年11月~今：山东省重大新药创制中心理事会秘书长，山东省新药产业技术创新战略示范联盟秘书长。 2012年3月~今：山东大学淄博生物医药研究院院长； 2015年8月～2020年3月：山东大学齐鲁医学院副院长； 2020年5月~今：山东大学药品监管科学研究院执行院长。

微生物与生化药学

1. 生物技术药物研究 2. 酶与蛋白质的化学修饰研究 3. 多糖类药物研究

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Lu Lu, Hongyuan Chen, Longkun Wang, Lin Zhao, Yanna Cheng, Aijun Wang,Fengshan Wang*, Xinke Zhang*. A Dual Receptor Targeting- and BBB PenetratingPeptide Functionalized Polyethyleneimine Nanocomplex for Secretory Endostatin Gene Delivery to Malignant Glioma.International Journal of Nanomedicine, 2020, 15: 8875–8892. 5. Congcong Chen, Shuaishuai Wang, Madhusudhan Reddy Gadi, He Zhu, Fei Liu, Chang-Cheng Liu*, Lei Li*,Fengshan Wang*, Peixue Ling*, Hongzhi Cao *. Enzymatic modular synthesis and microarray assay of poly-N-acetyllactosamine derivatives.Chem. Commun., 2020, 56: 7549-7552. 6. Yiming Jin, Yue Mu, Shuhan Zhang, Pingli Li*,Fengshan Wang*. Preparation and evaluation of the adjuvant effect of curdlan sulfate in improving the efficacy of dendritic cell-based vaccine for antitumor immunotherapy.International Journal of Biological Macromolecules, 2020, 146: 273-284. 7. Shu Zhang, Honglei Jiang, Shengshi Huang, Pingli Li,Fengshan Wang*. Curdlan sulfate/O-linked quaternized chitosan nanoparticles acting as potential adjuvants promote multiple arms of immune responses.Carbohydrate Polymers, 2019, 213: 100-111. 8. L. X. Zang, R. R. Du, H. C. Zang,F. S. Wang*,J. Z. Sheng*. Production ofArabidopsis thalianaUDP-Sugar Pyrophosphorylase byPichia pastorisand Its Application in Efficient UDP-Glucose and UDP-Glucuronic Acid Synthesis.Applied Biochemistry and Microbiology, 2019, 55(6): 631–638. 9. Jinfeng Ye, Hui Xia, Na Sun, Chang-Cheng Liu, Anran Sheng, Lianli Chi, Xian-Wei Liu, Guofeng Gu, Shu-Qi Wang, Jie Zhao, Ping Wang, Min Xiao,Fengshan Wang,Hongzhi Cao*.Reprogramming the enzymatic assembly line for site-specific fucosylation.Nature Catalys,2019, 2: 514-522. 10. Lu Lu, Hongyuan Chen, Dake Hao, Xinke Zhang*,Fengshan Wang*.The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems.Asian Journal of Pharmaceutical Sciences, 2019, 14: 595–608. 11. Wenjie Jiang, Yanna Cheng, Na Zhao, Lian Li, Yikang Shi, Aizhen Zong,Fengshan Wang*. Sulfated polysaccharide of Sepiella Maindroni ink inhibits the migration, invasion and matrix metalloproteinase-2 expression through suppressing EGFR-mediated p38/MAPK and PI3K/Akt/mTOR signaling pathways in SKOV-3 cells.International Journal of Biological Macromolecules, 2018, 107: 349–362. 12. Yi-Jun Li, Feng-Xin Yin, Xin-Ke Zhang, Jie Yu, Shuang Zheng, Xin-Lei Song,Feng-Shan Wang,Ju-Zheng Sheng*. Characterization of heparan sulfate N-deacetylase/N-sulfotransferase isoform 4 using synthetic oligosaccharide substrates.Biochimica et Biophysica Acta (BBA) - General Subjects, 2018,1862 (3): 547-556. 13. Shu Zhang, Shengshi Huang, Lu Lu, Xinlei Song, Pingli Li,Fengshan Wang*. Curdlan sulfate–O-linked quaternized chitosan nanoparticles: potential adjuvants to improve the immunogenicity of exogenous antigens via intranasal vaccination.International Journal of Nanomedicine, 2018, 13: 2377-2394. 14. Caicai Meng, Aniruddha Sasmal, Yan Zhang, Tian Gao, Chang-Cheng Liu, Naazneen Khan, Ajit Varki,Fengshan Wang*, Hongzhi Cao*. Chemoenzymatic Assembly of mammalian O-mannose glycans.Angew. Chem. Int. Ed. 2018, 57, 9003-9007. 15. Yiming Jin, Pingli Li,Fengshan Wang*.b-glucans as potential immunoadjuvants: A review on the adjuvanticity, structure-activity relationship and receptor recognition properties.Vaccine, 2018, 36: 5235-5244. 16. Qixin Chen, Chengzhi Jin, Xintian Shao, Ruilin Guan, Zhiqi Tian, Chenran Wang, Fei Liu,Peixue Ling, Jun-Lin Guan, Liangnian Ji,Fengshan Wang*, Hui Chao*, Jiajie Diao*. Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore.Small, 2018, 14: 1802166. 17. Xintian Shao, Qixin Chen, Xixi Dou, Lei Chen, Jixu Wu, Wei Zhang, Huarong Shao, Peixue Ling*, Fei Liu*,Fengshan Wang*. Lower range of molecular weight of xanthan gum inhibits cartilage matrix destruction via intrinsic bax-mitochondria cytochrome c-caspase pathway.Carbohydrate Polymers, 2018, 198: 354–363. 18. Fuyan Liu, Xiaofeng Zhang, Yuqiu Li, Hui Gao,Peixue Ling*, Xiaoyan Li, Qixin Chen, Aibin Ma, Huarong Shao, Mei Li,Fengshan Wang*. Simultaneous Screening and Determination of Eight Tetracycline Antibiotics Illegally Adulterated in Herbal Preparations Using HPLC-DAD Combined with LC-MS-MS.Chromatographia, 2018, 81 (36):303-314. 19. Qixin Chen, Xintian Shao,Peixue Ling*, Fei Liu, Huarong Shao, Aibin Ma, Jixu Wu, Wei Zhang, Fuyan Liu,Guanying Han*,Fengshan Wang*. Low molecular weight xanthan gum suppresses oxidative stress-induced apoptosis in rabbit chondrocytes.Carbohydrate Polymers, 2017, 169: 255–263. 20. Feng-Xin Yin,Feng-Shan Wang*,Ju-Zheng Sheng*. Uncovering the Catalytic Direction of Chondroitin AC Exolyase. 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Chemoenzymatic synthesis of a-dystroglycan core M1 O-mannose glycans†.Chem. Commun., 2015, 51: 11654-11657. 25. Pingli Li, Xinke Zhang, Yanna Cheng, Juan Li, Yuliang Xiao, Qian Zhang,Aizhen Zong, Chuanqing Zhong,Fengshan Wang*. Preparation and in vitro immunomodulatory effect of curdlan sulfate.Carbohydrate Polymers, 2014, 102: 852– 861. 26. Xin Meng, Wenlong Yao, Jiansong Cheng, Xu Zhang, Lan Jin, Hai Yu, Xi Chen,Fengshan Wang*, Hongzhi Cao*. Regioselective Chemoenzymatic Synthesis of Ganglioside Disialyl Tetrasaccharide Epitopes.J. Am. Chem. Soc., 2014, 136, 5205−5208. 27. Jingzong Qi, Qingli Wang, Zhenhang Yu, Xin Chen andFengshan Wang*. Innovative drug R&D in China.Nature Reviews Drug Discovery, 2011, 10(5): 333-334.