个人简介
教育背景 中国/美国微生物学会会员,Applied Microbiology International会员,国家自然基金委和教育部评审专家,Frontiers in Bioengineering and Biotechnology和Scientific Reports编委/编辑,Biotechnology for Biofuels、AppliedMicrobiology andBiotechnology和Frontiers inMicrobiology等多个学术期刊审稿人 博士起止时间:2000.9-2005.7毕业院校:山东大学专业:微生物学 学士起止时间:1996.9-2000.7毕业院校:山东大学专业:微生物学 工作经历 2017.9至今 山东大学 教授 2007.9-2017.9山东大学 副教授 2005.7-2007.9山东大学 讲师 2008.7-2010.8 德国马普陆地微生物研究所(Rolf Thauer院士实验室)博士后 2011.4-2013.6 德国马普陆地微生物研究所(Rolf Thauer院士实验室)客座教授
研究领域
1. 厌氧微生物的生理代谢机制及其发酵应用 2. 环境污染物微生物降解的生化机制、资源化转化应用和环境修复 3. 高值化合物、平台化合物和生物能源的微生物发酵
近期论文
1.Liang J.1, Huang H., Wang Y., Li L., Yi J.,Wang S*. (2022) A cytoplasmic NAD(P)H-dependent polysulfide reductase with thiosulfate reductase activity from the hyperthermophilic bacteriumThermotoga maritima.Microbiol. Spectr.10(4):e0043622. 2.Wang, Y.1, Zhang, M., Li, L., Yi, J., Liang, J.,Wang, S.*, Xu P*. (2022) Biosynthesis ofL-5-methyltetrahydrofolate by genetically engineeredEscherichia coli.Microb. Biotechnol.15(11): 2758-2772. 3.Yi J.1, Huang H., Liang J., Wang R., Liu Z., Li F.,Wang S*. (2021) A heterodimeric reduced-ferredoxin-dependent methylenetetrahydrofolate reductase from syngas-fermentingClostridium ljungdahlii.Microbiol. Spectr.9: e00958-21. 4.Shang J.1,Wang X., Zhang M., Li L., Wang R., Huang H.,Wang S*. (2021) An NAD-specific 6-hydroxy-3-succinoyl-semialdehyde-pyridine dehydrogenase from nicotine-degradingAgrobacterium tumefaciensstrain S33.Microbiol. Spectr.9: e00924-21. 5.Shang J.1, Wang X., Zhang M., Wang R., Zhang C., Huang H.,Wang S*. (2021) Rid enhances the 6-hydroxypseudooxynicotine dehydrogenase reaction in nicotine degradation byAgrobacterium tumefaciensS33.Appl. Environ. Microbiol.87(7):e02769-20. 6.Huang H.1, Shang J.,Wang S*.(2020) Physiology of ahybridpathway fornicotinecatabolism inbacteria.Front. Microbiol.11:598207. 7.Wang R.1,Yi J., Shang J.,Yu W., LiZ., Huang H., Xie H.,Wang S*. (2019)6-Hydroxypseudooxynicotine dehydrogenase delivers electrons to electron transfer flavoprotein during nicotine degradation byAgrobacterium tumefaciensS33.Appl. Environ. Microbiol.85:e00454-19. 8.Liang J.1, Huang H.,Wang S*.(2019) Distribution, evolution, catalytic mechanism, and physiological functions of the flavin-based electron-bifurcating NADH-dependent reduced ferredoxin: NADP+oxidoreductase.Front. Microbiol.10:373. 9.Yu W.1, Wang R.1, Li H., Liang J., Wang Y., Huang H., Xie H.,Wang S*. (2017) Green route to synthesis of valuable chemical 6-hydroxynicotine from nicotine in tobacco wastes using genetically engineeredAgrobacterium tumefaciensS33.Biotechnol. Biofuels.10:288. 10.Yu W.1, Wang R., Huang H., Xie H.,Wang S*. (2017) Periplasmicnicotinedehydrogenase NdhAButilizespseudoazurin asitsphysiologicalelectronacceptor inAgrobacterium tumefaciensS33.Appl. Environ. Microbiol.83(17):e01050-17. 11.Huang H.1, Yu W., Wang R., Li H., Xie H.,Wang S*.(2017) Genomic and transcriptomic analyses ofAgrobacterium tumefaciensS33 reveal the molecular mechanism of a novel hybrid nicotine-degrading pathway.Sci.Rep.7(1):4813. 12.Li H.1, Xie K.1, Yu W., Hu L., Huang H., Xie, H., Wang S*.(2016) Nicotine dehydrogenase complexed with 6-hydroxypseudooxynicotine oxidase involved in the hybrid nicotine-degrading pathway in Agrobacterium tumefaciensS33.Appl. Environ. Microbiol.82(6): 1745–1755. 13.Yu W.1, Li H., Xie K., Huang H., Xie, H.,Wang S*.(2016) Genome sequence of the nicotine-degradingAgrobacterium tumefaciensS33.J. Biotechnol.228:1-2. 14.Hu L.1, Huang H.1, Yuan H., Tao F., Xie H.,Wang S*. (2016) Rex inClostridium kluyveriis a global redox-sensing transcriptional regulator.J. Biotechnol.233:17-25. 15.Huang H.1, Hu L., Yu W., Li H., Tao F., Xie H.,Wang S*. (2016) Heterologous overproduction of 2[4Fe4S]- and [2Fe2S]-type clostridial ferredoxins and [2Fe2S]-type agrobacterial ferredoxin.Protein Expres. Purif.121:1-8. 16.Demmer J. K.1, Huang H.1,Wang S., Demmer U., Thauer R. K.*, and Ermler U*. (2015) Insights into flavin-based electron bifurcation via the NADH- dependent reduced ferredoxin: NADP oxidoreductase structure.J. Biol. Chem.290(36): 21985-21995. 17.Li H.1, Xie K.1, Huang H.,Wang S*. (2014) 6-Hydroxy-3-succinoylpyridine hydroxylase catalyzes a central step of nicotine degradation inAgrobacterium tumefaciensS33.PLoS ONE9(7): e103324. 18.Mock J.1,Wang S., Huang H., Kahnt J., Thauer R.K*. (2014) Evidence for a hexaheteromeric methylenetetrahydrofolate reductase inMoorella thermoacetica.J. Bacteriol.196:3303-3314 19.Wang, S.1, Huang, H., Kahnt, J., Mueller, A., Köpke, M, Thauer, R. K*. (2013) NADP-specific electron-bifurcating[FeFe]-hydrogenase in a functional complex with formate dehydrogenase inClostridium autoethanogenumgrown on CO.J. Bacterial.195:4373-4386 20.Wang S.1, Huang, H., Kahnt, J., Thauer, R. K*. (2013)Clostridium aciduricielectron-bifurcating formate dehydrogenase.Appl. Environ. Microbiol.79: 6176-6179. 21.Wang S.1, Huang H.1, Kahnt J., Thauer R. K*. (2013) A reversible electron-bifurcating ferredoxin- and NAD-dependent [FeFe]-hydrogenase (HydABC) inMoorella thermoacetica.J. Bacteriol.195:1267-1275.(并列第一作者) 22.Huang H.1,Wang S.1, Moll J., Thauer R. K*. (2012) Electron bifurcation involved in the energy metabolism of the acetogenic bacteriumMoorella thermoaceticagrowing on glucose or H2plus CO2.J. Bacteriol.194:3689-3699.(并列第一作者) 23.Wang S.1*, Huang H.,Xie K., Xu P*.(2012)Identification of nicotine biotransformation intermediates byAgrobacterium tumefaciensstrain S33 suggests a novel nicotine degradation pathway.Appl. Microbiol. Biotechnol.95:1567-1578. 24.Wang S.1, Huang H.1, Moll J., Thauer R. K*. (2010) NADP+reduction with reduced ferredoxin and NADP+reduction with NADH are coupled via an electron-bifurcating enzyme complex inClostridium kluyveri.J. Bacteriol.192: 5115-5123.(并列第一作者) 25.Wang S. N.1, Liu Z., Xu P*. (2009) Biodegradation of nicotine by a newly isolatedAgrobacteriumsp. strain S33.J. Appl. Microbiol.107: 838-847. 26.Tang H. Z.,Wang S. N., Ma L. Y., Meng X. Z., Deng Z. X., Zhang D. K., Ma C. Q., Xu P.* (2008) A novel gene encoding 6-hydroxy-3-succinoylpyridine hydroxylase in nicotine degradation byPseudomonas putidastrain S16.Appl.Environ.Microbiol.74: 1567-1574. 27.Wang S. N.1, Liu Z., Tang H. Z., Meng J., Xu P.*(2007) Characterization of environmentally friendly nicotine degradation byPseudomonas putidabiotype A strain S16.Microbiology-SGM153: 1556-1565. 28.Wang S. N.1, Xu P.*, Tang H. Z., Meng J., Liu X. L., Ma C. Q. (2005) ‘Green’ route to 6-hydroxy-3-succinoyl-pyridine from (S)-nicotine of tobacco waste by whole cells of aPseudomonassp.Environ. Sci. Technol.39: 6877-6880. 29.Wang S. N.1,Xu P.*, Tang H. Z., Meng J., Liu X. L., Huang J., Chen H., Du Y., Blankespoor H. D. (2004) Biodegradation and detoxification of nicotine in tobacco solid waste by aPseudomonassp.Biotechnol. Lett.26: 1493-1496. 30.王书宁1,杜毅,陈洪,许平*(2004)微生物代谢尼古丁研究进展.中国生物工程杂志24: 50-54.