2003-2005 美国麻省理工学院(MIT)博士后 2009 “新世纪百千万人才工程”国家级人选 2012 Spring学术期刊“Bioprocess and Biosystems Engineering”副主编 2014 全国杰出专业技术人才 2014 国家“万人计划”科技创新领军人才 2016 国家杰出青年科学基金 2017 中国化工学会候德榜化工科技创新奖 2024 英国皇家生物学会会士 2024 英国皇家化学学会会士

1：天然药物生物智造 2：天然抗肿瘤新药创制

1.Shan Wang1,*, Kewen Wu1,Ya-Jie Tang*, Hai Deng*. Dehydroamino acid residues in bioactive natural products. Natural Product Reports 2024, 41: 273-297.(1with equal contribution to this work) 2.Wei Zhao, Xiao-Di Zheng, Paula Yun-Zhi Tang, Hong-Mei Li, Xue Liu, Jian-Jiang Zhong,Ya-Jie Tang*. Advances of antitumor drug discovery in traditional Chinese medicine and natural active products by using multi-active components combination. Medicinal Research Reviews 2023, 1:1-31. 3.Ying Cong, Shu-Yue Zhang, Paula Yunzhi Tang, Hong-Mei Li, Xue Liu, Wei Zhao*,Ya-Jie Tang*. Conjugating 4β-NH-(5-aminoindazole)-podophyllotoxin and galectin-1-targeted aptamer for synergistic chemo-immunotherapy of hepatocellular carcinoma. Advanced Healthcare Materials 2023, 2203144:1-11. 4.Ying Cong, Shu-Yue Zhang, Hong-Mei Li,Tao Chen,Jian-Jiang Zhong,Wei Zhao*,Ya-Jie Tang*. A truncated DNA aptamer with high selectivity for estrogen receptor-positive breast cancer cells. International Journal of Biological Macromolecules 2023, 252:126450. 5.Wei Zhao1, Cong Ying1, Hong-Mei Li, Shengying Li, Yuemao Shen, Qingsheng Qi, Youming Zhang, Yue-zhong Li,Ya-Jie Tang*. Challenges and potential on improving druggability of podophyllotoxin-derived drugs in cancer chemotherapy. Natural Product Reports 2021, 38: 470-488. (1with equal contribution to this work) 6.Kai-Zhi Jia, Li-Wen Zhu, Xu-Dong Qu, Youming Zhang, Yue-zhong Li, Shengying Li, Yuemao Shen, Qingsheng Qi,Ya-Jie Tang*. EnzymaticO-glycosylation of etoposide aglycone by exploration of the substrate promiscuity for glycosyltransferases. ACS Synthetic Biology 2019, 8:2718-2725. 7.Wei Zhao1, Long He1, Tian-Le Xiang, andYa-Jie Tang*. Discover 4β-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain. European Journal of Medicinal Chemistry 2019, 170:73-86. (1with equal contribution to this work) 8.Li-Wen Zhu,Ya-Jie Tang*.Current advances of succinate biosynthesis in metabolically engineeredEscherichia coli. Biotechnology Advances 2017, 35:1040-1048. 9.Jun-Han Yu1, Li-Wen Zhu1, Shi-Tao Xia1,Hong-Mei Li, Ya-Ling Tang, Xin-Hua Liang, Tao Chen,Ya-Jie Tang*. Combinatorial optimization of CO2transport and fixation to improve succinate production by promoter engineering. Biotechnology and Bioengineering 2016, 113:1531-1541. (1with equal contribution to this work) 10.Li-Wen Zhu1, Xiao-Hong Li1, Lei Zhang, Hong-Mei Li, Jian-Hua Liu, Zhan-Peng Yuan, Tao Chen,Ya-Jie Tang*. Activation ofglyoxylate pathway without the activation ofitsrelated gene in succinate-producing engineeredEscherichia coli. Metabolic Engineering 2013, 20:9-19. (1with equal contribution to this work)