生举正
教授
所属大学: 山东大学
所属学院: 药学院
个人简介
2013-今:副教授,山东大学,药学院,生化与生物技术药物研究所、国家糖工程技术中心 2009-2012:博士后,美国北卡罗来纳大学教堂山分校,药学院,药物化学及天然产物系,糖生物学课题组 2006-2009:博士研究生,山东大学,药学院,微生物与生化药学专业 2003-2006:硕士研究生,山东大学,生命科学学院,微生物技术国家重点实验室微生物遗传与分子生物学专业 1999-2003:本科,山东师范大学生命科学学院
研究领域
糖胺聚糖类药物生物合成系统的构建与应用研究; 糖胺聚糖化学生物学研究; 新型抗凝血糖类药物的开发。
近期论文
·Deng, J.-Q.; Li, Y.; Wang, Y.-J.; Cao, Y.-L.; Xin, S.-Y.; Li, X.-Y.; Xi, R.-M.; Wang, F.-S.; Sheng, J.-Z. Biosynthetic Production of Anticoagulant Heparin Polysaccharides through Metabolic and Sulfotransferases Engineering Strategies. Nat Commun 2024, 15 (1), 3755. https://doi.org/10.1038/s41467-024-48193-5. ·Cao, Y.-L.; Deng, J.-Q.; Li, Y.; Xin, S.-Y.; Chen, Y.-J.; Li, X.-Y.; Cao, H.-Z.; Guo, X.-P.; Wang, F.-S.; Sheng, J.-Z. N-Difluoroacetylhexosamine as a Substrate-Engineering Precursor for Glycosylation Reactions. Org. Lett. 2024, 26 (36), 7739–7743. ·Wang, Y.-J. #; Li, L.; Yu, J.; Hu, H.-Y.; Liu, Z.-X.; Jiang, W.-J.; Xu, W.; Guo, X.-P.; Wang, F.-S.; Sheng, J.-Z. * Imaging of Escherichia Coli K5 and Glycosaminoglycan Precursors via Targeted Metabolic Labeling of Capsular Polysaccharides in Bacteria. Science Advances 2023, 9 (7), eade4770. ·Ma, D.-X#.; Zhou, Y.; Wu, L.-D.; Li, Z.-Y.; Jiang, W.-J.; Huang, S.-L.; Guo, X.-P.; Sheng, J.-Z*.; Wang, F.-S*. Enhanced Stability and Function of Probiotic Streptococcus Thermophilus with Self-Encapsulation by Increasing the Biosynthesis of Hyaluronan. ACS Appl. Mater. Interfaces 2022, 14 (38), 42963–42975. ·Sun, J.-Y.; Deng, J.-Q.; Du, R.-R.; Xin, S.-Y.; Cao, Y.-L.; Lu, Z.; Guo, X.-P.; Wang, F.-S.; Sheng, J.-Z*. Novel Β1,4 N-Acetylglucosaminyltransferase in de Novo Enzymatic Synthesis of Hyaluronic Acid Oligosaccharides. Appl Microbiol Biotechnol 2023, 107 (16), 5119–5129. ·Hu, H.-Y.; Deng, J.-Q.; Wang, Y.-J.; Li, Y.; Meng, X.-L.; Jiang, W.-J.; Wang, F.-S.; Sheng, J.-Z*. Cell-Based Assay Approaches for Glycosaminoglycan Synthase High-Throughput Screening: Development and Applications. ACS Chem. Biol. 2023, 18 (7), 1632–1641. ·Chen L-Z, Huang S-L, Hou J, Guo X-P, Wang F-S, Sheng J-Z* (2020) Cell-based and cell-free biocatalysis for the production of d-glucaric acid. Biotechnology for Biofuels 13:203. ·Yang J, Du Q, Li L, Wang T, Feng Y, Nieh M-P, Sheng J-Z*, Chen G* (2020) Glycosyltransferase-Induced Morphology Transition of Glycopeptide Self-Assemblies with Proteoglycan Residues. ACS Macro Lett 929–936. ·Meng D-H, Du R-R, Chen L-Z, Li M-T, Liu F, Hou J, Shi Y-K, Wang F-S, Sheng J-Z* (2019) Cascade synthesis of uridine-5′-diphosphate glucuronic acid by coupling multiple whole cells expressing hyperthermophilic enzymes. Microbial Cell Factories 18:118 . ·Zheng S, Hou J, Zhou Y, Fang H, Wang T-T, Liu F, Wang F-S, Sheng J-Z* (2018) One-pot two-strain system based on glucaric acid biosensor for rapid screening of myo-inositol oxygenase mutations and glucaric acid production in recombinant cells. Metabolic Engineering 49:212–219. ·Wang T-T, Zhu C-Y, Zheng S, Meng C-C, Wang T-T, Meng D-H, Li Y-J, Zhu H-M, Wang F-S, Sheng J-Z* (2018) Identification and characterization of a chondroitin synthase from Avibacterium paragallinarum. Appl Microbiol Biotechnol 102:4785–4797. ·Li Y-J, Yin F-X, Zhang X-K, Yu J, Zheng S, Song X-L, Wang F-S, Sheng J-Z* (2018) Characterization of heparan sulfate N-deacetylase/N-sulfotransferase isoform 4 using synthetic oligosaccharide substrates. Biochimica et Biophysica Acta (BBA) - General Subjects 1862:547–556. ·Zhu H-M, Sun B, Li Y-J, Meng D-H, Zheng S, Wang T-T, Wang F-S, Sheng J-Z* (2018) KfoA, the UDP-glucose-4-epimerase of Escherichia coli strain O5:K4:H4, shows preference for acetylated substrates. Appl Microbiol Biotechnol 102:751–761. ·F.-X. Yin, F.-S. Wang*, J.-Z. Sheng*, Uncovering the Catalytic Direction of Chondroitin AC Exolyase FROM THE REDUCING END TOWARDS THE NON-REDUCING END, J. Biol. Chem. 291 (2016) 4399–4406.