教育背景 博士起止时间：毕业院校及专业：2000/09-2004/07山东大学发育生物学 硕士起止时间：毕业院校及专业：1991/09-1994/07山东师范大学遗传学 学士起止时间：毕业院校及专业：1987/09-1991/07山东师范大学生物学 工作经历 2013/09-至今山东大学微生物技术国家重点实验室教授 2006/09-2013/08山东大学微生物技术国家重点实验室副教授 2004/09-2006/08山东大学微生物技术国家重点实验室讲师 1996/09-2004/08山东大学医学院生物化学系讲师 1994/09-1996/08山东大学医学院生物化学系助教

1. 代谢疾病与微生物关系研究：微生物菌群与人类代谢疾病之间的关系及其在疾病发生发展过程中的作用机制；2. 肠胃道微生物生态和代谢组研究：胃肠道菌群结构及代谢产物对宿主代谢的影响；3. 肠胃道病原菌的致癌机制研究：病原菌与宿主粘膜细胞相互作用过程中的信号传递，影响宿主免疫调节和诱导肿瘤发生的过程。病原菌致癌的分子机制。

1. Wang YB, Ren MB, Wang YF, Wang L, Liu H, Shi M*, Zhong YH*. Constitutive overexpression of cellobiohydrolase 2 in Trichoderma reesei reveals its ability to initiate cellulose degradation. Engineering Microbiology3, 2023, 100059. 2. Wang L, Xie Y, Chang J, Wang J, Liu H, Shi M*, Zhong YH*.A novel sucrose-inducible expression system and its application for production of biomass-degrading enzymes in Aspergillus niger. Biotechnol Biofuels Bioprod. 2023, 16:23 3. Liu B, Li Y, Suo L, Zhang W, Cao H, Wang R, Luan J, Yu X, Dong L, Wang W, Xu S, Lu S, Shi M*. Characterizing microbiota and metabolomics analysis to identify candidate biomarkers in lung cancer. Front Oncol, 2022, 12:1058436. 4. Shi M, Wang HN, Xie ST, Luo Y, Sun CY, Chen XL, Zhang YZ. Antimicrobial peptaibols, novel suppressors of tumor cells, targeted calcium-mediated apoptosis and autophagy in human hepatocellular carcinoma cells. Mol Cancer, 2010, 9:26-41. 5. Shi M, Zhang T, Sun L, Luo Y, Liu DH, Xie ST, Song XY, Wang GF, Chen XL, Zhou BC, Zhang YZ. Calpain, Atg5 and Bak play important roles in the crosstalk between apoptosis and autophagy induced by influx of extracellular calcium. Apoptosis, 2013, 18:435-451. 6. Shi M, Chen L, Wang XW, Zhang T, Zhao PB, Song XY, Sun CY, Chen XL, Zhou BC, Zhang YZ. Antimicrobial peptaibols from Trichoderma pseudokoningii induce programmed cell death in plant fungal pathogens. Microbiology,2012, 158(Pt 1):166-175. 7. Luo Y, Zhang DD, Dong XW, Zhao PB, Chen LL, Song XY, Wang XJ, Chen XL, Shi M*, Zhang YZ. Antimicrobial peptaibols induce defense responses and systemic resistance in tobacco against tobacco mosaic virus. FEMS Microbiol Lett, 2010, 313:120-126. 8. Zhang XY, Han XX, Chen XL, Dang HY, Xie BB, Qin QL, Shi M*, Zhou BC, Zhang YZ. Diversity of cultivable protease-producing bacteria in sediments of Jiaozhou Bay, China. Front Microbiol, 2015, 6:1021. 9. Liu C, Zhang XY, Song XY, Su HN, Qin QL, Xie BB, Chen XL, Zhang YZ, Shi M*. Algimonas arctica sp. nov., isolated from intertidal sand, and emended description of the genus Algimonas. Int J Syst Evol Microbiol, 2015, 65:3256-3261. 10. Li DD, Peng M, Wang N, Wang XJ, Zhang XY, Chen XL, Su HN, Zhang YZ, Shi M*. Arcticibacterium luteifluviistationis gen. nov., sp. nov., isolated from Arctic seawater. Int J Syst Evol Microbiol, 2017, 67:664-669. 11. Li DD, Liu C, Zhang YQ, Wang XJ, Wang N, Peng M, Song XY, Su HN, Zhang XY, Zhang YZ, Shi M*. Flavobacterium arcticum sp. nov., isolated from Arctic seawater. Int J Syst Evol Microbiol, 2017, 67:1070-1074. 12. Wang N, Xu F, Zhang XY, Chen XL, Qin QL, Zhou BC, Zhang YZ, Shi M*. Changchengzhania lutea gen. nov., sp. nov., a new member of the family Flavobacteriaceae isolated from Antarctic intertidal sediment. Int J Syst Evol Microbiol, 2017,67:5187-5192. 13. Shi M*, Yan SG, Xie ST, Wang HN. Tip30-induced apoptosis requires translocation of Bax and involves mitochondrial release of cytochrome c and Smac/DIABLO in hepatocellular carcinoma cells. Biochim Biophys Acta, 2008, 1783:263-274. 14. Zhao J, Zhang X, Shi M, Xu H, Jin J, Ni H, Yang S, Dai J, Wu M, Guo Y. TIP30 inhibits growth of HCC cell lines and inhibits HCC xenografts in mice in combination with 5-FU. Hepatology, 2006，44:205-215.