沈月毛 照片

沈月毛

教授

所属大学: 山东大学

所属学院: 药学院

邮箱:
yshen@sdu.edu.cn

个人主页:
https://www.pharm.sdu.edu.cn/info/1058/4164.htm

个人简介

1986.07毕业于安徽师范大学化学系,获学士学位; 1989.07毕业于中国科学院昆明植物研究所,获天然产物化学硕士学位; 1995.08-1998.08在美国华盛顿大学化学系留学并从事博士学位论文研究; 1999.11获中国科学院植物学博士学位; 1989.07-2004.01在中国科学院昆明植物研究所先后任实习研究员、助理研究员、副研究员和研究员; 2004.2-2010.06任厦门大学生命科学学院教授; 2010.07至今任山东大学药学院和微生物技术国家重点实验室教授。

研究领域

天然产物的合成生物学与化学生物学。

学术兼职

厦门大学生命科学学院客座教授;中国科学院南海海洋研究所客座教授。中国化学会会员;国家级、省部级科技项目和人才评审专家;多家国际著名期刊审稿人。

近期论文

1.Feng Ye, Xia Zhao, Yanrong Shi, Yanlei Hu, Yanjiao Ding, Chunhua Lu, Yaoyao Li, Haoxin Wang, Gang Lu,*Yuemao Shen*(2023). Deciphering the timing of naphthalenic ring formation in the biosynthesis of 8‑deoxyrifamycins. Org. Lett. 2023, 25, 6474−6478. 2.Jie Qi, Guangsen Xu, Xiaoxia Wu, Chunhua Lu,Yuemao Shen*, Baobing Zhao*(2023). PELI1 and EGFR cooperate to promote breast cancer metastasis.Oncogenesis,202312(1): 9. doi: 10.1038/s41389-023-00457-3. 3.Guangsen Xu, Zhiying Li, Yanjiao Ding, Yuemao Shen *(2022). Discovery of 1,2-diphenylethene derivatives as human DNA topoisomerase II catalytic inhibitors and antitumor agents European Journal of Medicinal Chemistry 243: 114706. https://doi.org/10.1016/j.ejmech.2022.114706. 4.Yanrong Shi,Feng Ye,Yuliang Song,Xiaochun Zhang,Chunhua Lu,Yuemao Shen* (2021).Rifamycin W analogues fromAmycolatopsis mediterraneiS699 Δrif-orf5 Strain. Biomolecules, 11(7): 920. 5.Yanrong Shi, Juanli Zhang, Xiuyu Tian, Xingkang Wu, Tianhong Li, Chunhua Lu,Yuemao Shen*(2019). Isolation of 11,12-seco-rifamycin W derivatives reveals a cleavage pattern of the rifamycinansachain.Org. Lett.21, 900–903. 6.Xiaoman Li, Xingkang Wu, andYuemao Shen* (2019). Identification of the bacterial maytansinoid gene clusterascprovides insights into the Post-PKS modifications of ansacarbamitocin biosynthesis,Org. Lett.21, 5823–5826. 7.Rentai Song, Haixia Shi, Jing Zhu, Haoxin Wang*,Yuemao Shen* (2019). A single-component flavoenzyme catalyzed regioselective halogenation of pyrone in the biosynthesis of venemycins. ACS Chem. Biol. 14, 2533−2537 8.Chuanpeng Liang, Xingkang Wu, Zhenyu Li, Jing Zhu, Chunhua Lu,Yuemao Shen* (2018). Design, synthesis and pharmacological evaluation of N-(5-chloro-2,4-dihydroxybenzoyl)-(R)-N-arylmethyl-1,2,3,4-tetrahydro-3-isoquinolinecarboxamides as potent Hsp90 inhibitors. Eur. J. Med. Chem. 143, 85–96. 9.Xingkang Wu, Zhenyu Li,Yuemao Shen⁎(2018).The small molecule CS1 inhibits mitosis and sister chromatid resolution in HeLa cells. BBA - General Subjects 1862, 1134–1147 10.Shanren Li, Xiuli Wu, Limei Zhang,Yuemao Shen,* and Liangcheng Du* (2017). Activation of a cryptic gene cluster in Lysobacter enzymogenes reveals a module/domain portable mechanism of nonribosomal peptide synthetases in the biosynthesis of pyrrolopyrazines.Org. Lett. 19, 5010–5013.