彭鹏
教授
所属大学: 山东大学
所属学院: 国家糖工程技术研究中心
个人简介
教育经历 2006.9 – 2011.7 北京大学药学院,天然药物及仿生药物国家重点实验室 化学生物学博士(导师:叶新山 教授) 2002.9 – 2006.7 兰州大学化学与化工学院,化学基地班 理学学士(论文指导老师:曹小平教授) 工作经历 2016.6 – 今 山东大学国家糖工程技术研究中心,研究员、教授 2014.2 – 2016.5 Konstanz大学化学系,博士后(合作导师:Richard R. Schmidt 教授) 2012.8 – 2014.2 香港大学化学系,博士后研究助理(合作导师:李学臣 教授)
研究领域
新的寡糖化学合成方法的发展。 生物活性寡糖(肿瘤、病毒、细菌相关糖抗原)的合成及药物活性评价。 以糖类化合物为基础的抗菌、抗癌疫苗的研制(设计、合成及评价)。
近期论文
1. Tianlu Li, Tong Li, Yue Yang, Haoru Zhuang, Jianwu Lv, Ning Zhou, Miaomiao Zhang, Fengshan Wang, Yiqun Geng, Richard R. Schmidt*, Peng Peng* Concise Synthesis of Lactococcus garvieae Lipoteichoic Acids Through an Additive-Modulated Preactivation Protocol and the Immunological Studies. CCS Chem. 2024, 6, 403-414. 2. Yue Yang, Tong Li, Huiran Hao, Ju-Zheng Sheng, Tianlu Li*, Peng Peng* Convergent Synthesis of Glycoalkaloids Solasonine and its Saponin Derivative. Chem. Commun. 2024, 60, 9753-9756. 3. Tianlu Li, Miaomiao Zhang, Panpan Lv, Yue Yang, Richard R. Schmidt*, Peng Peng* Synthesis of Core M3 Matriglycan Constituents via an Additive-Controlled 1,2-cis-Xylopyranosylation with O-Xylosyl Imidates as Donors. J. Org. Chem. 2024, 89, 804-809. 4. Tianlu Li, Tong Li, Yue Yang, Yongshun Qiu, Yingguo Liu, Miaomiao Zhang, Haoru Zhuang, Richard R. Schmidt*, Peng Peng* Reaction Rate and Stereoselectivity Enhancement in Glycosidations with O-Glycosyl Trihaloacetimidate Donors due to Catalysis by a Lewis Acid–Nitrile Cooperative Effect. J. Org. Chem. 2024, 89, 7865-7876. 5. Dengxian Fu, Shuxin Zhang, Bingbing Xu, Peng Peng, Qian Wan*, Jing Zeng* Selective Reduction Leading to 3,5-cis-3-Aminosugars: Synthesis and Stereoselective Glycosylation. J. Org. Chem. 2023, 88, 727-731. 6. Miaomiao Zhang, Tianlu Li, Peng Peng* Recent Development in Additive Modulated Stereoselective Glycosidation Reactions. J. Carbohydr. Chem. 2022, 40, 339-360. 7. Tianlu Li, Tong Li, Youqin Zhang, Richard R. Schmidt*, Peng Peng* Preparation of Tea Aroma Precursor Glycosides: An Efficient and Sustainable Approach via Chemical Glycosidation. J. Agric. Food. Chem. 2022, 70, 2320-2327. 8. Tianlu Li*, Youqin Zhang, Tong Li, Haoru Zhuang, Fengshan Wang, Ning Wang, Richard R. Schmidt, Peng Peng Divergent Synthesis of Core m1, Core m2 and Core m3 O-Mannosyl Glycopeptides via a Chemoenzymatic Approach. Chin. J. Chem . 2022, 40, 1571-1577. 9. Tianlu Li*, Tong Li, Yajing Sun, Yue Yang, Panpan Lv, Fengshan Wang, Hongxiang Lou, Richard R. Schmidt*, Peng Peng* Regioselective Benzoylation of Unprotected β-glycopyranosides with Benzoyl Cyanide and an Amine Catalyst – Application to Saponin Synthesis. Org. Chem. Front. 2021, 8, 260-265. 10. Tong Li+, Tianlu Li+, Haoru Zhuang, Fengshan Wang, Richard R. Schmidt*, Peng Peng*, O-Glycosyl Trichloroacetimidates as Glycosyl Donors and Platinum(IV) Chloride as a Dual Catalyst Permitting Stereo- and Regioselective Glycosidations. ACS Catal. 2021, 11, 10279-10287. 11. Wei Song, Yong Sun, Lintao Xu, Yajing Sun, Tianlu Li, Peng Peng*, Hongxiang Lou, Synthesis of nature product kinsenoside analogues with anti-inflammatory activity. Bioorg. Med. Chem. 2021, 29, 115854. 12. Wenzheng Wang, Yajing Sun, Peng Peng, Guofeng Gu, Guoying Du, Li Xu*, Xiao, Min* Two-Step Enzymatic Conversion of Rebaudioside A into a Mono-α-1,4-Glucosylated Rebaudioside A Derivative. J. Agric. Food. Chem. 2021, 69, 2522-2530. 13. Tianlu Li+, Tong Li+, Michael Linseis+, Fengshan Wang, Rainer F. Winter, Richard R. Schmidt*, Peng Peng* Catalytic Regioselective Benzoylation of 1,2-trans-Diols in Carbohydrates with Benzoyl Cyanide: The Axial Oxy Group Effect and the Action of Achiral and Chiral Amine Catalysts. ACS Catal. 2020, 10, 11406-11416. 14. Tong Li+, Tianlu Li+, Tongxiao Cui, Yajing Sun, Fengshan Wang, Hongzhi Cao, Richard R. Schmidt*, Peng Peng* Regioselective One-Pot Benzoylation of Triol and Tetraol Arrays in Carbohydrates. Org. Lett. 2018, 20, 3862-3865. 15. Peng Peng, Richard R. Schmidt* Acid–Base Catalysis in Glycosidations: A Nature Derived Alternative to the Generally Employed Methodology. Acc. Chem. Res. 2017, 50, 1171-1183. 16. Peng Peng, Michael Linseis, Rainer F. Winter and Richard R. Schmidt* Regioselective Acylation of Diols and Triols: The Cyanide Effect J. Am. Chem. Soc. 2016, 138, 6002-6009. 17. Peng Peng, Richard R. Schmidt* An Alternative Reaction Course in O-glycosidation with O-glycosyl Trichloroacetimidates as Glycosyl Donors and Lewis Acidic Metal Salts as Catalyst: Acid-Base Catalysis with Gold Chloride-Glycosyl Acceptor Adducts J. Am. Chem. Soc. 2015, 137, 12653-12659. 18. Peng Peng, Yiqun Geng, Göttker-Schnetmann, Inigo and Richard R. Schmidt* 2-Nitro-thioglycosides: α- and β-Selective Generation and Their Potential as β-Selective Glycosyl Donors Org. Lett. 2015, 17, 1421-1424. 19. Peng Peng, Han Liu, Jianzhi Gong, John M. Nicholls, Xuechen Li* A Facile Synthesis of Sialylated Oligolactosamine Glycans from Lactose via the Lafont Intermediate Chem. Sci. 2014, 5, 3634-3639. 20. Peng Peng, De-Cai, Xiong, Xin-Shan Ye* Ortho-Methylphenylthioglycosides as Glycosyl Building Blocks for Preactivation-based Oligosaccharide Synthesis Carbohydr. Res. 2014, 384, 1-8. 21. Peng Peng, Xin-Shan Ye* O,O-Dimethylthiophosphonosulfenyl Bromide-silver Triflate: a New Powerful Promoter System for the Preactivation of Thioglycosides Org. Biomol. Chem. 2011, 9, 616-622. 22. Yinping Li, Weiying Hong, Henan Zhang, Tiantian Zhang, Zhiyong Chen, Shiling Yuan, Peng Peng,* Min Xiao,* Li Xu* Photothermally triggered cytosolic drug delivery of glucose functionalized polydopamine nanoparticles in response to tumor microenvironment for the GLUT1-targeting chemo-phototherapy. J. Control release 2020, 317, 232-245. 23. Ye Jinfeng, Liu Xian -Wei, Peng Peng, Yi Wen, Chen Xi, Wang Fengshan, Cao Hong Zhi* Diversity-Oriented Enzymatic Modular Assembly of ABO Histo-blood Group Antigens. ACS Catal. 2016, 6, 8140-8144.