鲁春华 照片

鲁春华

教授

所属大学: 山东大学

所属学院: 药学院

邮箱:
ahua0966@sdu.edu.cn

个人主页:
https://www.pharm.sdu.edu.cn/info/1058/4150.htm

个人简介

1994年9月~1998年6月:云南大学生物系,获学士学位; 1998年9月~2004年3月:中科院昆明植物研究所,获植物学博士学位; 2004年6月~2010年7月:厦门大学生物系,讲师,副教授; 2010年7月~至今:山东大学药学院,副教授,教授。

研究领域

活性天然产物发现 基于细菌毒力系统的抗感染药物的发现及其机制研究

近期论文

1.Zeyuan Gao, Yuliang Song, Xintong Li, Tianhong Li,Chunhua Lu*, Yuemao Shen (2022). Effects of hydrolysable tannins fromTerminalia citrinaon T3SS and their intestinal metabolite urolithin B represses Salmonella T3SS through Hha–H-NS–HilD–HilC–RtsA–HilA regulatory pathway. Microbial Pathogenesis, 173: 105837. 2.Rongrong Gao, Zhifang Liu, Xuefei Yang, Yuliang Song, Xiaoyun Cui, Jiyuan Yang,Chunhua Lu*, Yuemao Shen (2021). Specialised metabolites as chemotaxonomic markers ofCoptosapelta diffusa, supporting its delimitation as sisterhood phylogenetic relationships with Rubioideae. Phytochemistry 192:112929. 3.Yuliang Song, Guangsen Xu, Chaoqun Li, Zhiying Li,Chunhua Lu*, Yuemao Shen (2021). Structural optimization of natural product fusaric acid to discover novel T3SS inhibitors of Salmonella. Biochem. Biophy. Res. Commun. 582:72-76. 4.Wu Yang, Yang Xuefei, Zhang Dongdong,Lu Chunhua* (2020). Myricanol inhibits the type III secretion systemofSalmonella entericaSerovar Typhimurium by interfering with the DNA-binding activity of HilD. Front. Microbiol. 11:571217. 5.Jianxiong Wang, Wen Li, Haoxin Wang,Chunhua Lu* (2018). Pentaketide ansamycin microansamycins A−I fromMicromonosporasp. reveal diverse post-PKS modifications. Org. Lett., 20: 1058−1061. 6.Juanli Zhang, Shanren Li, Xingkang Wu, Zhixing Guo,Chunhua Lu*, Yuemao Shen (2017). Nam7 hydroxylase is responsible for the formation of the naphthalenic ring in the biosynthesis of neoansamycins. Org. Lett., 19: 2442−2445. 7.Chunhua Lu, Fei Xie, Chuan Shan, Yuemao Shen* (2017). Two novel cyclic hexapeptides from the genetically engineeredActinosynnema pretiosum. Appl. Microbiol. Biotech, 101(6): 2273–2279. 2273–2279. 8.Shanren LiÑ,Chunhua LuÑ, Xiaoyan Chang, Yuemao Shen(2016)Constitutive overexpression of asm18 increases the production and diversity of maytansinoids in Actinosynnema pretiosum. Appl Microbiol Biotechnol., 100: 2641–2649 (ÑFirst coauthor). 9.Guishi Zhao,Shanren Li,,Zhixing Guo,Mingwei Sun,Chunhua Lu*(2015). Overexpression of div8 increases the production and diversity of divergolides inStreptomycessp. W112. RSC Adv., 2015, 5, 98209-98214. 10.Mingwei Sun, Xiaomei Zhang, Huilin Hao, Wenjun Li*, and Chunhua Lu*(2015).Nocarbenzoxazoles A–G, Benzoxazoles Produced by HalophilicNocardiopsis lucentensisDSM 44048.J. Nat. Prod., 78 (8): 2123–2127.