林贵梅 照片

林贵梅

教授

所属大学: 山东大学

所属学院: 药学院

邮箱:
guimeilin@sdu.edu.cn

个人主页:
https://www.pharm.sdu.edu.cn/info/1058/4127.htm

个人简介

教育经历 2001-09至2006-06,浙江大学,物理化学,博士。 1997-09至2001-06,曲阜师范大学,化学教育,学士。 科研与学术工作经历 2006.7-2013.12山东大学药学院讲师 2009.5-2011.12山东大学药学院天然药物化学研究所博士后 2013.1-2014.1美国北卡罗来纳大学教堂山分校访问学者 2014.1-2023.8山东大学药学院博士生导师,副教授 2023.9-至今山东大学药学院博士生导师,教授

研究领域

药剂学、生物物理化学

近期论文

1.Fu, M., Qiu, S., Wang, F.,Lin, G., Shi, Y., Qin, Z., Tang, B., Li, X., Zhang, J. (2023). Enhanced Osteogenic Properties of Bone Repair Scaffolds through Synergistic Effects of Mechanical and Biochemical Stimulation. Advanced Engineering Materials, 25 (13). 2.Wang, W., Shi, Y.,Lin, G., Tang, B., Li, X., Zhang, J., Ding, X., Zhou, G. (2023). Advances in Mechanical Properties of Hydrogels for Cartilage Tissue Defect Repair. Macromolecular Bioscience, 23 (7). 3.Zhou, G., Wang, F.,Lin, G., Tang, B., Li, X., Ding, X., Wang, W., Zhang, J., Shi, Y. (2023). Novel coatings for the continuous repair of human bone defects. Colloids and Surfaces B: Biointerfaces, 222. 113127 4.Wu, Y., Wang, F., Shi, Y.,Lin, G., Qiao, J., Wang, L. (2022).Molecular dynamics simulation of hyaluronic acid hydrogels: Effect of water content on mechanical and tribological properties.Computer Methods and Programs in Biomedicine, 226,107169. 5.Fu, X., Shi, Ye microenvironment. Journal of controlled release : official journal of the Controlled Rele., Zang, H., Wang, Q., Wang, Y., Wu, H., Qiu, S., Shen, H., Mo, F., Zhang, Y., &Lin, G.(2022). Combination of oxaliplatin and POM-1 by nanoliposomes to reprogram the tumor immun ase Society, 347, 1–13. 6.Zhang, Y., Tang, B., Xin, Y., Wu, Q., Liu, L., Wang, Y., Zhu, K.,Lin, G.,& Wang, H. (2022). Nanobubbles loaded with carbon quantum dots for ultrasonic fluorescence dual detection.Journal of Zhejiang University. Science. B,23(9), 778–783. 7.Wu, Y., Li, X., Wang, Y., Shi, Y., Wang, F.,Lin, G.(2022).Research progress on mechanical properties and wear resistance of cartilage repair hydrogel.Materials and Design,216,110575, . 8.Liu, H., Wang, L.,Lin, G., Feng, Y. (2022). Recent progress in the fabrication of flexible materials for wearable sensors.Biomaterials Science,10 (3). 614-632. 9.Fu, M., Wang, F., &Lin, G. (2021). Design and research of bone repair scaffold based on two-way fluid-structure interaction. Computer methods and programs in biomedicine, 204, 106055. 10.Zhou, S., Li, J., Yu, J., Wang, Y., Liu, H.,Lin, G., He, Z., & Wang, Y. (2021). Unique flower-like Cur-metal complexes loaded liposomes for primary and metastatic breast cancer therapy. Materials science & engineering. C, Materials for biological applications, 121, 111835. 11.Zhou, S., Li, J., Yu, J., Yang, L., Kuang, X., Wang, Z., Wang, Y., Liu, H.,Lin, G., He, Z., Liu, D., & Wang, Y. (2021). A facile and universal method to achieve liposomal remote loading of non-ionizable drugs with outstanding safety profiles and therapeutic effect. Acta pharmaceutica Sinica. B, 11(1), 258–270. 12.Jiang, B., Gao, Y., Shi, Y., Qi, T., Qiu, S.,Lin, G., Feng, Y. (2021). Numerical simulation analysis and structural optimization design of microspheres prepared by a high-pressure homogenizer.Separation and Purification Technology, 277, 119374, . 13.Fu, X., Shi, Y., Qi, T., Qiu, S., Huang, Y., Zhao, X., Sun, Q., &Lin, G*. (2020). Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting. Signal transduction and targeted therapy, 5(1), 262. 14.Yu J, Wang Y, Zhou S, Li J, Wang J, Chi D, Wang X,Lin G, He Z, Wang Y. Remote loading paclitaxel-doxorubicin prodrug into liposomes for cancer combination therapy. Acta Pharm Sin B. 2020 Sep;10(9):1730-1740. 15.Wang, Z., Lin, X., Chi, D., Xu, Z.,Lin, G., Liu, H., Sun, J., He, Z., & Wang, Y. (2020). Single-ligand dual-targeting irinotecan liposomes: Control of targeting ligand display by pH-responsive PEG-shedding strategy to enhance tumor-specific therapy and attenuate toxicity. International journal of pharmaceutics, 587, 119680. 16.Kong, D., Shi, Y., Gao, Y., Fu, M., Kong, S., &Lin, G. (2020). Preparation of BMP-2 loaded MPEG-PCL microspheres and evaluation of their bone repair properties. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 130, 110516. 17.Gao, Y., Shi, Y., Fu, M., Feng, Y.,Lin, G., Kong, D., & Jiang, B. (2020). Simulation study of the effects of interstitial fluid pressure and blood flow velocity on transvascular transport of nanoparticles in tumor microenvironment. Computer methods and programs in biomedicine, 193, 105493. 18.Yan, W.,Lin, G., Zhang, R., Liang, Z., & Wu, W. (2020). Studies on the bioactivities and molecular mechanism of antioxidant peptides by 3D-QSAR, in vitro evaluation and molecular dynamic simulations. Food & function, 11(4), 3043–3052. 19.Fu, X., Shi, Y., Wang, H., Zhao, X., Sun, Q., Huang, Y., Qi, T., &Lin, G*. (2019). Ethosomal Gel for Improving Transdermal Delivery of Thymosin β-4. International journal of nanomedicine, 14, 9275–9284. 20.Huang, Y., Shi, Y., Wang, Q., Qi, T., Fu, X., Gu, Z., Zhang, Y., Zhai, G., Zhao, X., Sun, Q., &Lin, G*. (2019). Enzyme responsiveness enhances the specificity and effectiveness of nanoparticles for the treatment of B16F10 melanoma. Journal of controlled release : official journal of the Controlled Release Society, 316, 208–222. 21.Gao, Y., Shi, Y., Wang, L., Kong, S., Du, J.,Lin, G., & Feng, Y. (2020). Advances in mathematical models of the active targeting of tumor cells by functional nanoparticles. Computer methods and programs in biomedicine, 184, 105106 22.Huang, Y., Gu, Z., Fan, Y., Zhai, G., Zhao, X., Sun, Q., Shi, Y., &Lin, G*. (2019). Inhibition of the adenosinergic pathway: the indispensable part of oncological therapy in the future. Purinergic signalling, 15(1), 53–67. 23.Liu, M., Khan, A. R., Ji, J.,Lin, G., Zhao, X., & Zhai, G. (2018). Crosslinked self-assembled nanoparticles for chemo-sonodynamic combination therapy favoring antitumor, antimetastasis management and immune responses. Journal of controlled release : official journal of the Controlled Release Society, 290, 150–164. 24.Gu, Z., Wang, Q., Shi, Y., Huang, Y., Zhang, J., Zhang, X., &Lin, G*. (2018). Nanotechnology-mediated immunochemotherapy combined with docetaxel and PD-L1 antibody increase therapeutic effects and decrease systemic toxicity. Journal of controlled release : official journal of the Controlled Release Society, 286, 369–380. 25.Gu, Z., Shaikh, A. S., &Lin, G*. (2018). Novel 'Stereoscopic Response' Strategy Can Be Used in Combination Therapy. Critical reviews in therapeutic drug carrier systems, 35(4), 369–390. 26.Gu, Z., Chang, M., Fan, Y., Shi, Y., &Lin, G*. (2017). NGR-modified pH-sensitive liposomes for controlled release and tumor target delivery of docetaxel. Colloids and surfaces. B, Biointerfaces, 160, 395–405. 27.Fan, Y., Wang, Q.,Lin, G*., Shi, Y., Gu, Z., & Ding, T. (2017). Combination of using prodrug-modified cationic liposome nanocomplexes and a potentiating strategy via targeted co-delivery of gemcitabine and docetaxel for CD44-overexpressed triple negative breast cancer therapy. Acta biomaterialia, 62, 257–272. 28.Han, X., Chen, J., Jiang, M., Zhang, N., Na, K., Luo, C., Zhang, R., Sun, M.,Lin, G., Zhang, R., Ma, Y., Liu, D., & Wang, Y. (2016). Paclitaxel-Paclitaxel Prodrug Nanoassembly as a Versatile Nanoplatform for Combinational Cancer Therapy. ACS applied materials & interfaces, 8(49), 33506–33513. 29.Fan, Y., Chen, C., Huang, Y., Zhang, F., &Lin, G*. (2017). Study of the pH-sensitive mechanism of tumor-targeting liposomes. Colloids and surfaces. B, Biointerfaces, 151, 19–25. 30.Zuo, T., Guan, Y., Chang, M., Zhang, F., Lu, S., Wei, T., Shao, W., &Lin, G*. (2016).RGD(Arg-Gly-Asp) internalized docetaxel-loaded pH sensitive liposomes: Preparation, characterization and antitumor efficacy in vivo and in vitro. Colloids and surfaces. B, Biointerfaces, 147, 90–99. 31.Chang, M., Zhang, F., Wei, T., Zuo, T., Guan, Y.,Lin, G*., & Shao, W. (2016). Smart linkers in polymer-drug conjugates for tumor-targeted delivery. Journal of drug targeting, 24(6), 475–491. 32.Zhang, F., Zhang, Y., Wang, K., Zhu, X.,Lin, G., Zhao, Z., Li, S., Cai, J., & Cao, J. (2015). Diallyl trisulfide inhibits naphthalene-induced oxidative injury and the production of inflammatory responses in A549 cells and mice. International immunopharmacology, 29(2), 326–333. 33.Zhang, F., Chang, M., Yu, Y., Zhang, Y.,Liu, G*., Wei, T., Zuo, T., Guan, Y., Lin, G., & Zhao, Z. (2015). Preparation and evaluation of lipid emulsified docetaxel-loaded nanoparticles. The Journal of pharmacy and pharmacology, 67(11), 1546–1555. 34.Shi, Y. B., Liu, L., Shao, W., Wei, T., &Lin, G*. M. (2015). Microcalorimetry studies of the antimicrobial actions of Aconitum alkaloids. Journal of Zhejiang University. Science. B, 16(8), 690–695. 35.Guan, Y., Zuo, T., Chang, M., Zhang, F., Wei, T., Shao, W., &Lin, G*. (2015). Propranolol hydrochloride-loaded liposomal gel for transdermal delivery: Characterization and in vivo evaluation. International journal of pharmaceutics, 487(1-2), 135–141. 36.Chang, M., Lu, S., Zhang, F., Zuo, T., Guan, Y., Wei, T., Shao, W., &Lin, G*. (2015). RGD-modified pH-sensitive liposomes for docetaxel tumor targeting. Colloids and surfaces. B, Biointerfaces, 129, 175–182. 37.Lin, G*., Zhang, H., & Huang, L. (2015). Smart polymeric nanoparticles for cancer gene delivery. Molecular pharmaceutics, 12(2), 314–321. 38.Zhang, H., Wang, K.,Lin, G*., & Zhao, Z. (2014). Antitumor mechanisms of S-allyl mercaptocysteine for breast cancer therapy. BMC complementary and alternative medicine, 14, 270. 39.Zhang, H., Li, R. Y., Lu, X., Mou, Z. Z., &Lin, G*. M. (2012). Docetaxel-loaded liposomes: preparation, pH sensitivity, pharmacokinetics, and tissue distribution. Journal of Zhejiang University. Science. B, 13(12), 981–989. 40.Lin, G. M., Liu, L., & Shao, W. (2011). Microcalorimetry studies on the antibacterial effect of crude monkshood polysaccharide. Journal of Zhejiang University. Science. B, 12(7), 563–567.