2022.09 -至今，山东大学，药学院，教授； 2016.09 – 2022.08，山东大学，药学院，副教授； 2012.10 - 2016.09，山东大学，药学院，讲师； 2010.10 - 2012.10，山东大学，药学院，博士后； 2005.09 - 2010.07，厦门大学，生命科学学院，博士； 2008.10 - 2009.10，美国内布拉斯加州立大学-林肯分校，化学系，联合培养； 2001.09 - 2005.06，厦门大学，生命科学学院，本科。

新资源溶杆菌中新型抗菌及抗肿瘤活性成分的发现，以及相关的生物合成机制和作用机理研究。

1.Li, X.#,Liu, Q.#,Zou, H., Luo, J., Jiao, Y., Wang, H., Du, L., Shen, Y.,Li, Y.*(2023) Discovery and biosynthesis of pseudoamides reveal enzymatic cyclization of the polyene precursor to 5-5 bicyclic tetramate macrolactams.ACS Catal13, 4760-4767. 2. Zou, H.#, Xia, X.#, Xu, Q., Wang, H., Shen, Y.,Li, Y.*(2022) Discovery of oxidized polycyclic tetramate macrolactams bearing one or two rings through combinatorial pathway reassembly,Org Lett24, 6515-6519. 3. Luo, J.#, Li, X.#, Wang, H., Du, L., Shen, Y.,Li, Y.*(2022) Identification and characterization of the 28-N-methyltransferase involved in HSAF analogue biosynthesis.Biochemistry61, 2879-2883. 4. Yan, Y., Wang, H., Song, Y., Zhu, D., Shen, Y.,Li, Y.*(2021) Combinatorial biosynthesis of oxidized combamides using cytochrome P450 enzymes from different polycyclic tetramate macrolactam pathways.ACS Synth Biol10, 2434-2439. 5. Jiao, Y.#, Liu, Y.#, Wang, H., Zhu, D., Shen, Y. andLi, Y.*(2020) Expression of the clifednamide biosynthetic pathway inStreptomycesgenerates 27,28-seco-derivatives,J Nat Prod83, 2803-2808. 6. Sang, M., Wang, H., Shen, Y., Rodrigues de Almeida, N., Conda-Sheridan, M., Li, S.,Li, Y.*and Du, L.* (2019) Identification of an anti-MRSA cyclic lipodepsipeptide, WBP-29479A1, by genome mining ofLysobacter antibioticus,Org Lett21, 6432-6436. 7. Li, X., Wang, H., Shen, Y.,Li, Y.*and Du, L.* (2019) OX4 is an NADPH-dependent dehydrogenase catalyzing an extended Michael addition reaction to form the six-membered ring in the antifungal HSAF,Biochemistry58, 5245- 5248. 8. Liu, Y., Wang, H., Song, R., Chen, J., Li, T.,Li, Y.*, Du, L. and Shen, Y. (2018) Targeted discovery and combinatorial biosynthesis of polycyclic tetramate macrolactam combamides A–E,Org Lett20, 3504-3508. 9.Li, Y., Wang, H., Liu, Y., Jiao, Y., Li, S., Shen, Y.* and Du, L.* (2018) Biosynthesis of the polycyclic system in the antifungal HSAF and analogues fromLysobacter enzymogenes,Angew Chem Int Ed Engl57, 6221-6225. 10.Li, Y.#, Chen, H.#, Ding, Y., Xie, Y., Wang, H., Cerny, R. L., Shen, Y.* and Du, L.* (2014) Iterative assembly of two separate polyketide chains by the same single-module bacterial polyketide synthase in the biosynthesis of HSAF,Angew Chem Int Ed Engl53, 7524-7530.