教育背景 博士1997-2000 华中农业大学 生化与分子生物学 硕士 1994-1997 山东大学 微生物学 本科 1990-1994 山东大学 微生物工程 工作经历 2001/3--2003/8 德国马普学会化学生态所博士后 2003/10/--2005/10日本东京大学博士后 2005/12--2014/3华中师范大学副教授 2014/4--至今山东大学副教授、教授

1.天然产物的生物合成机制及药物创新 2.极端环境微生物的基因资源利用

1.Khorshed Alam, Jinfang Hao, Youming Zhang*, Aiying Li*. Synthetic biology-inspired Strategies and tools for engineering of microbial natural product biosynthetic pathways.Biotechnology Advances. 2021, 49 (2021) :107759 2.Xiaofeng Cai, Takaaki Taguchi, Huili Wang, Megumi Yuki, Megumi Tanaka, Kai Gong, Jinghua Xu, Yiming Zhao, Koji Ichinose* and Aiying Li*. Identification of a C-glycosyltransferase involved in medermycin biosynthesis.ACS Chemical Biology.2021,16(6):1059-1069 3.Xiaofeng Cai#,Caiyun Li#, Koji Ichinose#, Yali Jiang, Ming Liu, Huili Wang, Caixia Gong, Le Li, Juan Wan, Yiming Zhao, Qing Yang, Aiying Li*. A single-domain small protein Med-ORF10 regulates the production of antitumor agent medermycin in Streptomyces.Microbial Biotechnology.2021, 14(5):1918-1930 4.Caiyun Li, Le Li, Luyao Huang, AiyingLi*. Pleiotropic effects of ActVI-ORFA as an unusual regulatory factor identified in the biosynthetic pathway of actinorhodin in Streptomyces coelicolor.Microbiological Research. 2021, 250:126792 5.Caiyun Li, Khorshed Alam, Yiming Zhao, Hao Jinfang, Qing Yang, Youming Zhang* and Ruijuan Li*,Aiying Li*. Mining and biosynthesis of bioactive lanthipeptides from microorganisms.Frontier in Bioengineering and Biotechnology. 2021, 9:692466 6.Khorshed Alam, Md. Mahmudul Islam, Kai Gong, Muhammad Nazeer Abbasi, Ruijuan Li*, Youming Zhang*, Aiying Li*. In silico genome mining of potential novel biosynthetic gene clusters for drug discovery from Burkholderia bacteria.Computer in Biology and Medicne. 2022, 140: 105046 7.Ruijuan Li#,, Hongbo Shi#,, Xiaoyu Zhao, Xianqi Liu, Hanna Chen, Wentao Zheng, Qiyao Shen, Maoqin Wang, Xue Wang, Kai Gong, Jia Yin, Youming Zhang*, Aiying Li*, Jun Fu*. Development and application of an efficient recombineering system for Burkholderia glumae and Burkholderia plantarii.Microbial Biotechnology, 2021,14:1809-1826 8.Wentao Zheng#, Xue Wang#, Yuwei Chen, Yachao Dong, Diao Zhou, Ruxin Liu, Haibo Zhou, Xiaoying Bian, Hailong Wang, Qiang Tu, Ravichandran Vinothkannan, Youming Zhang, Aiying Li*, Jun Fu*, Jia Yin*. Recombineering facilitates the discovery of natural product biosynthetic pathways in Pseudomonas Parafulva,Biotechnology Journal. 2021,16(8):e2000575. 9.Yanping Zhu, Peipei Zhang, Ting Lu, Xinyuan Wang, Aiying Li*, Yinhua Lu, Meifeng Tao, Xiuhua Pang*. Impact of MtrA on phosphate metabolism genes and the response to altered phosphate conditions in Streptomyces.Environmental Microbiology.2021, 23(11):6907-6923 10.Muhammad Nazeer Abbasi, Jun Fu, Xiaoying Bian, Hailong Wang* Youming Zhang*, Aiying Li*. Recombineering for genetic engineering of natural product biosynthetic pathways.Trends in Biotechnology. 2020, 38(7): 715-728 11.Wentao Zheng, Xue Wang, Haibo Zhou, Youming Zhang*, Aiying Li*, Xiaoying Bian*. Establishment of recombineering genome editing system in Paraburkholderia megapolitana empowers activation of silent biosynthetic gene clusters.Microbial Biotechnology. 2020, 13(2): 397-405 12.Lin Zhong, Vinothakannan Ravichandran, Na Zhang, Hailong Wang, Xiaoying Bian *, Youming Zhang*, Aiying Li*. Attenuation of Pseudomonas aeruginosa quorum sensing by natural products: Virtual screening, evaluation and biomolecular interactions.International Journal of Molecular Sciences. 2020, 21(6):2190 13.Ruijuan Li#,, Linda Helbig#,, Jun Fu, Xiaoying Bian, Jennifer Herrmann, Michael Baumann, A Francis Stewart, Rolf Müller, Aiying Li*, Daniel Zips*, Youming Zhang*. Expressing cytotoxic compounds in Escherichia coli Nissle 1917 for tumor-targeting therapy.Research in Microbiology.2019, 170(2):74-79 14.Vinothkannan Ravichandran,Lin Zhong,Hailong Wang,Guangle Yu,Youming Zhang*,Aiying Li*. Virtual screening and biomolecular interactions of CviR-based quorum sensing inhibitors against Chromobacterium violaceum.Frontiers in Cellular and Infection Microbiology. 2018, 8:292