2008.09~至今，山东大学药学院/国家糖工程技术中心，讲师、副教授、教授； 2012.05~2013.05，美国北卡罗来纳大学教堂山分校，访问学者； 2006.09~2008.09，山东大学药学院，博士后； 2003.09~2006.03，中国药科大学生命科学与技术学院，理学博士； 1998.07~2003.07，山东中医药大学中药学院，讲师； 1995.09~1998.07，山东大学生命科学学院，理学硕士； 1991.09~1995.07，山东大学生物系，理学学士。

糖胺聚糖药物的生物法合成研究。基于糖胺聚糖的体内生物合成途径，采用多步酶促反应为主、温和的化学修饰为辅的组合策略，合成不同链长和修饰模式的肝素、硫酸软骨素分子及其衍生物，以发现具有抗血栓、抗肿瘤、抗炎和抗AD作用的糖胺聚糖创新药物。 蛋白质多肽药物的结构修饰研究。以合理改造的活性多糖或寡糖为修饰剂，采用化学或酶法策略对蛋白质多肽进行结构修饰，以期得到稳定性、体内半衰期、靶向性及入胞能力显著改善的糖-蛋白质多肽缀合物，提升蛋白质多肽药物的治疗效果。 糖分析研究与产品研发。主要涉及天然活性多糖的结构解析，微量多组分寡糖的分离分析与鉴定，肝素与低分子量肝素精细结构解析与一致性评价研究。

1. Xin Gao#, Yaqing Ma#, Guijiao Zhang, Fengyan Tang, Jingjing Zhang, Jichao Cao,Chunhui Liu*. Targeted elimination of intracellular reactive oxygen species using nanoparticle-like chitosan-superoxide dismutase conjugate for treatment of monoiodoacetate-induced osteoarthritis. Int. J. Pharmaceut., 2020, 590: 119947. 2. Kaishuo Fu, Zhifeng Bai, Lanlan Chen, Wenchong Ye, Meizhu Wang, JiliangHu,Chunhui Liu*, Wen Zhou*. Antitumor activity and structure-activity relationship of heparanase inhibitors: Recent advances. Eur. J. Med. Chem., 2020, 193: 112221. 3. Chengying Zhang, Fengyan Tang, Jingjing Zhang, Jichao Cao, Huijuan Li,Chunhui Liu*. Uncovering the detailed mode of cleavage of heparinase I toward structurally defined heparin oligosaccharides. Int. J. Biol. Macromol., 2019, 141: 756-764. 4. Guixin Hu, Meng Shao, Xin Gao, Fengshan Wang, and,Chunhui Liu*. Probing cleavage promiscuity of heparinase III towards chemoenzymatically synthetic heparan sulfate oligosaccharides. Carbohydr. Polym., 2017, 173: 276-285 5. Nan Zhao, Zhaolong Feng, Meng Shao, Jichao Cao, Fengshan Wang, andChunhui Liu*. Stability profiles and therapeutic effect of Cu/Zn superoxide dismutase chemically coupled toO-quaternary chitosan derivatives against dextran dodium sulfate-induced colitis. Int. J. Mol. Sci., 2017, 18(6): 1121-1135 6. Xiaohu Ji, Guixin Hu, Qiongyan Zhang, Fengshan Wang &Chunhui Liu*. Simultaneous analysis of heparosan oligosaccharides by isocratic liquid chromatography with charged aerosol detection/mass spectrometry. Carbohydr. Polym., 2016,152: 337-342 7. Linghua Xu#, Xiaohu Ji#, Nan Zhao, Chunxia Song, Fengshan Wang and ChunhuiLiu*. The conjugation of Cu/Zn superoxide dismutase (SOD) toO-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride (O-HTCC) enhances its therapeutic potential against radiation-induced oxidative damage. Polym. Chem, 2016, 7: 1826-1835 8.Chunhui Liu, Juzheng Sheng, Juno M. Krahn, Lalith Perera, Yongmei Xu, Po-Hung Hsieh, Wenfang Dou, Jian Liu* and Lars C. Pedersen. Molecular mechanism of substrate specificity for heparan sulfate 2-O-sulfotransferase. J. Biol. Chem., 2014, 289(19):13407-18 9.Chunhui Liu#, Juan Lu #, Lili Lu, Yuhong Liu, Fengshan Wang and Min Xiao*. Isolation, structural characterization and immunological activity of an exopolysaccharide produced byBacillus licheniformis8-37-0-1. Bioresource Technol., 2010, 101(14):5528-33 10.Chunhui Liu, Xiaodong Li, Yuhua Li, You Feng, Shuai Zhou, Fengshan Wang*. Structural characterization and antimutagenic activity of a novel polysaccharide isolated fromSepiella maindroniink. Food Chem., 2008, 110(4): 807-813 11.Chunhui Liu*, Tao Xi*, Qinxiong Lin, Yingying Xing, Liang Ye, Fengshan Wang. Immunomodulatory activity of polysaccharides isolated fromStrongylocentrotus nuduseggs. Int. Immunopharmacol, 2008, 4(13-14): 1835-1841 12.Chunhui Liu, Qinxiong Lin, Liang Ye, Yingying Xing, Tao Xi*. Characterization and antitumor activity of a polysaccharide fromStrongylocentrotus nuduseggs. Carbohydr. Polym., 2007, 67(3): 313-318