刘现伟 照片

刘现伟

副教授

所属大学: 山东大学

所属学院: 国家糖工程技术研究中心

邮箱:
xianweiliu@sdu.edu.cn

个人主页:
http://www.glycoeng.sdu.edu.cn/info/1059/1075.htm

个人简介

2009年7月至今,受聘于山东大学国家糖工程技术研究中心,从事科研教学工作。 2003年9月至2009年6月,硕博连读研究生,山东大学微生物技术国家重点实验室,微生物学专业,获理学博士学位。主要从事微生物多糖生物合成相关酶类的生化研究,以及酶法合成寡糖研究。 研究生学习期间,2007年2月至2009年2月,在美国俄亥俄州立大学(The Ohio State University)生物化学和化学院交流访问。 1999年9月至2003年6月,本科生,山西大学生命科学学院,生物科学专业,获理学学士学位。

研究领域

糖科学与糖工程、化学生物学、合成生物学,包括糖及糖缀合物的化学酶法与生物合成,糖及蛋白等生物大分子的化学标记和修饰,糖及蛋白的生物学功能及应用研究等。

近期论文

1. Jing Liu, Xuefei Yin, Zitao Li, Xiaocong Wu, Zhaoxuan Zheng, Junqiang Fang, Guofeng Gu, Peng G. Wang, Xianwei Liu*. 2021, Facile enzymatic synthesis of diverse naturally-occurring β-D-mannopyranosides catalyzed by glycoside phosphorylases. ACS Catalysis, 2021, 11(5): 2763-2768 2. Jinfeng Ye#, Xian-wei Liu#, Peng Peng, Wen Yi, Xi Chen, Fengshan Wang, Hongzhi Cao*, Diversity-Oriented Enzymatic Modular Assembly of ABO Histo-blood Group Antigens, ACS Catalysis, 2016, 6 (12): 8140-8144 3. Wenjing Shang, Yafei Zhai, Zhongrui Ma, Gongjin Yang, Yan Ding, Donglei Han, Jiang Li, Houcheng Zhang, Jun Liu, Peng George Wang, Xian-wei Liu*, Min Chen*, Production of human blood group B antigen epitope conjugated protein in Escherichia coli and utilization of the adsorption blood group B antibody, Microbial Cell Factories, 2016, 15: 138 4. Yafei Zhai, Donglei Han, Ying Pan, Shuaishuai Wang, Junqiang Fang, Peng Wang, Xian-wei Liu*, Enhancing GDP-fucose production in recombinant Escherichia coli by metabolic pathway engineering, Enzyme and Microbial Technology, 2015, 69: 38-45 5. Junqiang Fang, Mengyang Xue, Guofeng Gu, Xian-wei Liu*, Peng George Wang, A chemoenzymatic route to synthesize unnatural sugar nucleotides using a novel N-acetylglucosamine-1-phosphate pyrophosphorylase from Camphylobacter jejuni NCTC 11168, Bioorganic & Medicinal Chemistry Letters, 2013, 23(15): 4303-4307 6. Mengyang Xue, Wanyi Guan, Yang Zou, Junqiang Fang*, Xian-wei Liu*, Peng George Wang, Fengshan Wang, Investigation of the nucleotide triphosphate substrate specificity of Homo sapiens UDP-N-acetylgalactosamine pyrophosphorylase (AGX1), Bioorganic & Medicinal Chemistry Letters, 2012, 22 (12): 3957-3961 7. Yafei Zhai, Min Liang, Junqiang Fang, Xiaoyue Wang, Wanyi Guan, Xian-wei Liu*, Peng Wang, Fengshan Wang, NahK/GlmU fusion enzyme: Characterization and one-step enzymatic synthesis of UDP-N-acetylglucosamine, Biotechnology Letters, 2012, 34(7): 1321-1326 8. Min Liang, Min Chen, Xinying Liu, Yafei Zhai, Xian-wei Liu*, Houcheng Zhang*, Min Xiao, Peng Wang, Bioconversion of D-galactose to D-tagatose: continuous packed bed reaction with an immobilized thermostable L-arabinose isomerase and efficient purification by selective microbial degradation, Applied Microbiology and Biotechnology, 2012, 93(4): 1469-1474 9. Junqiang Fang, Wanyi Guan, Li Cai, Guofeng Gu*, Xianwei Liu*, Peng George Wang, Systematic study on the broad nucleotide triphosphate specificity of the pyrophosphorylase domain of the N-acetylglucosamine-1-phosphate uridyltransferase from Escherichia coli K12, Bioorganic & Medicinal Chemistry Letters, 2009, 19(22): 6429-6432 10. Xian-wei Liu, Chengfeng Xia, Lei Li, Wan-yi Guan, Nicholas Pettit, Hou-cheng Zhang, Min Chen*, Peng George Wang, Characterization and synthetic application of a novel β1,3-galactosyltransferase from Escherichia coli O55:H7, Bioorganic & Medicinal Chemistry, 2009, 17(14): 4910-4915 11. Robert Woodward, Wen Yi, Lei Li, Guohui Zhao, Hironobu Eguchi, Perali Ramu Sridhar, Hongjie Guo, Jing Katherine Song, Edwin Motari, Li Cai, Patrick Kelleher, Xianwei Liu, Weiqing Han, Wenpeng Zhang, Yan Ding, Mei Li, Peng George Wang*, In vitro bacterial polysaccharide biosynthesis: defining the functions of Wzy and Wzz. Nature Chemical Biology, 2010, 6(6): 418-423 12. Lei Li, Robert Woodward, Yan Ding, Xian-wei Liu, Wen Yi, Veer S. Bhatt, Min Chen, Lian-wen Zhang, Peng George Wang*, Overexpression and topology of bacterial oligosaccharyltransferase PglB, Biochemical and Biophysical Research Communications, 2010, 394(4): 1069-1074 13. Wen Yi, Xianwei Liu, Yanhong Li, Jianjun Li, Chengfeng Xia, Guangyan Zhou, Wenpeng Zhang, Wei Zhao, Xi Chen, Peng George Wang*, Remodeling bacterial polysaccharides by metabolic pathway engineering, Proceedings of the National Academy of Sciences of the United States of America, 2009, 106(11): 4207-4212