1984.07 － 1991.12 山东大学化学系，助教 1991.12 － 1997.09 山东大学化学与化工学院，讲师 1997.09 － 2002.09 山东大学化学与化工学院，副教授 2002.09 － 现在 山东大学化学与化工学院，教授 2006.06 － 现在 山东大学化学与化工学院，教授，博士生导师 1999.11 － 2003.12 山东大学化学与化工学院，副院长 2004.01 － 2007.12 山东大学研究生院，副院长 2004.06 － 2007.12 兼任山东大学威海分校研究生处，处长 2007.12 － 2013.01 山东大学化学与化工学院，党委书记兼副院长 2013.01 － 2018.04 山东大学化学与化工学院，党委书记

研究领域为生物分析化学，研究工作集中在： 1、DNA纳米材料的设计、制备、表征与功能化； 2、多模态、多维度荧光显微成像技术与单分子检测、单细胞分析； 3、新型荧光信号放大策略与生物分子超灵敏检测技术； 4、新型纳米荧光生物传感器的设计、构建与生物医学应用。

103. A bipedal-unequivalent three-dimensional DNA walker and its biosensing application Sensors and Actuators: B. Chemical 327 (2021) 128942 102.A bimolecular i-motif mediated FRET strategy for imaging protein homodimerization on a living tumor cell surface Chemical Communications, 2020, 56, 13405-13408 101.An interparticle relatively motional DNA walker and its sensing application Chemical Science, 2020, 11, 7415-7423 100.A track-regenerated DNA walker: Construction and its derived sensing application Sensors and Actuators B-Chemical, 2020, 314, 128053 99.Multifunctional molecular beacons-modified gold nanoparticles as a nanocarrier for synergistic inhibition and in situ imaging of drug-resistant-related mRNAs in living cells. ACS Appl. Mater. Interfaces, 2019, 11, 35548-35555 98.A DNA walker powered by endogenous enzymes for imaging uracil-DNA glycosylase activity in living cells Chemical Communications, 2019, 55, 6026-6029 97.pH-responsive ZnO nanoprobe mediated DNAzyme signal amplification strategy for sensitive detection and live cell imaging of multiple microRNAs Sensors and Actuators B-Chemical, 2019, 293, 93-99 96.MnO2 nanosheet-mediated ratiometric fluorescence biosensor for microRNA detection and imaging in living cells Analytica Chimica Acta, 2019, 1063, 152-158 95.Multiple sealed primers-mediated rolling circle amplification strategy for sensitive and specific detection of DNA methyltransferase activity Talanta, 2019, 194, 282-288. 94.T7 exonuclease-assisted and target-triggered cascade dual recycling signal amplification strategy for the sensitive and specific detection of adenosine Talanta, 2019, 197, 234-238 93.Endogenous stimuli-responsive nucleus-targeted nanocarrier for intracellular mRNA imaging and drug delivery ACS Appl. Mater. Interfaces 2018, 10, 39524-39531 92.Binding-induced nicking site reconstruction strategy for quantitative detection of membrane protein on living cell Talanta, 2018, 189, 383-388 91.An enzyme-free and label-free fluorescence biosensor for microRNA detection based on cascade amplification of DNAzyme-powered three-dimensional DNA walker and hybridization chain reaction Sensors and Actuators B-Chemical, 2018, 268, 287-292 90.Protein binding protection in combination with DNA masking for sensitive and reliable transcription factor detection Talanta, 2018, 186, 293-298 89.A smart DNA tweezer for detection of human telomerase activity Analytical Chemistry, 2018, 90, 3521-3530 88.An integrated and restructive probe mediated strand displacement amplification strategy for sensitive and specific DNA methyltransferase activity detection Sensors and Actuators B-Chemical, 2018, 266, 124-130 87.Multifunctional aptamer probe mediated cascade amplification for label-free detection of adenosine Sensors and Actuators B-Chemical, 2018, 260, 581-586 86.A dual-targeting DNA tetrahedron nanocarrier for breast cancer cell imaging and drug delivery Talanta, 2018, 179, 356-363 85.Target binding protection mediated rolling circle amplification for sensitive detection of transcription factors Talanta, 2018, 179, 331-336 84.Self-primer and self-template recycle rolling circle amplification strategy for sensitive detection of uracil-DNA glycosylase activity Analytica Chimica Acta, 2018, 1001, 119-124 83.Convertible DNA ends-based silver nanoprobes for colorimetric detection human telomerase activity Talanta, 2018, 178, 458-463 82.Integrating DNA structure switch with branched hairpins for the detection of uracil-DNA glycosylase activity and inhibitor screening Talanta, 2018, 179, 51-56 81.Sensitive and selective detection of the p53 gene based on a triple-helix magnetic probe coupled to a fluorescent liposome hybridization assembly via rolling circle amplification Analyst, 2017, 142, 3598-3604 80.Ultrasensitive and accurate assay of human methyltransferase activity at the single-cell level based on a single integrated magnetic microprobe ACS Appl. Mater. Interfaces, 2017, 9, 29554-29561 79.Liposome-encoded magnetic beads initiated by padlock exponential rolling circle amplification for portable and accurate quantification of microRNAs Chemical Communications, 2017, 53, 10772-10775 78.Uracil removal-inhibited ligase reaction in combination with catalytic hairpin assembly for sensitive and specific detection of uracil-DNA glycosylase activity Analyst, 2017, 142, 4655-4660 77.DNA nanostructure-based drug delivery nanosystems in cancer therapy International Journal of Pharmaceutics, 2017, 533, 169-178 76.A catalytic assembled enzyme-free three-dimensional DNA walker and its sensing application Chemical Communications, 2017, 53, 5527-5530 75.Terminal protection-mediated autocatalytic cascade amplification coupled with graphene oxide fluorescence switch for sensitive and rapid detection of folate receptor Talanta, 2017, 174, 684-688 74.A target triggered proximity combination-based fluorescence sensing strategy for adenosine detection Analyst, 2017, 142, 2247-2252 73.A loop-mediated cascade amplification strategy for highly sensitive detection of DNA methyltransferase activity Sensors and Actuators B-Chemical, 2017, 244, 599-605 72.Sensitive detection of T4 polynucleotide kinase activity based on multifunctional magnetic probes and polymerization nicking reactions mediated hyperbranched rolling circle amplification Biosensors and Bioelectronics, 2017, 91, 631-636 71.Label-free molecular beacons-based cascade amplification DNA machine for sensitive detection of telomerase activity Talanta, 2017, 167, 645-650 70.Toehold-mediated strand displacement reaction-dependent fluorescent strategy for sensitive detection of uracil-DNA glycosylase activity Biosensors and Bioelectronics, 2017, 89, 984-988 69.Colocalization recognition-activated cascade signal amplification strategy for ultrasensitive detection of transcription factors Biosensors and Bioelectronics, 2017, 89, 978-983 68.A bicyclo-hairpin probe mediated strand displacement amplification strategy for label-free and sensitive detection of bleomycin Sensors and Actuators B, 2017, 238, 318-324 67.Model-guided interface probe arrangement for sensitive protein detection Analytical Chemistry, 2016, 88, 9885-9889 66.Application of an ultrahigh-performance liquid chromatography coupled to quadrupole-Orbitrap high-resolution mass spectrometry for the rapid screening, identification and quantification of illegal adulterated glucocorticoids in herbal medicines Journal of Chromatography B, 2016, 1038, 34-42 65.Target-controlled gating liposome "off–on"cascade amplification for sensitive and accurate detection of phospholipase D in breast cancer cells with a low-background signal Chemical Communications, 2016, 52, 10660-10663 64.Binding Induced Colocalization Activated Hybridization Chain Reaction on the Surface of Magnetic Nanobead for Sensitive Detection of Adenosine Biosensors and Bioelectronics, 2016, 86, 966--970 63.A split recognition mode combined with cascade signal amplification strategy for highly specific, sensitive detection of microRNA Biosensors and Bioelectronics, 2016, 86, 834-839 62.T-Hg2+-T metallo-base pair-mediated dual amplification fluorescent strategy for the selective and sensitive detection of Hg2+ RSC Advances, 2016, 6, 70984-70989 61.Protein binding-protected DNA three-way junction-mediated rolling circle amplification for sensitive and specific detection of transcription factors RSC Advances, 2016, 6, 68846-68851 60.Modular nuclease-responsive DNA three-way junctions-based dynamic assembly of DNA device and its sensing application Analytical Chemistry, 2016, 88, 3817-3825 59.A unique dual recognition hairpin probe mediated fluorescent amplification method for sensitive detection of uracil-DNA glycosylase and endonuclease IV activities Analyst，2016, 141, 1789-1795 58.Au Nanoparticles Fluorescence Switch-mediated Target Recycling Amplification Strategy for Sensitive Nucleic Acid Detection RSC Advances, 2016, 6, 10650-10654 57.Cascade Signal Amplification Based on Copper Nanoparticle-Reported Rolling Circle Amplification for Ultrasensitive Electrochemical Detection of the Prostate Cancer Biomarker ACS Appl. Mater. Interfaces 2016, 8, 2573−2581 56.Multiplexed detection of cytokines based on dual bar-code strategy and single-molecule counting Analytical Chemistry, 2016, 88, 1578-1584 55.Target-protected dumbbell molecular probe mediated cascade rolling circle amplification strategy for the sensitive assay of DNA methyltransferase activity Chemical Communications, 2016, 52, 2517-2520 54.A dual amplification fluorescent strategy for sensitive detection of DNA methyltransferase activity based on strand displacement amplification and DNAzyme amplification Biosensors and Bioelectronics, 2016, 77, 650-655 53.Label-free and enzyme-free detection of transcription factors with graphene oxide fluorescence switch-based multifunctional G-quadruplex-hairpin probe Biosensors and Bioelectronics，2016, 75, 155-160 52.Label-free detection of nicotinamide adenine dinucleotide based on ligation-triggered exonuclease III-assisted signal amplification RSC Advances, 2015, 5, 86625-86630 51.Label-free Molecular Beacons-Based Quadratic Isothermal exponential Amplification: A simple and Sensitive One-Pot Method to Detection DNA Methyltransferase Activity Chemical Communications, 2015, 51, 13538-13541 50.Hairpin assembly circuit-based fluorescence cooperative amplification strategy for enzyme-free and label-free detection of small molecule Talanta, 2015, 143: 101-106 49.FokI cleavage–inhibition strategy for the specific and accurate detection of transcription factors Talanta, 2015,144, 44-50 48.Label-free and dual-amplified detection of protein via small molecule-ligand linked DNA and a cooperative DNA machine Biosensors and Bioelectronics, 2015, 72, 107-113 47.Highly selective and sensitive detection of miRNA based on toehold-mediated strand displacement reaction and DNA tetrahedron substrate Biosensors and Bioelectronics, 2015, 71, 401-406 46.Label-free fluorescence dual-amplified detection of adenosine based on exonucleaseIII-assisted DNA cycling and hybridization chain reaction Biosensors and Bioelectronics, 2015, 70, 15-20 45.Label-free Nucleic Acid Detection Based on DNA Templated Silver Nanoclusters Fluorescent Probe Talanta, 2015, 138, 163-168 44.A DNA machine-based fluorescence amplification strategy for sensitive detection of uracil-DNA glycosylase activity Biosensors and Bioelectronics, 2015, 68, 654-659 43.A Binding-induced Sutured Toehold Activation for Controllable DNA Strand Displacement Reactions Chemical Communications, 2015, 51, 2903-2906 42.Sensitive detection of transcription factors with Ag+-stabilized self-assembly triplex DNA molecular switch Chemical Communications, 2014, 50, 14987-14990 41.Visualizing the endocytosis of phenylephrine in living cells by quantum dot-based tracking Biomaterials, 2014, 35, 7042-7049 40.Quantitative detection of tumor necrosis factor-α by single molecule counting based on hybridization chain reaction Biosensors and Bioelectronics, 2014, 60, 180-184 39.Toehold-mediated Strand Displacement Reaction Triggered Isothermal DNA Amplification for Highly Sensitive and Selective Fluorescent Detection of Single-base Mutation Biosensors and Bioelectronics, 2014, 59, 276-281 38.Cascade Signal Amplification Strategy for Sensitive and Label-free DNA Detection Based on Exo III-catalyzed Recycling Coupled with Rolling Circle Amplification Analyst, 2014, 139, 2884-2889 37.Aptamer-Based Exonuclease Protection and Enzymatic Recycling Cleavage Amplification Homogeneous Assay for Highly sensitive Detection of thrombin Analyst, 2014, 139, 3167-3173 36.Quantitative Single-molecule Detection of Protein Based on DNA Tetrahedron Fluorescent Nanolabels Talanta, 2014, 125, 393-399 35.An ultrasensitive fluorescence assay for protein detection by hybridization chain reaction-based DNA nanotags Biosensors and Bioelectronics, 2014, 51, 421-425 34.Surface-enhanced Raman spectroscopy detection of polybrominated diphenylethers using a portable Raman spectrometer Talanta, 2013, 116, 14-17 33.Cysteamine-Modified Silver Nanoparticle Aggregates for Quantitative SERS Sensing of Pentachlorophenol with a Portable Raman Spectrometer ACS Appl. Mater. Interfaces, 2013, 5 (15), 6902-6908 32.Cysteine-Modulated Colorimetric Sensing of Extracellular Mg2+ in Rat Brain Based on the Strong Chelation Interaction between Dithiothreitol and Mg2+ Analyst, 2013,138, 3046-3052 31.A novel label-free cascade amplification strategy based on dumbbell probe-mediated rolling circle amplification-responsive G-quadruplex formation for highly sensitive and selective detection of NAD+ or ATP Chemical Communications, 2013, 49, 2640-2642 30.A Novel Enzyme-free and Label-free Fluorescence Aptasensor for Amplified Detection of Adenosine Biosensors and Bioelectronics, 2013, 44, 52-56 29.Selective and Sensitive Mercuric (II) Ion Detection Based on Quantum Dots and Nicking Endonuclease Assisted Signal Amplification Biosensors and Bioelectronics, 2013, 43, 84-87 28.Electrospun porous CuO-Ag nanofibers for quantitative sensitive SERS detection CrystEngComm, 2013, 15, 1339-1344 27.Visualization the Intracellular Location and Stability of DNA origami with a Label-free Fluorescent Probe Chemical Communications, 2012, 48, 11301-11303 26.Quantitative Detection of Single DNA Molecules on DNA Tetrahedron Decorated Substrates Chemical Communications, 2012, 48, 9661-9663 25.In situ fabrication of single-crystalline porous ZnO nanoplates on zinc foil to support silver nanoparticles as a stable SERS substrate CrystEngComm, 2012, 14, 6023-6028 24.UV Photolysis-induced Generation of Graphene/M (M=Ag/Au) Hybrid Nanomaterials Materials Letters, 2012, 84, 120-123 23.Silver nanoparticle aggregates on copper foil for reliable quantitative SERS analtsis of polycyclic aromatic hydrocarbons with a portable Raman spectrometer Analyst, 2012, 137, 3995-4000 22.Micrococcal Nuclease Detection Based on Peptide-Bridged Energy Transfer between Quantum Dots and Dye-Labeled DNA Talanta, 2012, 97, 533-538 21.Sensitive Detection of Proteins Using Assembled Cascade Fluorescent DNA Nanotags Based on Rolling Circle Amplication Bioconjugate Chemistry, 2012, 23, 734-739 20.Strong Interaction between Imidazolium-Based Polycationic Polymer and Ferricyanide: toward Redox Potential Regulation for Selective In Vivo Electrochemical Measurements Analytical Chemistry, 2012, 84, 1900-1906 19.A versatile platform for highly sensitive detection of protein: DNA enriching magnetic nanoparticles based rolling circle amplication immunoassay Chemical Communications, 2012, 33, 3930-3932. Inside cover paper 18.Synthesis of a quinazoline derivative: A new a 1-adrenoceptors ligand for conjugation to quantum dots to study a 1-adrenoceptors in living cells Bioorganic & Medicinal Chemistry Letters, 2011, 21, 5905-5909 17.Label free DNA detection based on gold nanoparticles quenching fluorescence of Rhodamine B Talanta, 2011, 85, 725-729 16.A Sensitive Enzymatic Method for Paraoxon Detection based on Enzyme Inhibition and Fluorescence Quenching Talanta, 2011, 84, 400-405 15.Quantitative Detection of Single Molecules Using Enhancement of Dye/DNA Conjugate-Labeled Nanoparticles Bioconjugate Chemistry, 2010, 21, 1987-1993 14.Solid phase single-molecule counting of antibody binding to supported protein layers surface with low nonspecific adsorption Talanta, 2010, 82, 1003-1009 13.Fluorescence single-molecule counting assays for protein quantification using epi-fluorescence microscopy with quantum dots labeling Analytical Chimica Acta, 2010, 662, 170-176 12.DNA Quantification Based on FRET Realized by Combination with Surfactant CPB Talanta, 2010, 81, 597-601 11.The co-luminescence effect of a europium(III)-lanthanum(III)-gatifloxacin-sodium dodecylbenzene sulfonate system and its application for the determination of trace amount of europium(III) Journal of Luminescence, 2010, 130, 591-597 10.Quantitative detection of antibody based on single-molecule counting by total internal reflection fluorescence microscopy with quantum dot labeling Analytica Chimica Acta, 2009, 634, 83-88 09.Rapid Determination of Minocycline in Pharmaceutical Formulations and Human Urine/Serum Samples Based on the Minocycline-Europium-Sodium Dodecylbenzene Sulfonate Luminescence System Analytical Letters, 2009, 42, 228-242 08.Luminescence enhancement effect for the determination of balofloxacin with balofloxacin–europium (III)–sodium dodecylbenzene sulfonate system Journal of Luminescence, 2009, 129, 90-94 07.Micelle-enhanced and terbium-sensitized spectrofluorimetric determination of gatifloxacin and its interaction mechanism Spectrochimica Acta Part A, 2009, 72, 766-771 06.Rapid determination of gatifloxacin in biological samples and pharmaceutical products using europium-sensitized fluorescence spectrophotometry Luminescence, 2008, 23, 7-13 05.Quantification of protein based on single-molecule counting by total internal reflection fluorescence microscopy with adsorption equilibrium Analytica Chimica Acta, 2007, 590, 104-109 04.Fluorimetric Determination of Europium Based on the Co-fluorescence System Eu-Y-Sparfloxacin-SDS Mikrochimica Acta, 2004, 144, 29-34 03.Determination of trace europium based on a new fluorescence system of europium-sparfloxacin-1,10-phenanthroline-sodium dodecyl sulfate Analytical Bioanalytical Chemstry, 2003, 377(4), 681-684 02.Spectrofluorimetric determination of trace amounts terbium with 4-chlorsalicylic acid, EDTA, and cetyltrimethylammonium bromide Analytical Sciences, 2003, 19, 923-925 01.Study of the absorption spectra of the 4f electron transitions of the praseodymium complex with ciprofloxacin and its analytical application Analyst, 2001, 126, 1440-1443