教育经历 1990.9-1994.6 山东医科大学药学系，学士 1998.9-2002.6 山东大学，药理学，硕士 2005.9-2008.6 山东大学，药物化学，天然产物生物活性研究，博士 研究工作经历 1994.7-1997.3 山东莱芜钢铁总厂医院，药剂师. 2002.7-2003.8 山东大学，药学院新药药理研究所，助教. 2003.9-2008.9 山东大学，药学院新药药理研究所，讲师. 2008.10-至今 山东大学，药学院新药药理研究所，副教授. 2009.9-2010.9 Louisiana State University, USA,访问学者. 2019.9-2019.11 University of British Columbia(UBC), Canada,访问学者

1.抗氧化与心肌保护,心肌细胞内源性抗氧化酶的诱导,心肌细胞凋亡和自噬的调控。 2.肿瘤细胞的代谢调节，探讨药物影响肿瘤的代谢重编程来抑制肿瘤的生长、侵袭、转移和血管形成作用机制及细胞运动过程中信号转导。 3.活性化合物筛选和药效学评价

1. Guan Y, Zhou L, Zhang Y, Tian H, Li A,Han X*. Effects of PP2A/Nrf2 on experimental diabetes mellitus-related cardiomyopathy by regulation of autophagy and apoptosis through ROS dependent pathway.Cell Signal. 2019;62:109339. 2. Tian H,Zhang Y,Zhang Q, Li S, Liu Y,Han X*. Effects of BENC-511, a novel PI3K inhibitor, on the proliferation and apoptosis of A549 human lung adenocarcinoma cells.Biosci Trends.2019;13(1):40-48. 3. Li A, Zhang Y, Wang Z, Dong H, Fu N,Han X*.The roles and signaling pathways of prolyl-4-hydroxylase 2 in the tumor microenvironment.Chem Biol Interact.2019;303:40-49. 4. Zhang Y, Xu L, Li A,Han X*. The roles of ZEB1 in tumorigenic progression and epigenetic modifications.Biomed Pharmacother.2019;110:400-408. 5. Zhang Q, Zhou L, Guan Y, Cheng Y,Han X*. BENC-511, a novel PI3K inhibitor, suppresses metastasis of non-small cell lung cancer cells by modulating β-catenin/ZEB1 regulatory loop.Chem Biol Interact. 2018;294:18-27. 6. Chen S, Zhou Y, Zhou L, Guan Y, Zhang Y,Han X*. Anti-neovascularization effects of DMBT in age-related macular degeneration by inhibition of VEGF secretion through ROS-dependent signaling pathway.Mol Cell Biochem.2018;448:225-235. 7. Li S, Zhang Q, Zhou L, Guan Y, Chen S, Zhang Y,Han X*. Inhibitory effects of compound DMBT on hypoxia-induced vasculogenic mimicry in human breast cancer.Biomed Pharmacother.2017, 96:982-992. 8. Yao H, Zhou L, Tang L, Guan Y, Chen S, Zhang Y,Han X*. Protective effects of luteolin-7-O-glucoside against starvation-induced injury through upregulation of autophagy in H9c2 Cells.Biosci Trends.2017;11(5):557-564. 9. Zhou L, Ma B,Han X*. The role of autophagy in angiotensin II induced pathological cardiac hypertrophy.J Mol Endocrinol. 2016;57(4):R143-R152. 10. Yao H, Shang Z, Wang P, Li S, Zhang Q, Tian H, Ren D,Han X*. Protection of Luteolin-7-O-Glucoside Against Doxorubicin-Induced Injury Through PTEN/Akt and ERK Pathway in H9c2 Cells.Cardiovasc Toxicol.2016;16(2):101-10. 11. Li S,Meng W, Guan Z, Guo Y,Han X*.The hypoxia-related signaling pathways of vasculogenic mimicry in tumor treatment.Biomed Pharmacother.2016; 80:127-135. 12. Jiang YL#, Li SX#, Liu YJ, Ge LP,Han XZ*, Liu ZP*. Synthesis and Evaluation of Trehalose-Based Compounds as Novel Inhibitors of Cancer Cell Migration and Invasion.Chem Biol Drug Des.2015,86(5) :1017-1029. 13. Song ZY, Gao ZH, Chu JH,Han XZ*, Qu XJ*. Downregulation of the CXCR4/CXCL12 axis blocks the activation of the Wnt/β-catenin pathway in human colon cancer cells.Biomed Pharmacother. 2015,71:46-52. 14. Tang L, Yue B, Cheng Y, Yao H, Ma X, Tian Q, Ge L, Liu Z,Han X*.Inhibition of invasion and metastasis by DMBT, a novel trehalose derivative, through Akt/GSK-3beta/beta-catenin pathway in B16BL6 cells.Chemico-Biological Interactions. 2014; 222:7-17. 15. Yao H, Han X,Han X*. The cardioprotection of insulin-mediated PI3K/Akt/mTOR signaling pathway.American Journal of Cardiovascular Drugs.2014; 14(6):433-42. 16. Tang L, Ma X, Tian Q, Cheng Y, Yao H, Liu Z, Qu X,Han X*. Inhibition of angiogenesis and invasion by DMBT is mediated by downregulation of VEGF and MMP-9 through Akt pathway in MDA-MB-231 breast cancer cells.Food and Chemical Toxicology. 2013, 56:204-213. 17. Tang L,Han X*. The urokinase plasminogen activator system in breast cancerinvasion and metastasis.Biomedicine＆Pharmacotherapy. 2013, 67(2):179-182. 18. Jiang YL, Miyanaga S,Han XZ, Tang LQ, Igarashi Y, Saiki I, Liu ZP*. Synthesis and structure –activity relationships studies of brartemicin analogs as anti-invasiveagents.J Antibiot (Tokyo).2013 ; 66(9) :531-537. 19.Han X#, Xu B#, Beevers CS, Odaka Y, Chen L, Liu L, Luo Y, Zhou H, Chen W, Shen T, Huang S*. Curcumin inhibits protein phosphatases 2A and 5, leading to activation of mitogenactivated protein kinases and apoptosis in tumor cells.Carcinogenesis.2012; 33(4):868-875. 20.Han XZ*, Gao S, Cheng YN, Sun YZ, Liu W, Tang LL, Ren DM. Protective effect of naringenin-7-O-glucoside against oxidative stress induced by doxorubicin in H9c2 cardiomyocytes.BioScience Trends. 2012; 6(1):19-25. 21. Wang SQ,Han XZ, Li X, Ren DM, Wang XN, Lou HX*.Flavonoids from Dracocephalum tanguticum and their cardioprotective effects against doxorubicin-induced toxicity in H9c2 cells.Bioorganic & Medicinal Chemistry Letters. 2010; 20(22):6411-6415. 22. Chen W, Luo Y, Liu L, Zhou H, Xu B,Han X, Shen T, Liu Z, Lu Y, Huang S*. Cryptotanshinone Inhibits Cancer Cell Proliferation by Suppressing Mammalian Target of Rapamycin–Mediated Cyclin D1 Expression and Rb Phosphorylation.Cancer prevention research2010;3(8):1015-25. 23. Liu L, Luo Y, Chen L, Shen T, Xu B, Chen W, Zhou H,Han X, Huang S*. Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity.J Biol Chem. 2010; 285(49):38362-73. 24. Zhou H, Shen T, Luo Y, Liu L, Chen W, Xu B,Han X,Pang J, Rivera CA, Huang S*. The antitumor activity of the fungicide ciclopirox.International Journal of Cancer.2010; 127(10):2467-77. 25. Chen L, Xu B, Liu L, Luo Y, Yin J, Zhou H, Chen W, Shen T,Han X, Huang S*. Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells.Laboratory Investigation.2010, 90(5):762-73. 26. Liu L, Chen L, Luo Y, Chen W, Zhou H, Xu B,Han X,Shen T, Huang S*. Rapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway.PLoS One. 2010, 5(5):e10578. 27.Han X, Ren D, Fan P, Shen T, Lou H*. Protective effects of naringenin-7-O- glucoside on doxorubicin-induced apoptosis in H9c2 cells.European Journal of Pharmacology. 2008，581 (1-2): 47-53. 28.Han X, Pan J, Ren D, Cheng Y, Fan P, Lou H*. Naringenin-7-O-glucoside protects against doxorubicin-induced toxicity in H9c2 cardiomyocytes by induction of endogenous antioxidant enzymes.Food and Chemical Toxicology. 2008, 46(9): 3140-3146. 29.Han X,Shen T, Lou H*. Dietary Polyphenols and Their Biological Significances. International Journal of Molecular Science 2007, 8: 950-988. 30. Yu B,Han X,Lou H*. Oligomers of resveratrol and ferulic Acid prepared by peroxidase-catalyzed oxidation and their protective effects on cardiac injury.Journal of Agricultural and Food Chemistry2007，55(19): 7753-7757. 31. Zhang N, Ping Q, Huang G,Han X, Cheng Y, Xu W*. Transport Characteristics of WGA-modified Insulin-Liposomes and Solid Lipid Nanoparticles in a Perfused Rat Intestinal Model. J Nanosci Nanotech., 2006, 6(9-10):2959-66. 32. Zhang N, Ping Q, Huang G, Xu W*, Cheng Y,Han X. Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin. Int.J.Pharm. 2006, 327(1-2):153-159. 33.韩秀珍，焦波*，尚雪原，程艳娜.低分子量肝素对致敏豚鼠平滑肌及肺组织液中白三烯及NO的影响.山东大学学报医学版. 2005; 43(1): 26-29. 34.韩秀珍，焦波*，尚雪原，程艳娜，纪建波.低分子量肝素对白细胞粘附和粘附分子表达的影响.中国生化药物杂志. 2003; 24(4): 179-181. 35. 田慧芹，张倩云，韩秀珍*.基于Wnt/b-catenin信号通路的结直肠癌研究进展.生命的化学.2016; 9(3):175-184. 36. 申培博，韩秀珍*.新型HIV-1蛋白酶抑制剂的研究进展.生命的化学, 2019, 39(6): 1175 -1187.