教育背景 博士2006年-2009年 山东大学 微生物学 联合培养博士2007年-2008年 丹麦科技大学 系统生物学 硕士2004年-2006年 山东大学 微生物学 学士2000年-2004年 山东农业大学 生物技术 工作经历 2009年-2010年 英国Green Biologics Ltd高级技术协调 2010年-2012年 瑞典查尔姆斯技术大学 博士后 2012年-2017年 山东大学 副研究员 2017年-至今 山东大学 教授

主要研究方向：酵母合成生物学、代谢工程 利用微生物合成重要的化工产品、医药产品等，对于替代化学法合成、促进低碳环保、实现资源的可持续利用具有重要意义。具体研究方向为： 1. 重要天然产物、生物基化合物、生物燃料等的生物合成 通过代谢工程、合成生物学技术，构建高效的酵母细胞工厂，合成天然药物、保健品、香料、有机酸等重要的化合物 2.合成生物学调控元器件的设计和构建 开发基于CRISPR的调控元件、代谢物响应的生物传感元件等用于微生物的动态调控 2. 开发新的基因编辑和微生物进化的方法

1. Yang X, Liu J, Zhang J, Shen Y, Qi Q, Bao X,Hou J*. Quorum sensing-mediated protein degradation for dynamic metabolic pathway control inSaccharomyces cerevisiae. Metab Eng. 2021; 64: 85–94 2. Cui Z, Zheng H, Zhang J, Jiang Z, Zhu Z, Liu X, Qi Q*,Hou J*. A CRISPR/Cas9-mediated, homology-independent tool developed for targeted genome integration inYarrowia lipolytica.Appl Environ Microbiol. 2021 Feb 26;87(6):e02666-20 3. Qiu C, Chen X, Rexida R, Shen Y, Qi Q, Bao X,Hou J*. Engineering transcription factor-based biosensors for repressive regulation through transcriptional deactivation design in Saccharomyces cerevisiae.Microb Cell Fact. 2020, 19:146. 4. Liu J, Hou J. Multidimensional Metabolic Engineering for Constructing Efficient Cell Factories.Trends Biotechnol. 2020 May;38(5):468-469. 5. Qiu C, Zhai H,Hou J*. Biosensors Design in Yeast and Applications in Metabolic Engineering, FEMS Yeast Res. 2019 Dec 1;19(8). 6. Liu Y, Jiang X, Cui Z, Wang Z, Qi Q,Hou J*. Engineering the oleaginous yeastYarrowia lipolyticafor production of α-farnesene. Biotechnol Biofuels. 2019; 12:296 7. Cui Z, Jiang X, Zheng H, Qi Q*,Hou J*. Homology-independent genome integration enables rapid library construction for enzyme expression and pathway optimization inYarrowia lipolytica. Biotechnol Bioeng. 2019 Feb;116(2):354-363. 8. Yang X, Tang H, Song M, Shen Y,Hou J*, Bao X*. Development of novel surface display platforms for anchoring heterologous proteins in Saccharomyces cerevisiae. Microb Cell Fact. 2019 May 18;18(1):85. 9. Wang J, Zhai H, Rexida R, Shen Y,Hou J*, Bao X. Developing synthetic hybrid promoters to increase constitutive or diauxic shift-induced expression inSaccharomyces cerevisiae. FEMS Yeast Res. 2018 Dec 1;18(8). 10. Tang H, Wang J, Wang S, Shen Y, Petranovic D,Hou J*, Bao X*. Efficient yeast surface-display of novel complex synthetic cellulosomes. Microb Cell Fact. 2018 Aug 7;17(1):122. 11. Chen X, Yang X, Shen Y,Hou J*, Bao X*. Screening Phosphorylation Site Mutations in Yeast Acetyl-CoA Carboxylase Using Malonyl-CoA Sensor to Improve Malonyl-CoA-Derived Product. Front Microbiol. 2018 Jan 25;9:47. 12. Hou J. Creating an oil yeast from brewing yeast. Synth Syst Biotechnol. 2018 Nov 2;3(4):252-253. 13. Zheng S,Hou J, Zhou Y, Fang H, Wang TT, Liu F, Wang FS, Sheng JZ. One-pot two-strain system based on glucaric acid biosensor for rapid screening of myo-inositol oxygenase mutations and glucaric acid production in recombinant cells. Metab Eng. 2018 Sep;49:212-219. 14. Hou J,Qiu C, Shen Y, Li H, Bao X. Engineering of Saccharomyces cerevisiae for the efficient co-utilization of glucose and xylose.FEMS Yeast Res. 2017 Jun 1;17(4). 15. Chen X, Yang X, Shen Y,Hou J*, Bao X. Increasing Malonyl-CoA Derived Product through Controlling the Transcription Regulators of Phospholipid Synthesis inSaccharomyces cerevisiae, ACS Synth Biol. 2017 May 19;6(5):905-912. 16. Tang H, Song M, He Y, Wang J, Wang S, Shen Y,Hou J*, Bao X. Engineering vesicle trafficking improves the extracellular activity and surface display efficiency of cellulases inSaccharomyces cerevisiae, Biotechnol Biofuels.2017 Feb 27;10:53. 17. Zhao J, Li C, Zhang Y, Shen Y,Hou J*, Bao X*. Dynamic control of ERG20expression combined with minimized endogenous downstream metabolism contributes to the improvement of geraniol production in Saccharomyces cerevisiae, Microb Cell Fact. 2017 Jan 31;16(1):17. 18. Hou J,Jiao C, Peng B, Shen Y, Bao X. Mutation of a regulator Ask10p improves xylose isomerase activity through up-regulation of molecular chaperones inSaccharomyces cerevisiae, Metab Eng.2016 Nov;38:241-250. 19. Zhao J, Bao X, Li C, Shen Y,Hou J*.Improving monoterpene geraniol production through geranyl diphosphate synthesis regulation in Saccharomyces cerevisiae, Appl Microbiol Biotechnol. 2016 May;100(10):4561-71. 20. Tang H, Bao X, Shen Y, Song M, Wang S, Wang C,Hou J*. Engineering protein folding and translocation improves heterologous protein secretion inSaccharomyces cerevisiae, Biotechnol Bioeng. 2015,112(9):1872-82