学习经历 2001—2004: 博士，神经药理学，中国海洋大学； 1991—1994: 硕士，心血管药理学，山东医科大学； 1987—1991: 学士，药学，山东医科大学. 工作经历 教 授：2007.9—至今，山东大学药学院新药药理研究所； 副教授：2001.9—2007.8，山东大学药学院新药药理研究室； 讲 师：1996.9—2001.8，山东医科大学药学院新药药理教研室. 访问学者：2006.3—2007.2，英国利物浦大学临床科学学院

1. 肿瘤药理学 主要研究肿瘤发生、迁袭和转移的分子机制及肿瘤耐药的分子机制。在研国家自然基金项目1项，已结题国家自然基金项目1项，主要致力于肿瘤转移生物标志物的研究和肿瘤多药耐药分子机制研究，在此基础上寻找抗肿瘤转移新药及逆转肿瘤多药耐药的药物。与英国利物浦大学的合作项目主要是探讨肿瘤发生过程中蛋白分子的作用。另外，负责多项国家“十一五”和“十二五”重大新药创制专项的药效学研究。 2. 心脑血管药理学 主要致力于研究活性氧和钙离子在心脑血管疾病发病过程中的作用，在此基础上寻找具有治疗心脑血管疾病潜力的抗氧化剂和钙拮抗剂，尤其是植物来源的化合物。已结题国家自然基金项目1项，山东省优秀中青年科学家奖励基金项目1项。主要研究体内或细胞内不同浓度活性氧水平与心脑血管疾病以及血管内皮细胞、血管平滑肌细胞和神经细胞间的相关性。 3. 活性化合物筛选和新药药效学评价工作 开展化合物的活性筛选工作，包括体外筛选和体内筛选；开展候选化合物的药效学评价工作并揭示其作用机制。

国家执业药师工作专家（国家药监局执业药师资格认证中心）； 国家食品药品监督管理局保健食品审评专家； 山东省新药创制大平台药物筛选单元技术平台主任； 中国药理学会理事； 中国药理学会心血管专业委员会委员； 中国药理学会教学与科普专业委员会委员； 山东药理学会常务理事； 山东药理学会临床药理专业委员会副主任委员. “Neurosci Lett”, “J Pharmacy Pharmacol”, “Central Eur J Biol”, 《中国药理学通报》，《生命的化学》，《天然产物研究与开发》、《神经药理学报》等杂志审稿专家。

1. Xiong Wang,Li Ma, Qiao-yan Ding, Yong-gang Chen, Jun-hua Meng, Jin-hu Wu, Hong-feng Zhang,Xiu-li Guo*. Mircoglial NLRP3 inflammasome activation-mediated inflammation promotes prolactinomas development.Endocr Relat Cancer.2021, 28(7): 433-448 2. Xiao-xia Yang, Peng-fei Shang, Bing-fang Yu, Qiu-yang Jin, Jing Liao, Lei Wang, Jian-bo Ji,Xiu-li Guo*. Combination therapy withmiR34a and doxorubicin synergistically inhibit DOX-resistance breast cancer progressionviadownregulation of Snail through suppressing Notch/NF-κB and Ras/Raf/MEK/ERK signaling pathway.Acta Pharmaceutica Sinica B. 2021 3. Paris Fouladian, Qiuyang Jin, Mohammad Arafat, Yunmei Song,Xiuli Guo*, Anton Blencowe*, Sanjay Garg*. Drug-loaded, polyurethane coated nitinol stents for the controlled release of Docetaxel for the treatment of Oesophageal cancer.Pharmaceuticals.2021, 14: 311. 4. Qiu-Yang Jin, Ying-Shuang Li, Xing-Hui Qiao, Jia-Wei Yang,Xiu-Li Guo*. Targeting galectins in T cell-based immunotherapy within tumor microenvironment.Life Sci. 2021, 277: 119426. 5. Yi-Fan Dang, Shao-Hui Yang, Xiao-Ning Jiang,Fu-Lian Gong, Xiao-Xia Yang, Yan-Na Cheng,Xiu-Li Guo*. Commination treatment strategies with a focus on rosiglitazone and adriamycin for insulin resistant liver cancer.J Drug Targeting.2021, 29 (3): 336-348 6. Lin Zhao, Hongyuan Chen, Lu Lu, Chunqian Zhao, Christina V. Malichewe, Lei Wang,Xiuli Guo*, Xinke Zhang*.Design and screening of a novel neuropilin-1 targeted penetrating peptide for anti-angiogenic therapy in glioma.Life Sci.2021, 270:119113 7. Lin Zhao, Hongyuan Chen, Lu Lu, Lei Wang, Xinke Zhang*,Xiuli Guo*.New insights into the role of co-receptor neuropilins in tumor angiogenesis and lymphangiogenesis and targeted therapy strategies.J Drug Targeting.2020, 29(2): 155-167. 8. Lei Wang,Ying-Shuang Li, Lu-Gang Yu,Xin-Ke Zhang, Lin Zhao, Fu-Lian Gong, Xiao-Xia Yang,Xiu-Li Guo*.Galectin-3 expression and secretion by tumor-associated macrophages in hypoxia promotes breast cancer progression.Biochem Pharmacol.2020, 178:114113. 9. Zhao-Yu Shi, Xiao-Xia Yang, ChristinaYallen Malichewe, Ying-Shuang Li,Xiu-Li Guo*. Exosomal miRNAs-mediated intercellular communication and exosome-based cancer treatment.Int J Biol Macromol. 2020, 158: 530-541. 10. Xiao-Tong Li,Ying-Shuang Li, Zhao-Yu Shi,Xiu-Li Guo*.New insights into molecular chaperone TRAP1 as a feasible target for future cancer treatments.Life Sci. 2020, 254: 117737. 11. Fu-Lian Gong, Lei Wang, Lu-Gang Yu, Yi-Fan Dang, Xiao-Ning Jiang, Lin Zhao,Xiu-Li Guo*.DHPAC, a novel microtubule depolymerizing agent, suppresses angiogenesis and vasculogenic mimicry formation of human non-small cell lung cancer.J Cellu Biochem. 2020, 121:4756-4771 12. Ying-Shuang Li, Xiao-Tong Li, Lu-Gang Yu, Lei Wang, Zhao-Yu Shi,Xiu-Li Guo*. Roles of galectin-3 in metabolic disorders and tumor cell metabolism.Int J Biol Macromol.2020, 142: 463-473. 13. Zhen-Ning Lu, Zhao-Yu Shi, Yi-Fan Dang, Yan-Na Cheng, Yan-Hui Guan, Zhao-Jun Hao, Bing Tian, Hong-Wei He*,Xiu-Li Guo*.Pantoprazole pretreatment elevates sensitization to vincristine in drug-resistant oral epidermoid carcinoma in vitro and in vivo.Biomed Pharmacother.2019, 120: 109478. 14. Xiao-Xia Yang, Chao Sun, Lei Wang,Xiu-Li Guo*. New insight into isolation, identification techniques and medical applications of exosomes.J Control Release.2019, 308: 119-129. 15. Xiaoxia Yang, Yongfang Zhang, Christina Malichewe, Zhaoyu Shi, Lei Wang, Zhenning Lu,Xiuli Guo*. Chitosan nanoparticle mediated upregulation of microRNA34a expression to suppress the proliferation, migration, invasion of MDA-MB-231 cells.J Drug Deliv Sci Technol.2019, 52: 1061-1069. 16. Xiao-Ning Jiang, Yi-Fan Dang, Fu-Lian Gong, Xiu-Li Guo*. Role and regulation mechanism of galectin-3 in non-small cell lung cancer and its potential clinical therapeutic significance.Chem Biol Interact. 2019, 309: 108724. 17. Chao Sun, Lei Wang, Xiao-Xia Yang, Yu-Hua Jiang,Xiu-Li Guo*. The aberrant expression or disruption of desmocollin2 in human diseases.Int J Biol Macromol.2019, 131: 378-386. 18. Lu-Ning Li, Lei Wang, Yan-Na Cheng, Zhan-Qi Cao, Xin-Ke Zhang,Xiu-Li Guo*.Discovery and characterization of 4-hydroxy-2-pyridone derivative sambutoxin as a potent and promising anticancer drug candidate: activity and molecular mechanism.Mol Pharm.2018, 15(11): 4898-4911. 19. Zhan-Qi Cao#, Zhao-Jun Hao#, Ming Xin, Lu-Gang Yu, Lei Wang, Ying Zhang, Xin-Ke Zhang,Xiu-Li Guo*. Endogenous and exogenous galectin-3 promote the adhesion of tumor cells with low expression of MUC1 to HUVECs through upregulating N-cadherin and CD44.Lab Invest.2018, 98 (12): 1642-1656. 20. Hui-Hui Zhang, Ying Zhang, Yan-Na Cheng, Fu-Lian Gong, Zhan-Qi Cao, Lu-Gang Yu,Xiu-Li Guo*.Metformin incombination with curcumin inhibits the growth, metastasis and angiogenesis of hepatocellular carcinoma in vitro and in vivo.Mol Carcinog.2018, 57: 44-56. 21. Yi-Fan Dang, Xiao-Ning Jiang, Fu-Lian Gong,Xiu-Li Guo*. New insights into molecular mechanisms of rosiglitazone in monotherapy or combination therapy against cancers.Chem Biol Interact.2018, 296: 162-170. 22. Bing Tian, Zhen-Ning Lu,Xiu-Li Guo*.Regulation and role of nuclear factor-E2-related factor2 (Nrf2) in multidrug resistance of hepatocellular carcinoma.Chem Biol Interact.2018, 280: 70-76. 23. Ying Zhang, Fu-Lian Gong, Zhen-Ning Lu, Hong-Yuan Wang, Yan-Na Cheng, Zhao-Peng Liu, Lu-Gang Yu, Hui-Hui Zhang,Xiu-Li Guo*.DHPAC, a novel synthetic microtubule destabilizing agent, possess high antitumor activity in vincristine-resistant oral epidermoid carcinoma in vitro and in vivo.Int J Biochem Cell Biol.2017, 93: 1-11. 24. Ying Zhang, Shao-Hui Yang,Xiu-Li Guo*. New insights into Vinca alkaloids resistance mechanism and circumvention in lung cancer.Biomed Pharmacother.2017, 96:659-666. 25. Zhen-Ning Lu, Bing Tian,Xiu-Li Guo*. Repositioning of proton pump inhibitors in cancer therapy.Cancer Chemother Pharmacol. 2017, 80: 925-937. 26.Yue Zhou, Zhan-Qi Cao, Hong-Yuan Wang, Yan-Na Cheng, Lu-Gang Yu, Xin-Ke Zhang, Yan Sun andXiu-Li Guo*.The anti-inflammatory effect of Morin hydrate in atherosclerosis is associated with autophagyinduction through cAMP signaling.Mol Nutr Food Res, 2017, 61(9).1600966. 27.Yan-Na Liu, Jing-Jing Wang, Ya-Ting Ji, Guo-Dong Zhao, Long-Qian Tang, Cheng-Mei Zhang,Xiu-Li Guo*, Zhao-Peng Liu*. Design, Synthesis, and Biological Evaluation of 1-Methyl-1,4-dihydroindeno[1,2-c]pyrazole Analogues as Potential Anticancer Agents Targeting Tubulin Colchicine Binding Site.J Med Chem, 2016, 59 (11): 53 41-55. 28.Hong-Yuan Wang, Ying Zhang, Yue Zhou, Yu-Yin Lu, Wen-Fang Wang, Ming Xin,Xiu-Li Guo*. Rosiglitazone elevates sensitization of drug-resistant oral epidermoid carcinoma cells to vincristine by G2/M-phase arrest, independent of PPAR-γ pathway.Biomed Pharmacother.2016, 83:349-361. 29. Zhan-Qi Cao,Xiu-Li Guo*. The role of galectin-4 in physiology and diseases.Protein Cell2016, 7(5): 314-325. 30. Hui-Hui Zhang,Xiu-Li Guo*. Combinational Strategies of Metformin and Chemotherapy in Cancers.Cancer Chemother Pharmacol.,2016, 78(1):13-26. 31.Lei Wang,Xiu-Li Guo*. Molecular regulation of galectin-3 expression and therapeutic implication in cancer progression.Biomed Pharmacother.2016, 78: 165-171.