1996.9-2000.6 湖北师范学院化学系学习，获理学学士学位 2000.9-2003.6 四川大学化学学院分析化学专业学习，获理学硕士学位 2003.9-2006.6 四川大学化学学院有机化学专业学习，获理学博士学位 2006.7-2010.6 四川大学化学学院副教授，硕士生导师 2010.7-至今 四川大学化学学院教授，2012年担任博士生导师 2011年获教育部新世纪优秀人才计划资助；2012年获国家自然科学基金委优秀青年基金资助；2013年入选四川省学术和技术带头人后备人选；获霍英东青年教师基金资助；2015年入选第二届国家高层次人才特殊支持计划青年人才，享受国务院政府特殊津贴专家；2016年获国家杰出青年科学基金资助；2017年国家百千万人才工程入选者和有突出贡献中青年专家；2018年入选四川省学术和技术带头人；2020年获全国三八红旗手称号；2021年当选英国皇家化学会会士。

主要从事新型手性催化剂的设计合成、不对称催化反应、手性药物和生理活性化合物的高效高选择性合成研究。

Mingyi Jiang, Zengcheng Yu, Linhan Yang, Fei Wang, Weidi Cao,* Xiaohua Liu,* Xiaoming Feng,* Reductant-Free Enantioselective Aza-Reformatsky Reaction Enabled by Synergistic Visible Light Photocatalysis and Lewis Acid Catalysis, Angew. Chem. Int. Ed. 2025, 64, e202500756. Zhijie Xiao,† Maoping Pu,† Yuzhen Li, Wei Yang, Fei Wang, Xiaoming Feng,* Xiaohua Liu,* Asymmetric Catalytic Synthesis of Allylic Sulfenamides from Vinyl α-Diazo Compounds by a Rearrangement Route, Angew. Chem. Int. Ed. 2025, 64, e202414712. Xin He, Yihua Fu, Ruiying Xi, Cefei Zhang, Kexin Lan, Zhishan Su, Fei Wang, Xiaoming Feng, Xiaohua Liu,* Asymmetric Carbene Insertion into Se−S Bonds by Synergistic Rh(II)/Guanidine Catalysis Involving Chalcogen-Bond Assistance, Angew. Chem. Int. Ed. 2025, 64, e202417636. Han Yu,† Zun Yang,† Hongda Wu, Yao Luo, Weidi Cao,* Xiaohua Liu,* Xiaoming Feng,* Visible Light-Promoted Enantioselective Catalytic Alkylation of α-Ketoamides with Hydrocarbons, ChemCatChem 2025, 17, e202402112. Ziwei Zhong, Hongda Wu, Xiaofan Chen, Yao Luo, Longqing Yang, Xiaoming Feng,* Xiaohua Liu,* Visible-Light-Promoted Enantioselective Acylation and Alkylation of Aldimines Enabled by 9-Fluorenone Electron-Shuttle Catalysis, J. Am. Chem. Soc. 2024, 146, 20401−20413. Liuzhen Hou,† Longqing Yang,† Gaofei Yang, Zhe Luo, Wanlong Xiao, Linhan Yang, Fei Wang, Liu-Zhu Gong, Xiaohua Liu,* Weidi Cao,* Xiaoming Feng,* Catalytic Asymmetric Dearomative [2 + 2] Photocycloaddition/Ring-Expansion Sequence of Indoles with Diversified Alkenes, J. Am. Chem. Soc. 2024, 146, 23457–23466. Nian Xu,† Maoping Pu,† Han Yu, Gaofei Yang, Xiaohua Liu,* Xiaoming Feng,* Iron-Catalyzed Asymmetric α-Alkylation of 2-Acylimidazoles via Dehydrogenative Radical Cross-Coupling with Alkanes, Angew. Chem. Int. Ed. 2024, 63, e202314256. Yao Luo, Yuqiao Zhou, Fengnan Xiao, Xin He, Ziwei Zhong, Qi-Lin Zhou, Weidi Cao,* Xiaohua Liu,* Xiaoming Feng,* Quinone-Initiated Photocatalytic Enantioselective Giese Radical Addition with Ethers, Thioethers, Amines and Alkanes, ACS Catal. 2024, 14, 12031−12041. Tangyu Zhan, Liang Zhou, Yuqiao Zhou, Bingqian Yang, Xiaoming Feng,* Xiaohua Liu,* IronIII-Catalyzed Asymmetric Inverse-Electrondemand Hetero-Diels–Alder Reaction of Dioxopyrrolidines with Simple Olefins, Chem. Sci. 2024, 15, 4797−4803. Yi Li,† Lichao Ning,† Qi Tang, Kexin Lan, Bingqian Yang, Qianchi Lin, Xiaoming Feng,* Xiaohua Liu,* Asymmetric Catalytic [1,3]- or [3,3]-Sigmatropic Rearrangement of 3-Allyloxy-4H-chromenones and Their Analogues, Chem. Sci. 2024, 15, 11005–11012. Min Chen,† Longqing Yang,† Yuzhen Li, Yinhe Qu, Guihua Pan, Xiaoming Feng,* Xiaohua Liu,* Regioselective and Asymmetric Allylic Alkylation of Vinyl Epoxides for the Construction of Allylic Alcohols via Synergistic Catalysis, Sci. China Chem. 2024, 67, 542−550. Aying Yihuo, Maoping Pu, Zheng Tan, Jibang Liao, Jiuqi Tan, Qilin Zhou, Xiaohua Liu,* Xiaoming Feng,* Copper-Catalyzed Asymmetric Dearomatizing Amination of 2-Naphthols: C(sp2)-N Coupling via 1,3-Reductive Elimination, Sci. China Chem. 2024, 67, 2694–2700. Qianping Chen, Yan Zhang, Yanji Song, Yang Zhang, Zhishan Su, Xiaoming Feng, Xiaohua Liu,* Asymmetric Synthesis of Hydroindoles via Desymmetrizing [3+2] Annulation of p‑Quinamines and Arylalkyl ketenes, Org. Lett. 2024, 26, 3366−3370. Siyuan Wang, Lichao Ning, Zhiqiang Li, Xiaoming Feng*, Xiaohua Liu* Asymmetric Synthesis of Hydrodibenzofurans from Norcaradienes: Kinetic Resolutionvia [3 + 2] Cycloaddition with Quinones, Org. Lett. 2024, 26, 3844−3849. Hongye Li, Yuqiao Zhou, Zheng Tan, Xiangyu Wang, Yuxin Zhang, Fei Wang, Xiaoming Feng,* Xiaohua Liu,* Enantioselective Sulfonylation to Construct 3-Sulfonylated Oxindoles, Chem. Commun. 2024, 60, 4354−4357. Yongyan Zhang,† Lichao Ning,† Tianxin Zhu, Zheng Xie, Shunxi Dong, Xiaoming Feng Xiaohua Liu,* Chiral Guanidine Catalyzed Cyclization Reactions of 1,3-Enynes for Lactone Synthesis: Switchable H-bond Catalysis, Org. Chem. Front. 2024, 11, 2897−2904. Dong Zhang,† Maoping Pu,† Zhenzhong Liu, Yuqiao Zhou, Zhendong Yang, Xiaohua Liu,* Yun-Dong Wu,* and Xiaoming Feng,* Enantioselective anti-Dihalogenation of Electron-Deficient Olefin: A Triplet Halo-Radical Pylon Intermediate, J. Am. Chem. Soc. 2023, 145, 4808−4818. Qianwen He,† Mao-Ping Pu,† Zheng Jiang, Hongyu Wang, Xiaoming Feng,* Xiaohua Liu,* Asymmetric Epoxidation of Alkenes Catalyzed by a Cobalt Complex, J. Am. Chem. Soc. 2023, 145, 15611−15618. Guihua Pan, Maoping Pu, Hongyu Wang, Meijia Ying, Yi Li, Shunxi Dong, Xiaoming Feng, Xiaohua Liu,* Catalytic Enantioselective Nucleophilic Addition to Arynes by a New Quaternary Guanidinium Salt Based Phase-Transfer Catalyst, J. Am. Chem. Soc. 2023, 145, 26318−26327. Kaixuan Wang, Longqing Yang, Yi Li, Hongye Li, Zhili Liu, Lichao Ning, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic Ring-Expansion of 3-Methyleneazetidines with α-Diazo Pyrazoamides towards Proline-Derivatives, Angew. Chem. Int. Ed. 2023, 62, e202307249. Tangyu Zhan, Liangkun Yang, Qiyou Chen, Rui Weng, Xiaohua Liu,* Xiaoming Feng,* Chiral Lewis Acid-Catalyzed Norrish Type II Cyclization to Synthesize α-Oxazolidinones via Enantioselective Protonation, CCS Chem. 2023, 5, 2101–2110. Shunxi Dong, Weidi Cao, Maoping Pu, Xiaohua Liu,* Xiaoming Feng,* Ligand-Acceleration in Chiral Lewis Acid Catalysis, CCS Chem. 2023, 5, 2717–2735. Zhikun Wu,† Xiying Zhang,† Nian Xu, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic Aerobic Oxidative Radical Addition/Hydroxylation/1,4-Aryl Migration Reaction of Olefins, ACS Catal. 2023, 13, 815−823. Yuhao Mo, Qiyou Chen, Jinzhao Li, Dong Ye, Yuqiao Zhou, Shunxi Dong, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic Conjugate Addition of Cyanide to Chromones and β‑Substituted Cyclohexenones, ACS Catal. 2023, 13, 877−886. Shiyang Li, Cefei Zhang, Guihua Pan, Liangkun Yang, Zhishan Su, Xiaoming Feng, Xiaohua Liu,* Enantioselective Photochemical Carbene Insertion into C−C and C−H Bonds of 1,3-Diketones by a Guanidine-Amide Organocatalyst, ACS Catal. 2023, 13, 4656−4666. Xinyue Hu, Long Chen, Hongye Li, Qifan Xu, Xiaohua Liu,* Xiaoming Feng,* Enantioselective Catalytic Hantzsch Dihydropyridine Synthesis, ACS Catal. 2023, 13, 6675−6682. Yongyan Zhang, Jin Wu, Lichao Ning, Qianping Chen, Xiaoming Feng, Xiaohua Liu,* Enantioselective Synthesis of Tetrasubstituted Allenes via Addition/Arylation Tandem Reaction of 2-Activated 1,3-Enynes, Sci. China Chem. 2023, 66, 526−533. Siyuan Wang, Yuqiao Zhou, Wanlong Xiao, Zegong Li, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Synthesis of Complex Tricyclo[3.2.2.0]nonenes from Racemic Norcaradienes: Kinetic Resolution via Diels–Alder Reaction, Chem. Sci. 2023, 14, 1844−1851. Peiran Ruan, Cefei Zhang, Jin Wu, Fengnan Xiao, Yongyan Zhang, Qingfa Tan, Zhishan Su, Xiaoming Feng, Xiaohua Liu,* Asymmetric [3+2]-cyclization of a-Iminoamide Surrogates to Construct 3,4-Diaminopyrrolidine-2,5-diones, Chem. Commun. 2023, 59, 8250−8253. Yanji Song, Shi Tang, Qianping Chen, Qingfa Tan, Weidi Cao, Xiaoming Feng, Xiaohua Liu,* Asymmetric Synthesis of Cyclopenta[b]indoles via Organocatalytic Formal (3 + 2) Cyclization of β-Ketoester with Azonaphthalene, Org. Chem. Front. 2023, 10, 2734–2739. Changli He, Xiaoxue Tang, Xin He, Yuqiao Zhou, Xiaohua Liu,* Xiaoming Feng,* Regio- and Enantioselective Conjugate Addition of β-Nitro α,β-Unsaturated Carbonyls to Construct 3-Alkenyl Disubstituted Oxindoles, Chin. Chem. Lett. 2023, 34, 107487. Wei Yang, Zhendong Yang, Long Chen, Yican Lu, Cefei Zhang, Zhishan Su, Xiaohua Liu,* Xiaoming Feng,* Chiral Nickel(II) Complex Catalyzed Asymmetric (3 + 2) Cycloaddition of α-Diazo Pyrazoleamides with 2-Siloxy-1-alkenes, Chin. Chem. Lett. 2023, 33, 107791. Jianglin Qiao, Shiyu Wang, Xiaohua Liu,* Xiaoming Feng,* Enantioselective [3+2] Cycloaddition of Donor-Acceptor Aziridines and Imines to Construct 2,5-trans-Imidazolidines, Chem. Eur. J. 2023, 29, e202203757. Qingfa Tan, Ning Guo, Linhan Yang, Fei Wang, Xiaoming Feng, and Xiaohua Liu,* Asymmetric Organocatalytic 1,6-Conjugate Addition of para-Quinone Methides Using [1,2]-Phospha-Brook Rearrangement, J. Org. Chem. 2023, 88, 9332−9342. Zegong Li, Zi Zeng, Qi Tang, Ziwei Zhong, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Synthesis of 3-Lactone Substituted 2-Oxindoles with Vicinal Quaternary Carbon Centers via Vinylogous Conjugate Addition, Synlett 2023, 34, 2405−2410. Weidi Cao, Xiaohua Liu,* Recent Advances on Catalytic Enantioselective Protonation for Construction of α-Tertiary Carbonyl Compounds, Chin. J. Org. Chem. 2023, 43, 961–973. Shunxi Dong, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic Rearrangements with α‑Diazocarbonyl Compounds, Acc. Chem. Res. 2022, 55, 415−428. Xiaobin Lin,# Maoping Pu,# Xinpeng Sang, Shiyang Li, Xiaohua Liu,* Yun-Dong Wu,* Xiaoming Feng,* Asymmetric Catalytic (2+1) Cycloaddition of Thioketones to Synthesize Tetrasubstituted Thiiranes, Angew. Chem. Int. Ed. 2022, 61, e202201151. Wanlong Xiao, Lichao Ning, Shuang Xin, Shunxi Dong, Xiaohua Liu,* XiaomingFeng,* Enantioselective [2+2] Cycloaddition of Allenyl Imidewith Mono-, or Disubstituted Alkenes, Angew. Chem. Int. Ed. 2022, 61, e202211596. Lifeng Wang, Yuqiao Zhou, Zhishan Su, Fengcai Zhang, Weidi Cao, Xiaohua Liu,* Xiaoming Feng,* [3,3]-Sigmatropic Rearrangements of Naphthyl 1-Propargyl Ethers: para-Propargylation and Catalytic Asymmetric Dearomatization, Angew. Chem. Int. Ed. 2022, 61, e202211785. Han Yu, Tangyu Zhan, Yuqiao Zhou, Long Chen, Xiaohua Liu,* Xiaoming Feng,* Visible-Light-Activated Asymmetric Addition of Hydrocarbons to Pyridine-Based Ketones, ACS Catal. 2022, 12, 5136−5144. Yao Luo, Qi Wei, Liangkun Yang, Yuqiao Zhou, Weidi Cao, Zhishan Su, Xiaohua Liu,* Xiaoming Feng,* Enantioselective Radical Hydroacylation of α,β-Unsaturated Carbonyl Compounds with Aldehydes by Triplet Excited Anthraquinone, ACS Catal. 2022, 12, 12984−12992. Jiawen Lang, Siyuan Wang, Changli He, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Synthesis of Isochromanone Derivatives via Trapping Carboxylic Oxonium Ylides and Aldol Cascade, Chem. Sci. 2022, 13, 1163−1168. Linfeng Hu, Jinzhao Li, Yongyan Zhang, Xiaoming Feng, Xiaohua Liu,* Enantioselective [1,2]-Stevens Rearrangement of Thiosulfonates to Construct Dithio-substituted Quaternary Carbon Centers, Chem. Sci. 2022, 13, 4103–4108. Yi Li, Shuang Xin, Rui Weng, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Synthesis of Chromanone Lactones via Vinylogous Conjugate Addition of Butenolide to 2-Ester Chromones, Chem. Sci. 2022, 13, 8871–8875. Peiran Ruan, Qiong Tang, Zun Yang, Xiaohua Liu,* Xiaoming Feng,* Enantioselective Formal [2+2+2] Cycloaddition of 1,3,5-Triazinanes to Construct Tetrahydropyrimidin-4-one Derivatives, Chem. Commun. 2022, 58, 1001−1004. Chaoqi Ke, Qiuhui Cao, Yao Luo, Xiaohua Liu,* Xiaoming Feng,* Catalytic Asymmetric Amination of Azlactones with Azobenzenes, Chem. Commun. 2022, 58, 5881−5884. Qingfa Tan, Qianping Chen, Zitong Zhu, Xiaohua Liu,* Asymmetric Organocatalytic Sulfenylation for the Construction of a Diheteroatom-bearing Tetrasubstituted Carbon Centre, Chem. Commun. 2022, 58, 9686–9689. Yi Li, Wang-Yuren Li, Xiaoxue Tang, Xiaohua Liu,* Xiaoming Feng,* Synthesis of Chiral Pyridine-oxazolines via Catalytic Asymmetric Heine Reaction of meso-N-(2-picolinoyl)-aziridines, Org. Chem. Front. 2022, 9, 1531−1535. Jinzhao Li, Lichao Ning, Qingfa Tan, Xiaoming Feng, Xiaohua Liu,* Asymmetric Sonogashira C(sp3 )-C(sp) Bond Coupling Enabled by Copper(I) Complex of New Guanidine-hybrid Ligand, Org. Chem. Front. 2022, 9, 6312−6318. Fei Tan,# Maoping Pu,# Jun He, Jinzhao Li, Jian Yang, Shunxi Dong, Xiaohua Liu,* Yun-Dong Wu,* Xiaoming Feng,* Catalytic Asymmetric Homologation of Ketones with α-Alkyl-α-diazoesters, J. Am. Chem. Soc. 2021, 143, 2394−2402. Wei Yang,# Maoping Pu,# Xiaobin Lin, Min Chen, Yanji Song, Xiaohua Liu,* Yun-Dong Wu,* Xiaoming Feng,* Enantioselective Formal Vinylogous N−H Insertion of Secondary Aliphatic Amines Catalyzed by a High-Spin Cobalt(II) Complex, J. Am. Chem. Soc. 2021, 143, 9648−9656. Wen Liu,# Maoping Pu,# Jun He, Tinghui Zhang, Shunxi Dong, Xiaohua Liu,* Yun-Dong Wu,* Xiaoming Feng,* Iron-Catalyzed Enantioselective Radical Carboazidation and Diazidation of , a,b-Unsaturated Carbonyl Compounds, J. Am. Chem. Soc. 2021, 143, 11856−11863. Long Chen,# Maoping Pu,# Shiyang Li, Xinpeng Sang, Xiaohua Liu,* Yun-Dong Wu,* and Xiaoming Feng,* Enantioselective Synthesis of Nitriles Containing a Quaternary Carbon Center by Michael Reactions of Silyl Ketene Imines with 1‑Acrylpyrazoles, J. Am. Chem. Soc. 2021, 143, 19091–19098. Yong Xia, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic Reactions of Donor-Acceptor Cyclopropanes, Angew. Chem. Int. Ed. 2021, 60, 9192–9204. Jinzhao Li, Yuhao Mo, Liqiao Yan, Xiaoming Feng, Zhishan Su,* Xiaohua Liu,* Organocatalytic Stereoselective [8+2] Cycloaddition of Tropones with Azlactones, CCS Chem. 2021, 3, 784–793. Xia Zhong, Ziwei Zhong, Zhikun Wu, Zhen Ye, Yuxiang Feng, Shunxi Dong, Xiaohua Liu,* Qian Peng,* Xiaoming Feng,* Chiral Lewis Acid-bonded Picolinaldehyde Enables Enantiodivergent Carbonyl Catalysis in Mannich/Condensation Reaction of Glycine Ester, Chem. Sci. 2021, 12, 4353–4360. Lihua Xie, Yi Li, Shunxi Dong, Xiaoming Feng, Xiaohua Liu,* Catalytic Asymmetric Formal [3+2] Cycloaddition of Isatogens with Azlactones to Construct Indolin-3-one Derivatives, Chem. Commun., 2021, 57, 239−242. Qingfa Tan, Han Yu, Yao Luo, Fenzhen Chang, Xiaohua Liu,* Yuqiao Zhou,* Xiaoming Feng,* Asymmetric Catalytic [4+3] Cycloaddition of ortho-Quinone Methides with Oxirances, Chem. Commun., 2021, 57, 3018−3021. Linfeng Hu, Weidi Cao, Kaixuan Wang, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Synthesis of Dihydrocarbazoles through Friedel-Crafts Alkylation/annulation Sequential Reaction of Indoles, Chem. Commun., 2021, 57, 13138−13141. Jian Xu, Runze Li, Nian Xu, Xiaohua Liu,* Fei Wang,* Xiaoming Feng,* Enantioselective [4 + 2] Cycloaddition/Cyclization Cascade Reaction and Total Synthesis of cis-Bis(cyclotryptamine) Alkaloids, Org. Lett. 2021, 23, 1856−1861. Qianwen He, Dong Zhang, Fengcai Zhang, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic Epoxidation of Terminal Enones for the Synthesis of Triazole Antifungal Agents, Org. Lett. 2021, 23, 6961−6966. Wenkun Yang, Pei Dong, Jian Xu, Jian Yang, Xiaohua Liu,* Xiaoming Feng,* Enantioselective synthesis of 3-substituted 3-amino-2-oxindoles via amination with anilines, Chem. Eur. J. 2021, 27, 9272−9275. Chaoqi Ke, Zhenzhong Liu, Sai Ruan, Xiaoming Feng, Xiaohua Liu,* Organocatalytic Asymmetric Synthesis of Benzothiazolopyrimidines via a [4 + 2] Cycloaddition of Azlactones with 2-Benzothiazolimines, Org. Chem. Front. 2021, 8, 5705−5709. Peng Zhao, Zegong Li, Jun He, Xiaohua Liu,* Xiaoming Feng,* Asymmetric Catalytic 1,3-Dipolar Cycloaddition of α-Diazoesters for Synthesis of 1-Pyrazoline-based Spirochromanones and Beyond, Sci. China Chem. 2021, 64, 1355−1360. Peng Zhao, Zi Zeng, Xiaoming Feng,* Xiaohua Liu,* Multisubstituted Pyrazole Synthesis via [3+2] Cycloaddition/Rearrangement/N-H Insertion Cascade Reaction of α-Diazoesters and Ynones, Chin. Chem. Lett. 2021, 32, 132−135. Yi Li, Hao Pan, Wangyuren Li, Xiaoming Feng, Xiaohua Liu,* Enantioselective Nucleophilic Aromatic Substitution Reaction of Azlactones to Synthesize Quaternary α-Amino Acid Derivatives, Synlett 2021, 32, 587−592. Weidi Cao, Xiaohua Liu,* Asymmetric Formal Hetero-Ene Reaction of Allylgold Intermediates, Chin. J. Org. Chem. 2021, 41, 857−858.