Prof. Dr. Dingbin Liu received his B.S. in 2006 from Lanzhou University and his Ph.D. in 2012 from the National Center for Nanoscience and Technology, China (NCNST) under the direction of Prof. Xingyu Jiang. After a short postdoctoral training at Dr. Xiaoyuan Chen' lab at the National Institutes of Health (NIH) under the support of NRC NIH/NIST Joint Postdoctoral Associateship, he joined the College of Chemistry at Nankai University as a Tenure-Track Professor in 2014. He was promoted as a Tenured Full Professor in 2020. Now, he is the director of Research Center for Analytical Science and a principal investigator at the State Key Laboratory of Medicinal Chemical Biology.

(1) Discovery of novel biomarkers based on extracellular vesicles/exosomes and creation of urinary “synthetic biomarkers” for noninvasive diagnosis and monitoring of diseases. (2) Development of high-sensitivity in vitro assays and in vivo imaging probes for rapid analysis of these discovered biomarkers.

Moxuan Ji, Jiantong Dong*, Zhuo Ye, Jingjing Kang, Guimei Han, Xiaoqin Hong, Yongchun Wei, Xin Chen*, Wei Sun*, and Dingbin Liu*, Endogenous HClO-Gated Cascade MicroRNA Imaging for Precise Diagnosis of Atherosclerosis In Vivo Journal of the American Chemical Society, 2025, doi.org/10.1021/jacs.5c00031. Yingna Bing, and Dingbin Liu*, Internal Standard Method-based Surface-enhanced Raman Spectroscopy for Quantitative Analysis Chemical Journal of Chinese Universities, 2025, 46(2):20240457. Cai Zhang*, Wenhui Zhang, Weijie Song, Miao Jiang, Wenjing Hou, Dong Li, Zhaoxiang Ye*, and Dingbin Liu*, Identification of SERS Fingerprints for Diagnosis and Staging of Liver Injury Analytical chemistry, 2025, doi.org/10.1021/acs.analchem.4c04758. Jingqi Li, Zhaoyu Wang, Yongchun Wei, Wenshuai Li, Mingzhu He, Jingjing Kang, Jia Xu, and Dingbin Liu*, Advances in Tracing Techniques: Mapping the Trajectory of Mesenchymal Stem-Cell-Derived Extracellular Vesicles Chemical ＆ Biomedical Imaging, 2025, doi.org/10.1021/cbmi.4c00085. Ning Sun, Zhaowei Zhang, Xiaoqing Yang*, Jingqi Li, Qiang Li, Jingjing Kang, Yongchun Wei, Xiaoxuan Yu, Rui Du, Xiaoqin Hong, Guangming Liu, Hongmei Gao*, and Dingbin Liu*, Unveiling urinary extracellular vesicle mRNA signature for early diagnosis and prognosis of bladder cancer Theranostics, 2025, 15(4):1272-1284. Jinru Xiao, Linjie Shen, Mingmin Li, Jifeng Liu, Dingbin Liu, Yang Lu*, and Xia Gao*, Simultaneous detection of multiple food allergens using high signal-to-background SERS probes Food Chemistry, 2025, 465(2):142098. Hua Xu, Lin Dou, Yongqiang Wang, Yin Li, Dingbin Liu*, and Hongmei Gao*, Whole transcriptome sequencing identifies key lncRNAs, circRNAs and miRNAs in sepsis-associated acute lung injury Experimental Lung Research, 2024, 50(1):242-258. Jinru Xiao, Jiachen Ding, Chenyang Sun, Dingbin Liu, Hongmei Gao*, Yaqing Liu*, Yang Lu*, and Xia Gao*, Simultaneous Detection of Clenbuterol and Higenamine in Urine Samples Using Interference-Free SERS Tags Combined with Magnetic Separation ACS Sensors, 2024, 9(10):5394–5404. Guangming Liu, Wenshuai Li*, Siya Li, Jia Xu, Xinsheng Wang, Hua Xu, Dingbin Liu*, and Hongmei Gao*, Culture-free detection of β-lactamase-Producing bacteria in urinary tract infections using a paper sensor Biosensors and Bioelectronics, 2024, 257:116300. Chen Li, Shuixian Guo, Min Sun, Jingping Niu, Congcong Yin, Weijun Du, Jinzhong Zhao*, Dingbin Liu*, and Aiqin Yue*, A Colorimetric RT-LAMP Assay for Rapid Detection of Soybean mosaic Virus SC15 ACS Omega, 2024, 9(27):29765–29775. Leping Lin, Anan Liu, Wei Zhao, Yin Yang, Dongliang Zhu, Boran Dong, Fei Ding, Di Ning, Xiaobo Zhu, Dingbin Liu, and Daiwen Pang*, Multihierarchical Regulation To Achieve Quantum Dot Nanospheres with a Photoluminescence Quantum Yield Close to 100% Journal of the American Chemical Society, 2024, 146(31):21348–21356. Qiang Li, Saisong Zhan, Xiaoqing Yang, Zhaowei Zhang, Ning Sun, Xiang Wang, Jingjing Kang, Rui Du, Xiaoqin Hong, Minghao Yue, Xiaomin Li, Yujing Tang, Guangming Liu, Yue Liu,and Dingbin Liu*, Choline Phosphate-Grafted Nanozymes as Universal Extracellular Vesicle Probes for Bladder Cancer Detection ACS Nano, 2024, 18(25):16113–16125. Moxuan Ji, Yongchun Wei, Zhuo Ye, Xiaoqin Hong, Xiaoxuan Yu, Rui Du, Qiang Li, Wei Sun, and Dingbin Liu*, In Vivo Fluorescent Labeling of Foam Cell-Derived Extracellular Vesicles as Circulating Biomarkers for In Vitro Detection of Atherosclerosis Journal of the American Chemical Society, 2024, 146(14):10093–10102. Wenshuai Li, Jingqi Li, Hua Xu, Hongmei Gao and Dingbin Liu*, Rapid and visual identification of β-lactamase subtypes for precision antibiotic therapy. Nature Communications, 2024, 15:719. Shuo Zheng, Jinru Xiao, Jing Zhang, Qixiu Sun, Dingbin Liu, Yaqing Liu* and Xia Gao*, Python-assisted detection and photothermal inactivation of Salmonella typhimurium and Staphylococcus aureus on a background-free SERS chip Biosensors and Bioelectronics, 2024, 247:115913. Bo Liu, Guimei Han, Dongxia Wang, Dingbin Liu, Anan Liu, Jing Wang*, Yuling Xiao*, Lin Yuan, and Deming Kong*, Red blood cell membrane biomimetic nanoprobes for ratiometric imaging of reactive oxygen species level in atherosclerosis Chemical Engineering Journal, 2024, 479:147515. Jiani Li, Fanfan Liang, Han Li, Xiaoxuan Yu, Dingbin Liu, Wensheng Cai*, and Xueguang Shao*, Determination of Extra- and Intra-Cellular pH Using Characteristic Absorption of Water by Near-Infrared Spectroscopy Chemosensors, 2023, 11(8): 425. Lin Zhang, Dongna Li, Pengrong Yi, Jiangwei Shi, Mengqing Guo, Qingsheng Yin, Dingbin Liu*, Pengwei Zhuang*, and Yanjun Zhang*, Peripheral origin exosomal microRNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment. Acta Pharmaceutica Sinica B, 2023, 13(7): 2817-2825. Hong Cai, Xuan Liu, Dingbin Liu,and Bin Liu*, GEO data mining identifies potential immune-related genes in hypertrophic scar and verities in a rabbit model. Heliyon, 2023, 9(7): e17266. Qiang Li, Zhaowei Zhang, Fengchao Wang, Xiang Wang, Saisong Zhan, Xiaoqing Yang, Chen Xu and Dingbin Liu*, Reversible Zwitterionic Coordination Enables Rapid, High-yield, and High-purity Isolation of Extracellular Vesicles from Biofluids. Science Advances, 2023, 9: eadf4568. Wei Zhang, Long Ngo, Simon Chang-Hao Tsao, Dingbin Liu*, and Yuling Wang*, Engineered Cancer-Derived Small Extracellular Vesicle-Liposome Hybrid Delivery System for Targeted Treatment of Breast Cancer. ACS Applied Materials & Interfaces, 2023, 15: 16420-16433. Lizong Tang, Congrui Zhao, Yufei Liu, Jie Zhou, Yunsheng Dong, Jiaxing Huang, Tingting Yang, Hui Xiao, Dingbin Liu*, Shufang Wang*, and Hong Cai*, GelMA Hydrogel Loaded with Extracellular Vesicles Derived from Umbilical Cord Mesenchymal Stem Cells for Promoting Cutaneous Diabetic Wound Healing. ACS Omega, 2023, 8(11): 10030-10039. Zhiyou Zong, Xinzhuo Liu, Zhuo Ye, and Dingbin Liu*, A Double-switch pHLIP System Enables Selective Enrichment of Circulating Tumor Microenvironment-derived Extracellular Vesicles. Proceedings of National Academy of Sciences of the United States of America, 2023, 120(2): e2214912120. Zhaowei Zhang#, Xuehui Liu#, Xiaoqing Yang#, Ying Jiang, Ang Li, Jiying Cong, Yuwei Li, Qinjian Xie, Chen Xu*, and Dingbin Liu*, Identification of Faecal Extracellular Vesicles as Novel Biomarkers for Non-invasive Diagnosis and Prognosis of Colorectal Cancer. Journal of Extracellular Vesicles, 2023, 12(1): 12300. Wenshuai Li, Jingjing Wang, Chen Li, Zhiyou Zong, Jinzhong Zhao, Hongmei Gao, and Dingbin Liu*, Achieving Ultrasensitive Chromogenic Probes for Rapid, Direct Detection of Carbapenemase-Producing Bacteria in Sputum JACS Au, 2023, 3(1): 227-238. Fengchao Wang, Ning Sun, Qiang Li, Jie Yang, Xiaoqing Yang, and Dingbin Liu*, Self-Referenced Synthetic Urinary Biomarker for Quantitative Monitoring of Cancer Development. Journal of the American Chemical Society, 2023, 145(2): 919-928.[cover picture] Wenjuan Wu, Congcong Yin, Aiqin Yue*, Jingping Niu, Weijun Du*, Dingbin Liu, and Jinzhong Zhao*, Rapid and Visual Detection of Soybean Mosaic Virus SC7 with a Loop-mediated Isothermal Amplification Strategy. Sensors and Actuators B-Chemical, 2022, 373: 132733. Zhuo Ye, Moxuan Ji, and Dingbin Liu*, Advances of Optical Probes in Atherosclerosis Imaging. Chemical Journal of Chinese Universities-Chinese, 2022, 43(12): 20220556. Wei Zhang, Douglas H. Campbell, Bradley J. Walsh, Nicolle H. Packer, Dingbin Liu*, and Yuling Wang*, Cancer-derived Small Extracellular Vesicles: Emerging Biomarkers and Therapies for Pancreatic Ductal Adenocarcinoma Diagnosis/Prognosis and Treatment. Journal of Nanobiotechnology, 2022, 20:446. Kefeng Wu, Qiang Li*, Chi Yao, Dayong Yang*, and Dingbin Liu*, Trojan Horse Delivery of Spherical Nucleic Acid Probes into the Cytoplasm for High-fidelity Imaging of MicroRNAs. Analytical Chemistry, 2022, 94(31): 10942-10948. [cover picture] Zhuo Ye, Moxuan Ji, Kefeng Wu, Jie Yang, An-an Liu, Wei Sun, Dan Ding, and Dingbin Liu*, In-Sequence High-Specificity Dual-reporter Unlocking of Fluorescent Probe enables the Precise Identification of Atherosclerotic Plaques. Angewandte Chemie International Edition, 2022, 61(29); e202204518. [cover picture] Dingbin Liu*, Rapid and Visual Detection of SARS-Cov-2 Nucleic Acid: Analysis of Problem 1 of the 54th International Chemistry Olympiad. University Chemistry, 2022, 37(12): 2209049. Kefeng Wu, Chi Yao, Dayong Yang*, and Dingbin Liu*, A Functional DNA Nanosensor for Highly Sensitive and Selective Imaging of ClO- in Atherosclerotic Plaques. Biosensors & Bioelectronics, 2022, 209: 114273. Ying Zhang, Qian Liu, Mengting Liu, Xueni Zhang, Xiaoya Li, Lihui Dai, Meng Meng, Dingbin Liu, Yongmei Yin*, and Rimo Xi*, Dual Functional Molecule aided Background-free SERS Sensor for Intracellular pH Dynamic Monitoring based on Foldable DNA Transition. Sensors and Actuators B: Chemical, 2022, 353: 131162. Kai Wang, Heqi Gao, Yuwen Zhang, Hongyu Yan, Jianghua Si, Xingyan Mi, Shuang Xia, Xuequan Feng, Dingbin Liu, Deling Kong, Ting Wang*, and Dan Ding*, Highly Bright AIE Nanoparticles by Regulating the Substituent of Rhodanine for Precise Early Detection of Atherosclerosis and Drug Screening. Advanced Materials, 2022, 34(6): 202106994. Huiqiao Liu#, Xia Gao#, Chen Xu*, and Dingbin Liu*, SERS Tags for Biomedical Detection and Bioimaging. Theranostics, 2022, 12(4): 1870-1903. Xuehui Liu, Zhiyou Zong, Xinzhuo Liu, Qiang Li, Ang Li, Chen Xu*, and Dingbin Liu*, Stimuli-mediated Specific Isolation of Exosomes from Blood Plasma for High-throughput Profiling of Cancer Biomarkers. Small Methods, 2022, 6(2): 2101234. Wen Zhou, Xiaoyue Ni, Chen Xie*, Quli Fan*, and Dingbin Liu*, Advanced Technologies for Single-cell in Situ Protein Profiling. Science China Chemistry, 2022, 65: 48-67. Guorui Wu, Wenshuai Li, Weijun Du, Aiqin Yue*, Jinzhong Zhao, and Dingbin Liu*, In-situ Monitoring of Nitrile-bearing Pesticide Residues by Background-free Surface-enhanced Raman Spectroscopy. Chinese Chemical Letters, 2022, 33(1): 519-522. Qian Liu, Fang Wu, Huixia Di, Yingna Bi, Meng Meng, Dingbin Liu, Yongmei Yin*, and Rimo Xi*, A Novel SERS Biosensor for Ultrasensitive Detection of Mercury(II) in Complex Biological samples. Sensors and Actuators B-Chemical, 2022, 351: 130934. Xinzhuo Liu, Zhiyou Zong, Mindan Xing, Xuehui Liu, Jia Li, and Dingbin Liu*, pH-Mediated Clustering of Exosomes: Breaking Through the Size Limit of Exosome Analysis in Conventional Flow Cytometry. Nano Letters, 2021, 21(20): 8817-8823. Zhiwen Xu, Cai Zhang, Xiang Wang, and Dingbin Liu*, Release Strategies of Silver Ions from Materials for Bacterial Killing. ACS Applied Bio Materials, 2021, 4(5): 3985-3999. Zhiwen Xu, Cai Zhang, Yunjian Yu, Wenshuai Li, Zhuang Ma, Jingjing Wang, Xinge Zhang, Hongmei Gao*, and Dingbin Liu*, Photoactive Silver Nanoagents for Backgroundless Monitoring and Precision Killing of Multidrug-Resistant Bacteria. Nanotheranostics, 2021, 5(4): 472-487. Xiang Wang, Qiang Li, Zhaowei Zhang, and Dingbin Liu*, Coating Polymers on Nanoparticles for Biomedical Uses. Encyclopedia of Nanomaterials, 2021, 302-317. Yongxi Zhao, Xiaolei Zuo, Qian Li, Feng Chen, Yan-Ru Chen, Jinqi Deng, Da Han, Changlong Hao, Fujian Huang, Yanyi Huang, Guoliang Ke, Hua Kuang, Fan Li, Jiang Li, Min Li, Na Li, Zhenyu Lin, Dingbin Liu, Juewen Liu, Libing Liu, Xiaoguo Liu, Chunhua Lu, Fang Luo, Xiuhai Mao, Jiashu Sun, Bo Tang, Fei Wang, Jianbin Wang, Lihua Wang, Shu Wang, Lingling Wu, Zai-Sheng Wu, Fan Xia, Chuanlai Xu, Yang Yang, Bi-Feng Yuan, Quan Yuan, Chao Zhang, Zhi Zhu, Chaoyong Yang*, Xiao-Bing Zhang*, Huanghao Yang*, Weihong Tan*, and Chunhai Fan*, Nucleic Acids Analysis. Science China Chemistry, 2021, 64: 171–203. Congcong Yin, Qiaoling Zhao, Aiqin Yue, Weijun Du, Dingbin Liu, Jinzhong Zhao*, Yongpo Zhang, and Min Wang, Colorimetric Detection of Class A Soybean Saponins by G-Quadruplex-Based Hybridization Chain Reaction. Journal of Analytical Methods in Chemistry, 2020, 2020: 8813239. Cai Zhang, Xinzhuo Liu, Zhiwen Xu, and Dingbin Liu*, Multichannel Stimulus-Responsive Nanoprobes for H2O2 Sensing in Diverse Biological Milieus. Analytical Chemistry, 2020, 92(18): 12639-12646. Yingna Bi, Huixia Di, Erzao Zeng, Qiang Li, Wenshuai Li, Jie Yang, and Dingbin Liu*, Reliable Quantification of pH Variation in Live Cells Using Prussian Blue-Caged Surface-Enhanced Raman Scattering Probes. Analytical Chemistry, 2020, 92(14): 9574-9582. Wenshuai Li, Guorui Wu, Min Wang, Aiqin Yue*, Weijun Du*, Dingbin Liu, and Jinzhong Zhao*, Colorimetric Detection of class A Soybean Saponins by Coupling DNAzyme with the Gap Ligase Chain Reaction. Analytical Methods, 2020, 12(26): 3361-3367. Cai Zhang, Xiaoyu Cui, Jie Yang, Xueguang Shao, Yuying Zhang, and Dingbin Liu*, Stimulus-responsive Surface-enhanced Raman Scattering: a “Trojan Horse” Strategy for Precision Molecular Diagnosis of Cancer. Chemical Science, 2020, 11(24): 6111-6120. Wenshuai Li, Guorui Wu, Xijing Zhang, Aiqin Yue, Weijun Du, Jinzhong Zhao*, and Dingbin Liu*, Advances in Bacterial Detection Based on Raman Spectroscopy. Chemical Journal of Chinese Universities-Chinese, 2020, 41(5): 872-883. Qiang Li, Fengchao Wang, Jie Yang, and Dingbin Liu*, Direct Cytoplasm Delivery of Gold Nanoparticles for Real-time Apoptosis Detection. Nano Research, 2020, 13(3): 853-860. Xuehui Liu, Xiaoman Liu, Pengfei Rong*, and Dingbin Liu*, Recent Advances in Background-free Raman Scattering for Bioanalysis. Trac-Trends in Analytical Chemistry, 2020, 123: 115765. Shuxin Song, Jingyu Wang, Na Song, Huixia Di, Dingbin Liu, and Zhilin Yu*, Peptide Interdigitation-induced Twisted Nanoribbons as Chiral Scaffolds for Supramolecular Nanozymes. Nanoscale, 2020, 12(4): 2422-2433. Ying Jiang, Lei Wang, Pengjuan Zhang, Xuehui Liu, Huixia Di, Jie yang, Shulin Liu, Daiwen Pang, and Dingbin Liu*, Chemoenzymatic Labeling of Extracellular Vesicles for Visualizing Their Cellular Internalization in Real Time. Analytical Chemistry, 2020, 92(2): 2103-2111. Huixia Di, Ze Mi, Yan Sun, Xuehui Liu, Xinzhuo Liu, Ang Li, Ying Jiang, Hongmei Gao*, Pengfei Rong*, and Dingbin Liu*, Nanozyme-assisted Sensitive Profiling of Exosomal Proteins for Rapid Cancer Diagnosis. Theranostics, 2020, 10(20): 9303-9314. Cai Zhang, Zhiwen Xu, Huixia Di, Erzao Zeng, Ying Jiang, and Dingbin Liu*, Gadolinium-doped Au@prussian Blue Nanoparticles as MR/SERS Bimodal Agents for Dendritic Cell Aactivating and Tracking. Theranostics, 2020, 10(13): 6061-6071.