教育经历

1995.9–1999.7,首都医科大学,内科学,博士

1991.9–1994.7,天津医科大学,内科学,硕士

1984.9–1989.7,华中科技大学同济医学院,临床医学,学士

2004.9-2005.9,美国MayoClinic,SRF

工作经历

1989.8-1994.7天津市第三中心医院消化（肝病）科

医师

1994.7-1999.7天津市第三中心医院消化（肝病）科

主治医师

1999.7-2004.11天津市第三中心医院消化（肝病）科

副主任医师

2004.11-至今天津市第三中心医院消化（肝病）科

主任医师

2005.12-2013.9天津市第三中心医院消化（肝病）科

科主任

2006.11-至今天津市第三中心医院副院长

主要承担课题项目：

1.“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项，2017ZX10203201007，重症乙型肝炎（肝衰竭）临床治疗新技术研究及新方案推广（子课题），2017/01-2020/12，主持

2.“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项，2012ZX10002004-011，乙肝肝衰竭新型预警及干预策略的研究（子课题），2015/01-2019/12，主持

3.国家自然科学基金面上项目，81870429，Tβ4通过下调lncRNA-AIRN抑制肝细胞焦亡缓解急性肝损伤的机制研究，2019/01-2022/12，主持

4.国家自然科学基金面上项目，81670558，lncRNA-LFAR1在肝纤维化发病过程中的作用及机制研究，2017/01-2020/12，第二完成人

荣誉和奖励

曾获天津市首批有突出贡献专家、天津市科技奖6项。

肝脏疾病的临床与基础研究

目前兼任中华医学会肝病学分会常委、中华医学会重型肝病与人工肝学组组长、全国疑难及重症肝病攻关协作组副组长、天津市肝病学分会主任委员等，曾任天津市生天津物医学工程学会理事、常务理事；中国抗癌协会纳米肿瘤分会委员、天津市中西医结合肝病分会副主任委员、中国医师协会消化分会全国委员、中国医师协会感染病分会常委等。为国内外10余种专业期刊编委。

1.WangF,LiuH,WangF,XuR,WangP,TangF,ZhangX,ZhuZ,LvH,HanT.Propranololsuppressestheproliferationandinducestheapoptosisoflivercancercells.MolMedRep.2018,17(4):5213-5221.

2.JiangY,HanT,ZhangZG,ZhangY,QiFX.Serumthymosinbeta4asanoninvasivebiomarkerinpatientswithnonalcoholicsteatohepatitis.RevEspEnfermDig.2018,110(1):19-24.

3.ZhangK,HanXH,ZhangZ,ZhengLN,HuZM,YaoQB,CuiHM,ShuGM,SiMJ,LiC,ShZM,ChenT,HanYW,ChangYN,YaoZ,HanT&HongW.Theliver-enrichedlnc-LFAR1promotesliverfibrosisbyactivatingTGFβandNotchpathways.NatureCommunications.2017,8(1):144.

4.YeQ,YinW,ZhangL,XiaoH,QiY,LiuS,QianB,WangF,HanT.Thevalueofgriptest,lysophosphatidlycholines,glycerophosphocholine,ornithine,glucuronicaciddecrementinassessmentofnutritionalandmetaboliccharacteristicsinhepatitisBcirrhosis.PloSOne,2017,12(4):e0175165.

5.CaiJJ,ZhangM,HanT,JiangHQ.Characteristicsofinfectionanditsimpactonshort-termoutcomeinpatientswithacute-on-chronicliverfailure.Medicine(Baltimore).2017,96(37):e8057.

6.JiangY,HanT,ZhangZG,LiM,QiFX,ZhangY,JiYL.Potentialroleofthymosinbeta4inthetreatmentofnonalcoholicfattyliverdisease.ChronicDisTranslMed.2017,3(3):165-168.

7.ZhangK,ChangYN,ShiZM,HanXH,HanYW,YaoQB,HuZM,CuiHM,ZhengLN,HanT,HongW.ω-3PUFAsameliorateliverfibrosisandinhibithepaticstellatecellsproliferationandactivationbypromotingYAP/TAZdegradation.ScientificReports.2016,6:30029.

8.YeQ,QianBX,YinWL,WangFM,HanT.AssociationbetweentheHFEC282Y,H63DPolymorphismsandtheRisksofNon-AlcoholicFattyLiverDisease,LiverCirrhosisandHepatocellularCarcinoma:AnUpdatedSystematicReviewandMeta-Analysisof5,758Casesand14,741Controls.PloSOne.2016,11(9):e0163423.

9.LiangJ,CaiWJ,HanT,JingL,MaZ,GaoYT.Theexpressionofthymosinbeta4inchronichepatitisBcombinednonalcoholicfattyliverdisease.Medicine(Baltimore).2016,95(52):e5763.

10.JiangY,ZhangZG,QiFX,ZhangY,HanY.Comparisonofmaintenanceeffectofprobiotifcsandaminosalicylatesonulcerativecolitis:Ameta-analysisofrandomizedcontrolledtrials.ChronicDiseasesandTranslationalMedicine.2016,2(1):34-41.

11.CaiJJ,HanT,NieCY,JiaXB,LiuY,ZhuZY,GaoYT.Biomarkersofoxidationstress,inflammation,necrosisandapoptosisareassociatedwithhepatitisB-relatedacute-on-chronicliverfailure.ClinResHepatolGastroentero.2016,40(1):41-50.

12.YinWL,YeQ,WangFM,LiangJ,XuBG,ZhangX,ZhangQ,LiuY,LiG,HanT.ARTscoreandhepatocellularcarcinoma:Anappraisalofitsapplicability.ClinResHepatolGastroenterol,2016,40(6):705-714.

13.ZhangQ,HanT,LiY,etal.Predictorsofprogressionintoacute-on-chronicliverfailurefromacutedeteriorationofpreexistingchronicliverdisease.HepatolRes.2016,46(4):320-328.

14.ZhangQ,LiY,HanT,NieCY,CaiJJ,LiuH,LiuY.Comparisonofcurrentdiagnosticcriteriaforacute-on-chronicliverfailure.PLoSOne.2015,10(3):e0122158.

15.LiangJ,HanT,GaoYT,JingL,MaZ.TheexpressionofserumM30andM65inchronichepatitisBpatientswithnon-alcoholicfattyliverdisease.EuropeanReviewforMedicalandPharmacologicalSciences.2015,19(21):4123-4129.

16.ZhangQ,HanT,NieCY,etal.TenofovirrescueregimenfollowingpriorsuboptimalresponsetoentecavirandadefovircombinationtherapyinchronichepatitisBpatientsexposedtomultipletreatmentfailures.JMedVirol.2015,87(6):1013-1021.

17.HanLY,HanT,NieCY,etal.Elevatedmeanplateletvolumeisassociatedwithpoorshort-termoutcomesinhepatitisBvirus-relatedacute-on-chronicliverfailurepatients.ClinResHepatolGastroenterol.2015,39(3):331-339.

18.NieXH,HanT,ZhangL,LiY,LiuH,XiaoSX,LiY,KangH,LiuSY.ComparisonofeffectsofthepretreatmentandtreatmentwithRhIL-11onacuteliverfailureinducedbyD-galactosamine.EuropeanReviewforMedicalandPharmacologicalScience.2014,18(8):1142-1150.

19.LiuY,HanT,ZhuZY,LiY.Thymosinbeta4:anovelassessedbiomarkeroftheprognosisofacute-on-chronicliverfailurepatient.ClinResHepatolGastroenterol.2014,38(3):310-317.

20.NieCY,HanT,ZhangL,LiY,LiuH,XiaoSX,LiY,KangH,LiuSY.Cross-sectionalanddynamicchangeofserummetaboliteprofilingforHepatitisB-relatedacute-on-chronicliverfailurebyUPLC/MS.JViralHepatitis.2014,21(1):53-63.