南京大学化学化工学院教授，主要从事生物无机化学研究工作，重点关注金属及金属配合物、多聚磷酸盐和无机纳米材料的化学生物学功能及应用。1998年本科毕业于南京大学化学系，之后在耶鲁大学攻读博士学位。2005年至2006年于加州大学伯克利分校从事博士后研究。2006年至2007年于芝加哥大学从事博士后研究。2007年至2008年在罗门哈斯公司研发部工作。2008年6月加入南京大学任教授、博士生导师。2009年-2014年担任北京大学深圳研究生院化学生物学与生物技术学院副院长、博士生导师。2013年入选创新人才推进计划中青年科技创新领军人才计划，2016年获得国家自然科学基金委员会“优秀青年基金”支持，2020年获得国家自然科学基金委员会“杰出青年基金”支持。作为主要完成人参与的“活细胞化学反应工具的开发与应用”项目获2020年国家自然科学奖二等奖(第二完成人)。同时，课题组还长期承担本科生科研实践项目，指导学生团队参加国际遗传工程机器大赛（iGEM），并多次斩获国际金奖。 工作经历 2014年——至今 南京大学化学化工学院 教授、博士生导师 2008年——2014年 南京大学生命科学学院 教授、博士生导师 2007年——2008年 美国罗门哈斯公司 任高级研究员 2005年——2007年 先后于加州大学伯克利分校、芝加哥大学进行博士后研究，合作导师：Dean Toste、何川 2005年 耶鲁大学 化学博士 导师：John Hartwig 1998年 南京大学化学系 学士

一、人工智能与合成生物学 通过人工酶智能进化，生物合成长链DNA 生物合成长链无机多聚磷酸盐 二、配位化学 纳米材料结合生物大分子的机理研究 配位选矿药剂的设计及其应用 半人工光合系统在合成生物学中的应用 三、化学生物学 金属药物的设计与合成 矿物中药的现代化研究

Jing Wang, Xinyang Zhao, Yucheng Tao, XiuxiuWang, Li Yan, Kuang Yu,Yi Hsu , Yuncong Chen*, Jing Zhao*, Yong Huang* and Wei Wei*. Biocompatible aggregation-induced emission active polyphosphate-manganese nanosheets with glutamine synthetase-like activity in excitotoxic nerve cells. Nat Commun. 2024;15(1):3534. Xinyang Zhao+, Xingyun Wang+, Wei Zhang, Tian Tian, Jingyi Zhang, Jing Wang, Wei Wei,* Zijian Guo, Jing Zhao,* and Xiuxiu Wang*.A Ferroptosis-Inducing Arsenene-Iridium Nanoplatform for Synergistic Immunotherapy in Pancreatic Cancer. Angew Chem Int Ed Engl. 2024;63(15):e202400829. Zhang J, Qin Y, Chen Y, Zhao X, Wang J, Wang Z, Li J, Zhao J, Liu S, Guo Z, Wei W*, Zhao J*, Wang X*. Ultrathin 2D As2Se3 Nanosheets for Photothermal-Triggered Cancer Immunotherapy. ACS Nano. 2024 Feb 6;18(5):4398-4413. Zhao X, Wang X, Zhang W, Tian T, Zhang J, Wang J, Wei W*, Guo Z, Zhao J*, Wang X*. A Ferroptosis-Inducing Arsenene-Iridium Nanoplatform for Synergistic Immunotherapy in Pancreatic Cancer. Angew Chem Int Ed Engl. 2024 Feb 13:e202400829. Chen Y, Hao T, Wang J, Chen Y, Wang X, Wei W*, Zhao J*, Qian Y*. A Near-Infrared Fluorogenic Probe for Rapid, Specific, and Ultrasensitive Detection of Sphingosine in Living Cells and In Vivo. Adv Sci (Weinh). 2024 Jan;11(2):e2307598. Lu Zhu, Wenjing Du, Yanrong Li*, Ding Li, Wei Wei*, Jing Zhao*, and Xiuxiu Wang*.Chiral SPINOL-Based Pt(II) Metallacycles For Immunogenic Cell Death.Inorg. Chem.2023, 62, 37, 14922–14930 Li X*, Wang Z, Hao X, Zhang J, Zhao X, Yao Y, Wei W, Cai R, He C, Duan C*, Guo Z, Zhao J*, Wang X*. Optically Pure Double-Stranded Dinuclear Ir(III) Metallohelices Enabled Chirality-Induced Photodynamic Responses. J Am Chem Soc. 2023 Jun 27. doi: 10.1021/jacs.3c03310. Xue Wu, Ding Li, Lei Xu, Yu-Fei Jiang, Yue Zhao* and Jing Zhao*. Construction of Cd (ii)-based metal–organic frameworks incorporating SiF 6 2− as fluorescence sensors for arginine. CrystEngComm, 2023, 25(21): 3222-3228. Jingyi Zhang, Yue Qin, Zhicheng Wang, Wei Zhang, Shengjin Liu, Wei Wei*, Xiuxiu Wang*, Jing Zhao* Ferroptosis-inducing Inorganic Arsenic (II) Sulfide Nanocrystals Enhance Immune Activation. Nano Research, 2023, https://doi.org/10.1007/s12274-023-5617-y Sun P, Li K, Liu X, Wang J, Qiu X, Wei W, Zhao J. Peptide-mediated Aqueous Synthesis of NIR-II Emitting Ag2 S Quantum Dots for Rapid Photocatalytic Bacteria Disinfection. Angew Chem Int Ed Engl. 2023 Feb 11:e202300085. doi: 10.1002/anie.202300085. Epub ahead of print. Zhang X, Wang J, Juan Y, Yang H, Wei W, Zhao J. A novel fluorescence method for detection of phosphate anions based on porphyrin metalation. Spectrochim Acta A Mol Biomol Spectrosc. 2022 Jun 5;274:121136. Xinyang Zhao,‡ Jingyi Zhang,‡ Wei Zhang, Zijian Guo, Wei Wei,* Xiuxiu Wang* and Jing Zhao*.A chiral fluorescent Ir(III) complex that targets the GPX4 and ErbB pathways to induce cellular ferroptosis.Chemical Science.2023.DOI: 10.1039/d2sc06171f Jing Wang, Yucheng Tao, Yewen Juan, Hang Zhou, Xinyang Zhao, Xiaomei Cheng,Xiuxiu Wang, Xuebo Quan, Junyan Li, Kai Huang,* Wei Wei,* and Jing Zhao*.Hierarchical Assembly of Flexible Biopolymer Polyphosphate-Manganese into Nanosheets.Small 2022,2203200| https://onlinelibrary.wiley.com/doi/10.1002/smll.202203200 Xiuxiu Wang, Jingyi Zhang, Yi Hu, Xinyang Zhao, Zhicheng Wang, Wei Zhang, Junchuan Liang, Wenhao Yu, Tian Tian, Hang Zhou, Jie Li, Shengjin Liu, Jing Zhao*, Zhong Jin*, Wei Wei*, and Zijian Guo.Multi-Omics Analysis Reveals the Unexpected Immune Regulatory Effects of Arsenene Nanosheets in Tumor Microenvironment ACS Appl. Mater. Interfaces 2022, XXXX, XXX, XXX-XXX https://pubs.acs.org/doi/10.1021/acsami.2c10743 Peiqing Sun, Kunlun Li, Kai Lin,* Wei Wei,* and Jing Zhao*.Ag2S Quantum Dots for Use in Whole-Cell Biohybrid Catalyst for Visible-Light-Driven Photocatalytic Organic Pollutant Degradation.ACS Appl. Nano Mater. 2022, XXXX, XXX, XXX-XXX Xiuxiu Wang, Zong-Chang Han, Wei Wei*, Hanshi Hu, Pengfei Li, Peiqing Sun, Xiangzhi Liu, Zhijia Lv, Feng Wang, Yi Cao, Zijian Guo,Jun Li* and Jing Zhao*.An unexpected all-metal aromatic tetranuclear silver cluster in human copper chaperone Atox1.Chem. Sci., 2022, Advance Article Z. Chen, D. Li, L. Xu, Y. Jiang, K. Lin*, Y. Zhao* and J. Zhao*, Cationic metal-organic frameworks constructed from a trigonal imidazole-containing ligand for the removal of Cr2O7 2- in water. New J. Chem., 2022, DOI: 10.1039/D2NJ01567F Xiao-Mei Cheng, Xiao-Yu Zhang, Xaio-Yao Dao, Shi-Qing Wang, Jing Zhao* and Wei-Yin Sun*, High-index facets exposed on metal-organic framework for boosting photocatalytic carbon dioxide reduction, Chemical Engineering Journal, 2022, 431,134125. (IF = 13.274) Xiao-Mei Cheng, Yuming Gu, Xiao-Yu Zhang, Xiao-Yao Dao, Shi-Qing Wang, Jing Ma*, Jing Zhao* and Wei-Yin Sun*, Crystallographic facet heterojunction of MIL-125-NH2(Ti) for carbon dioxide photoreduction, Applied Catalysis B: Environmental, 2021, 298, 120542. (IF = 19.509) Xiao-Mei Cheng, Xiao-Yao Dao, Shi-Qing Wang, Jing Zhao* and Wei-Yin Sun*, Enhanced photocatalytic CO2 reduction activity over NH2-MIL-125(Ti) by facet regulation, ACS Catalysis, 2021, 11, 650-658. (IF = 13.084) Wang, X.; Chen, F.; Zhang, J.; Sun, J.; Zhao, X.; Zhu, Y.; Wei, W.*; Zhao, J.*; and Guo,Z.*A ferroptosis-inducing iridium(III) complex. SCIENCE CHINA Chemistry.2020, 63 (1),:65-72. Jianbin Mo , Yun Xu, Longqian Zhu, Wei Wei* and Jing Zhao*.A Cysteine-Mediated Synthesis of Red Phosphorus Nanosheets. Angew. Chem. Int. Ed. 10.1002/anie.202101486 Miaomiao Han, Longqian Zhu, Jianbin Mo, Wei Wei, Biao Yuan, Jing Zhao,* and Chongjiang Cao*.Protein Corona and Immune Responses of Borophene: A Comparison of Nanosheet−Plasma Interface with Graphene and Phosphorene. ACS Appl. Bio Mater. 2020, 3, 4220−4229. Xuling Xue, Chenggen Qian, Qin Tao, Yuanxin Dai, Mengdi Lv, Jingwen Dong, Zhi Su, Yong Qian, Jing Zhao*, Hongke Liu*, Zijian Guo*.Using bioorthogonally catalyzed lethality strategy to generate mitochondria-targeting antitumor metallodrugs in vitro and in vivo. National Science Review 2020 , nwaa286, https://doi.org/10.1093/nsr/nwaa286 Yuelu Zhu, Feng Chen, Donghui Cheng, Ying Chen, Xinyang Zhao, Wei Wei, Yi Lu,* and Jing Zhao*.Rhodium(III)-Catalyzed Alkenyl C−H Functionalization to Dienes and Allenes.Org. Lett. 2020, 22, 8786−8790|https://dx.doi.org/10.1021/acs.orglett.0c03126 Yun Xu, Jianbin Mo, Wei Wei* & Jing Zhao*.Oxidized Black Phosphorus Nanosheets as an Inorganic Antiresorptive Agent. CCS Chem. 2020, 2, 1105–1115|https://doi.org/10.31635/ccschem.020.202000212 Xiuxiu Wang, Yi Hu, Jianbin Mo, Jingyi Zhang, Zhenzhen Wang, Wei Wei, Huanlin Li, Yun Xu, Jing Ma, Jing Zhao*, Zhong Jin*, Zijian Guo*. Arsenene: A Potential Therapeutic Agent for Acute Promyelocytic Leukaemia Cells by Acting on Nuclear Proteins.Angew. Chem. Int. Ed. 2020, 59, 2–1.|DOI:10.1002/anie.201913675