StockholmUniversity DepartmentofMolecularBiosciences,theWenner-GrenInstitute ArrheniuslaboratoriesE3,SE-10691Stockholm,Sweden BorninStockholm,Sweden,August16th1967. Professionalpreparation UndergraduateUniversity:StockholmUniversity.BachelorofScienceinChemistryandMicrobiology,1991

GraduateUniversity:UppsalaUniversity,Dept.ofMedicalImmunology&Microbiology.Areaofmolecularbiology.DoctorofMedicalScience,November10,1997

Thesis:Transcriptionalregulationbyadenovirusearlyregion1and4proteins.Supervisor:Prof.GöranAkusjärvi

PostdocUniversity:UniversityofCalifornia,Berkeley,Dept.ofMolecular&CellBiology,DivisionofGeneticsandDevelopment.Areaofdevelopmentalbiology,Jan.1998–Nov.1999Supervisor:Prof.MikeLevine

Docent(AssociateProfessor):Docentizoologiskutvecklingsbiologi,StockholmsUniversitet,2004-03-11. Position ProfessorofMoleculardevelopmentalbiologyatStockholmUniversitysince2011-12-01Directorofstudiesindevelopmentalbiology

Previouspositions

LecturerinmoleculardevelopmentalbiologyatStockholmUniversity,2011-01-01–2011-11-30

Researcher(Associateprofessor)inzoologicaldevelopmentalbiologyatStockholmUniversity,2004-05-01–2010-12-31

AssistantProfessoratStockholmUniversityfundedbytheSwedishResearchCouncil,

2000-05-01–2004-04-30.

Assignments Externalexaminer(Opponent)atdoctoraldisputations4times

Memberofdoctoralexaminationboard~20times

RevieweronAssistantProfessorappointmentinhematologyandepigenomics,andonAssociateProfessorappointmentinmolecularcellbiology(bothatKarolinskaInstitute)AdhocreviewerofNSF(USA),FRM(France)andSwedishCancerSocietygrants

IhaveservedasarefereeforthejournalsPLoSBiology,PNAS,CellReports,CurrentBiology,PLoSGenetics,Development,DevelomentalBiology,MolecularandCellularBiology(MCB),NucleicAcidsResearch(NAR),PLoSOne,MechanismsofDevelopment,Chromosoma,MolecularGeneticsandGenomics,DevelopmentalDynamics,andFEBSLetters.

MannervikM.,P.Putkonen,U.Ruden,K.Kent,E.Norrby,B.WahrenandP.A.Broliden(1992).IdentificationofB-cellantigenicsitesonHIV-2gp125.J.AIDS5,177-187.

BondessonM.,M.Mannervik,G.AkusjärviandC.Svensson(1994).AnadenovirusE1Atranscriptionalrepressordomainfunctionsasanactivatorwhentetheredtoapromoter.NucleicAcidsRes.22,3053-3060.

BondessonM.,K.Öhman,M.Mannervik,S.FanandG.Akusjärvi(1996).AdenovirusE4openreadingframe4proteinautoregulatesE4transcriptionbyinhibitingE1AtransactivationoftheE4promoter.J.Virol.70,3844-3851.

JordanP.,M.Mannervik,L.ToraandM.Carmo-Fonseca(1996).InvivoevidencethatTATA-bindingproteinSL1colocalizeswithUBFandRNApolymeraseIwhenrRNAsynthesisiseitheractiveorinactive.J.Cell.Biol.133,225-234.

MannervikM.andG.Akusjärvi(1997).Thetranscriptionalco-activatorproteinsp300andCBPstimulateadenovirusE1Aconservedregion1transactivationindependentofadirectinteraction.FEBSLett.414,111-116.

MannervikM.,S.Fan,A.-C.Ström,K.HelinandG.Akusjärvi(1999).AdenovirusE4-ORF4induceddephosphorylationinhibitsE1AactivationoftheE2promoterandE2F-1mediatedtransactivationindependentlyoftheretinoblastomatumorsuppressorprotein.Virology256,313-321.

MannervikM.(1999).Targetgenesofhomeodomainproteins.BioEssays21,267-270.

MannervikM.,Y.Nibu,H.ZhangandM.Levine(1999).Transcriptionalcoregulatorsindevelopment.Science284,606-609.

MannervikM.andM.Levine(1999).TheRpd3histonedeacetylaseisrequiredforsegmentationoftheDrosophilaembryo.Proc.Natl.Acad.Sci.U.S.A.96,6797-6801.

AsheH.,M.MannervikandM.Levine(2000).DppsignalingthresholdsinthedorsalectodermoftheDrosophilaembryo.Development127,3305-3312.

MannervikM.(2001).CorepressorproteinsinDrosophiladevelopment.CurrentTopicsinMicrobiologyandImmunology254,79-100.

OronE.,M.Mannervik,S.Rencus,O.Harari-Steinberg,S.L.Zipursky,S.Neuman-Silberberg,D.SegalandD.A.Chamovitz(2002).COP9signalosomesubunits4and5regulatemultiplepleiotropicpathwaysinDrosophilamelanogaster.Development129,4399-4409.

LiljaT.,Q.Dai,M.StabellandM.Mannervik(2003).TheCBPcoactivatorfunctionsbothupstreamanddownstreamofDpp/ScrewsignalingintheearlyDrosophilaembryo.Dev.Biol.262,294-302.

DaiQ.,LarssonJ.andM.Mannervik.(2004)DrosophilaAda2bisrequiredforviabilityandnormalhistoneH3acetylation.Mol.Cell.Biol.,24,8080-8089.

DaiQ.,JinH.,T.LiljaandM.Mannervik(2006).DrosophilaReptinandotherTIP60complexcomponentspromotegenerationofsilentchromatin.Genetics174,241-251

LiljaT.,H.Aihara,M.Stabell,Y.NibuandM.Mannervik(2007).TheacetyltransferaseactivityofDrosophilaCBPisdispensableforregulationoftheDpppathwayintheearlyembryo.Dev.Biol.,305,650-658.

HaeckerA.,DaiQ.,LiljaT.,MoussianB.,AndrioliLP.,LuschnigS.,andM.Mannervik(2007).DrosophilaBrakelessInteractswithAtrophinandisRequiredforTailless-MediatedTranscriptionalRepressioninEarlyEmbryos.PLoSBiology,5,1298-1308.

DaiQ.M.Bergman,H.Aihara,Y.NibuandM.Mannervik(2008).DrosophilaEbimediatesSnail-dependenttranscriptionalrepressionthroughHDAC3-inducedhistonedeacetylation.EMBOJ,27,898-909.

HaeckerA.,BergmanM.,NeupertC.,MoussianB.,LuschnigS.,AebiM.,andM.Mannervik(2008).WollknäuelisrequiredforembryopatterningandencodestheDrosophilaALG5UDP-glucose:dolichyl-phosphateglucosyltransferase.Development,135,1745-1749.

NègreN,BrownCD,MaL,BristowCA,MillerSW,WagnerU,KheradpourP,EatonML,LoriauxP,SealfonR,LiZ,IshiiH,SpokonyRF,ChenJ,HwangL,ChengC,AuburnRP,DavisMB,DomanusM,ShahPK,MorrisonCA,ZiebaJ,SuchyS,SenderowiczL,VictorsenA,BildNA,GrundstadAJ,HanleyD,MacAlpineDM,MannervikM,VenkenK,BellenH,WhiteR,GersteinM,RussellS,GrossmanRL,RenB,PosakonyJW,KellisM,WhiteKP(2011).Acis-regulatorymapoftheDrosophilagenome.Nature,471,527-31.

MelasPA,MannervikM,MathéAA,LavebrattC(2012).NeuropeptideY:IdentificationofanovelratmRNAsplice-variantthatisdownregulatedinthehippocampusandtheprefrontalcortexofadepression-likemodel.Peptides,35,49-55.

HolmqvistPH,BoijaA,PhilipP,CronaF,StenbergP,andM.Mannervik(2012).PreferentialgenometargetingoftheCBPco-activatorbyRelandSmadproteinsinearlyDrosophilamelanogasterembryos.PLoSGenetics,8(6):e1002769

HolmqvistPHandM.Mannervik(2013).Genomicoccupancyofthetranscriptionalco-activatorsp300andCBP.Transcription,4(1),18-23.

MelasPA,LennartssonA,Vakifahmetoglu-NorbergH,WeiY,ÅbergE,WermeM,RogdakiM,MannervikM,WegenerG,BrenéS,MathéAA,LavebrattC.(2013)Allele-specificprogrammingofNpyandepigeneticeffectsofphysicalactivityinageneticmodelofdepression.TranslPsychiatry,3:e255

CronaF,DahlbergO,LundbergLE,LarssonJ,andM.Mannervik(2013)GeneregulationbythelysinedemethylaseKDM4AinDrosophila.DevBiol.,373,453-63.

MannervikM.(2014)ControlofDrosophilaembryopatterningbytranscriptionalco-regulators.

ExpCellRes.321(1):47-57

MazariAM,DahlbergO,MannervikB,andM.Mannervik(2014).OverexpressionofglutathionetransferaseE7inDrosophiladifferentiallyimpactstoxicityoforganicisothiocyanatesinmalesandfemales.PLoSOne,9(10):e110103.

DahlbergO,ShilkovaO,TangM,HolmqvistPH,andM.Mannervik(2015)P-TEFb,theSuperElongationComplexandMediatorRegulateaSubsetofNon-pausedGenesduringEarlyDrosophilaEmbryoDevelopment.PLoSGenet.11(2):e1004971.

Shir-ShapiraH,SharabanyJ,FildermanM,IdesesD,Ovadia-ShochatA,MannervikM,Juven-GershonT.(2015)Structure-FunctionAnalysisoftheDrosophilamelanogasterCaudalTranscriptionFactorProvidesInsightsintoCorePromoter-preferentialActivation.JBiolChem.290(28):17293-305.

CronaF,HolmqvistPH,TangM,SinglaB,Vakifahmetoglu-NorbergH,FanturK,MannervikM.(2015)TheBrakelessco-regulatorcandirectlyactivateandrepresstranscriptioninearlyDrosophilaembryos.DevBiol.Aug7:DBIO15182.

BoijaAandMannervikM.(2015)Atimeofchange:DynamicsofchromatinandtranscriptionalregulationduringnuclearprogramminginearlyDrosophiladevelopment.MolReprodDev.82:735-46

CronaF,SinglaB,MannervikM.(2015)GeneexpressionprofilingofbrakelessmutantDrosophilaembryos.DataBrief.5:134-7

PhilipP,BoijaA,VaidR,ChurcherAM,MeyersDJ,ColePA,MannervikM,StenbergP.(2015)CBPbindingoutsideofpromotersandenhancersinDrosophilamelanogaster.Epigenetics&Chromatin.8:48.

BoijaA,MannervikM.(2016)InitiationofdiverseepigeneticstatesduringnuclearprogrammingoftheDrosophilabodyplan.ProcNatlAcadSciUSA.113:8735-40.

DerkachevaM,LiuS,FigueiredoDD,GentryM,MozgovaI,NanniP,TangM,MannervikM,KöhlerC,HennigL.(2016)H2AdeubiquitinasesUBP12/13arepartoftheArabidopsispolycombgroupproteinsystem.NaturePlants.2:16126.