林英武
博士 教授
个人简介
林英武,男,1976年6月生,安徽安庆人,博士,南华大学教授。湖南省首届“优秀研究生导师”、湖南省121创新人才工程第三层次人选。南华大学“蒸湘学者”、“船山学者青年人才”。现任化学化工学院党委书记,蛋白质结构与功能实验室副主任,无机与分析化学研究所所长,南华大学侨联副主席。 2005年12月博士毕业于复旦大学化学系,导师黄仲贤教授。2008年7月-2010年6月在美国伊利诺伊大学香槟分校(UniversityofIllinoisatUrbana-Champaign,UIUC)化学系从事博士后研究(导师:Prof.YiLu)。2013年5月-2013年11月在日本奈良先端科学技术大学院大学(NaraInstituteofScienceandTechnology,NAIST)从事科研合作研究(JSPS访问学者,合作者Prof.ShunHirota)。 主持国家自然基金面上项目、国家自然基金青年项目、教育部留学回国启动基金、湖南省自然科学杰出青年基金、南京大学配位化学国家重点实验室开放基金等。目前,相关科研成果发表于Nature、PNAS、JACS、AngewChem、CoordChemRev、ACSCatalysis、ChemCommun、DaltonTrans、InorgChem、InorgChemFront、ChemAsianJ、ChemBioChem、JInorgBiochem、中国科学(化学)等国内外期刊累计130余篇,其中第一作者或通讯作者SCI论文80余篇。
研究领域
(1)生物无机与蛋白质化学;(2)人工金属酶的分子设计及应用;(3)天然锕系元素的化学生物学效应。
学术兼职
国家自然基金(重大培育项目、面上项目、青年项目和地区项目)函评专家、北京市自然科学基金、河北省自然科学基金等函评专家。2017年1月起,任国际学术期刊ChemistryOpen期刊顾问委员会委员;2018年10月起,任国际学术期刊JournalofProteins&Peptides编委。
近期论文
1.Ying-WuLin*.Rationaldesignofmetalloenzymes:Fromsingletomultipleactivesites.CoordChemRev2017,336:1-27.(IF:13)(Review)(JCR分区:一区;IF=13.467高被引论文)
2.Ying-WuLin*.Understandingthechoicecopperbyheme-copperoixdaseusingbiosyntheticmodelsinmyoglobin.InorgChemFront.2017,DOI:10.1039/C6QI00603E.(Highlight)(JCR分区:二区;IF=5.934)
3.ShanHu,BoHe,Ke-JieDu,Xiao-JuanWang,Shu-QinGao,Ying-WuLin*.PeroxidaseActivityofac-typeCytochromeb5inNon-nativeStateisComparabletothatofNativePeroxidases.ChemistryOpen2017,DOL:10.1002/open.201700055(InsideFrontCover)(JCR分区:三区;IF=2.801)
4.ShanHu,BoHe,Xiao-JuanWang,Shu-QinGao,Ge-BoWen,Ying-WuLin*.Stabilizationofcytochromeb5byaconservedtyrosineinthesecondarysphereofhemeactivesite:Aspectroscopicandcomputationalstudy.SpectrochimicaActaA,2017,174:118-123.(JCR分区:二区;IF=2.880)
5.Le-LeLi,HongYuan,FeiLiao,BoHe,Shu-QinGao,Ge-BoWen,XiangshiTanandYing-WuLin*.RationalDesignofArtificialDye-decolorizingPeroxidasesusingMyoglobinbyEngineeringTyr/TrpintheHemeCenter.DaltonTransactions,2017,DOI:10.1039/C7DT02302B.(JCR分区:二区;IF=4.099)
6.MingChen,ZhonghuaWang,*JinxiaShu,XiaohuiJiang,WeiWang,Zhen-HuaShiandYing-WuLin*.MimickingaNaturalEnzymeSystem:CytochromecOxidase-LikeActivityofCu2ONanoparticlesbyReceivingElectronsfromCytochromec.InorganicChemistry,2017,DOI:10.1021/acs.inorgchem.7b01393.(JCR分区:二区;IF=4.85)
7.Zhen-HuaShi,Ke-JieDu,*BoHe,Shu-QinGao,Ge-BoWen,Ying-WuLin*.Photo-inducedDNAcleavagebyzinc-substitutedmyoglobinwitharedesignedactivecenter.InorgChemFront.2017,DOI:10.1039/c7qi00384f.(JCR分区:二区;IF=5.934)
8.ShunHirota*andYing-WuLin*.Designofartificialmetalloenzymes/metalloproteinsbytuningnoncovalentinteractions.JBiolInorgChem,2018,23(1):7-25.(Invitedreviewtocelebratethe80thbirthdayofProf.HelmutSigel)(IF=2.952)
9.Ying-WuLin*.Structureandfunctionofhemeproteinsregulatedbypost-translationalmodifications.ArchBiochemBiophys,2018,641:1-30.(Review).(IF=3.118)
10.XiaojuanWang,ChuanwanWei*,Ji-HuSu,BoHe,Ge-BoWen,Ying-WuLin*andYiZhang*.AChiralLigandAssemblythatConfersOne-electronO2ReductionActivityforaCu2+-selectiveMetallohydrogel.AngewChemIntEd,2018,doi:10.1002/anie.201801290.(JCR分区:一区;IF=12.257)
11.Hui-MinCheng,HongYuan,Xiao-JuanWang,Jia-KunXu,Shu-QinGao,Ge-BoWen,XiangshiTanandYing-WuLin*.FormationofCys-hemecross-linkinK42Cmyoglobinunderreductiveconditionswithmolecularoxygen.JInorgBiochem,2018,182:141-149.(IF=3.063)
12.Lu-LuYin,HongYuan,Ke-JieDu,BoHe,Shu-QinGao,Ge-BoWen,XiangshiTanandYing-WuLin*.Regulationofbothstructureandfunctionbyadenovodesigneddisulfidebond:Acasestudyofhemeproteininmyoglobin.ChemCommun,2018,DOI:10.1039/C8CC01646A.(JCR分区:一区;IF=6.164)
13.Hai-XiaoLiu,LianzhiLi,BoHe,Shu-QinGao,Ge-BoWen,andYing-WuLin*.Neuroglobiniscapableofself-oxidationofmethionine64introducedatthehemeaxialposition.DaltonTransactions,2018,DOI:10.1039/C8DT02397B.(JCR分区:二区;IF=4.099)
14.Chuan-WanWei,Xiao-JuanWang*,Shu-QinGao,Ge-BoWen,andYing-WuLin*.ALa3+-selectivemetallohydrogelwithafacilegelatorofphenylalaninederivativecontaininganimidazolegroup.DaltonTransactions,2018,DOI:10.1039/C8DT03557A.(JCR分区:二区;IF=4.099)
15.Lu-LuYin,HongYuan,CanLiu,BoHe,Shu-QinGao,Ge-BoWen,XiangshiTanandYing-WuLin*.ARationallyDesignedMyoglobinExhibitsaCatalyticdehalogenationEfficiencyMorethan1000-FoldthatofaNativeDehaloperoxidase.ACSCatalysis,2018,DOI:10.1021/acscatal.8b02979.(JCR分区:一区;IF=12.221)
16.CanLiu,JiakunXu,Shu-QinGao,BoHe,Chuan-WanWei*,Xiao-JuanWang,ZhonghuaWang,andYing-WuLin*.Greenandefficientbiosynthesisofindigofromindolebyengineeredmyoglobins.RSCAdvances,2018,8:33325-33330.
17.Hai-XiaoLiu,LianzhiLi,Xin-ZhiYang,Chuan-WanWei,Hui-MinCheng,Shu-QinGao,Ge-BoWenandYing-WuLin*.Enhancementofproteinstabilitybyanadditionaldisulfidebonddesignedinhumanneuroglobin.RSCAdvances,2019,9:4172-4179.
18.Chuan-WanWei,Xiao-JuanWang*,Shu-QinGao,Ge-BoWen,andYing-WuLin*.Aphenylalaninederivativecontaininga4-pyridinegroupisabletoconstructbothsinglecrystalsandaselectiveCu-Agbimetallohydrogel.EurJInorgChem,2019,DOI:10.1002/ejic.200900078(VeryImportantPaper)
19.CanLiu,HongYuan,FeiLiao,Chuan-WanWei,Ke-JieDu,Shu-QinGao,XiangshiTanandYing-WuLin*.UniqueTyr-hemedoublecross-linksinF43Y/T67Rmyoglobin:anartificialenzymewithaperoxidaseactivitycomparabletothatofnativeperoxidases.ChemCommun,2019,DOI:10.1039/C9CC02714A(JCR分区:一区;IF=6.164)
20.Xiao-JuanWang,Chuan-WanWei,*Shu-QinGao,BoHe,andYing-WuLin*.Assemblyof(L+D)-TryptophanderivativescontaininganimidazolegroupselectivelyformsararepurpleNi2+-hydrogel.ChemistryOpen.2019,DOI:10.1002/open.201900214.
21.Xiao-QingGong,Chuan-WanWei,Jia-KunXu,Xiao-JuanWang,*Shu-QinGaoandYing-WuLin*.BiomimeticMineralizationofCytochromecImprovestheCatalyticEfficiencyandConfersaFunctionalMulti-enzymeComposite.Catalysts.2019,inpress.(InvitedArtical)
22.Ying-WuLin*.Rationaldesignofhemeenzymesforbiodegradationofpollutantstowardagreenfuture.BiotechnolApplBiochem.2019,DOI:10.1002/bab.1788(InvitedReview)
23.Ying-WuLin*.Rationaldesignofartificialmetalloproteinsandmetalloenzymeswithmetalclusters.Molecules.2019,inpress(InvitedReview)
24.PingZhang,JiakunXu,Xiao-JuanWang,BoHe,Shu-QinGao,Ying-WuLin*.TheThirdGenerationofArtificialDye-DecolorizingPeroxidaseRationallyDesignedinMyoglobin,ACSCatalysis,2019,DOI:10.1021/acscatal.9b02226.(JCR分区:一区;IF=12.221)
25.PingZhang,HongYuan,JiakunXu,Xiao-JuanWang,Shu-QinGao,XianshiTan,Ying-WuLin*.ACatalyticBindingSitetogetherwithaDistalTyrinMyoglobinAffordsCatalyticEfficienciesSimilartoNaturalPeroxidases,ACSCatalysis,2019,DOI:10.1021/acscatal.9b05080.(JCR分区:一区;IF=12.221)
26.Xiao-FengWang*,YangyangChen,Li-PingSong,ZhenFang,JianZhang,FanianShi,Ying-WuLin*,YunkaiSun,Yue-BiaoZhang*,JoãoRocha*.CooperativeCaptureofUranylIonsbyaCarbonyl-BearingHierarchical-PorousCu-OrganicFramework.AngewChemIntEd,2019,doi.org/10.1002/anie.201909045(JCR分区:一区;IF=12.257)(HotPaper)
其他十篇代表性论文:
1.NatashaYeung,Ying-WuLin,Yi-GuiGao,XuanZhao,BrandyS.Russell,LanyuLei,KyleD.Miner,HowardRobinson,andYiLu*.Rationaldesignofastructuralandfunctionalnitricoxidereductase.Nature,2009,462(7276):1097-1082.
2.Ying-WuLin,NatashaYeung,Yi-GuiGao,KyleD.Miner,ShiliangTian,HowardRobinson,andYiLu*.Rolesofglutamatesandmetalionsinarationallydesignednitricoxidereductasebasedonmyoglobin.ProcNatlAcadSciUSA,2010,107(19):8581-8586.
3.Ying-WuLin,NatashaYeung,Yi-GuiGao,KyleD.Miner,LanyuLei,HowardRobinson,andYiLu*.Introducinganon-hemeironcenterintomyoglobinconfersnitricoxidereductaseactivity.JAmChemSoc,2010,132(29):9970-9972.
4.LinYing-Wu*.Structuralinsightsintoalow-spinmyoglobinvariantwithbis-Hiscoordinationfrommolecularmodeling.Proteins,2011,79(3):679-684.
5.LinYing-Wu,ElizabethB.Sawyer*,JiangyunWang*.Hemeproteindesign:AllroadsleadtoRome.ChemAsianJ,2013,8(11):2534-2544.(Invitedreview)
6.LinYing-Wu*,JiangyunWang*.Structureandfunctionofhemeproteinsinnon-nativestates:Amini-review.JInorgBiochem.2013,129(12):162-171.(Invitedreview)
7.Ying-WuLin*,JiangyunWang*,YiLu*.Functionaltuningandexpandingofmyoglobinbyrationalproteindesign.ScienceChinaChemistry,2014,57(3):346-355.(Invitedreview)
8.Ying-WuLin*.Thebroaddiversityofheme-proteincross-links:anoverview.BBA-ProteinsandProteomics,2015,1854(8):844-859.
9.Ying-WuLin,SatoshiNagao,MohanZhang,YasuhitoShomura,YoshikiHiguchi,ShunHirota*.RationalDesignofHeterodimericProteinUsingDomainSwappingforMyoglobin.Angew.Chem.Int.Ed.2015,54:511-515.
10.Lei-BinWu,HongYuan,Shu-QinGao,YongYou,Chang-MingNie,Ge-BoWen,Ying-WuLin*,XiangshiTan*.Regulatingthenitritereductaseactivityofmyoglobinbyredesigningthehemeactivecenter.NitricOxide,2016,57:21-29.