个人简介 2008年获香港科技大学生物工程学专业博士学位，之后在香港科技大学生命科学部从事博士后研究，并相继被聘为副研究员、研究助理教授。2011年受聘“南方医科大学引进人才”教授岗位。 关注遗传变异介导的表观修饰变化调控胎儿血红蛋白表达的分子机制。在Molecular Psychiatry，AJHG, Epigenetics, Journal Psychiatric Research, Schizophrenia Research等专业期刊发表SCI论文30多篇（累计影响因子100多点）。主持或参与国家重点研发项目、国家十二五重大科技专项、国家自然科学基金、教育部博士点新教师基金、广东省自然科学基金、广东省教育厅引进人才专项基金、广东省科技计划项目、广州市科技计划项目、南方医科大学引进人才专项基金和第八批广东省“千百十人才培养工程”培养对象等项目资助，并获2010年教育部高等学校科学研究优秀成果奖-自然科学类2等奖（第3完成人）。 Professor Cunyou Zhao is Professor and Associate Director of Department of Medical Genetics in Southern Medical University. He obtained his Ph.D. in Bioengineering from the Hong Kong University of Science and Technology (HKUST) in 2008. He then worked at the Division of Life Science in HKUST as a postdoctoral fellow. Professor Zhao was appointed as Research Assistant Professor at Applied Genomics Center in HKUST in 2009. He joined Southern Medical University in 2011 as a full professor. The research interests of Professor Zhao focus on Epigenetics including DNA methylation & hydroxymethylation and non-coding RNAs in human diseases, including psychiatric disorders and b-thalassemia. (ORCID ID: https://orcid.org/0000-0001-6116-4584 ) 获得奖励

1. 以伽玛氨基丁酸受体为靶点攻克人类神经精神疾患，获教育部自然科学奖二等奖 2011年1月，第三完成人

主持课题

序号 课题名称 项目来源 资助金额 起止年份 1 等位基因特异性DNA甲基化（ASM）参与同卵双生子单发精神分裂症发病机制的研究(Involvement of allele-specific DNA methylation (ASM) in the etiology of monozygotic twins discordant for schizophrenia) 国家自然科学基金 52 2017-2020 2 GABRB2 基因羟甲基化修饰与精神分裂症的相关性研究(Hydroxymethylation in schizophrenia candidate gene GABRB2 encoding GABAA receptor beta 2 subunit) 国家自然科学基金 70 2014-2017 3 表观遗传学修饰在双相障碍发病中的作用机制及其在早期诊断应用的研究(Epigenetics modifications in bipolar disorder: functional mechanism and potential utility in early diagnosis) 广东省科技计划粤港合作项目 50 2017-2019 4 耐药结核分子诊断产品的研发 广东省科技计划项目（对外科技合作类） 25 2014-2016 5 Alu-Y亚家族DNA甲基化修饰与精神分裂症的关联研究 高等学校博士学科点专项科研基金（新教师类） 4 2013-2015 6 结核病生物标志物和诊断技术的研究 重大传染病防治国家科技重大专项“十二五”计划 70 2013-2015 7 单碱基延伸结合荧光偏振检测的结核杆菌耐多药分子诊断方法的建立 广州市科技计划项目（对外科技合作类） 20 2013-2015

表观遗传学修饰（DNA甲基化及羟甲基化和非编码RNA）与人类遗传病（精神疾病和beta-地中海贫血）

中国中医药研究促进会心身医学专业委员会常委、中国遗传学会科学道德与伦理委员会委员、广东省医学会医学遗传学会常委兼秘书、广东省医学会精神病学学会委员、广东省干细胞临床研究专家委员会委员等职务。Frontiers in Genetics 客座编辑，Neuroscience Letter、Clinical Epigenetics和Neuroscience Bulletin等杂志的同行评阅人。

代表性著作/论文

1) Hou, Y., W. Liang, J. Zhang, Q. Li, H. Ou, Z. Wang, S. Li, X. Huang, and C. Zhao*, Schizophrenia-associated rs4702 G allele-specific downregulation of FURIN expression by miR-338-3p reduces BDNF production. Schizophrenia Research, 2018 (PMID: 29499969) 2) Chen, D., Y. Zuo, X. Zhang, Y. Ye, X. Bao, H. Huang, W. Tepakhan, L. Wang, J. Ju, G. Chen, M. Zheng, D. Liu, S. Huang, L. Zong, C. Li, Y. Chen, C. Zheng, L. Shi, Q. Zhao, Q. Wu, S. Fucharoen, C. Zhao*, and X. Xu*, A Genetic Variant Ameliorates b-Thalassemia Severity by Epigenetic-Mediated Elevation of Human Fetal Hemoglobin Expression. Am J Hum Genet, 2017. 101(1): 130-138 (PMID: 28669403) 3) Zong, L., L. Zhou, Y. Hou, L. Zhang, W. Jiang, W. Zhang, L. Wang, X. Luo, S. Wang, C. Deng, Z. Peng, S. Li, J. Hu, H. Zhao, and C. Zhao*, Genetic and epigenetic regulation on the transcription of GABRB2: Genotype-dependent hydroxymethylation and methylation alterations in schizophrenia. J Psychiatr Res, 2017. 88: 9-17 (PMID:28063323) 4) Jiang, T., L. Zong, L. Zhou, Y. Hou, L. Zhang, X. Zheng, H. Han, S. Li, W. Zhang, J. Zhang, C. Deng, Y. Jia, and C. Zhao*, Variation in global DNA hydroxymethylation with age associated with schizophrenia. Psychiatry Res, 2017. 257: 497-500 (PMID: 28841512). 5) Wang, L., W. Jiang, Q. Lin, Y. Zhang, and C. Zhao*, DNA methylation regulates gabrb2 mRNA expression: developmental variations and disruptions in l-methionine-induced zebrafish with schizophrenia-like symptoms. Genes Brain Behav, 2016. 15(8): 702-710 (PMID: 27509263). 6) 周林，宗璐，张璐璐，邓聪，赵存友*, GABRB2基因启动子区单核苷酸多态性与精神分裂症的关联. 南方医科大学学报, 2015. 35(2): 256-259 (PMID:25736124) 7) Li, S., Z. Wang, L. Zhou, F. Luo, and C. Zhao*, Fluorescence polarization-based method with bisulfite conversion-specific one-label extension for quantification of single CpG dinucleotide methylation. Genome, 2015. 58(7): 357-63 (PMID: 26334496). 8) Sun, Y., S. Li, L. Zhou, L. Zhou, Q. Zhong, S. Fang, T. Chen, L. Bi, W.K. Mat, C. Zhao*, and H. Xue*, A rapid fluorescence polarization-based method for genotypic detection of drug resistance in Mycobacterium tuberculosis. Appl Microbiol Biotechnol, 2014. 98(9): 4095-105 (PMID:24449341). 9)Zhao, C*. and H. Xue*, A simple method for high-throughput quantification of genome-wide DNA methylation by fluorescence polarization. Epigenetics, 2012. 7(4): 335-339 (PMID: 22419070) 10) Zhao, C., F. Wang, F.W. Pun, L. Mei, L. Ren, Z. Yu, S.K. Ng, J. Chen, S.Y. Tsang, and H. Xue, Epigenetic regulation on GABRB2 isoforms expression: developmental variations and disruptions in psychotic disorders. Schizophr Res, 2012. 134(2-3): 260-266 (PMID: 22206711). 11) Pun, F.W., C. Zhao, W.S. Lo, S.K. Ng, S.Y. Tsang, V. Nimgaonkar, W.S. Chung, G.S. Ungvari, and H. Xue, Imprinting in the schizophrenia candidate gene GABRB2 encoding GABA(A) receptor beta(2) subunit. Mol Psychiatry, 2011. 16(5): 557-568. (PMID:20404824) 12) Zhao, C., Z. Xu, F. Wang, J. Chen, S.K. Ng, P.W. Wong, Z. Yu, F.W. Pun, L. Ren, W.S. Lo, S.Y. Tsang, and H. Xue, Alternative-splicing in the exon-10 region of GABA(A) receptor beta(2) subunit gene: relationships between novel isoforms and psychotic disorders. PLoS One, 2009. 4(9): e6977 (PMID:19763268) 13) Chen, J., S.Y. Tsang, C.Y. Zhao, F.W. Pun, Z. Yu, L. Mei, W.S. Lo, S. Fang, H. Liu, G. Stober, and H. Xue, GABRB2 in schizophrenia and bipolar disorder: disease association, gene expression and clinical correlations. Biochem Soc Trans, 2009. 37(Pt 6): 1415-1418 (PMID:19909288) 14) Zhao, C., Z. Xu, J. Chen, Z. Yu, K.L. Tong, W.S. Lo, F.W. Pun, S.K. Ng, S.Y. Tsang, and H. Xue, Two isoforms of GABA(A) receptor beta2 subunit with different electrophysiological properties: Differential expression and genotypical correlations in schizophrenia. Mol Psychiatry, 2006. 11(12): 1092-1105 (PMID:16983389)