陈建军 照片

陈建军

教授 博士生导师

所属大学: 南方医科大学

所属学院: 药学院

邮箱:
jchen21@smu.edu.cn

个人简介

学习经历: 1998.9-2003.7沈阳药科大学,药学(英语),学士 2004.5-2006.5韩国江原国立大学,药物化学,硕士 2006.8-2011.5美国田纳西大学,药物化学,博士 2011.5-2013.12美国田纳西大学,博士后

工作经历: 2003.7-2004.5中国中化集团青岛公司,医药外贸与技术助理 2006.8-2011.5美国田纳西大学,研究助理 2014.1-2015.8美国南方大学药学院,助理教授(AssistantProfessor) 2015.8-2017.8美国芝加哥州立大学药学院,助理/副教授(Assistant/AssociateProfessor) 2017.8-南方医科大学药学院,教授

主要获奖情况: 1.青年海外高层次人才项目,中组部,2017 2.“NewInvestigatorAward”,美国药学院联合会/AACP,2016 3.“DistinguishedScholaroftheYear”,美国南方大学药学院,2015 4.“Travelaward”,美国田纳西大学,2011 5.“Travelaward”,泛美色素细胞研究学会会员/PASPCR,2009 6.“BEST-KNUfellowship”韩国江原国立大学,2004

主要科研课题: 1.广东省科技厅国际合作项目:靶向维生素D受体(VDR)的激动剂作为抗癌药物的研究与开发。2019-2021,主持(PI)。 2.广东省高水平大学建设/南方医科大学高层次人才引进科研启动项目。2017-2020,主持(PI)。 3.中组部青年海外高层次人才项目。新型小分子抗癌药物的研究。2017-2022,主持(PI)。 4.美国国立卫生研究院/NIH/NIGMS,SC3,1SC3GM122599。NovelHIF1αInhibitorsfortheTreatmentofBreastCancer。2016.8-2019.7。经费总额:36万美金,主持(PI)。 5.美国药学院联合会/AACP。NewInvestigatorAward。Novel&TargetedProdrugStrategyForTheTreatmentofResistantOvarianCancer。2016.1-2016.12。经费总额:1万美金,主持(PI)。 6.美国国立卫生研究院/NIH,1S10OD016226-01A1,MassSpectrometerforSmallMoleculeDrugDevelopment。2014.1-2014.12。经费总额:30万美金,合作研究者(Co-I)。 7.美国国立卫生研究院/NIH,1S10OD010678-01,AcquisitionofaQ-TOFMassSpectrometer。2012.5-2013.4。经费总额:32万美金,合作研究者(Co-I)。

专利: 1.陈建军,程斌斌。一种含取代联苯的黄酮及其应用,CN109456284A 2.陈建军,程斌斌。一种含取代联苯的查尔酮及其应用,CN109336857A 3.陈建军,程斌斌。一种含取代联苯的萘及其应用,CN109438263A 4.陈建军,程斌斌。一种间苯二酚二苯甲醚及其应用,CN109503546A. 5.陈建军,李玲,吕琳,全东令。一种咪唑衍生物及其用途,CN109438358A/CN109438249A 6.陈建军,李玲,吕琳,全东令。一种苯甲酸生物及其用途,201811461871.0 7.陈建军,李刚,邓欣,任益昌。一种2-(吲哚-3-基)-吡啶并咪唑及其应用,中国,CN109776528A 8.陈建军,程斌斌。一种含取代联苯的间苯二酚甲醚衍生物及其用途,CN109761952A 9.陈建军,程斌斌。一种间苯二酚二苯甲醚衍生物及其用途。PCT/CN2019/091193 10.陈建军,任益昌,程斌斌。一种苯并五元杂环衍生物及其应用。201910812479.1 11.Compoundsfortreatmentofcancer.JP2016510748;US20160015688;US10022356;MX2015011713;IN2015DN08964.Wang,Jin;Chen,Jianjun;Miller,DuaneD.;Li,Wei. 12.Preparationofimidazole-containingcompoundsandanalogsusefulinthetreatmentofcancer.KR2016-7017425A3;KR2017-7006276;AU2015202828;.Miller,DuaneD.;Wei,Li;Chen,Jianjun;Dalton,JamesT.;Li,Chien-Ming;Ahn,Sunjoo. 13.Preparationofaryl-andheterocycliccompoundsfortreatmentofcanceranddrug-resistanttumors.IN201718037031.Lu,Yan;Li,Chien-Ming;Wang,Zhao;Chen,Jianjun;Li,Wei;Dalton,JamesT.;Miller,DuaneD.;Duke,Charles;Ahn,Sunjoo. 14.Aroylazolecompoundsasanticanceragentsandtheirpreparationandusefortreatmentofcancersanddrugresistantcancers.US20180093971.Lu,Yan;Li,Chien-Ming;Wang,Zhao;Chen,Jianjun;Li,Wei;Dalton,JamesT.;Miller,DuaneD.;Duke,Charles;Ahn,Sunjoo. 15.Preparationofaryl-andheterocycliccompoundsfortreatmentofcanceranddrug-resistanttumors.JP2017008091.Dalton,JamesT.;Miller,DuaneD.;Ahn,Sunjoo;Chen,Jianjun;Duke,Charles;Li,Chien-Ming;Li,Wei;Lu,Yan;Wang,Zhao. 16.Enzymaticproductionorchemicalsynthesisandusesforandrosta-5,7-dienesorpregna-5,7-dienesandUVBconversionproductsthereof.US20140200201.Zjawiony,JordanK.;Li,Wei;Zbytek,Blazej;Tuckey,RobertC.;ZjawionyJordan,K.;Nguyen,MinhNgoc;Zmijewski,MichalA.;Janjetovic,Zorica;Sweatman,TrevorW.;Miller,DuaneD.;Chen,Jianjun. 17.Preparationofazolecompoundsfortreatmentofcancer.IN201718037031.Miller,DuaneD.;Li,Wei;Wang,Zhao;Lu,Yan;Chen,Jianjun;Dalton,JamesT.;Li,Chien-Ming. 18.Azolesandrelatedcompoundsfortreatmentofcancerandtheirpreparation.US20170226086;Li,Wei;Xiao,Mi;Dalton,James;Ahn,Sunjoo;Miller,DuaneD.;Chen,Jianjun;Wang,Jin. 19.Compoundsfortreatmentofcancer.WO2014138279;AU2014225761;KR2015123328.ByWang,Jin;Chen,Jianjun;Miller,DuaneD.;Li,Wei. 20.Preparationofazolecompoundsfortreatmentofcancer.US12/485,881.Miller,DuaneD.;Li,Wei;Wang,Zhao;Lu,Yan;Chen,Jianjun;Dalton,JamesT.;Li,Chien-Ming. 21.Enzymaticproductionorchemicalsynthesisandusesforandrosta-5,7-dienesorpregna-5,7-dienesandUVBconversionproductsthereof.US12/807,178.AndrzejT.Slominski.;Li,Wei;Zbytek,Blazej;Tuckey,RobertC.;ZjawionyJordan,K.;Nguyen,MinhNgoc;ZmijewsklMichal,A.;Janjetovic,Zorica;SweatmanTrevor,W.;Miller,DuaneD.;Chen,Jianjun,Postlethwaite,ArnoldE. 22.Design,synthesisandbiologicalstudiesofanewclassofcytotoxicagents,2-arylthiazolidine-4-carboxylicacidamidesforprostatecancer,2014.US7,307,093;US7,662,842;US8,592,465;Mexico262836;Japan5507552;RussianFederation2514427.JianjunChen,JamesDalton,DukeCharles,DongjinHwang,WeiLi,Chien-MingLi,YanLu,DuaneMiller,ZhaoWang.

研究领域

研究方向: 1.新型抗癌小分子药物的合成及体内外活性研究 2.新药筛选/研发计算机辅助药物设计合成药物化学

学术兼职

主要学术任职: 1.广东省药学会-药物化学专业委员会委员 2.美国制药科学家协会(AAPS)会员 3.美国药学院联合会(AACP)会员 4.美国癌症协会(AACR)会员 5.美国化学会(ACS)会员

近期论文

论文发表: 1.LingLi#,DonglingQuan#,JingxuanChen,JiahaoDing,JinwuZhao,LinLv*,JianjunChen*.Design,synthesis,andbiologicalevaluationof1-substituted-2-arylimidazolestargetingtubulinpolymerizationaspotentialanticanceragents.EurJMedChem.,2019,Sep26,184:111732. 2.HaoCao#,LingLi#,DeyingYang,LimingZeng,YeweiXie,BinYu*,GuochaoLiao*,JianjunChen*,RecentProgressinHistoneMethyltransferase(G9a)InhibitorsasAnticancerAgents.EurJMedChem.,2019Jun28,179:537-546. 3.JingxuanChen,SiboJiang,JinWang,JwalaRenukuntla,SumanSirimullaandJianjunChen*.AComprehensiveReviewofCytochromeP4502E1forXenobioticMetabolism.DrugMetabolismReviews.2019May,51(2):178-195. 4.XiaopengPeng,GuochaoLiao,PinghuaSun,ZhiqiangYu,JianjunChen*,AnoverviewofHDACinhibitorsandtheirsyntheticroutes.CurrentTopicsinMedicinalChemistry,2019,19(12):1005-1040. 5.Wu,Peng;Wang,Xuefeng;Wang,Zigui;Ma,Wen;Guo,Jinshan;Chen,Jianjun;Yu,Zhiqiang;Li,Jizhen;Zhou,Dongfang.Light-ActivatableProdrugandAIEgenCopolymerNanoparticleforDual-DrugMonitoringandCombinationTherapy.ACSApplMaterInterfaces.2019May22,11(20):18691-18700. 6.BinbinCheng,Wei-EnYuan,JingSu,YaoLiu,JianjunChen*,RecentAdvancesinSmallMoleculebasedCancerImmunotherapy,EurJMedChem.,2018,157:582-598. 7.XiaoxunLi,PeterD.Livant,JianjunChen*,Analkene-formingcascadereactionenrouteto2,2'-bi(glycerol),SynLett,2018,29(13):1769-1772. 8.LingLi,SiboJiang,XiaoxunLi,YaoLiu,JingSu,JianjunChen*,Recentadvancesintrimethoxyphenyl(TMP)basedtubulininhibitorstargetingthecolchicinebindingsite,EurJMedChem.,2018,151,482-494. 9.XiaoshuangGuo;YuanCheng;XiaotianZhao;YanliLuo;JianjunChen*;Wei-EnYuan*,Advancesinredox-responsivedrugdeliverysystemsoftumormicroenvironment,JournalofNanobiotechnology,2018,16(1):74.doi:10.1186/s12951-018-0398-2. 10.SiboJiang,YeseniaLFranco,YanZhou,JianjunChen*,NanotechnologyinRetinalDrugDelivery,InternationalJournalofOphthalmology,2018,11(6),1038-1044. 11.ZhongyaoCheng,YumeiLian,ZulKamal,XinMa,JianjunChen,XinboZhou*,JingSu*,MingfengQiu*.NanocrystalsTechnologyforPharmaceuticalScience.CurrPharmDes.2018,24(21):2497-2507. 12.XiaomingLi,XiaoshuangGuo,YuanCheng,XiaotianZhao,ZhiweiFang,YanliLuo,ShujunXia,YunFeng,JianjunChen*,Wei-enYuan*.pH-responsivecross-linkedlowmolecularweightpolyethylenimineasanefficientgenevectorfordeliveryofplasmidDNAencodinganti-VEGF-shRNAfortumortreatment.FrontiersinOncology,2018Sep25;8:354. 13.WangBin,YuLiu,LianyanHuang,JianjunChen,JingJingLi,RuishanWang,DehnaM.Fong,CarlesJusticia,AnnaPlanas,DeborahYoung,WeiLi,MichaelP.McDonald,RuihongChen&Francesca-FangLiao,“ACNS-permeableHsp90inhibitorrescuessynapticdysfunctionandmemorylossinAlzheimer’smiceviaHSF-1mediatedmechanism”,MolecularPsychiatry.2017,22(7):990–1001. 14.XuelanTang,PingLu,MingfengQiu,JianjunChen,JingSheng,JingSu,“ScreeningPEGylatedPolyethylenimineDerivativesforSafeandEfficientDeliveryofGeneMaterials”,EurJPharmSci.2017,96:115-128. 15.JianjunChen*,ReviewofDesignofPrecursorsforSustainableChemistry,JournalofNaturalProducts,2017,80(5),1701–1702. 16.YananSun,JingSu,GeyiLiu,JianjunChen,XiumeiZhang,RanZhang,MinhanJiang,MingfengQiu,“Advancesofbloodcell-baseddrugdeliverysystems”,RSCAdv.,2016,6,106316–106326. 17.Chuan-LingSi,Xiao-FengHuang,Liang-LiangAn,Cui-YunLiu,SuFan,Dan-NiXie,Yi-MeiHong,JianjunChen*.“ExtractionandStructuralCharacterizationofFlavonoidsfromTwigsofSophorajaponica”.BioResources,2015,10(4),8397-8404. 18.ParkHaeil,Chuan-LingSi,JianjunChen*.“TotalSynthesisofAmentoflavone”.MedicinalChemistry,2015,5(11),467-469. 19.ElaineW.Tieu,WeiLi,JianjunChen,Tae-KangKim,DejianMa,AndrzejT.Slominski,andRobertC.Tuckey,“Metabolismof20-hydroxyvitaminD3and20,23-dihydroxyvitaminD3byratandhumanCYP24A1”,JournalofSteroidBiochemistryandMolecularBiology,2015,149,153–165. 20.GeorginaN.Masoud,JinWang,JianjunChen,DuaneMiller,WeiLi.“Design,SynthesisandBiologicalEvaluationofNovelHIF-1αInhibitors”.AnticancerResearch,2015,35(7):3849-59. 21.JianjunChen,JinWang,Tae-KangKim,ElaineWTieu,EdithTang,ZongtaoLin,DianneKovacic,DuaneDMiller,ArnoldPostlethwaite,RobertTuckey,AndrzejTSlominski,WeiLi,“NovelVitaminDAnalogsasPotentialTherapeutics:Metabolism,ToxicityProfiling,andAntiproliferativeActivity”,AnticancerResearch,2014,34(5),2153-2163. 22.JianjunChen,JinWang,LucianaP.Schwab,Kyung-TaePark,TiffanyNSeagroves,LisaK.Jennings,DuaneD.Miller,WeiLi.“Benzimidazoleanalogsaspotenthypoxiainduciblefactorinhibitors:synthesis,biologicalevaluation,andprofilingdrug-likeproperties”,AnticancerResearch,2014,34(8)3891-3904. 23.JinWang,JianjunChen,DuaneD.MillerandWeiLi,“SynergisticCombinationsofNovelTubulinInhibitorsandVemurafenibOvercomeVemurafenibAcquiredResistanceinBRAFV600EMelanoma”,MolecularCancerTherapeutics,2014,13,16-26. 24.YanLu,JianjunChen,JinWang,Chien-MingLi,SunjooAhn,ChristinaM.Barrett,JamesT.Dalton,WeiLi,DuaneD.Miller,“Design,Synthesis,MolecularModeling,andBiologicalEvaluationofNovelColchicineBindingSiteTubulinInhibitorsasPotentialAnticancerAgents”,JournalofMedicinalChemistry,2014,57(17),7355–7366. 25.RobertC.Tuckey,AndrzejT.Slominski,ChloeY.S.Cheng,JianjunChen,Tae-KangKim,MinXiaoandWeiLi.“LumisterolismetabolizedbyCYP11A1:discoveryofanewpathway”,TheInternationalJournalofBiochemistry&CellBiology,2014,55,24-34. 26.JianjunChen,AndrzejT.Slominski,DuaneD.Miller,WeiLi.“EffectsofsidechainlengthandcompositiononthekineticconversionandproductdistributionofvitaminD3analogsdeterminedbyreal-timeNMR”,Dermato-Endocrinology,2013,5,142-149. 27.AndrzejT.Slominski,Tae-KangKim,MichalA.Zmijewski,ZoricaJanjetovic,WeiLi,JianjunChen,EkaterinaI.Kusniatsova,IgorSemak,ArnoldPostlethwaite,DuaneD.Miller,JordanK.Zjawiony,RobertC.Tuckey.“NovelvitaminDphotoproductsandtheirprecursorsintheskin”,Dermato-Endocrinology,2013,5,8-19. 28.EdithK.Y.Tang,JianjunChen,ZoricaJanjetovic,ElaineW.Tieu,AndrzejT.Slominski,WeiLiandRobertC.Tuckey.“HydroxylationofCYP11A1-derivedproductsofvitaminD3metabolismbyhumanandmouseCYP27B1”,DrugMetabolismandDisposition,2013,41,1112-1124. 29.HovigKouyoumdjian;DavidC.Zhu;MohammadH.El-Dakdouki;KellyLorenz;JianjunChen;WeiLi;XuefeiHuang.“GlyconanoparticleAidedDetectionofβ-AmyloidbyMagneticResonanceImagingandAttenuationofβ-AmyloidInducedCytotoxicity”,ACSChemicalNeuroscience,2013,4,575-584. 30.MinXiao,SunjooAhn,JinWang,JianjunChen,DuaneMiller,JamesDalton,WeiLi.“Discoveryof4-Aryl-2-benzoyl-imidazolesAsTubulinPolymerizationInhibitorwithPotentAntiproliferativeProperties”,JournalofMedicinalChemistry,2013,56,3318–3329. 31.JianjunChen,SunjooAhn,JinWang,YanLu,JamesT.Dalton,DuaneD.Miller,WeiLi,“Discoveryofnovel2-aryl-4-benzoyl-imidazole(ABI-III)analoguestargetingtubulinpolymerizationasantiproliferativeagents”,JournalofMedicinalChemistry,2012,55,7285-7289(本文首次报道的化合物已转让给美国VeruPharm公司,2019年开始在美国进行临床I/II期试验,治疗晚期前列腺癌;化合物代号:VERU-111;ClinicalTrials.govIdentifier:NCT03752099). 32.YanLu,JianjunChen,ZoricaJanjetovic,PhillipMichaels,EdithKYTang,Jinwang,RobertC.Tuckey,AndrzejT.Slominski,WeiLi,DuaneD.Miller,"Design,SynthesisandBiologicalBehavioroftheR-Epimerof20-HydroxyvitaminD3",JournalofMedicinalChemistry,2012,55(7),3573–3577. 33.ZhaoWang,JianjunChen,JinWang,SunjooAhn,Chien-MingLi,YanLu,VivianS.Loveless,JamesT.Dalton,DuaneD.Miller,WeiLi,“NovelTubulinPolymerizationInhibitorsOvercomeMultidrugResistanceandReduceMelanomaLungMetastasis”,PharmaceuticalResearch,2012,29,3040-3052. 34.YanLu,JianjunChen,MinXiao,WeiLi,DuaneD.Miller,“AnOverviewofTubulinInhibitorsThatInteractWiththeColchicineBindingSite”,PharmaceuticalResearch,2012,29,2943-2971. 35.ElaineW.Tieu,EdithK.Y.Tang,JianjunChen,WeiLi,MinhN.Nguyen,ZoricaJanjetovic,AndrzejSlominskiandRobertC.Tuckey,“RatCYP24A1actson20-hydroxyvitaminD3producinghydroxylatedproductswithincreasedbiologicalactivity”,BiochemicalPharmacology,2012,84,1696-1704. 36.Chien-MingLi,YanLu,JianjunChen,TerrenceA.Costello,RameshNarayanan,MaraN.Dalton,LindaM.Snyder,SunjooAhn,WeiLi,DuaneD.Miller,andJamesT.Dalton,“OrallyBioavailableTubulinAntagonistsforPaclitaxel-RefractoryCancer”,PharmaceuticalResearch,2012,29,3053-3063. 37.AndrzejT.Slominski,Tae-KangKim,JianjunChen,MinhN.Nguyen,WeiLi,CharlesR.Yates,TrevorSweatman,RobertC.Tuckey,"CytochromeP450scc-dependentmetabolismof7-dehydrocholesterolinthehumanplacenta",TheInternationalJournalofBiochemistry&CellBiology,2012,44,2003-2018. 38.RobertC.Tuckey,MinhN.Nguyen,JianjunChen,AndrzejSlominski,DonnaM.Baldisseri,ElaineW.Tieu,JordanK.Zjawiony,andWeiLi,“HumancytochromeP450scc(CYP11A1)catalysesepoxideformationwithergosterol”,DrugMetabolismandDisposition,2012,40,436-444. 39.ElaineW.Tieu,WeiLi,JianjunChen,DonnaM.Baldisseri,AndrzejT.Slominski,andRobertC.Tuckey.“Metabolismofcholesterol,vitaminD3and20-hydroxyvitaminD3incorporatedintophospholipidvesiclesbyhumanCYP27A1”,JournalofSteroidBiochemistryandMolecularBiology,2012,129,163-171. 40.JinWang,AndrzejSlominski,RobertTuckey,ZoricaJanjetovic,AnandKulkarni,JianjunChen,ArnoldE.Postlethwaite,DuaneMiller,WeiLi,"20-HydroxylvitaminD3possesseshighefficacyagainstproliferationofcancercellswhilebeingnon-toxic",AnticancerResearch,2012,32,739-746. 41.MohammadH.El-Dakdouki;DavidC.Zhu;KheireddineEl-Boubbou;MedhaKamat;JianjunChen;WeiLi;XuefeiHuang.“DevelopmentofMultifunctionalHyaluronanCoatedNanoparticlesforImagingandDrugDeliverytoCancerCells”.Biomacromolecules,2012,13(4),1144–1151. 42.ShivaputraA.Patila,JinWang,XiaochenS.Li,JianjunChen,TerreiaS.Jones,AmiraHosni-Ahmed,RenukadeviPatil,WilliamL.Seibel,WeiLi,andDuaneD.Millera,“NewSubstituted4H-Chromenesasanti-canceragents”.Bioorganic&MedicinalChemistryLetters,2012,22,4458-4461. 43.Tae-KangKim,JinWang,ZoricaJanjetovic,JianjunChen,RobertC.Tuckey,MinhN.Nguyen,EdithK.Y.Tang,DuaneMiller,WeiLi,andAndrzejT.Slominski,"CorrelationbetweensecosteroidinducedvitaminDreceptoractivityinmelanomacellsandcomputer-modeledreceptorbindingstrength".MolecularandCellularEndocrinology,2012,361,143-152. 44.AndrzejT.Slominski1,Tae-KangKim,HaleemZ.Shehabi,IgorSemak,EdithKYTang,MinhN.Nguyen,HeatherA.E.Benson,ElenaKorik,ZoricaJanjetovic,JianjunChen,CharlesR.Yates,ArnoldPostlethwaite,WeiLi,RobertC.Tuckey.“InvivoevidencefornovelpathwayofvitaminD3metabolisminitiatedbyP450scc”.FASEBJ,2012,26,7901-7915. 45.JianjunChen,Chien-MingLi,SunjooAhn,JinWang,ZhaoWang,YanLu,JamesDalton,Duane.D.Miller,WeiLi,“Synthesisandantiproliferativeactivityofnovel2-aryl-4-benzoyl-imidazolederivativestargetingtubulinpolymerization”.Bioorganic&MedicinalChemistry,2011,19,4782–4795. 46.Chien-MingLi,JianjunChen,YanLu,RameshNarayanan,DeannaN.Parke,WeiLi,DuaneD.Miller,andJamesT.Dalton,“PharmacokineticOptimizationof4-SubstitutedMethoxybenzoyl-Aryl-Thiazole(SMART)and2-Aryl-4-Benzoyl-Imidazole(ABI)forImprovingOralBioavailability”,DrugMetabolismandDisposition,2011,39:1833-1839. 47.MichalA.Zmijewski,WeiLi,JianjunChen,Tae-KangKim,JordanK.Zjawiony,,TrevorW.Sweatman,DuaneD.MillerandAndrzejT.Slominski,“Synthesisandphotochemicaltransformationof3β,21-dihydroxypregna-5,7-dien-20-onetobiologicallyactiveproducts”,Steroids,2011,76,193-203. 48.YanLu,Chien-MingLi,ZhaoWang,JianjunChen,MichaelMohler,WeiLi,JamesDalton,Miller,Duane,“Design,Synthesis,andSARStudiesof4-SubstitutedMethoxylbenzoyl-aryl-thiazolesAnaloguesasPotentandOrallyBioavailableAnticancerAgents",JournalofMedicinalChemistry,2011,54(13),4678–4693. 49.RobertC.Tuckey,WeiLi,HaleemZ.Shehabi,ZoricaJanjetovic,MinhN.Nguyen,Tae-KangKim,JianjunChen,DanielleE.Howell,HeatherA.E.Benson,TrevorSweatman,DonnaM.Baldisseri,andAndrzejSlominski.Productionof22-hydroxy-metabolitesofvitaminD3bycytochromeP450scc(CYP11A1)andanalysisoftheirbiologicalactivitiesonskincells.DrugMetabolismandDisposition,2011,39,1577-1588. 50.AndrzejSlominski,WeiLi,SyamalK.Bhattacharya,RichardA.Smith,PatriciaJohnson,JianjunChen,KathleenNelson,RobertCTuckey,DuaneMiller,ArnoldE.Postlethwaite,“NovelVitaminDAnalogues17,20S(OH)2pDand17,20R(OH)2pDareNoncalcemicandShowAntifibroticActivity”,TheJournalofInvestigativeDermatology,2011,131,1167–1169. 51.AndrzejT.Slominski,Tae-KangKim,ZoricaJanjetovic,RobertC.Tuckey,RadoslawBieniek,JunmingYue,WeiLi,JianjunChen,MinhN.Nguyen,DuaneMiller,TaiC.Chen,MichaelHolick,“20-hydroxyvitaminD2isanon-calcemicanalogofvitaminDwithpotentantiproliferativeandprodifferentiationactivitiesinnormalandmalignantcells”,AmericanJournalofPhysiologyCellPhysiology,2011,300,C526-C541. 52.JianjunChen,ZhaoWang,Chien-MingLi,YanLu,PavanK.Vaddady,BerndMeibohm,JamesDalton,Duane.D.Miller,WeiLi,“Discoveryofnovel2-aryl-4-benzoyl-imidazolestargetingthecolchicinesbindingsiteintubulinaspotentialanticanceragents”,JournalofMedicinalChemistry,2010,53,7414–7427. 53.WeiLi,JianjunChen,ZoricaJanjetovic,Tae-KangKim,TrevorSweatsman,JordanZjawiony,RobertCTuckey,DuaneMiller,AndrzejSlominski,“ChemicalSynthesisof20S-hydroxyvitaminD3,whichshowsanti-proliferativeactivity”,Steroids,2010,75,926-935. 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