工作经历 2016年-至今 南方科技大学生物系 助理教授(课题组长) 2009年-2016年 新加坡生物处理科技研究院免疫学组 博士后

学习经历 2002年-2009年 复旦大学 微生物学专业 博士学位 1997年-2001年 华中农业大学 微生物学专业 学士学位

免疫记忆的产生是判断疫苗接种是否成功和有效的关键。具有产生高亲和力抗体能力的记忆B细胞来自于生发中心，在这里，被抗原活化后的B细胞经过细胞分裂、抗体类别转换、体细胞高频突变以及抗体亲和力成熟等过程，最终分化发育成浆细胞和记忆B细胞，这些细胞对于体内病原体的清除至关重要。 本课题组的研究兴趣在于： （1）浆细胞和记忆B细胞产生和维持的分子机制； （2）B细胞相关自身免疫疾病以及肿瘤发生的分子机理

1. Ou X*, Huo J, Huang Y, Li YF, Xu S*, Lam KP*. Transcription factor YY1 is essential for iNKT cell development. Cellular & Molecular Immunology. 2018 Mar 2. doi: 10.1038/s41423-018-0002-6. (*co-corresponding author) 2. Li YF, Xu S, Huang Y, Ou X, Lam KP. Tyrosine kinase c-Abl regulates the survival of plasma cells. Scientific Reports. 2017 Jan 6;7:40133. 3. Li YF#, Ou X#, Xu S, Jin ZB, Iwai N, Lam KP. Loss of miR-182 affects B-cell extrafollicular antibody response. Immunology 2016, 148(2):140-9. (#co-first author) 4. Xu S#, Ou X#, Huo J, Lim K, Huang Y, Chee S, Lam KP. Mir-17-92 regulates bone marrow homing of plasma cells and production of immunoglobulin G2c. Nature Communications 2015, 6:6764. (#co-first author) 5. Li YF, Lee KG, Ou X, Lam KP. Bruton’s tyrosine kinase and protein kinase C µ are required for TLR7/9-induced IKKα and IRF-1 activation and interferon-β production in conventional dendritic cells. PLoS One 2014, 9(8):e105420. 6. Ou X, Xu S, Li YF, Lam KP. Adaptor protein DOK3 promotes plasma cell differentiation by regulating the expression of programmed cell death 1 ligands. PNAS 2014, 111(31):11431-6. 7. Li YF, Xu S, Ou X, Lam KP. Shp1 signalling is required to establish the long-lived bone marrow plasma cell pool. Nature Communications 2014, 5:4273. 8. Ou X, Xu S, Lam KP. Deficiency in TNFRSF13B (TACI) expands T-follicular helper and germinal center B cells via increased ICOS-ligand expression but impairs plasma cell survival. PNAS 2012, 109(38):15401-6. 9. Zhang X, Bao Y, Shi X, Ou X, Zhou P, Ding X. Efficient transposition of IS204-derived plasmids in Streptomyces coelicolor. Journal of Microbiological Methods 2012, 88(1):67-72. 10. Zhang L, Wang L, Wang J, Ou X, Zhao G, Ding X. DNA cleavage is independent of synapsis during Streptomyces phage phiBT1 integrase-mediated site-specific recombination. Journal of Molecular Cell Biology 2010, 2(5):264-75. 11. Ou X, Zhang B, Zhang L, Zhao G, Ding X. Characterization of rrdA, a TetR family protein gene involved in the regulation of secondary metabolism in Streptomyces coelicolor. Applied and Environmental Microbiology 2009, 75(7):2158-65. 12. Ou X, Zhang B, Zhang L, Dong K, Liu C, Zhao G, Ding X. SarA influences the sporulation and secondary metabolism in Streptomyces coelicolor M145. Acta Biochimica et Biophysica Sinica 2008, 40(10):877-82. 13. Zhang L, Ou X, Zhao G, Ding X. Highly efficient in vitro site-specific recombination system based on streptomyces phage phiBT1 integrase. Journal of Bacteriology 2008, 190(19):6392-7.