籍贯/山东聊城 讲授课程 《有机金属化学》（研究生课程）

《现代合成化学》（研究生课程）

教育经历

1984年本科毕业于山东师范大学化学系，1989年毕业于原杭州大学化学系并获硕士学位，后在原聊城师范学院工作。1993-96年在浙江大学攻读博士学位，从事金属有机化学、有机杂原子化学的研究，1996-98年在南开大学进行博士后研究工作。1998-2001年，在日本物质工学工业技术研究所担任STA研究员，从事有机磷化学的研究工作，2001年至2003年在加拿大西安大略大学做博士后，从事含磷配体的设计合成以及相关配合物超分子化学的研究工作，2003年回到日本产业技术综合研究所，担任特别研究员，继续从事有机磷化学的研究，2007年进入聊城大学化学系工作。

科研项目

碳磷多手性叔膦化合物的合成、应用及不对称诱导作用机理研究（山东省自然科学基金面上项目）

不对称磷氢化反应及相关手性含磷化合物的制备方法研究（国家自然科学基金面上项目）

科研方向/有机化学，不对称合成化学

1.T.Chen,C.-Q.Zhao,L.-B.Han,HydrophosphorylationofAlkynesCatalyzedbyPalladium:GeneralityandMechanism,J.Am.Chem.Soc.2017,139,inpress.

2.L.-J.Liu,W.-M.Wang,L.Yao,F.-J.Meng,Y.-M.Sun,H.Xu,Z.-Y.Xu,Q.Li,C.-Q.Zhao*andL.-B.Han,ReinvestigationoftheSubstitutionsReactionofStereogenicPhosphorylCompounds:Stereochemistry,MechanismandApplications,J.Org.Chem.,2017,82,inpress.

3.Jing-JingYe,Shao-ZhenNie,Ji-PingWang,Jing-HongWen,YuZhang,Mao-RanQiu,andChang-QiuZhao*NucleophilicSubstitutionofP-StereogenicChlorophosphines:TheMechanism,StereochemistryandStereoselectiveConversionsofDiastereomericSecondaryPhosphineOxidestoTertiaryPhosphines,Org.Lett.,2017,19(19),5384–5387.

4.Shao-ZhenNie†,Zhong-YangZhou†,Ji-PingWang,HuiYan,Jing-HongWen,Jing-JingYe,Yun-YaoCui,andChang-QiuZhao*Non-epimerizingAlkylationofH-PSpeciestoStereospecificallyGenerateP-StereogenicPhosphineOxides:AShortcuttoBidentateTertiaryPhosphineLigands,J.Org.Chem.,2017,82(18),9425–9434.

5.Ji-PingWang,Shao-ZhenNie,Zhong-YangZhou,Jing-JingYe,Jing-HongWen,andChang-QiuZhao*PreparationofOpticallyPureTertiaryPhosphineOxidesviatheAdditionofP‑StereogenicSecondaryPhosphineOxidetoActivatedAlkenes,J.Org.Chem.2016,81,7644−7653.

6.MengYang,HaoXu,Zhong-YangZhou,HeZhang,Li-JuanLiu,Yong-MingSun,Shao-ZhenNie,Chang-QiuZhao*AsymmetricinductionintheadditionofenantiomericallypureH-phosphinatetochiralaldimines:diastereoselectivegenerationofa-aminophosphinateswithP,C-stereogeniccenters,Tetrahedron:Asymmetry,2016,27,815–822.

7.Wei-MinWang,Li-JuanLiu,LanYao,Fan-JieMeng,Yong-MingSun,Chang-QiuZhao*,QingXu,andLi-BiaoHan,StereospecificPreparationsofP-StereogenicPhosphonothioatesandPhosphonoselenoates,J.Org.Chem.2016,81,6843−6847.

8.LanYao,Li-JuanLiu,Zhong-YuanXu,Shao-ZhenNie,Xiao-QingXiaoandChang-QiuZhao,VariablemechanismofnucleophilicsubstitutionofP-stereogenicphosphorylchloridewithalkynylmetallicreagents,Org.Biomol.Chem.2016,14,1702–1706.

9.Zhong-YangZhou,HeZhang,LanYao,Jing-HongWen,Shao-ZhenNie,andChang-QiuZhao*DoubleAsymmetricInductionDuringtheAdditionof(RP)-MenthylPhenylPhosphineOxidetoChiralAldimines,Chirality,2016,28,132–135.

10.HeZhang,MengYang,LanYao,Si-YuJi,Zhong-YuanXu,Yong-MingSun,andChang-QiuZhao*AFacileSynthesisofNovelAllenylphosphinatesContainingMultiPotentialAsymmetricCenters,J.HeterocyclicChem.,2016,54,1155-1158.

11.H.Zhang,Y.-M.Sun,Y.Zhao,Z.-Y.Zhou,J.-P.Wang,N.Xin,S.-Z.Nie,C.-Q.Zhao*andL.-B.Han,One-PotProcessThatEfficientlyGeneratesSingleStereoisomersof1,3-BisphosphinylpropanesHavingFiveChiralCenters，Org.Lett.,2015,17,142-145.

12.W.-M.Wang,L.-J.Liu,C.-Q.Zhao*,L.-B.HanDiastereoselectiveHydrolysisofAsymmetricP–ClSpeciesandSynthesisofOpticallyPure(RP)-(–)-MenthylH-Phenylphosphinate,Eur.J.Org.Chem.,2015,2342–2345.

13.Y.Zhao,T.Chen,D.Han,C.-Q.Zhao*,L.-B.Han,FacileBase-MediatedRedoxTransformation:AnEfficientStrategyfortheSynthesisofα-AcyloxyphosphorylCompounds,Org.Lett.,2014,16,6152–6155.

14.Y.-M.Sun,N.Xin,Z.-Y.Xu,L.-J.Liu,F.-J.Meng,H.Zhang,B.-C.Fu,Q.-J.Liang,H.-X.Zheng,L.-J.Sun,C.-Q.Zhao*,L.-B.Han,AdditionofopticallypureH-phoshphinatetoketones:selectivity,stereochemistryandmechanism,Org.Biomol.Chem.,2014,12,9457–9465.

15.S.-Y.Ji,Y.-M.Sun,H.Zhang,Q.-G.Hou,C.-Q.Zhao*Phosphoniumsaltinducedstereoselectiveallylicrearrangementduringchlorinationofα-hydroxyallylphosphinates,TetrahedronLett.,2014,55,5742-5744.

16.Y.-M.Sun,Z.-Y.Xu,L.-J.Liu,F.-J.Meng,H.Zhang,B.-C.Fu,L.-J.Sun,M.-J.Niu,S.-W.Gong,C.-Q.Zhao*,L.-B.Han,Preparationofenantiomericallypurea-hydroxylphosphinatesviahydrophosphorylationofaldehydeswithH-phosphinate,Tetrahedron:Asy.,2014,25,1520–1526.

17.H.Zhang,Y.-M.Sun,L.Yao,S.-Y.Ji,C.-Q.Zhao*,L.-B.Han,StereogenicPhosphorus-InducedDiastereoselectiveFormationofChiralCarbonduringNucleophilicAdditionofChiralH–PSpeciestoAldehydesorKetones,Chem.AsianJ.,2014,9,1329−1333.