个人简介
李彬,博士,研究员,博士生导师,江苏省农业科学院兽医研究所,所长。南京农业大学、江苏大学、河北农业大学、西藏农牧学院研究生导师。江苏省杰出青年基金获得者,江苏省十大青年科技之星,江苏省产业教授,江苏省“333高层次人才培养工程”中青年科学技术带头人,江苏省“六大人才高峰”资助对象,江苏省科技社团(学会)优秀青年人才,美国斯坦福大学访问学者,教育部学位论文评议专家。兼任江苏省畜牧兽医学会副理事长,中国微生物学会兽医微生物学会青年委员,中国畜牧兽医学会兽医公共卫生学分会理事,江苏省兽医免疫学常务委员,江苏省农业科学院欧美同学会副会长。
研究领域
动物腹泻病防控技术研究、重要猪病感染的分子机制、新型免疫佐剂和抗原递呈系统的开发。
近期论文
Baochao Fan, Jie Sun, Lin Zhu, Jinzhu Zhou, Yongxiang Zhao, Zhengyu Yu, Bing Sun, Rongli Guo, Kongwang He, Bin Li. Development of a Novel Double Antibody Sandwich Quantitative Enzyme-Linked Immunosorbent Assay for Detection of Porcine Epidemic Diarrhea Virus Antigen. Front Vet Sci. 2020, 7: 540248. Guangzhi Zhang*, Bin Li*, Dongwan Yoo*, Tong Qin, Xiaodong Zhang, Yaxiong Jia, Shangjin Cui. Animal coronaviruses and SARS-CoV-2. 2020; doi: 10.1111/tbed.13791. Xu X, Du L, Fan B, Sun B, Zhou J, Guo R, Yu Z, Shi D, He K, Li B. A flagellin-adjuvanted inactivated porcine epidemic diarrhea virus (PEDV) vaccine provides enhanced immune protection against PEDV challenge in piglets. Arch Virol. 2020, 165(6):1299-1309. Rongli Guo, Baochao Fan, Xinjian Chang, Jinzhu Zhou, Yongxiang Zhao, Danyi Shi, Zhengyu Yu, Kongwang He*, Bin Li*. Characterization and evaluation of the pathogenicity of a natural recombinant transmissible gastroenteritis virus in China. Virology, 2020, 545:24-32. Fan B, Zhu L, Chang X, Zhou J, Guo R, Zhao Y, Shi D, Niu B, Gu J, Yu Z, Song T, Luo C, Ma Z, Bai J, Zhou B, Ding S, He K*, Li B*. Mortalin restricts porcine epidemic diarrhea virus entry by downregulating clathrin-mediated endocytosis. Vet Microbiol. 2019, 239:108455. Fan B, Jiao D, Zhang R, Zhou J, Guo R, Yu Z, Shi D, Zhao Y, Gu J, Niu B, Ma Z, Gao S, He K, Li B*. Origin and epidemic status of porcine epidemic diarrhea virus variants in China. Transbound Emerg Dis. 2020,67(3):1364-1370. Luo L, Wang S, Zhu L, Fan B, Liu T, Wang L, Zhao P, Dang Y, Sun P, Chen J, Zhang Y, Chang X, Yu Z, Wang H, Guo R, Li B*, Zhang K*. Aminopeptidase N-null neonatal piglets are protected from transmissible gastroenteritis virus but not porcine epidemic diarrhea virus. Scientific Reports, 2019, 9(1):13186. Ren L*, Ding S*#, Song Y*, Li B*, Co J, Ramanathan M, Amieva MR, Khavari PA, and Greenberg HB#. Profiling of rotavirus 3’ UTR binding proteins reveals ATP synthase subunit ATP5B as a novel host factor that supports late stage virus replication. J Biol. Chem. 2019, 294(15): 5993-6006. Du L, Yu Z, Pang F, Xu X, Mao A, Yuan W, He K*, Li B*. Targeted Delivery of GP5 Antigen of PRRSV to M Cells Enhances the Antigen-Specific Systemic and Mucosal Immune Responses. Front Cell Infect Microbiol. 2018, 25;8:7. doi: 10.3389/fcimb. Bin Li, Luping Du, Zhengyu Yu, Bing Sun, Xiangwei Xu, Baochao Fan, Rongli Guo, Wanzhe Yuan, Kongwang He. Poly (D, L-lactide-co-glycolide) nanoparticle-entrapped vaccine induces a protective immune response against porcine epidemic diarrhea virus infection in piglets. Vaccine, 2017.15;35(50):7010-7017. Bin Li, Siyuan Ding, Ningguo Feng, Nancie Mooney, Yaw Shin Ooi, Lili Ren, Jonathan Diep, Marcus R. Kelly, Linda L. Yasukawa, John T. Patton, Hiroyuki Yamazaki, Tomoaki Shirao, Peter K. Jackson, and Harry B. Greenberg*. Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis. Proc Natl Acad Sci USA. 2017. 114(18):E3642-E3651. Lin H, Li B, Chen L, Ma Z, He K, Fan H. Differential Protein Analysis of IPEC-J2 Cells Infected with Porcine Epidemic Diarrhea Virus Pandemic and Classical Strains Elucidates the Pathogenesis of Infection. J Proteome Res. 2017, 16(6):2113-2120. Fan B, Jiao D, Zhao X, Pang F, Xiao Q, Yu Z, Mao A, Guo R, Yuan W, Zhao P, He K, Li B*. Characterization of Chinese Porcine Epidemic Diarrhea Virus with Novel Insertions and Deletions in Genome. Sci Rep. 2017, 7:44209. Du L, Pang F, Yu Z, Xu X, Fan B, Huang K, He K, Li B*. Assessment of the efficacy of two novel DNA vaccine formulations against highly pathogenic Porcine Reproductive and Respiratory Syndrome Virus. Sci Rep. 2017, 7: 41886; Luping Du, Bin Li, Fengjiao Pang, Zhengyu Yu, Xiangwei Xu, Baochao Fan, Yeping Tan, Kongwang He, Kehe Huang. Porcine GPX1 enhances GP5-based DNA vaccination against porcine reproductive and respiratory syndrome virus. Veterinary Immunology and Immunopathology, 2017, 183, 31-39. Fan B, Yu Z, Pang F, Xu X, Zhang B, Guo R, He K, Li B*. Characterization of a pathogenic full-length cDNA clone of a virulent porcine epidemic diarrhea virus strain AH2012/12 in China. Virology. 2017 500, 50-61. Ding S, Mooney N, Li B, Kelly MR, Feng N, Loktev AV, Sen A, Patton JT, Jackson PK, Greenberg HB. Comparative Proteomics Reveals Strain-Specific β-TrCP Degradation via Rotavirus NSP1 Hijacking a Host Cullin-3-Rbx1 Complex. PLoS Pathog. 2016, 5;12(10):e1005929. Du L1, Bin Li (co-first author), Xu X, Sun B, Pang F, Wen L, Huang K, He K. Adsorption of a porcine reproductive and respiratory syndrome virus DNA vaccine candidate onto biodegradable nanoparticles improves immunogenicity in mice. Arch Virol. 2015, 160(6):1543-7. Bin Li, Luping Du, Xiangwei Xu, Bing Sun, Zhengyu Yu, Zhixin Feng, Maojun Liu, Yanna Wei, Haiyan Wang, Guoqing Shao, Kongwang He.Transcription analysis on response of porcine alveolar macrophages to co-infection of the highly pathogenic porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae. Virus research, 2015, 196,60-69. Bin Li, Luping Du, Bing Sun, Zhengyu Yu, Maojun Liu, Zhixin Feng, Yanna Wei, Haiyan Wang, Guoqing Shao, Kongwang He. Transcription Analysis of the Porcine Alveolar MacrophageResponse to Mycoplasma hyopneumoniae. PLoS ONE 2014, 9(8): e101968.