基于活性天然产物的合成与结构修饰、基于虚拟筛选的药物设计与合成

Cheng-Shi Jiang, et al. Discovery of new multifunctional selective acetylcholinesterase inhibitor: structure-based virtual screening and biological evaluation. J. Comput. Aided. Mol. Des., 2019, DOI: 10.1007/s10822-019-00202-2. Cheng-Shi Jiang*, Hua Zhang*, et al. Total synthesis of pulmonarin B and design of bromated-phenylacetic acid/tacrine hybrids: marine pharmacophore inspired discovery of new ChE and Aβ aggregation inhibitors. Mar. Drugs, 2018, 16(9), 293. Cheng-Shi Jiang, et al. Disulfide- and multisulfide-containing metabolites from marine organisms. Chem. Rev., 2012, 112, 2179-2207.