董栋 照片

董栋

副教授 硕导

所属大学: 暨南大学

所属学院: 基础医学院

邮箱:
orangefume@hotmail.com

个人主页:
https://jnumed.jnu.edu.cn/b1/31/c7395a307505/page.htm

个人简介

2015.09-至今,暨南大学,基础医学院,副研究员

2013.08-2015.08,暨南大学, 生物医学工程转业,博士后

2009.08-2012.12,美国休斯敦大学,药剂学专业,博士

2005.09-2008.07,复旦大学,生药学专业,硕士

2001.09-2005.07,苏州大学,药学专业,学士

研究领域

药代动力学及药物新剂型

近期论文

1. Dong D, Wu B, Chow D, Hu M. Substrate selectivity of drug-metabolizing cytochrome P450s predicted from crystal structures and in silico modeling. Drug Metab Rev. 2012;44(2):192-208.

2. Zhang X, Dong D#, Wang H, Ma Z, Wang Y, Wu B. Stable Knock-down of Efflux Transporters Leads to Reduced Glucuronidation in UGT1A1-Overexpressing HeLa Cells: The Evidence for Glucuronidation-Transport Interplay. Mol Pharm. 2015;12(4):1268-78.

3. Dong D, Wang X, Wang H, Zhang X, Wang Y, Wu B. Elucidating the in vivo fate of nanocrystals using a physiologically based pharmacokinetic model: a case study with the anticancer agent SNX-2112. Int J Nanomedicine. 2015;10:2521-35.

4. Dong D, Peng X, Liu J, Qian H, Li J, Wu B. Morbid Obesity Alters Both Pharmacokinetics and Pharmacodynamics of Propofol: Dosing Recommendation for Anesthesia Induction. Drug Metab Dispos. 2016;44(10):1579-83.

5. Zhang T, Dong D#, Lu D, Wang S, Wu B. Cremophor EL-based nanoemulsion enhances transcellular permeation of emodin through glucuronidation reduction in UGT1A1-overexpressing MDCKII cells. Int J Pharm. 2016;501(1-2):190-8.

6. Dong D, Quan E, Yuan X, Xie Q, Li Z, Wu B. Sodium Oleate-Based Nanoemulsion Enhances Oral Absorption of Chrysin through Inhibition of UGT-Mediated Metabolism. Mol Pharm. 2017;14(9):2864-2874.

7. Yuan X, Xie Q, Su K, Li Z, Dong D*, Wu B. Systemic delivery of the anticancer agent arenobufagin using polymeric nanomicelles. Int J Nanomedicine. 2017;12:4981-4989.

8. Lu D, Dong D#, Xie Q, Li Z, Wu B. Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as an N-Glucoside Transporter. Drug Metab Dispos. 2018;46(7):970-979.

9. Xue Yuan, Dong D#, Zhijie Li, Baojian Wu. Rev-erba activation down-regulates hepatic Pck1 enzyme to lower plasma glucose in mice. Pharmacol Res. 2019;141:310-318.