于湘晖
教授
个人简介
教育经历 1999/09-2003/12,吉林大学,生物化学与分子生物学,博士 1994/09-1997/07,吉林大学,生物化学与分子生物学,硕士 1990/09-1994/07,吉林大学,生物化学与分子生物学,学士 工作经历 2008/06 - 至今,吉林大学,艾滋病疫苗国家工程实验室,教授 2003/12 - 至今,吉林大学,生命科学学院,教授 2001/03 - 2003/12,美国约翰霍普金斯大学,公共卫生学院,访问学者 荣誉称号 吉林省“长白山学者”、教育部“新世纪人才”、吉林大学“唐敖庆”特聘教授、吉林省拔尖创新人才、第四届中国青年女科学家奖提名奖
研究领域
1. 艾滋病病毒(HIV)感染机制研究:Serinc等宿主蛋白抗HIV-1分子机制研究;以病毒与宿主蛋白相互作用为靶点的多肽类抑制剂和药物前体化合物设计与筛选;利用基于CRISPR-Cas9方法进行全基因组筛选影响HIV-1复制传播的宿主限制因子 2. 新型艾滋病疫苗设计与临床研究:基于BLP等新型佐剂的HIV-1蛋白疫苗设计与评价;可诱导广谱中和抗体的新型HIV-1疫苗设计
近期论文
1. Gao N, Gai Y, Meng L, Wang C, Wang W, Li X, Gu T, Louder MK, Doria-Rose NA, Wiehe K, Nazzari AF, Olia AS, Gorman J, Rawi R, Wu W, Smith C, Khant H, de Val N, Yu B, Luo J, Niu H, Tsybovsky Y, Liao H, Kepler TB, Kwong PD, Mascola JR, Qin C*, Zhou T*, Yu X*, Gao F*. Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2. Adv Sci (Weinh). 2022 Mar 23;e2200063. 2. Wenmo Liu, Xupu Wang, Xinyao Feng, Jiahao Yu, Xinyao Liu, Xinyuan Jia, Haihong Zhang, Hui Wu, Chu Wang, Jiaxin Wu, Bin Yu∗and Xianghui Yu∗. Oncolytic adenovirus-mediated intratumoral expression of TRAIL and CD40L enhances immunotherapy by modulating the tumor microenvironment in immunocompetent mouse models. Cancer Letters. 535 (2022) 215661. 3. Xinyao Feng, Fangshen Li, Liangliang Zhang, Wenmo Liu, Xupu Wang, Rui Zhu, Zhen-An Qiao, Bin Yu∗, Xianghui Yu∗. TRAIL-modified, doxorubicin-embedded periodic mesoporous organosilica nanoparticles for targeted drug delivery and efficient antitumor immunotherapy. Acta Biomaterialia. 143 (2022) 392-405. 4. Huaiyu Wang, Pingchao Li, Mo Zhang, Jinpeng Bi, Yizi He, Fangshen Li, Rongzhen Yu, Feng Gao, Wei Kong, Bin Yu∗, Ling Chen∗, Xianghui Yu∗. Vaccine with bacterium-like particles displaying HIV-1 gp120 trimer elicits specific mucosal responses and neutralizing antibodies in rhesus macaques. Microbial Biotechnology. 2022, Mar 15. doi: 10.1111/1751-7915.14022. 5. Wang C, Meng L, Wang J, Zhang K, Duan S, Ren P, Wei Y, Fu X, Yu B, Wu J, Yu X∗. Role of Intracellular Distribution of Feline and Bovine SAMHD1 Proteins in Lentiviral Restriction. Virologica Sinica 2021, 36:981-996. 6. Liu C, Cong X, Wang Y, Guo Q, Xie Y, Geng F, Guo J, Dong L, Zhou Y, Wu H, Yu B, Wu J, Zhang H∗, Yu X∗, Kong W. Fast DNA Vaccination Strategy Elicits a Stronger Immune Response Dependent on CD8(+)CD11c(+) Cell Accumulation. Frontiers in oncology 2021, 11:752444. 7. Duan S; Wang S; Song Y; Gao N; Meng L; Gai Y; Zhang Y; Wang S; Wang C; Yu B; Wu J; Yu X*, A novel HIV-1 inhibitor that blocks viral replication and rescues APOBEC3s by interrupting vif/CBFβ interaction. J Biol Chem. 2020, 295:14592-14605 8. Zixuan Wang, Wenmo Liu, Lizheng Wang, Peng Gao, Zhe Li, Jiaxin Wu, Haihong Zhang, Hui Wu, Wei Kong, Bin Yu∗, Xianghui Yu∗. Enhancing the antitumor activity of an engineered TRAIL-coated oncolytic adenovirus for treating acute myeloid leukemia. Signal Transduction and Targeted Therapy. 2020, 5(1):40. 9. Chu Wang, Kaikai Zhang, Lina Meng, Xin Zhang, Yanan Song, Ying Zhang, Yanxin Gai, Yuepeng Zhang, Bin Yu, Jiaxin Wu, Song Wang, Xianghui Yu*. The C-terminal Domain of Feline and Bovine SAMHD1 Proteins Has a Crucial Role in Lentiviral Restriction. J Biol Chem. 2020, 295(13):4252-4264. 10. Jinpeng Bi, Fangshen Li, Mo Zhang, Huaiyu Wang, Jingcai Lu, Yong Zhang, Hong Ling, Jiaye Wang, Feng Gao, Wei Kong, Bin Yu∗, Xianghui Yu∗. An HIV-1 vaccine based on bacterium-like particles elicits Env-specific mucosal immune responses. Immunology Letters. 2020, 222:29-39. 11. Lizheng Wang, Wenmo Liu, Zhe Li, Xupu Wang, Xinyao Feng, Zixuan Wang, Jiaxin Wu, Haihong Zhang, Hui Wu, Wei Kong, Bin Yu∗, Xianghui Yu∗. A tropism-transformed Oncolytic Adenovirus with Dual Capsid Modifications for enhanced Glioblastoma Therapy. Journal of Cancer. 2020, 11(19):5713-5726. 12. Sun Y, Guo Y, Feng X, Jia M, Ai N, Dong Y, Zheng Y, Fu L, Yu B, Zhang H, Wu J, Yu X*, Wu H*, Kong W*. The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer's disease. J Neuroinflammation. 2020 17(1):72 13. Fei Geng, Xin Bao, Ling Dong, Qianqian Guo, Jie Guo, Yu Xie, Yi Zhou, Bin Yu, Hui Wu, Jiaxin Wu, Haihong Zhang*, Xianghui Yu*, Wei Kong. Doxorubicin pretreatment enhances FAPα/survivin co-targeting DNA vaccine anti-tumor activity primarily through decreasing peripheral MDSCs in the 4T1 murine breast cancer model. OncoImmunology. 2020, 9(1):1747350. 14. Meng Qu#, Weiran Wang#, Weiting Li, Jiaming Cao, Xin Zhang, Chu Wang, Jiaxin Wu, Bin Yu, Haihong Zhang, Hui Wu, Wei Kong, Xianghui Yu*. Antiviral Activity of Feline BCA2 Is Mainly Dependent on Its Interference With Proviral Transcription Rather Than Degradation of FIV Gag. Front Microbiol. 2020 Jun 11;11:1230. 15. Nan Gao, Yanxin Gai, Lina Meng, Chu Wang, Xin Zhang, Wei Wang, Chuan Qin, Xianghui Yu* and Feng Gao*. Development of Antibodies with Broad Neutralization Specificities against HIV-1 after Long Term SHIV Infection in Macaques. Viruses. 12(2) pii: E163 (2020). 16. Chu Wang#, Nan Gao#, Yanan Song, Sizhu Duan, Wei Wang, Zhe Cong, Chuan Qin, Chunlai Jiang, Xianghui Yu*, Feng Gao*. Reduction of peak viremia by an integration-defective SIV proviral DNA vaccine in rhesus macaques. Microbiol Immunol. 2020, 64(1):52-62. 17. Yue Hu, Yayuan Zheng, Mingrui Dai, Xueju Wang, Jiaxin Wu, Bin Yu, Haihong Zhang, Yinqiu Cui, Wei Kong, Hui Wu*, Xianghui Yu*, G9a and histone deacetylases are crucial for Snail2-mediated E-cadherin repression and metastasis in hepatocellular carcinoma. Cancer Science, 2019, 110(11):3442-3452. 18. Yue Hu, Yayuan Zheng, Mingrui Dai, Jiaxin Wu, Bin Yu, Haihong Zhang, Wei Kong, Hui Wu*, Xianghui Yu*, Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs. Cell Adhesion and Migration. 2019, 13(1):285-292. 19. Yue Hu, Mingrui Dai, Yayuan Zheng, Jiaxin Wu, Bin Yu, Haihong Zhang, Wei Kong, Hui Wu*, Xianghui Yu*, Epigenetic suppression of E-cadherin expression by Snail2 during the metastasis of colorectal cancer. Clinical epigenetics, 2018, 10(1):154. 20. Nan Gao#, Wei Wang#, Chu Wang#, Tiejun Gu, Rui Guo, Bin Yu, Wei Kong, Chuan Qin, Elena E Giorgi, Zhiwei Chen, Samantha Townsley, Shiu-Lok Hu, Xianghui Yu*, Feng Gao*. Development of broad neutralization activity in simian/human immunodeficiency virus-infected rhesus macaques after long-term infection, AIDS, 2018; 32(5): 555-563. 21. Di Liu, Lin Liu, Lizheng Wang, Sizhu Duan, Yanan Song, Meng Qu, Nan Gao, Jiaxin Wu, Haihong Zhang, Hui Wu, Wei Kong, Bin Yu*, Xianghui Yu*, Therapeutic effects of mesenchymal stem cells combined with short hairpin RNA on liver injury induced by hepatitis B virus infection, Mol Med Rep. 2018; 17(1): 1731-1741. 22. Weiran Wang, Meng Qu, Jiawen Wang, Xin Zhang, Haihong Zhang, Jiaxin Wu, Bin Yu, Hui Wu, Wei Kong*, Xianghui Yu*, Autoubiquitination of feline E3 ubiquitin ligase BCA2. Gene, 2018, 638:1-6. 23. Lizheng Wang, Zixuan Wang, Rui Zhu, Jinpeng Bi, Xinyao Feng, Wenmo Liu, Jiaxin Wu, Haihong Zhang, Hui Wu, Wei Kong, Bin Yu*, Xianghui Yu*, Therapeutic efficacy of AAV8-mediated intrastriatal delivery of human cerebral dopamine neurotrophic factor in 6-OHDA-induced parkinsonian rat models with different disease progression, PLoS One, 2017, 12(6):e0179476. 24. Chu Wang, Chunlai Jiang, Nan Gao, Kaikai Zhang, Donglai Liu, Wei Wang, Zhe Cong, Chuan Qin, Vitaly V. Ganusov, Guido Ferrari, Celia LaBranche, David C. Montefiori, Wei Kong, Xianghui Yu *, Feng Gao*, Immunologic and Virologic Mechanisms for Partial Protection from Intravenous Challenge by an Integration-Defective SIV Vaccine, Viruses. 2017, 9(6): 135. 25. Lu Fu, Yingnan Li, Yue Hu, Yayuan Zheng, Bin Yu, Haihong Zhang, Jiaxin Wu, Hui Wu*, Xianghui Yu*, Wei Kong*, A norovirus P particle-based active Aβ immunotherapy elicits sufficient immunogenicity and improves cognitive capacity in mouse model of Alzheimer’s disease. Scientific Reports, 2017, 7: 41041.