教育经历 2006/09 - 2012/06，吉林大学，微生物学，博士 2002/09 - 2006/06，吉林大学，制药工程，学士 工作经历 2019/09 - 至今 吉林大学，生命科学学院，教授 2018/03 - 2019/03，苏黎世大学，分子生命科学研究所，访问学者 2014/09 - 2019/09，吉林大学，生命科学学院，副教授 2012/09 - 2016/09，中科院长春应化所，博士后 2012/07 - 2014/09，吉林大学，生命科学学院，讲师 荣誉称号 中华医学会医学病毒学分会第十届青委会委员（2021），入选吉林大学首批“培英工程计划”、吉林大学优秀青年教师培养计划精英培养阶段，获得“吉林大学唐敖庆青年人才奖励基金”。

1、新型病毒载体设计与肿瘤基因治疗； 2、新型HIV-1蛋白和基因疫苗设计

1. Wenmo Liu, Xupu Wang, Xinyao Feng, Jiahao Yu, Xinyao Liu, Xinyuan Jia, Haihong Zhang, Hui Wu, Chu Wang, Jiaxin Wu,Bin Yu∗and Xianghui Yu∗. Oncolytic adenovirus-mediated intratumoral expression of TRAIL and CD40L enhances immunotherapy by modulating the tumor microenvironment in immunocompetent mouse models. Cancer Letters. 535 (2022) 215661. (中科院1区，IF= 8.679) 2. Xinyao Feng, Fangshen Li, Liangliang Zhang, Wenmo Liu, Xupu Wang, Rui Zhu, Zhen-An Qiao,Bin Yu∗, Xianghui Yu∗. TRAIL-modified, doxorubicin-embedded periodic mesoporous organosilica nanoparticles for targeted drug delivery and efficient antitumor immunotherapy. Acta Biomaterialia. 143 (2022) 392–405. (中科院1区，IF= 8.947) 3. Huaiyu Wang, Pingchao Li, Mo Zhang, Jinpeng Bi, Yizi He, Fangshen Li, Rongzhen Yu, Feng Gao, Wei Kong,Bin Yu∗, Ling Chen∗, Xianghui Yu∗. Vaccine with bacterium-like particles displaying HIV-1 gp120 trimer elicits specific mucosal responses and neutralizing antibodies in rhesus macaques. Microbial Biotechnology. 2022, Mar 15. doi: 10.1111/1751-7915.14022. (中科院2区，IF= 5.813) 4. Zixuan Wang, Wenmo Liu, Lizheng Wang, Peng Gao, Zhe Li, Jiaxin Wu, Haihong Zhang, Hui Wu, Wei Kong, Bin Yu∗, Xianghui Yu∗. Enhancing the antitumor activity of an engineered TRAIL-coated oncolytic adenovirus for treating acute myeloid leukemia. Signal Transduction and Targeted Therapy. 2020, 5(1):40. (中科院1区，IF= 18.1873) 5. Jinpeng Bi, Fangshen Li, Mo Zhang, Huaiyu Wang, Jingcai Lu, Yong Zhang, Hong Ling, Jiaye Wang, Feng Gao, Wei Kong,Bin Yu∗, Xianghui Yu∗. An HIV-1 vaccine based on bacterium-like particles elicits Env-specific mucosal immune responses. Immunology Letters. 2020, 222:29-39. 6. Lizheng Wang, Wenmo Liu, Zhe Li, Xupu Wang, Xinyao Feng, Zixuan Wang, Jiaxin Wu, Haihong Zhang, Hui Wu, Wei Kong,Bin Yu∗, Xianghui Yu∗. A tropism-transformed Oncolytic Adenovirus with Dual Capsid Modifications for enhanced Glioblastoma Therapy. Journal of Cancer. 2020, 11(19):5713-5726. 7. Lizheng Wang, Zixuan Wang, Rui Zhu, Jinpeng Bi, Xinyao Feng, Wenmo Liu, Jiaxin Wu, Haihong Zhang, Hui Wu, Wei Kong,Bin Yu∗, Xianghui Yu∗. Therapeutic efficacy of AAV8-mediated intrastriatal delivery of human cerebral dopamine neurotrophic factor in 6-OHDA-induced parkinsonian rat models with different disease progression. PLoS One. 2017, 12(6):e0179476. 8. Lizheng Wang, Zixuan Wang, Xiaoyu Xu, Rui Zhu, Jinpeng Bi, Wenmo Liu, Xinyao Feng, Hui Wu, Haihong Zhang, Jiaxin Wu, Wei Kong,Bin Yu∗, Xianghui Yu∗. Recombinant AAV8-mediated intrastriatal gene delivery of CDNF protects rats against methamphetamine neurotoxicity. Int J Med Sci. 2017, 14(4):340-347. 9. Jingyi Yan, Lizheng Wang, Zixuan Wang, Zhen Wang, Baoming Wang, Rui Zhu, Jinpeng Bi, Jiaxin Wu, Haihong Zhang, Hui Wu,Bin Yu∗, Wei Kong, Xianghui Yu∗. Engineered adenovirus fiber shaft fusion homotrimer of soluble TRAIL with enhanced stability and antitumor activity, Cell Death and Disease, 2016, 7(6): e2274. 10. Zhen Wang#,Bin Yu#, Baoming Wang, Jingyi Yan, Xiao Feng, Zixuan Wang, Lizheng Wang, Haihong Zhang, Hui Wu, Jiaxin Wu, Wei Kong, Xianghui Yu. A novel capsid-modified oncolytic recombinant adenovirus type 5 for tumor-targeting gene therapy by intravenous route. Oncotarget, 2016, 7(30):47287-47301. 11. Jingyi Yan, Jianing Dong, Jiaxin Wu, Rui Zhu, Zhen Wang, Baoming Wang, Lizheng Wang, Zixuan Wang, Haihong Zhang, Hui Wu,Bin Yu∗, Wei Kong, Xianghui Yu∗. Interaction between hexonand L4-100K determines virus rescue and growth of hexon-chimeric recombinant Ad5 vectors, Scientific Reports, 2016, 6: 22464-22477. 12. Shuai Lang, Lizheng Wang, Zixuan Wang, Rui Zhu, Jingyi Yan, Baoming Wang, Jiaxin Wu, Haihong Zhang, Hui Wu, Yan Zhou, Wei Kong,Bin Yu* and Xianghui Yu*. Localization of neutralization epitopes on adenovirus fiber knob from species C. Journal of General Virology. 2016, 97: 955-962. 13. Lizheng Wang, Zixuan Wang, Fangfang Zhang, Rui Zhu, Jinpeng Bi, Jiaxin Wu, Haihong Zhang, Hui Wu, Wei Kong,Bin Yu*, Xianghui Yu*. Enhancing Transgene Expression from Recombinant AAV8 Vectors in Different Tissues Using Woodchuck Hepatitis Virus Post-Transcriptional Regulatory Element. Int J Med Sci. 2016, 13(4): 286-291.