教育经历 1985.9-1990.7，吉林大学分子生物学系，生物化学，本科 1990.9-1993.7，吉林大学分子生物学系，生物化学，硕士 1996.9-1999.7，吉林大学生命科学学院，生物化学，博士 工作经历 1993.9-1995.9， 吉林大学分子生物学系 助教 1995.9-1999.12， 吉林大学分子生物学系 讲师 2000.1-2005.9，吉林大学生命科学学院，副教授 2005.10-至今， 吉林大学生命科学学院，教授 荣誉称号 获得2011-2013年度吉林大学 “巾帼建功”标兵

小分子多功能肽的研究与开发；功能抗体的设计、表达及临床应用研究；过氧化物模拟酶的设计及应用研究

Ye Yuan, Zhendong Fu , Kai Wang , Zhenyu Zhao , Hui Li , Zhi Wang * and Liping Wang *, Design and characterization of a hypersensitive glucose sensor : two enzymes co-fixed on a copper phosphate skeleton, Journal of Materials Chemistry B, 2020, 8, 244 -250.( IF5.344) Yi Ding, Zhiying Li, Wei Jiang, Bolei Yuan, Tingting Huang, Liping Wang*, Jun Tang*. Degradation of phenol using a peroxidase mimetic catalyst through conjugating deuterohemin-peptide onto metalorganic framework with enhanced catalytic activity, Catalysis Communications, 2020,134: 105859.(IF 3.612) Kai Wang , Yuting Liang, Yu Su and Liping Wang*. DhHP-6 Ameliorates Hepatic Oxidative Stress and Insulin Resistance in Type 2 Diabetes Mellitus Through the PI3K/AKT and AMPK Pathway. Biochem J. 2020,477(12):2363-2381(IF 4.097) Kai Wang, Yanhui Song, Yu Su , Yuting Liang, Liping Wang*. Effect of the hairpin structure of peptide inhibitors on the blockade of PD-1/PD-L1 axis. Biochem Biophys Res Commun.2020, 527 (2): 453-457.( IF 2.985) Ye Yuan,Liping Wang, Lizeng Gao. Nano-Sized Iron Sulfide: Structure, Synthesis, Properties, and Biomedical Applications. Front. Chem., 2020,00818(IF 3.693) Jia Xu, Ye Yuan, Ruining Zhang, Yanhui Song, Tianzhuo Sui, Jiaqi Wang, Chonghan Wang, Yujia Chen, Shuwen Guan, Liping Wang*. A deuterohemin peptide protects a transgenic Caenorhabditis elegans model of Alzheimer’s disease by inhibiting Aβ1–42 aggregation. Bioorganic Chemistry. 82 (2019) 332–339. (IF 3.88) Ye Yuan, Jia Xu, Zhenyu Zhao, Hui Li, Kai Wang, Zhi Wang,* and Liping Wang*, Design and 8. Characterization of a Novel Artificial Peroxidase, Catalysts 2019, 9, 168-172 (IF 3.58) Kai Wang , Yu Su, Yuting Liang, Yanhui Song and Liping Wang *, Oral DhHP-6 for the Treatment of Type 2 Diabetes Mellitus. Int. J. Mol. Sci. 2019, 20, 1517-1523.(IF 4.32) Han W, Yuan Y, Li H, Fu Z, Wang M, Guan S, Wang L. Design and anti-tumor activity of self-loaded nanocarriers of siRNA. Colloids Surf B Biointerfaces. 2019,183: 110385-110393(IF 4.11) Jia Xu, Kai Wang, Ye Yuan, Hui Li, Ruining Zhang, Shuwen Guan and Liping Wang * A Novel Peroxidase Mimics and Ameliorates Alzheimer’s Disease-Related Pathology and Cognitive Decline in Mice. Int. J. Mol. Sci. 2018, 19, 11:3304-3341 (IF4.187) Xu J,Guo Y,Sui T,Wang Q,Zhang Y,Zhang R,Wang M,Guan S,Wang L. Molecular Mechanisms of Anti-oxidant and Anti-aging Effects Induced by Convallatoxin in Caenorhabditis elegans.Free Radic Res.2017，51：529-544.(IF3.188) Tianshu Xu, Tianlei Ying, Lili Wang, Xiaohua Doug,Ying Wang, Lishan Kang, Tao Huang, Liang Cheng, Liping Wang* and Qi Zhao. A native-like bispecific antibody suppresses the inflammatory cytokine response by simultaneously neutralizing tumor necrosis factor-alpha and interleukin-17A, Oncotarget, 2017, 8(47):81860-81872 (IF5.168) Zhi-Ming Xiu, Li-Ping Wang, Jun Fu, Jia Xu, Li Liu, 1-Acetyl-5-phenyl-1H-pyrrol-3-ylacetate: an aldose reductase inhibitor for the treatment of diabetic nephropathy, Bioorganic &Medicinal ChemistryLetters,2017 27(18):4482-4487(IF 2.454) Wei, Ying; Lu, Jun; Lu, Tong; Meng, Feihong; Xu, Jia; Wang, Li; Li, Yang; Wang, Liping*; Li, Fei. Formation of lamellar micelle-like oligomers and membrane disruption revealed by the study of short peptide hIAPP(18-27). PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2016, 18:29847-29857.(IF4.449) Zhao, Zijian; Zhang, Ji; Wang, Mingyang; Wang, Zhi; Wang, Liping; Ma, Li; Huang, Xuri; Li, Zhengqiang. Structure advantage and peroxidase activity enhancement of deuterohemin-peptide-inorganic hybrid flowers. RSC ADVANCES, 2016, 6:104265-104272. (IF3.119) Zhao, Zijian; Wang, Dandan; Wang, Mingyang; Sun, Xiaoli; Wang, Liping; Huang, Xuri; Ma, Li; Li, Zhengqiang. Proximal environment controlling the reactivity between inorganic sulfide and heme-peptide model. RSC ADVANCES, 2016, 6:78858-78864. (IF3.119) Guo, Changrun; Goodwin, Andrew; Buie, Joy N. Jones; Cook, James; Halushka, Perry; Argraves, Kelley; Zingarelli, Basilia; Zhang, Xian; Wang, Liping; Fan, Hongkuan. A Stromal Cell-Derived Factor 1 alpha Analogue Improves Endothelial Cell Function in Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome.MOLECULAR MEDICINE, 2016, 22:1512-1524.（IF3.53）