教育经历 2006/09-2011/07，北京协和医学院，北京生命科学研究所，博士 2002/09-2006/07，北京师范大学，生命科学学院，学士 工作经历 2021/9至今，吉林大学，生命科学学院，艾滋病疫苗国家工程实验室，教授 2015/9-2021/８，吉林大学，生命科学学院，艾滋病疫苗国家工程实验室，副教授 2013/08-2015/8，吉林大学，生命科学学院，艾滋病疫苗国家工程实验室，讲师 2011/09-2013/07，吉林大学，生命科学学院，艾滋病疫苗国家工程实验室，博士后

慢性非传染性疾病的疫苗和分子机制研究，包括双靶向阿尔茨海默症疫苗及其作用机制研究，以及恶性肿瘤的侵袭转移机制研究

1、Sun Y*, Guo Y*, Feng X, Fu L, Zheng Y, Dong Y, Zhang Y, Yu X, Kong W, Wu H#, Norovirus P particle-based tau vaccine-generated phosphorylated tau antibodies markedly ameliorate tau pathology and improve behavioral deficits in mouse model of Alzheimer’s disease. Signal Transduction and Targeted Therapy, 2021, 6(1):61. 2、Dai M, Feng X, Mo Z, Sun Y, Fu L, Zhang Y, Wu J, Yu B, Zhang H, Yu X, Wu H#,Kong W#, Stimulation Effects and Mechanisms of Different Adjuvants on a Norovirus P Particle-Based Active Amyloid-β Vaccine. Journal of Alzheimers Disease, 2020,77(4):1717-1732 3、Hu Y, Nie Q, Dai M, Chen F#, Wu H#, Histone Deacetylases Inhibit the Snail2-Mediated EMT During Metastasis of Hepatocellular Carcinoma Cells. Frontiers in Cell and Developmental Biology,2020,8:752 4、Sun Y, Guo Y, Feng X, Jia M, Ai N, Dong Y, Zheng Y, Fu L, Yu B, Zhang H, Wu J, Yu X, Wu H#, Kong W#, The behavioural and neuropathologic sexual dimorphism and absence of MIP-3α in tau P301S mouse model of Alzheimer’s disease. Journal of neuroinflammation, 2020, 17(1):72 5、Hu Y, Zheng Y, Dai M, Wang X, Wu J, Yu B, Zhang H, Cui Y, Kong W, Wu H#, Yu X#, G9aand histone deacetylases are crucial for Snail2-mediated E-cadherin repression and metastasis in hepatocellular carcinoma. Cancer Science, 2019, 110(11):3442-3452 6、Hu Y, Zheng Y, Dai M, Wu J, Yu B, Zhang H, Kong W, Wu H#, Yu X#, Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs. Cell Adhesion and Migration. 2019, 13(1):285-292 7、Yang P, Guo Y, Sun Y, Yu B, Zhang H, Wu J, Yu X, Wu H#, Kong W#, Active immunization with norovirus P particle-based amyloid-β chimeric protein vaccine induces high titers of anti-Aβ antibodies in mice. BMC Immunology, 2019, 20: 9 8、Hu Y, Dai M, Zheng Y, Wu J, Yu B, Zhang H, Kong W, Wu H#, Yu X#, Epigenetic suppression of E-cadherin expression by Snail2 during the metastasis of colorectal cancer. Clinical epigenetics, 2018, 10(1):154 9、Fu L, Guo Y, Sun Y, Dong Y, Wu J, Yu B, Zhang H, Yu X, Wu H#, Kong W#, A novel Aβ epitope vaccine based on bacterium-like particle against Alzheimer's disease. Molecular immunology, 2018, 101:259-267. 10、Fu L, Sun Y, Guo Y, Yu B, Zhang H, Wu J, Yu X, Wu H#, Kong W#, Progressive spatial memory impairment, brain amyloid deposition and changes in serum amyloid levels as a function of age in APPswe/PS1dE9 mice. Current Alzheimer Research, 2018, 15: 1-9 11、Fu L, Li Y, Hu Y, Zheng Yn, Yu B, Zhang H, Wu J, Wu H#, Yu X#, Kong W#, A norovirus P particle-based active Aβ immunotherapy elicits sufficient immunogenicity and improves cognitive capacity in mouse model of Alzheimer’s disease. Scientific Reports, 2017, 2017, 7: 41041 12、Fu L , Li Y, Hu Y, Yu B, Zhang H, Wu J, Wu H#, Yu X#, Kong W#. Norovirus P particle: an excellent vaccine platform for antibody production against Alzheimer’s disease. Immunology Letters, 2015, 168(1):22-30. 13、Wang X, Wang X, Wang W, Zhang J, Wang J, Wang C, Lv M, Zuo T, Liu D, Zhang H, Wu J, Yu B, Kong W, Wu H#, Yu X#. Both Rbx1 and Rbx2 exhibit a functional role in the HIV-1 Vif-Cullin5 E3 ligase complex in vitro. Biochemical and biophysical research communications, 2015, 461(4):624-9 14、Liu N*, Zhang Z*, Wu H*,#, Jiang Y, Meng L, Xiong J, Zhao Z, Zhou X, Li J, Li H, Zheng Y, Chen S, Cai T, Gao S, Zhu B#. Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability. Genes & development, 2015, 29(4):379-93 15、Wu H*, Zhang H*, Wang P, Mao Z, Feng L, Wang Y, Liu C, Xia Q, Li B, Zhao H, Chen Y, Wu J, Kong W#, Yu X#, Short-Form CDYLb but not long-form CDYLa functions cooperatively with histone methyltransferase G9a in hepatocellular carcinomas. Genes chromosomes & cancer, 2013, 52(7):644-655 16、Wu H, Chen X, Xiong J, Li Y, Li H, Ding X, Liu S, Chen S, Gao S, Zhu B#. Histone methyltransferase G9a contributes to H3K27 methylation in vivo. Cell Research, 2011, 21(2): 365-7