李桂英 照片

李桂英

教授 博导

所属大学: 吉林大学

所属学院: 生命科学学院

邮箱:
ligy@jlu.edu.cn

个人主页:
https://life.jlu.edu.cn/info/1024/1164.htm

个人简介

教育经历 1997/09-2000/07, 东北师范大学遗传与细胞研究所,获理学博士学位 1994/09-1997/07, 东北师范大学遗传与细胞研究所,获理学硕士学位 1990/09-1994/07, 东北师范大学生命科学学院,获理学学士学位 工作经历 2008/09-至今, 吉林大学分子酶学工程教育部重点实验室,教授,博士生导师 2014/01-2014/04, 美国科罗拉多大学丹佛分校药学院,高级研究学者 2007/01-2008/02, 美国匹兹堡大学医学院,访问学者 2003/09-2008/09, 吉林大学分子酶学工程教育部重点实验室,副教授,硕士生导师 2000/09-2003/09, 吉林大学基础医学院免疫学系,基础医学博士后,2003年3月特评特聘为副教授 荣誉称号 教育部“新世纪优秀人才”、吉林大学“唐敖庆”特聘教授、吉林省首批“中青年科技创新领军人才”、吉林省拔尖创新人才、吉林省首批“学科领军教授” 学术兼职:《临床肝胆病杂志》编委、吉林省免疫学学会常务理事、吉林省生物治疗学会常务理事、吉林省生物化学与分子生物学学会常务理事等

研究领域

酶与细胞增殖调控及肿瘤靶向治疗研究、抗体工程、肝损伤及修复分子机制:1.重大疾病关键酶在细胞增殖调控中作用机制研究;2.肿瘤靶向胞内抗体药物研发;3.肝损伤机理及其防治药物研发;4.肿瘤生物标志物的发现及肿瘤早期诊断

近期论文

1. Clot structure-based physical-matching design of platelet cloaking nano-delivery system facilitates specific arteriovenous thrombolysis. Chem Eng J, 2022, 441: 135982. https://doi.org/10.1016/j.cej.2022.135982 2. The Role of Exosomes in Inflammatory Diseases and Tumor-Related Inflammation. Cells, 2022,11(6):1005. doi: 10.3390/cells11061005. 3. Expression, purification and characterisation of a human anti-CDK4 single-chain variable fragment antibody.BMC Biotechnol, 2021,21(1):71. doi: 10.1186/s12896-021-00729-z. 4. Intrabody against prolyl hydroxylase 2 ameliorates acetaminophen-induced acute liver injury in mice via concomitant promotion of angiogenesis and redox homeostasis.Biomed Pharmacother, 2020,123:109783. doi: 10.1016/j.biopha.2019.109783. 5. Cancer liquid biopsy using integrated microfluidic exosome analysis platforms. Biotechnol J, 2020,15(5):1900225.doi: 10.1002/biot.201900225. 6. Separation of macrophages using a dielectrophoresis-based microfluidic device.BioChip J, 2020, 14(2):185–194. doI: 10.1007/s13206-020-4207-2 7. A cyclin D1-specific single-chain variable fragment antibody that inhibits HepG2 cell growth and proliferation.Biotechnol J, 2020, 15(8):1900430. doi: 10.1002/biot.201900430. 8. Explore a novel function of human condensins in cellular senescence. Cell Biosci, 2020,10(1):147. doi: 10.1186/s13578-020-00512-1. 9. Extraction of cell-free whole blood plasma using a dielectrophoresis - based microfluidic device. Biotechnol J, 2019, 14(3): 1800181.doi: 10.1002/biot.201800181. 10. Intrabody against prolyl hydroxylase 2 promotes angiogenesis by stabilizing hypoxia-inducible factor-1α.Sci Rep, 2019,9(1):11861. doi: 10.1038/s41598-019-47891-1. 11. TRIM59 loss in M2 macrophages promotes melanoma migration and invasion by upregulating MMP-9 and Madcam1.Aging (Albany NY), 2019, 11(19):8623-8641. doi: 10.18632/aging.102351 12. TRIM59: A membrane protein expressed on Bacillus Calmette-Guérin-activated macrophages that induces apoptosis of fibrosarcoma cells by direct contact.Exp Cell Res, 2019, 384(1):111590. doi: 10.1016/j.yexcr.2019.111590. 13. Subunits of human condensins are potential therapeutic targets for cancers.Cell Div,2018, 13: 2. doi: 10.1186/s13008-018-0035-3. 14. Exosome separation using microfluidic systems: size-based, immunoaffinity-based and dynamic methodologies.Biotechnol J,2017, 12(4): 1600699. doi: 10.1002/biot.201600699 15. Role of gp91phox in hepatic macrophage programming and alcoholic liver disease.Hepatol Commun, 2017, 1(8): 765-779. doi: 10.1002/hep4.1078. 16. Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem Pharmacol, 2013, 86 (6): 836-843. doi: 10.1016/j.bcp.2013.07.006. 17. Cytosolic phospholipase A2α protects against Fas-but not LPS-induced liver injury.J Hepatol, 2011, 55(6):1281-1290. doi: 10.1016/j.jhep.2011.03.017. 18. Cytosolic phospholipase A2α and PPAR-γ signaling pathway counteracts TGF-β-mediated inhibition of primary and transformed hepatocyte growth.Hepatology, 2010, 52(2): 644-655. doi: 10.1002/hep.23703. 19. Cyclooxygenase-2 prevents Fas-induced liver injury through up-regulation of epidermal growth factor receptor.Hepatology, 2009, 50 (3): 834-843. doi: 10.1002/hep.23052. 20. A PSTAIRE-like protein is localized in nuclei and cytoplasm of Physarum polycephalumand functions in the mitosis. Cell Res,2004, 14 (2): 169-175. doi: 10.1038/sj.cr.7290217.