工作经历 2010.01—2012.09 吉林大学分子酶学工程教育部重点实验室 讲师 2010.04—2013.05 中国科学院长春应用化学研究所 博士后 2012.09—2015.09 吉林大学分子酶学工程教育部重点实验室 副教授 2015.09—至今 吉林大学分子酶学工程教育部重点实验室 教授 2016.03—2017.03 美国塔夫斯大学生物医学工程系 访问学者 2016.07—2019.12 吉林大学分子酶学工程教育部重点实验室 副主任 2020.12—2025.01 吉林大学生命科学学院 副院长 2019.12—至今 吉林大学分子酶学工程教育部重点实验室 主任 荣誉奖励 2014年，吉林大学教书育人先进个人称号 2015年，第十四届“挑战杯”全国大学生课外学术科技作品竞赛优秀指导教师奖 2017年，吉林大学唐敖庆青年人才奖 2017年，吉林省“挑战杯”大学生课外学术科技作品竞赛优秀指导教师奖 2019年，中国微生物学会新华扬优秀青年酶工程学家奖 2021年，入选吉林省首批长白山青年人才工程支持 2021年，入选吉林大学唐敖庆英才教授支持

一、 分子酶学与合成生物技术研究 (1) 酶分子催化机制探究 (2) 酶分子改造与设计研究 (3) 酶促合成功能高分子材料研究 (4) DNA信息存储工具酶设计研究 二、重要疾病关键酶及基因治疗研究 (1) 重要疾病关键酶分子结构与机制研究 (2) 酶分子仿生组装与递送研究 (3) 脱氧核酶设计与催化机制研究 (4) 肿瘤与炎症基因治疗研究

1. Haobo Han, Jiakai Xing, Wenqi Chen, Jiaxin Jia, Quanshun Li*. Fluorinated polyamidoamine dendrimer-mediated miR-23b delivery for the treatment of experimental rheumatoid arthritis. Nat. Commun. 2023, 14: 944. 2. Ruoyu Li, Shudi Zhang, Quanshun Li*, Greg G. Qiao, Zesheng An*. An atom-economic enzymatic cascade catalysis for high-throughput RAFT synthesis of ultrahigh molecular weight polymers. Angew. Chem. Int. Ed. 2022, 61: e202213396. 3. Wei Sun, Yingxuan Chen, Liang Wang, Ze Wang, Shuwei Liu, Mengzhu Zhang, Yi Liu*, Quanshun Li*, Hao Zhang. Gram-scale preparation of quercetin supramolecular nanoribbons for intestinal inflammatory diseases by oral administration. Biomaterials 2023, 295: 122039. 4. Jiakai Xing, Jiaxin Jia, Hugang Zhang, Haobo Han*, Quanshun Li*. Fluorinated dendrimer-mediated miR-30a delivery regulates the inflammation of macrophages and mitigates the symptoms of rheumatoid arthritis. J. Control. Release 2024, 376: 1143-1159. 5. Boyu Xiong, Xinxin Shao, Guangxu Fang, Mengmeng Dong, Haobo Han*, Quanshun Li*. Porous PLGA microspheres for the inhalation delivery of icariin and miR-23b in the treatment of metastatic lung cancer. Asian J. Pharm. Sci. 2024, in press. 6. Yu Tao, Qixuan Zhao, Fengmei Liu, Xiao Liang*, Quanshun Li*. Enzymes encapsulated in organic-inorganic hybrid nanoflower with spatial localization for sensitive and colorimetric detection of formate. J. Colloid Interface Sci. 2024, 672: 97-106. 7. Kai Wen, Yu Tao, Wenyan Jiang, Liyan Jiang, Jingxuan Zhu*, Quanshun Li*. (De)carboxylation mechanisms of heteroaromatic substrates catalyzed by prenylated FMN-dependent UbiD decarboxylases: an in-silico study. Int. J. Biol. Macromol. 2024, 260: 129294. 8. Kai Wen, Sirui Wang, Yixin Sun, Mengsong Wang, Yingjiu Zhang*, Jingxuan Zhu*, Quanshun Li*. Mechanistic insights into the conversion of flavin adenine dinucleotide (FAD) to 8‑formyl FAD in formate oxidase: a combined experimental and in-silico study. Bioresour. Bioprocess. 2024, 11: 67. 9. Lin Jiang, Xiao Liang, Jiaxin Jia, Haobo Han*, Jun Tang*, Quanshun Li*. Ribonuclease A-polymer conjugates via in situ growth for cancer treatment. J. Mater. Chem. B 2024, 12: 2869-2876. 10. Mengzhu Zhang, Siyu Sun, Xiao Liang, Zengguang Liu, Jiaxin Yin, Quanshun Li*, Shengcai Yang*. Quaternary ammonium-based nanosystem enables delivery of CRISPR/Cas9 for cancer therapy. Biomater. Sci. 2024, 12: 1197-1210. 11. 赵启轩，马骏，刘爱江，梁骁*，李全顺*. 核糖核酸酶A表面原位聚合构建抗肿瘤纳米胶囊研究. 高等学校化学学报, 2024, in press. 12. Huihui Qu, Cong Wang, Yixuan Guo, Ziying Zhao, Long Qiao, Jiebing Yang, Haixia Wu*, Quanshun Li*, Alideertu Dong*. Electrospun N-halamine/ ZnO-based platform eradicates bacteria through multimodal antimicrobial mechanism of action. Rare Metals 2023, 42: 222-233. 13. Xinxin Shao, Mengzhu Zhang, Yingxuan Chen, Siyu Sun, Shengcai Yang*, Quanshun Li*. Exosome-mediated delivery of superoxide dismutase for anti-aging studies in Caenorhabditis elegans. Int. J. Pharm. 2023, 641: 123090. 14. Siting Li, Shudi Zhang, Yu Tao, Yingxuan Chen, Yuhan Yang, Xiao Liang*, Quanshun Li*. Construction of β-galactosidase-inorganic hybrid nanoflowers through biomimetic mineralization for lactose degradation. Biochem. Eng. J. 2023, 197: 108980. 15. 李若雨，陈英翾，韩浩博，温凯，安泽胜*，李全顺*. 酶促聚合：绿色的高分子材料合成技术. 生物化学与生物物理进展, 2023, 50: 1017-1029. 16. Yingxuan Chen, Shudi Zhang, Zhenyu Zhai, Shuo Zhang, Jun Ma, Xiao Liang*, Quanshun Li*. Construction of fusion protein with carbohydrate-binding module and leaf-branch compost cutinase to enhance the degradation efficiency of polyethylene terephthalate. Int. J. Mol. Sci. 2023, 24: 2780. 17. Xiao Liang, Kai Wen, Yingxuan Chen, Guangxu Fang, Shengcai Yang*, Quanshun Li*. Oral administration of therapeutic enzyme capsule for the management of inflammatory bowel disease. Int. J. Nanomed. 2022, 17: 4843-4860. 18. Shaowei Bai, Xinxin Shao, Yu Tao, Song Wang, Haobo Han*, Quanshun Li*. Superoxide dismutase-embedded metal-organic frameworks via biomimetic mineralization for the treatment of inflammatory bowel disease. J. Mater. Chem. B 2022, 10: 5174-5181. 19. Simeng Wei, Xinxin Shao, Yong Liu, Boyu Xiong, Pengfei Cui, Ziling Liu*, Quanshun Li*. Genome editing of PD-L1 mediated by nucleobase-modified polyamidoamine for cancer immunotherapy. J. Mater. Chem. B 2022, 10: 1291-1300. 20. Tianyou Qin*, Jiaqi Han, Lan Sheng*, Quanshun Li*, Sean Xiao-An Zhang. Optically-manipulated multiaddressable all-ESIPT fluorescence nanomicelles prepared with a single fluorophore. J. Mater. Chem. C 2022, 10: 840-845.