教育经历 刘晋宇教授毕业于白求恩医科大学，获得医学学士、毒理学硕士和生物化学博士学位。曾在在瑞士苏黎世大学医院皮肤科和美国纽约州立大学布法罗分校化学与生物工程系专门从事干细胞基础与临床应用转化研究。 科研经历 2017/7－现 在 吉林大学公共卫生学院，副院长 研究方向：干细胞生物学与再生医学、生物制药、卫生毒理学 2015/5－2017/6 吉林大学公共卫生学院毒理学教研室，主任，院长助理 研究方向：干细胞生物学与再生医学、生物制药、卫生毒理学 2009/1－2015/4 吉林大学唐敖庆特聘教授，吉林大学病理生物学教育部重点实验室副主 任。研究方向：干细胞生物学与再生医学、生物制药 2004/6－2008/12 助理研究教授，美国纽约州立大学布法罗分校 研究方向：干细胞生物学与血管组织工程学 1999/6－2004/5 博士后，瑞士苏黎世大学医学院皮肤科。 研究方向：皮肤组织工程学与皮肤损伤修复 1991/8－1995/8 环评工程师，水利部松辽水资源保护局。 研究方向：环评污染物监测及人群流行病学调查 学术兼职 中华预防医学会卫生毒理分会第六届委员会委员，2019,10,13-2024,10,12 中国康复医学会修复重建专业委员会委员， 中国研究型医院学会细胞外囊泡研究与应用专业委员会委员，2017,06,03-2022,06,02 吉林省干细胞临床研究专家委员，2017 中国医药生物技术协会皮肤软组织修复与重建技术分会常务委员，2017,02-2021,01 中国医疗保健国际交流促进会糖尿病足病分会，2016 吉林省干细胞学会常务理事，2016 中华预防医学会组织感染与损伤预防与控制专业委员会委员，2016,09,01-2021,08,30 中华医学会组织修复与再生分会血管再生学组委员，2016 《中华细胞与干细胞杂志（电子版）》通讯编委，2016 国际人类基因变异组项目中国区工作委员会委员，2015 中华医学会医学工程学分会干细胞工程专业学组委员会委员，2015 中国生物化学与分子生物学第七届脂质与脂蛋白专业委员会委员，2014

再生医学、生物制药和卫生毒理学

Bo Wang, Feilin Liu, Zinan Liu, Xing Han, Aobo Lian, Yuying Zhang, Kuiyang Zuo, Yuan Wang, Mingsheng Liu, Fei Zou, Yixu Jiang, Minghua Jin, Xiaomei Liu, andJinyu Liu*Internalization of the TAT-PBX1 fusion protein significantly enhances the proliferation of human hair follicle-derived mesenchymal stem cells and delays their senescence. Biotechnology Letters 2020 Oct;42(10):1877-1885 Bo Wang, Xiaomei Liu, Zinan Liu, Yuan Wang, Xing Han, Aobo Lian,, Minghua Jin, andJinyu Liu*Humanhair follicle-derivedmesenchymal stem cells: isolation,expansion and differentiation.World Journal of Stem Cells 2020; Jun 26,12(6): 462-470 Guifang Zhao,Feilin Liu,Zinan Liu,Kuiyang Zuo,Bo Wang,Yuying Zhang,Xing Han,Aobo Lian,Yuan Wang,Mingsheng Liu,Fei Zou, Xiaomei Liu, Minghua, Jin andJin Yu Liu*MSC-Derived Exosomes Attenuate Cell Death through Suppressing AIF Nucleus Translocation and Enhance Cutaneous Wound Healing Stem Cell Research & Therapy 2020 May 11;11(1):174 Feilin Liu, Jiahong Shi,Yingyao Zhang, Aobo Lian, Xing Han, Kuiyang Zuo, Mingsheng Liu, Tong Zheng, Fei Zou, Xiaomei Liu, Ming-Hua Jin, Ying Mu, Gang Li,Guanfang Su*,andJin Yu Liu*NANOG Attenuates Hair Follicle-Derived Mesenchymal Stem Cell Senescence by Upregulating PBX1 and Activating AKT Signaling.Oxidative Medicine and Cellular Longevity, 2019.Published online 2019 Dec 4. doi:10.1155/2019/4286213 Yixu Jiang, Feilin Liu, Fei Zou, Yingyao Zhang, Bo Wang, Yuying Zhang, Aobo Lian, Xing Han, Zinan Liu, Xiaomei Liu, Minghua Jin, Dianliang Wang, Gang Li, andJinyu Liu*. PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis.Stem Cell Research & Therapy, 2019 Aug 23;10(1):268 SHI Jia Hong, ZUO Kui Yang, ZHANG Ying Yao, WANG Bo, HAN Xing, LIAN Ao Bo, andLIU Jin Yu*. NANOG Alleviates the Damage of Human Hair Follicle Mesenchymal Stem Cells Caused by H2O2through Activation of AKT Pathway.Biomed Environ Sci,2019; 32(4): 272-280 Fei Zou, Zhe Wang, Lei Wang, Yuying Zhang, Mingsheng Liu, and Jinyu Liu*Hot Spots and Trends of Research on Human Umbilical Cord Mesenchymal Stem Cells: A Bibliometric Analysis. Journal of Biomaterials and Tissue Engineering. 2019, 9, 1–8 Ma Y,Li M,Liu J,Pang C,Zhang J,Li Y,Fu X. Location, Isolation, and Identification of Mesenchymal Stem Cells from Adult Human Sweat Glands.Stem Cells International2018, Article ID 2090276, 12 pages Tingting Bai, Feilin Liu, Fei Zou, Guifang Zhao, Yixu Jiang, Li Liu, Jiahong Shi, Deshun Hao, Qi Zhang, Tong Zheng, Yingyao Zhang, Mingsheng Liu, Shilun Li, Liangchen Qi, and Jin Yu Liu*Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16. Stem Cells Dev. 2017 Jan 15;26(2):113-122 Dan Zhou, Hongjing Cheng, Jinyu Liu, Lei Zhang. Establishment of human hair follicle mesenchymal stem cells with overexpressed human hepatocyte growth factor. Iran J Basic Med Sci. 2017 Jun;20(6):662-675 Li, Pengdong; Liu, Feilin; Wu, Chunling; Jiang, Wenyue; Zhao, Guifang; Liu, Li; Bai, Tingting; Wang, Li; Lan, Shaowei; Guo, Lili; Li, Yulin; Jin Yu Liu* Feasibility of human hair follicle-derived mesenchymal stem cells/CultiSpher®-G constructs in regenerative medicine. Cell Tissue Res. 2015 Oct;362(1):69-86 G Zhao, F Liu, S Lan, P Li, Li Wang, J Kou, X Qi, R Fan, D Hao, C Wu, T Bai, Y Li and JY Liu* Large-scale expansion of Wharton's jelly-derived mesenchymal stem cells on gelatin microbeads, with retention of self-renewal and multipotency characteristics and the capacity for enhancing skin wound healing. Stem Cell Res Ther. 2015 Mar 19;6(38):1-16 S Lan, F Liu, G Zhao, T Zhou, C Wu, J Kou, R Fan, X Qi, Y Jiang, T Bai, P Li, L Liu, D Hao, L Zhang, Y Li,JY Liu* Cyclosporine A increases hair follicle growth by suppressing AIF nuclear translocation: A new mechanism.Fundam Clin Pharmacol.2015 Apr;29(2):191-203 C Wu, F Liu, P Li, G Zhao, S Lan, W Jiang, X Meng, L Tian, G Li, Y Li*, Jin Yu Liu*. Engineered Hair Follicle Mesenchymal Stem Cells Overexpressing Controlled-Release Insulin Reverse Hyperglycemia in Mice with Type l Diabetes. Cell Transplant. 2015 ;24(5):891-907 Zhang Y, Chen X,Liu J, Zhang Y . The protective effects and underlying mechanism of an anti-oligomeric Aβ42 single-chain variable fragment antibody.Neuropharmacology.2015 Dec;99:387-95 M Li,JinYu Liu, S Wang H, Xu, L Cui, S Lv, J Xu, S Liu, G Chi, Y Li，Multipotent neural crest stem cell-like cells from rat vibrissa dermal papilla induce neuronal differentiation of PC12 cells.Biomed Res Int. 2014; 2014:186239. doi: 10.1155/2014/186239. Epub 2014 Jun 18. Yunhe Gao, Feilin Liu, Lihong Zhang, Xuejin Su,Jin Yu Liu*, and Yulin Li* Acellular Blood Vessels Combined Human Hair Follicle Mesenchymal Stem Cells for Engineering of Functional Arterial Grafts.Ann Biomed Eng.2014 Oct;42(10):2177-89 Yunhe Gao, Meiying Li, Xueyan Zhang, Guangfan chi,Jin Yu Liu* and Yulin Li*. Isolation, culture and phenotypic characterization of human sweat gland epithelial cells.Int J Mol Med.2014 Oct;34(4):997-1003 Xuejuan Liu, Lei Song,Jinyu Liu, Shichao Wang, Xiaohua Tan, Xiaoguang Bai,Tingting Bai, Yimei Wang, Meiying Li, Yaolin Song, Yulin Li*, MiR-18b inhibites TGF-β1-induced differentiation of hair follicle stem cells into smooth muscle cells by targeting SMAD2.BBRC,2013 Aug. 30;438(3):551-6 Yimei Wang,Jinyu Liu, Xiaohua Tan, Gaofeng Li, Xuejuan Liu, Lihong Zhang, Yulin Li*, Induced pluripotent stem cells from human human hair follicle mesenchymal stem cells.Stem Cell Review and Reports.2013, 9(4):451–460 Xueyan Zhang, Yimei Wang, Yunhe Gao, Xuejuan Liu, Tingting Bai, Meiying Li, Guangfan Chi, Hui Xu, Feilin Liu,Jinyu Liu, Yulin Li*. Maintenance of high proliferation and multipotent potential of human hair follicle-derived mesenchymal stem cells by growth factors.Int J Mol Med.2013 Apr; 31(4): 913-21 Mohammed Nader Shalaby,Jin Yu Liu*, Mona Mahmoud Kassem, Mohammed Saad.Circulating Hematopoietic Stem Cell and Some Physiological Parameters in Different Training Programs.Life Sci J2012; 9(1):965-971 Mohamed Nader Shalaby,Jin Yu Liu*, Mohamed Saad and Hossam Elaraby. Impacts of Different Exercise Intensities on Hematopoietic Stem Cells and Certain Physiological Parameters onHandball Players and Non-Athletes.Life Sci J2012;9(3):2100-2105 Mohammed NaderShalaby,Jin Yu Liu, Hussein Heshmat,Nader M. Shalaby, Mohammed Salah Zaeid,Ahmed Ibrahim Shalgham ,MagedElazazy, SamyAkar, Hossam Elaraby, Mohammed AbdelrazikTaha and WaelElfiel. The Effect of Aerobic and Anaerobic Exercise Bouts on CD34+ Stem Cells and Some Physiological Parameters.Life Sci J2012; 9(2): 1037-1043 Hao Fan Peng，Jin Yu Liu,Stelios T. Andreadis andDaniel D. Swartz. Hair Follicle-Derived Smooth Muscle Cells and Small Intestinal Submucosa for Engineering Mechanically Robust and Vasoreactive Vascular Media.Tissue Eng Part A.2011 Apr;17(7-8):981-90 Jin Yu Liu, Hao Fan Peng，JunTian and Stelios T. Andreadis. Derivation of Functional Smooth Muscle Cells from Multipotent Human Hair Follicle Mesenchymal Stem Cells.Tissue Eng Part A.2010 Aug;16(8) :2553-64 Juhee Han,Jin Yu Liu,Daniel D. SwartzandStelios T. Andreadis. Molecular and functional effects of organismal ageing on smooth muscle cells derived from bone marrow mesenchymal stem cells.Cardiovasc Res.2010 Jul 1;87(1):147-55 Jin Yu Liu, Hao Fan Peng and Stelios T. Andreadis. Contractile smooth muscle cells derived from hair follicle stem cells.Cardiovasc Res.2008 Jul 1; 79(1):24-33论文摘要被“New England Journal of Medicine重新发表 Jin Yu Liu, Daniel D. Swartz, Hao Fan Peng, Silviya F. Gugino, James A. Russell, and Stelios T. Andreadis. Functional tissue-engineered blood vessels from bone marrow progenitor cells.Cardiovasc Res.2007 Aug 1;75(3):618-28 Yao Lan,Jin Yu Liu, Stelios Andreadis. Composite Fibrin Scaffolds Increase Mechanical Strength and Preserve Contractility of Tissue Engineered Blood Vessels.Pharmaceutical Research, 2008 May;25(5):1212-21 Jin Yu Liu, Jurg Hafner, Galya Dragieva, Gunter Burg. A novel bioreactor microcarrier cell culture system for high yields of proliferating autologous human keratinocytes.Cell Transplantation. 2006;15(5):435-43 Jin Yu Liu, Jurg Hafner, Galya Dragieva, Gunter Burg. High yields of autologous living dermal equivalents using porcine gelatin microbeads as microcarriers for autologous fibroblasts.Cell Transplantation. 2006;15(5):445-51 Jin Yu Liu, Gunter Burg. An improved organ culture for regeneration of pure autologous keratinocytes from small split-thickness skin specimens.Dermatology.2005;210(1):45-8. Jin Yu Liu, Jurg Hafner, Galya Dragieva, Burkhardt Seifert, Gunter Burg. Autologous cultured Keratinocytes on porcine gelatin microbeads effectively heal chronic venous leg ulcers.Wound Repair Regen.2004 Mar-Apr;12(2):148-56 Jin Yu Liu, Jurg Hafner, Galya Dragieva, Gunter Burg. Bioreactor microcarrier cell culture system (Bio-MCCS) for large-scale production of autologous melanocytes.Cell Transplantation. 2004;13(7-8):809-16 樊蕊蕊,刘菲琳，郝德顺，张琪，张莹瑶，郑彤，李士伦，王鸿艳，戚良晨，刘晋宇。毛囊源性黑色素细胞的生物学特性及其体外培养技术研究进展。中华细胞与干细胞杂志(电子版) 2017年4月第7卷第2期 池光范，李美英，赵贵芳，邓继鸿，刘晋宇，李王林。人皮肤真皮组织中角朊干细胞样细胞的分离与培养。中国组织工程研究与临床康复 2013 第23期 P4264-4271 刘晋宇，侯立中，颜炜群，杨同书。组织工程化人工复合皮肤的构建。中国修复重建外科杂志 ，2001年第4期 P235-239 刘晋宇，侯立中，杨同书，颜炜群。人的复合人工皮肤组织工程学研究--角朊细胞库的构建，白求恩医科大学学报2000第3期P231-234 马刚，陈世义，刘晋宇，敖艳霞，张林前。表皮角朊细胞的分离、培养和鉴定，白求恩医科大学学报1998第3期P324-325 周余来，侯立中，刘晋宇，陈昕，章培标，颜炜群，杨同书。以壳多糖为基质网架构建大鼠组织工程皮肤，生物医学工程与临床2003第2期P71-74 刘晋宇，周余来，侯立中，颜炜群，杨同书。牛脑垂体提取物是角朊细胞无血清培养的重要添加成分，白求恩医科大学学报2000第1期P17-19 刘晋宇、林秀武。甲基汞诱发大鼠肝脏过脂质氧化作用的研究。中华预防医学杂志。1993; 27(2):127 刘晋宇、林秀武。甲基汞对大鼠肝脏过氧化脂质及其效应关系的研究。环境与健康。1993; 10(6):275-278. 刘晋宇、林秀武。氯化甲基汞对大鼠脑组织过氧化脂质的影响。环境与健康。1998; 15(1):34-35. 孙志伟、刘晋宇、林秀武。甲基汞对小鼠精原细胞SCE的影响。中国公共卫生。1992; 11(1): 50-51. 刘晋宇、林秀武。甲基汞对大鼠肾脏过氧化脂质的探究。中国公共卫生。1998; 17(1):41-42. 孙志伟、刘晋宇、林秀武。甲基汞染毒小鼠睾丸超微结构的改变。中国公共卫生。1998; 17(2): 115-115. Liu Jinyuet. al. Effect of methylmercury on LPO levels, SH groups, GSH-Px, SOD and XOD in liver of rats.Journal of Environmental SciencesVol.12,Supplement, pp:115-120, 2000