姜春来 照片

姜春来

教授

所属大学: 吉林大学

所属学院: 生命科学学院

邮箱:
jiangcl@jlu.edu.cn

个人主页:
https://life.jlu.edu.cn/info/1023/1157.htm

个人简介

教育经历 1991~1995,四川大学,理学学士 1997~2000,长春生物制品所,医学免疫学硕士 2001~2005,吉林大学,生物化学和分子生物学博士 工作经历 1、2006~2009,美国杜克大学,博士后 2、2001至今,吉林大学,生命科学学院、艾滋病疫苗国家工程实验室,讲师、教授

研究领域

1、病原微生物致病分子机制研究 2、新型疫苗研究与开发

近期论文

Wan M, Yang X, Sun J, Ding X, Chen Z, Su W, Cai L, Hou A, Sun B, Gao F, Jiang C, Zhou Y. An Adenovirus-Based Recombinant Herpes Simplex Virus 2 (HSV-2) Therapeutic Vaccine Is Highly Protective against Acute and Recurrent HSV-2 Disease in a Guinea Pig Model. Viruses. 2023 Jan 13;15(1):219. doi: 10.3390/v15010219. PMID: 36680259; PM CID: PMC9861952. Wan M, Yang X, Chen Z, Su W, Cai L, Hou A, Sun B, Zhang Y, Kong W, Jiang C, Zhou Y. Comparison of effects of multiple adjuvants and immunization routes on the immunogenicity and protection of HSV-2 gD subunit vaccine. Immunol Lett. 2023 Aug;260:11-21. doi: 10.1016/j.imlet.2023.06.004. Epub 2023 Jun 7. PMID: 37290556. Liu H, Jiang C, Wu Y, Wu M, Wu J, Zhao G, Sun J, Huang X, Li J, Sheng R, Barbier J, Cintrat JC, Gillet D, Su W. Antiviral Effects of ABMA and DABMA against Influenza Virus In Vitro and In Vivo via Regulating the Endolysosomal Pathway and Autophagy. Int J Mol Sci. 2022 Apr 1;23(7):3940. doi: 10.3390/ijms23073940. PMID: 35409297; PMCID: PMC8999625. Liu J, Lin J, Cai L, Sun J, Ding X, Wang C, Wu Y, Gao X, Su W, Jiang C. Immunogenicity of Varicella Zoster Virus DNA Vaccines Encoding Glycoprotein E and Immediate Early Protein 63 in Mice. Viruses. 2022 Jun 2;14(6):1214. doi: 10.3390/v14061214. PMID: 35746685; PMCID: PMC9230688. Bian L, Zheng Y, Guo X, Li D, Zhou J, Jing L, Chen Y, Lu J, Zhang K, Jiang C, Zhang Y, Kong W. Intramuscular Inoculation of AS02-Adjuvanted Respiratory Syncytial Virus (RSV) F Subunit Vaccine Shows Better Efficiency and Safety Than Subcutaneous Inoculation in BALB/c Mice. Front Immunol. 2022 Jul 22;13:938598. doi: 10.3389/fimmu.2022.938598. PMID: 35935960; PMCID: PMC9354885. Wu M, Zhou E, Sheng R, Fu X, Li J, Jiang C, Su W. Defective Interfering Particles of Influenza Virus and Their Characteristics, Impacts, and Use in Vaccines and Antiviral Strategies: A Systematic Review. Viruses. 2022 Dec 12;14(12):2773. doi: 10.3390/v14122773. PMID: 36560777; PMCID: PMC9781619. Zhao S, Zheng B, Wang L, Cui W, Jiang C, Li Z, Gao W, Zhang W. Deubiquitinase ubiquitin-specific protease 3 (USP3) inhibits HIV-1 replication via promoting APOBEC3G (A3G) expression in both enzyme activity-dependent and -independent manners. Chin Med J (Engl). 2022 Nov 20;135(22):2706-2717. doi: 10.1097/CM9.0000000000002478. PMID: 36574218; PMCID: PMC9945250. Gao W, Li G, Zhao S, Wang H, Huan C, Zheng B, Jiang C, Zhang W. Deubiquitinating Enzyme USP21 Inhibits HIV-1 Replication by Downregulating Tat Expression. J Virol. 2021 Jun 10;95(13):e0046021. doi: 10.1128/JVI.00460-21. Epub 2021 Jun 10. PMID: 33827943; PMCID: PMC8316079. He L, Sun B, Guo Y, Yan K, Liu D, Zang Y, Jiang C, Zhang Y, Kong W. Immune response of C57BL/6J mice to herpes zoster subunit vaccines formulated with nanoemulsion-based and liposome-based adjuvants. Int Immunopharmacol. 2021 Dec;101(Pt B):108216. doi: 10.1016/j.intimp.2021.108216. Epub 2021 Oct 8. Erratum in: Int Immunopharmacol. 2023 Jun;119:110260. PMID: 34634689. Yang X, Wan M, Cai L, Hou A, Sun B, Zhou Y, Gao F, Su W, Jiang C. Interferon Inhibition Enhances the Pilot-Scale Production of Rabies Virus in Human Diploid MRC-5 Cells. Viruses. 2021 Dec 29;14(1):49. doi: 10.3390/v14010049. PMID: 35062253; PMCID: PMC8779192. Cao J, Qu M, Liu H, Wan X, Li F, Hou A, Zhou Y, Sun B, Cai L, Su W, Jiang C. Myristoylation of EV71 VP4 is Essential for Infectivity and Interaction with Membrane Structure. Virol Sin. 2020 Oct;35(5):599-613. doi: 10.1007/s12250-020-00226-1. Epub 2020 May 12. PMID: 32399947; PMCID: PMC7736455. Zheng Y, Bian L, Zhao H, Liu Y, Lu J, Liu D, Zhang K, Song Y, Luo Y, Jiang C, Chen Y, Zhang Y, Kong W. Respiratory Syncytial Virus F Subunit Vaccine With AS02 Adjuvant Elicits Balanced, Robust Humoral and Cellular Immunity in BALB/c Mice. Front Immunol. 2020 Sep 11;11:526965. doi: 10.3389/fimmu.2020.526965. PMID: 33013922; PMCID: PMC7516270. Yang P, Chen Z, Zhang J, Li W, Zhu C, Qiu P, Quan Y, Cui X, Yuan L, Jiang C. Evaluation of Varicella-zoster virus-specific cell-mediated immunity by interferon-γ Enzyme-Linked Immunosorbent Assay in adults ≥50 years of age administered a herpes zoster vaccine. J Med Virol. 2019 May;91(5):829-835. doi: 10.1002/jmv.25391. Epub 2019 Jan 12. PMID: 30613990. Wang J, Wu F, Liu C, Dai W, Teng Y, Su W, Kong W, Gao F, Cai L, Hou A, Jiang C. Exosomes Released from Rabies Virus-Infected Cells May be Involved in the Infection Process. Virol Sin. 2019 Feb;34(1):59-65. doi: 10.1007/s12250-019-00087-3. Epub 2019 Feb 6. PMID: 30725320; PMCID: PMC6420551. Wang J, Teng Y, Zhao G, Li F, Hou A, Sun B, Kong W, Gao F, Cai L, Jiang C. Exosome-Mediated Delivery of Inducible miR-423-5p Enhances Resistance of MRC-5 Cells to Rabies Virus Infection. Int J Mol Sci. 2019 Mar 27;20(7):1537. doi: 10.3390/ijms20071537. PMID: 30934732; PMCID: PMC6479321. Dai W, Bi J, Li F, Wang S, Huang X, Meng X, Sun B, Wang D, Kong W, Jiang C, Su W. Antiviral Efficacy of Flavonoids against Enterovirus 71 Infection in Vitro and in Newborn Mice. Viruses. 2019 Jul 7;11(7):625. doi: 10.3390/v11070625. PMID: 31284698; PMCID: PMC6669683. Cao J, Liu H, Qu M, Hou A, Zhou Y, Sun B, Cai L, Gao F, Su W, Jiang C. Determination of the cleavage site of enterovirus 71 VP0 and the effect of this cleavage on viral infectivity and assembly. Microb Pathog. 2019 Sep;134:103568. doi: 10.1016/j.micpath.2019.103568. Epub 2019 Jun 11. PMID: 31195113. Wang C, Gao N, Song Y, Duan S, Wang W, Cong Z, Qin C, Jiang C, Yu X, Gao F. Reduction of peak viremia by an integration-defective SIV proviral DNA vaccine in rhesus macaques. Microbiol Immunol. 2020 Jan;64(1):52-62. doi: 10.1111/1348-0421.12744. Epub 2019 Oct 14. PMID: 31544982. Shi W, Kou Y, Xiao J, Zhang L, Gao F, Kong W, Su W, Jiang C, Zhang Y. Comparison of immunogenicity, efficacy and transcriptome changes of inactivated rabies virus vaccine with different adjuvants. Vaccine. 2018 Aug 9;36(33):5020-5029. doi: 10.1016/j.vaccine.2018.07.006. Epub 2018 Jul 7. PMID: 30037417. Kou Y, Wan M, Shi W, Liu J, Zhao Z, Xu Y, Wei W, Sun B, Gao F, Cai L, Jiang C. Performance of Homologous and Heterologous Prime-Boost Immunization Regimens of Recombinant Adenovirus and Modified Vaccinia Virus Ankara Expressing an Ag85B-TB10.4 Fusion Protein against Mycobacterium tuberculosis. J Microbiol Biotechnol. 2018 Jun 28;28(6):1022-1029.doi: 10.4014/jmb.1712.12064. PMID: 29847865. Song H, Giorgi EE, Ganusov VV, Cai F, Athreya G, Yoon H, Carja O, Hora B, Hraber P, Romero-Severson E, Jiang C, Li X, Wang S, Li H, Salazar-Gonzalez JF, Salazar MG, Goonetilleke N, Keele BF, Montefiori DC, Cohen MS, Shaw GM, Hahn BH, McMichael AJ, Haynes BF, Korber B, Bhattacharya T, Gao F. Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection. Nat Commun. 2018 May 15;9(1):1928.doi: 10.1038/s41467-018-04217-5. PubMed PMID: 29765018; PubMed Central PMCID: PMC5954121. Shi W, Kou Y, Jiang H, Gao F, Kong W, Su W, Xu F, Jiang C. Novel intranasal pertussis vaccine based on bacterium-like particles as a mucosal adjuvant. Immunol Lett. 2018 Jun;198:26-32.doi: 10.1016/j.imlet.2018.03.012. Epub 2018 Mar 27. PubMed PMID: 29601940. Dai W, Wu Y, Bi J, Wang S, Li F, Kong W, Barbier J, Cintrat JC, Gao F, Gillet D, Su W, Jiang C. Antiviral Effects of ABMA against Herpes Simplex Virus Type 2 In Vitro and In Vivo. Viruses. 2018 Mar 9;10(3).pii: E119. doi: 10.3390/v10030119. PubMed PMID: 29522484; PubMed Central PMCID: PMC5869512. Wang D, Lu J, Yu J, Hou H, Leenhouts K, Van Roosmalen ML, Gu T, Jiang C, Kong W, Wu Y. A Novel PspA Protein Vaccine Intranasal Delivered by Bacterium-Like ParticlesProvides Broad Protection Against Pneumococcal Pneumonia in Mice. Immunol Invest. 2018 May;47(4):403-415.doi: 10.1080/08820139.2018.1439505. Epub 2018 Mar 2. PubMed PMID: 29498560. Du X, Zhang X, Jiang C, Zhang W, Yang L. The Trace Detection of Nitrite Ions Using Neutral Red Functionalized SH-β-Cyclodextrin @Au Nanoparticles. Sensors (Basel). 2018 Feb 25;18(3).pii: E681. doi: 10.3390/s18030681. PubMed PMID: 29495331; PubMed Central PMCID: PMC5877208.