教育经历 学士， 生物化学， 加拿大曼尼托巴大学 博士， 生物化学， 加拿大女王大学 工作经历 教授， 吉林大学生命科学学院

糖生物学研究 （1）聚糖在癌细胞增殖、转移和凋亡中的作用 （2）特异性糖基转移酶抑制素的抗癌/抗炎活性研究 （3）气体信号分子H2S和NO相互作用机理研究及新型降压药物的研发 （4）透明质酸（玻尿酸）衍生物的合成及抗炎抗癌活性及机理研究 （5）透明质酸、环糊精和瓜环等药物递送系统的应用研究 （6）基于透明质酸的抗衰老化合物研发

Role of Glycans onKey Cell Surface Receptors That Regulate Cell Proliferation and Cell Death. Yin Gao, Xue Luan, Jacob Melamed, Inka Brockhausen*, Cells, 2021, 10, 1252. https://doi.org/10.3390/cells10051252. 17O NMR spectroscopy-assisted in vitro bioactivity studies of the intermediates formed via Na2S and RSNO cross-linking reactions. Xingyu Zhu and Yin Gao*, RSC Advances,2020,10,39617-39626. The expression and functional analysis of the sialyl-T antigen in prostate cancer. Ruifeng Bai, Xue Luan, Yu Zhang, Catherine Robbe-Masselot, Inka Brockhausen, Yin Gao*, Glycoconj J, 2020,37(4):423-433. N-Butyrylated hyaluronic acid ameliorates gout and hyperuricemia in animal models.Lanzhou Li#, Di Wang#, Ruifeng Bai, Xueju Wang, Chunyu Wang, Yin Gao*, Tassos Anastassiades*, Pharmaceutical Biology, 2019; 57(1), 717-728, https://doi.org/10.1080/13880209.2019.1672755. A Low Molecular Weight Hyaluronic Acid Derivative Accelerates Excisional Wound Healing by Modulating Pro-Inflammation, Promoting Epithelialization and Neovascularization, and Remodeling Collagen.Yin Gao#, Yao Sun#, Hao Yang, Pengyu Qiu, Zhongcheng Cong, Yifang Zou, Liu Song, Jianfeng Guo* and Tassos P. Anastassiades, International Journal of Molecular Sciences, 2019;20(15). pii: E3722. doi: 10.3390/ijms20153722. Docetaxel-loaded human serum albumin (HSA) nanoparticles: synthesis, characterization, and evaluation Na Qu, Yating Sun, Yujing Li, Fei Hao, Pengyu Qiu, Lesheng Teng, Jing Xie*; Yin Gao*, Biomed Eng Online. 2019;18(1):11. doi: 10.1186/s12938-019-0624-7. Recent advances in single-cell analysis by mass spectrometry.Lei Yin, Zhi Zhang, Yingze Liu, Yin Gao* and Jingkai Gu*, Analyst. 2019;144(3):824-845. doi: 10.1039/c8an01190g. Antitumor effect of a liposome-encapsulated β1,4-galactosyltransferase inhibitor. Guangsheng Cai, Kun Wang, Na Qu, Pengyou Qiu, Jason Z. Vlahakis, Walter A. Szarek, Robert J. Lee*, Yin Gao*, International Journal of Pharmaceutics, 2018, 552: 388-393. Solid-State 15N and 17O NMR of S-Nitrosothiols.Yin Gao, Yizhe Dai, Gang Wu, Journal of Physical Chemistry B, 2017, 121: 7311-7317. Direct NMR detection of the unstable “red product” from reaction between nitroprusside and 2-mercaptosuccinic acid.Yin Gao, Brendan Mossing, Gang Wu, Dalton Transactions, 2015, 44(47): 20338-20343. Solving the 170-Year-Old mystery about red-violet and blue transient intermediates in the Gmelin reaction.Yin Gao, Abouzar Toubaei, Xianqi Kong, Gang Wu, European Journal of Chemistry, 2015-November, 21: 17172-17177. Acidity and hydrogen exchange dynamics of iron(II)-bound nitroxyl in aqueous solution.Yin Gao, Abouzar Toubaei, Xianqi Kong, Gang Wu, Angewandte Chemie International Edition, 2014, 53(43): 11547-11551. Acceptor specificities and selective inhibition of recombinant human Gal- and GlcNAc-transferases that synthesize core structures 1, 2, 3 and 4 of O-glycans.Yin Gao, Rajindra P. Aryal, Tongzhong Ju, Richard D. Cummings, Gagandeep Gahlay, Donald L. Jarvis, Khushi Matta, Jason Z. Vlahakis, Walter A. Szarek, Inka Brockhausen*, Biochimica et Biophysica Acta, 2013, 1830(8): 4274-4281. Selective inhibition of glycosyltransferases by bivalent imidazolium salts.Yin Gao, Jason Z. Vlahakis, Walter Szarek, Inak Brockhausen, Bioorganic & Medicinal Chemistry, 2013-March, 21(5): 1305-1311 (Impact factor: 3.21). Biochemical characterization of WbdN, a β1,3-glucosyltransferase involved in O-antigen synthesis in enterohemorrhagic Escherichia coli O157.Yin Gao#, Bin Liu#, Scott Strum, John S. Schutzbach, Tatyana N. Druzhinina, Natalia S. Utkina, Vladimir I. Torgov, Leonid L. Danilov, Vladimir V. Veselovsky, Jason Z. Vlahakis, Walter A. Szarek, Lei Wang, Inka Brockhausen, Glycobiology, 2012, 22(8): 1092 -1102. Functional identification of bacterial glucosyltransferase WbdN, Methods.Yin Gao, Anna Vinnikova, Inka Brockhausen, Mol. Biol., 2013, 1022: 199 – 214. Glycosylation potential of human prostate cancer cell lines.Yin Gao, Vishwanath Chachadi, Pi-Wan Cheng, Inka Brockhausen, Glycoconjugate Journal, 2012, 29(7): 525-537. Specificity of β1,4-galactosyltransferase inhibition by 2-naphthyl 2-butanamido-2-deoxy-1-thio-β-D-glucopyranoside.Yin Gao, Carmen Lazar, Walter A. Szarek, Inka Brockhausen, Glycoconjugate Journal, 2010, 27(7): 673 -684. Analysis of therapeutic monoclonal antibody glycoforms by mass spectrometry for pharmacokinetics study.Yuting Cong, Lianghai Hu, Zhang Zhang, Yin Gao, Mingming Dong, Hongqiang Qin, Mingliang Ye, Jingkai Gu, Hanfa Zou, , Talanta, 2017, 165: 664-670. Enhanced delivery of paclitaxel using electrostatically-conjugated hercepin-bearing PEI/PLGA nanoparticles against HER-positive brest cancer cells.Kongtong Yu, Jinglong Zhao, Zunkai Zhang, Yin Gao, Yulin Zhou, Lesheng Teng, Youxin Li, International Journal of Pharmaceutics, 2016, 497: 78-87. Determination of thymopentin in beagle dog blood by liquid chromatography with tandem mass spectrometry and its application to a preclinical pharmacokinetic study. Meiyun Shi, Yan Yang, Xiaotong Zhou, Lanlan Cai, Chunxue Fang, Can Wang, Heping Sun, Yantong Sun, Yin Gao, Jingkai Gu, J. Paul Fawcett, Journal of Separation Science, 2015, 38(8): 1351–1357. Characterization of two UDP-Gal: GalNAc-Diphosphate-lipid β1,3Galactosyltransferases Wbwc from Escherichia coli serotypes O104 and O5.Shuo Wang, Diana Czuchry, Bin Liu, Anna N. Vinnikova, Yin Gao, Jason Z. Vlahakis, Walter A. Szarek, Lei Wang, Feng Lu, Inka Brockhausen, Journal of Bacteriology, 2014, 196 (17): 3122 – 3133. Determination of a deuterohemin–peptide conjugate in rat plasma by liquid chromatography–tandem mass spectrometry and application to a preclinical pharmacokinetic study.Hao Wang, Yantong Sun, Wei Guo, Chunxue Fang, J. Paul Fawcett, Wei Lia, Yin Gao, Yan Yang, Jingkai Gu, Journal of Pharmaceutical and Biomedical Analysis, 2014, 98: 401-406. Enzyme-substrate complexes of allosteric citrate synthase: evidence for a novel intermediate in substrate binding.Harry W. Duckworth, Nham T. Nguyen, Yin Gao, Lynda J. Donald, Robert Maurus, Ayead Ayed, Brigitte Bruneau, Gary D. Brayer, Biochimica et Biophysica Acta, 2013, 1834(12): 2546 – 2553. Structural glycobiology: applications in cancer research.Inka Brockhausen, Yin Gao, CRC Press, Taylor & Francis Group (Print ISBN: 978-1-4398-5460-0), 2012