教育经历 1992.09-1996.07 吉林大学分子生物学系分子生物学专业， 获学士学位 1998.09-2003.12 吉林大学生命科学学院，获博士学位 2005.09-2007.08 中科院长春应用化学研究所和海王生物 博士后 工作经历 2000.04-2000.07 日本工业技术院生命工学研究所，访问学者 2001.09-2002.08 吉林大学分子酶学工程教育部重点实验室，助教 2002.09-2004.08 吉林大学分子酶学工程教育部重点实验室，讲师 2004.09-2009.08 吉林大学生命科学学院分子酶学工程教育部重点实验室，副教授 2009.09-现在 吉林大学生命科学学院分子酶学工程教育部重点实验室，教授, 博士生导师 2010.09-2011.09 丹麦奥胡斯大学分子生物学系，访问学者 荣誉称号 吉林大学“唐敖庆学者”领军教授 中国生物化学与分子生物学学会工业生物化学分会常务委员 吉林省生物化学与分子生物学会 理事

1) 新酶筛选与开发，特别关注嗜热酶的筛选 2) 基于蛋白质工程的酶的分子改造与固定化 3) 酶反应器设计、活性调控、工程化制备和酶催化应用

Zihao Huang, Zhenyu Gu, Xiemuxinuer Abuduwupuer, Deyuan Qin, Yuchen Liu, Zheng Guo*, Renjun Gao*, Engineering non-conservative substrate recognition sites of extradiol dioxygenase: Computation guided design to diversify and accelerate degradation of aromatic compounds, International Journal of Biological Macromolecules, 2024, 264, 130739. Fang Wang, Yi Ouyang, Pengfei Zhou, Yan Zhang, Renjun Gao*, Bekir Engin Eser * and Zheng Guo*, NIR-accelerated cascade reaction for degradation of organophosphorus compounds by Au/PTE/ZIF-8: cooperative effect and mechanism, Catalysis Science & Technology, 2024, 14, 3424. Xiuhui Tang, Lijuan Zhang, Mingwang Huang, Fang Wang, Guiqiu Xie, Rui Huo, Renjun Gao*, Selective enhanced cytotoxicity of amino acid deprivation for cancer therapy using thermozyme functionalized nanocatalyst, Journal of Nanobiotechnology, 2024, 22, 53. Lijuan Zhang, Simeng Ding, Xiuhui Tang, Renjun Gao, Rui Huo* and Guiqiu Xie*, The improved antineoplastic activity of thermophilic L‐asparaginase Tli10209 via site‐directed mutagenesis, Biomolecules, 2024, 14, 686. Yajing Li, Qi Chen, Siyao Liu, Lin Deng, Shichao Li, and Renjun Gao*, Efficient one-pot synthesis of uridine diphosphate galactose employing a tri-enzyme system, Journal of Agricultural and Food Chemistry. 2024, 72, 3644. Yiwen Xu, Xiaoran Xuan, Renjun Gao, Guiqiu Xie*, Increased expression levels of thermophilic serine protease TTHA0724 through signal peptide screening in Bacillus subtilis and applications of the enzyme, International Journal of Molecular Sciences, 2023, 24, 15950. Ye Zhou, Jannik Nedergaard Pedersen, Jacob Nedergaard Pedersen, Nykola C. Jones, Søren Vrønning Hoffmann, Steen Vang Petersen, Jan Skov Pedersen, Adam Perriman, Renjun Gao*, and Zheng Guo*, Superanionic solvent-free liquid enzymes exhibit enhanced structures and activities, Advanced. Science. 2022, 9, 2202359. Abidan Ainiwaer, Ao Li, Xingwang Zhao, Yujiao Xu, Siping Han*, and Renjun Gao*, Site-specific covalent immobilization of Methylobacterium extorquens non-blue laccse melac13220 on Fe3O4 nanoparticles by aldehyde Tag, Catalysts. 2022, 12, 1379. Abidan Ainiwaer, Yue Liang, Xiao Ye and Renjun Gao*, Characterization of a Novel Fe2+ Activated Non-Blue Laccase from Methylobacterium extorquens, International Journal of Molecular Sciences. 2022, 23, 9804. Yajing Li, Xue Yang and Renjun Gao*, Thermophilic inorganic pyrophosphatase ton1914 from Thermococcus onnurineus NA1 removes the inhibitory effect of pyrophosphate, International Journal of Molecular Sciences. 2022, 23, 12735. Fang Wang, Yuchen Liu, Chang Du and Renjun Gao*, Current strategies for real-time enzyme activation, Biomolecules, 2022, 12, 599. Jiabao Lyu, Jian Zhang, Jingxuan Zhu, Siao Chen, Tao Han, Yan Zhang, Renjun Gao, Guiqiu Xie*, Zheng Guo*, Molecular dynamics simulation guided distal mutation of Thermotoga naphthophila β-glucosidase for significantly enhanced synthesis of galactooligosaccharides and expanded product scope, International Journal of Biological Macromolecules, 2022, 210, 21. Xiaowen Zhang, Zihao Huang, Dan Wang, Yan Zhang, Bekir Engin Eser, Zhenyu Gu, Rongrong Dai, Renjun Gao*, Zheng Guo*, A new thermophilic extradiol dioxygenase promises biodegradation of catecholic pollutants, Journal of Hazardous Materials, 422 (2022), 126860. Li Zong, Yan Zhang, Zhengkang Shao, Yingwu Wang, Zheng Guo, Renjun Gao*, Bekir Engin Eser*, Optimization and engineering of a self-sufficient cyp102 enzyme from Bacillus amyloliquefaciens towards synthesis of in-chain hydroxy fatty acids, Catalysts, 2021, 11(6), 665. Li Zong, Renjun Gao, Zheng Guo, hengkang Shao, Yingwu Wang*, Bekir EnginEser*, Characterization and modification of two self-sufficient CYP102 family enzymes from Bacillus amyloliquefaciens DSM 7 with distinct regioselectivity towards fatty acid hydroxylation, Biochemical Engineering Journal, 2021, 166, 107871. Jiabao Lyu, Renjun Gao, and Zheng Guo*, Galactosyldiacylglycerols: From a Photosynthesis-Associated Apparatus to Structure-Defined In Vitro Assembling, Journal of Agricultural and Food Chemistry. 2021, 69, 32, 8910. Fang Wang, Rong Li, Hui Jian, Zihao Huang, Yingwu Wang*, Zheng Guo*, and Renjun Gao*, Design and construction of an effective expression system with aldehyde tag for site-specific enzyme immobilization, Catalysts, 2020, 10(4), 410. Dongni Liu, Lin Deng, Dan Wang, Wei Li, Renjun Gao*, “Bridge regions” regulate catalysis and protein stability of acylpeptide hydrolase, Biochemical Engineering Journal, 2019, 145, 42. Wei Li, Dongni Liu, Xu Geng, Zhengqiang Li* and Renjun Gao*, Real-time regulation of catalysis by remote-controlled enzyme-conjugated gold nanorod composites for aldol reaction-based applications, Catalysis Science & Technology, 2019, 9, 2221. Ye Zhou, Bianca Pérez, Weiwei Hao, Jiabao Lv, Renjun Gao*, Zheng Guo*, The additive mutational effects from surface charge engineering: A compromise between enzyme activity, thermostability and ionic liquid tolerance, Biochemical Engineering Journal, 2019, 148,195. Ye Zhou, Nykola C. Jones, Jannik Nedergaard Pedersen, Bianca Pérez, S. V. Hoffmann, Steen Vang Petersen, Jan Skov Pedersen, Adam Perriman, Peter Kristensen, Renjun Gao*, and Zheng Guo*, Insight into the Structure and Activity of Surface-Engineered Lipase Biofluids, ChemBioChem, 2019, 20, 1266. Jiabao Lyu, Zidan Li, Juncheng Men, Ruyun Jiang, Guilin Tang, Ye Zhou, Renjun Gao*, Covalent immobilization of Bacillus subtilis lipase A on Fe3O4 nanoparticles by aldehyde tag: An ideal immobilization with minimal chemical modification, Process Biochemistry, 2019, 81, 63. Dongni Liu, Wei Li, Xiaoyu Jiang, Shuju Bai, Jiyang Liu, Xutong Liu, Yuhua Shi, Ziyu Kuai, Wei Kong, Renjun Gao* and Yaming Shan*, Using near-infrared enhanced thermozyme and scFv dual-conjugated Au nanorods for detection and targeted photothermal treatment of Alzheimer’s disease, Theranostics, 2019, 9(8), 2268.