教育经历 2000/09 - 2003/07，吉林大学，放射医学，博士 1997/09 - 2000/07，白求恩医科大学，卫生毒理学，硕士 1992/09 - 1997/07，白求恩医科大学，预防医学，学士 工作经历 2014/09 - 至今， 吉林大学公共卫生学院卫生毒理学教研室，教授 2006/09 - 2014/09，吉林大学公共卫生学院卫生毒理学教研室，副教授 2004/12 - 2005/12 澳大利亚新南威尔士大学访问学者 2002/09 - 2006/09，吉林大学公共卫生学院卫生毒理学教研室，讲师 2000/09 - 2002/09，吉林大学公共卫生学院卫生毒理学教研室，助教 社会兼职 吉林省预防医学会卫生毒理学专业委员会常务委员 中国毒理学会毒理学教育专业委员会委员

干细胞与药理学、毒理学 环境有害因素对干细胞的影响 干细胞对疑难疾病及化学物中毒等治疗作用

Zhao Y, Yan J, Li AP, Zhang ZL, Li ZR, Guo KJ, Zhao KC, Ruan Q, Guo L. Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats. Toxicol Lett, 2019, 310:31-38. (通讯作者) Yin F, Yan J, Zhao Y, Guo KJ, Zhang ZL, Li AP, Meng CY, Guo L. Bone marrow mesenchymal stem cells repair Cr (VI)-injured kidney by regulating mitochondria-mediated apoptosis and mitophagy mediated via the MAPK signaling pathway. Ecotoxicol Environ Saf, 2019, 176: 234-241. (通讯作者) Wang YJ, Yan J, Zou XL, Guo KJ, Zhao Y, Meng CY, Yin F, Guo L. Bone marrow mesenchymal stem cells repair cadmium-induced rat testis injury by inhibiting mitochondrial apoptosis. Chem Biol Interact, 2017, 271: 39-47. (通讯作者) Wang YJ, Yan J, Yin F, Li L, Qin YG, Meng CY, Lu RF, Guo L. Role of autophagy in cadmium-induced testicular injury. Hum Exp Toxicol, 2017, 36(10): 1039-1048. (通讯作者) Zhang H, Su X, Guo L, Zhong L, Li W, Yue Z, Wang X, Mu Y, Li X, Li R, Wang Z. Silencing SATB1 Inhibits the Malignant Phenotype and Increases Sensitivity of Human Osteosarcoma U2OS Cells to Arsenic Trioxide. Int J Med Sci, 2014, 11(12):1262-1269. (通讯作者) Yin F, Meng C, Lu R, Li L, Zhang Y, Chen H, Qin Y, Guo L. Bone marrow mesenchymal stem cells repair spinal cord ischemia/reperfusion injury by promoting axonal growth and anti-autophagy. Neural Regen Res, 2014, 9(18): 1665-1671. (通讯作者) Guo L, Li P, Meng C, Lu R, Yang Y, Zhou Y, Zhang Y, Chen H, Yin F. Protective Effect of Zinc on Mouse Renal Ischemia-reperfusion Injury by Anti-apoptosis and Antioxidation. Curr Pharm Biotechnol, 2014, 15(6): 577-582. in F, Guo L, Meng CY, Liu YJ, Lu RF, Li P, Zhou YB. Transplantation of mesenchymal stem cells exerts anti-apoptotic effects in adult rats after spinal cord ischemia-reperfusion injury. Brain Res, 2014, 1561:1-10. (通讯作者) Zhang Xing, Yin Fei, Guo Li, Zhao Dongxu, Gong Gu, Gao Lei, Zhu Qingsan. Transplantation of neural stem cells, Schwann cells and olfactory ensheathing cells for spinal cord injury. Neural Regen Res, 2012, (35): 2818-2825. Yin F, Guo L, Lu RF, Zhu QS. Spontaneous differentiation of porcine neural progenitors in vitro. Cytotechnology, 2011, 63(4): 363-370. (通讯作者) Guo L, Yin F, Meng HQ, Ling L, Hu-He TN, Li P, Zhang CX, Yu S, Duan DS, Fan HX. Differentiation of mesenchymal stem cells into dopaminergic neuron-like cells in vitro. Biomed Environ Sci, 2005, 18(1): 36-42. 王永杰, 严珺, 李雷, 尹飞, 卢日峰, 郭丽. 干细胞因子在严重烧伤大鼠肠组织中的表达.中国实验诊断学, 2016, 20(6): 875-878. (通讯作者) 严珺, 王永杰, 孟春阳, 李雷, 赵嘉勋, 郭贵君, 彭川莉, 尹飞, 郭丽. 锌对大鼠骨髓间充质干细胞增殖与向神经样细胞分化的影响. 中国实验诊断学, 2016, 20(7): 1045-1048.(通讯作者) 李雷, 王永杰, 陈浩, 秦永刚, 周煜博, 赵嘉勋, 郭丽. 严重烧伤对大鼠海马神经细胞自噬和神经胶质细胞反应的诱导作用. 吉林大学学报(医学版), 2015, 41(5): 898-901. (通讯作者) 秦永刚, 李晨旭, 李雷, 王永杰, 卢日峰, 杜海英, 陈巾宇, 郭丽. 自噬在镉致大鼠肾脏损伤中的作用. 吉林大学学报(医学版), 2015,41(2): 213-217. (通讯作者) 陈浩, 尹飞, 孟春阳, 周煜博, 张颖, 秦永刚, 杨小玉, 郭丽. 骨髓间充质干细胞移植对严重烧伤大鼠肝损伤的修复作用及其机制. 吉林大学学报(医学版), 2014, 40(2): 219-223 (通讯作者)