教育经历 1979.09-1984.07吉林大学/化学/本科/学士 1988.09-1991.06吉林大学/生物化学/研究生/硕士 1991.09-1994.06吉林大学/化学/研究生/博士 工作经历 1984.07/1988.08/吉林省中医中药研究院/研究实习员 1992.09/1997.08/吉林大学酶工程国家重点实验室/讲师 1994.11/1996.01/白求恩医科大学/基础医学/博士后 1996.01/1997.07/以色列希伯来大学/化学/博士后 1997.09/2001.08/吉林大学分子生物学系/副教授 2001.09/2008.12/吉林大学生命科学学院/系主任/教授 2009.01/现在/吉林大学生命科学学院/副院长/教授 2001.04/2002.03/日本关西学院大学/生命科学/访问学者 2006.09/2007.02/美国俄克拉荷马大学/生命科学/访问学者 2009.09/2009.12/美国俄克拉荷马大学/生命科学/访问学者 2010.11/2010.12/美国俄克拉荷马大学/生命科学/访问学者

蛋白质酪氨酸磷酸酶和激酶的结构与功能的研究及抑制剂的筛选，揭示酪氨酸磷酸酶和激酶的异常与人类重大疾病的发生、发展之间的关系

Wang Z, Xu B, Zhang L, Zhang J, Ma T, Zhang J, Fu X*, Tian W*，Folic acid-functionalized mesoporous silica nanospheres hybridized with AIE luminogens for targeted cancer cell imaging, Nanoscale, 5(5), 2065-2072,2013 Cao B, Liu X, Li J, Liu S, Qi Y, Xiong Z, Zhang A, Wiese T, Fu X, Gu J, Rennie PS, Sartor O, Lee BR, Ip C, Zhao L, Zhang H, Dong Y*, 20(S)- protopanaxadiol- aglycone downregulation of the full-length and splice variants of androgen receptor, Int J Cancer, 132(6),1277-1287,2013 Li Y, Deng C, Hu X, Patel B, Fu X, Qiu Y, Brand M, Zhao K, Huang S*, Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis, Oncogene, 31 (48), 5007-5008, 2012 Guo Y, Chen Y, Xu X, Fu X*, Zhao ZJ*,SU11652 Inhibits tyrosine kinase activity of FLT3 and growth of MV-4-11 cells, J Hematol Oncol, 5:72, 2012 Zhao W, Du Y, Ho WT, Fu X, Zhao ZJ*, JAK2V617F and p53 mutations coexist in erythroleukemia and megakaryoblastic leukemic cell lines, Exp Hematol Oncol, 1(1):15,2012 Li T, Zeng L, Gao W, Cui MZ, Fu X, Xu X*, PSAP induces a unique Apaf-1 and Smac-dependent mitochondrial apoptotic pathway independent of Bcl-2 family proteins,Biochim Biophys Acta,1832(3):453-474, 2013 Yu X, Ma J, Lin F, Zhao W, Fu X, Zhao ZJ*, Myotubularin family phosphatase ceMTM3 is required for muscle maintenance by preventing excessive autophagy in Caenorhabditis elegans,BMC Cell Biol, 13:28, 2012 Yang T, Jian W, Luo Y, Fu X, Noguchi C, Bungert J, Huang S*, Qiu Y*, Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity,J Biol Chem, 287(48),40279-40291,2012 Han H, Lu L, Wang Q, Zhu M, Yuan C, Xing S*, Fu X ,Synthesis and evaluation of oxovanadium(IV) complexes of Schiff-base condensates from 5-substituted-2-hydroxybenzaldehyde and 2-substituted-benzenamine as selective inhibitors of protein tyrosine phosphatase 1B,Dalton Trans, 41(36),11116-11124,2012 Chen Y, Guo Y, Han J, Ho WT, Li S, Fu X, Zhao ZJ*,Generation and characterization of a highly effective protein substrate for analysis of FLT3 activity,J Hematol Oncol, 5:39, 2012 Zeng L, Li T, Xu DC, Liu J, Mao G, Cui MZ, Fu X, Xu X*,Death receptor 6 induces apoptosis not through type I or type II pathways, but via a unique mitochondria-dependent pathway by interacting with Bax protein,J Biol Chem, 287(34),29125-29133,2012 Lu L, Gao X, Zhu M*, Wang S, Wu Q, Xing S*, Fu X, Liu Z, Guo M*, Exploration of biguanido-oxovanadium complexes as potent and selective inhibitors of protein tyrosine phosphatases,Biometals,25(3),599-610,2012 Qi Y, Fu X, Xiong Z, Zhang H, Hill SM, Rowan BG, Dong Y* ,Methylseleninic acid enhances paclitaxel efficacy for the treatment of triple-negative breast cancer, PLoS One, 7(2), 2012 Wang Q, Zhu M*, Zhu R, Lu L*, Yuan C, Xing S, Fu X*, Mei Y, Hang Q,Exploration of α-aminophosphonate N-derivatives as novel, potent and selective inhibitors of protein tyrosine phosphatases, Eur J Med Chem, 49,354-364,2012 Dong B, Zhang Y, Fu X, Wang G*, Absence of JAK2V617F mutation in Chinese deep vein thrombosis patients without myeloproliferative neoplasms, Thromb Res, 129(5), 664-665,2012 Yuan C, Zhu M*, Wang Q, Lu L, Xing S, Fu X*, Jiang Z, Zhang S, Li Z, Li Z, Zhu R, Ma L, Xu L,Potent and selective inhibition of T-cell protein tyrosine phosphatase (TCPTP) by a dinuclear copper(II) complex, Chem Commun (Camb), 48(8), 1153-1155,2012 Wang Q, Zhu M*, Lu L*, Yuan C, Xing S, Fu X*, Potent inhibition of protein tyrosine phosphatases by quinquedentate binuclear copper complexes: synthesis, characterization and biological activities, Dalton Trans,40(48),12926-12934,2011 Yu X, Zhao W, Ma J, Fu X, Zhao ZJ*, Beneficial and harmful effects of alcohol exposure on Caenorhabditis elegans worms, Biochem Biophys Res Commun, 412(4),757-762,2011 Ma L, Lu L*, Zhu M*, Wang Q, Gao F, Yuan C, Wu Y, Xing S, Fu X*, Mei Y, Gao X, Dinuclear copper complexes of organic claw: potent inhibition of protein tyrosine phosphatases,J Inorg Biochem,105(9),1138-1147,2011 Li Y, Lu L*, Zhu M*, Wang Q, Yuan C, Xing S, Fu X*, Mei Y, Potent inhibition of protein tyrosine phosphatases by copper complexes with multi- benzimidazole derivatives,Biometals,24(6),993-1004,2011 Li J, Cao B, Liu X, Fu X, Xiong Z, Chen L, Sartor O, Dong Y, Zhang H*, Berberine suppresses androgen receptor signaling in prostate cancer, Mol Cancer Ther, 10(8), 1346-1356,2011 Ma L, Lu L*, Zhu M*, Wang Q, Li Y, Xing S, Fu X*, Gao Z, Dong Y, Mononuclear copper(II) complexes with 3,5-substituted-4-salicylidene-amino-3,5- dimethyl-1,2,4-triazole: synthesis, structure and potent inhibition of protein tyrosine phosphatases, Dalton Trans, 40(24),6532-6540,2011 Ma J, Li Z, Xing S, Ho WT, Fu X*, Zhao ZJ*, Tea contains potent inhibitors of tyrosine phosphatase PTP1B, Biochem Biophys Res Commun, 407(1),98-102, 2011 Zhao W, Gao R, Lee J, Xing S, Ho WT, Fu X, Li S, Zhao ZJ*,Relevance of JAK2V617F positivity to hematological diseases--survey of samples from a clinical genetics laboratory, J Hematol Oncol, 4:4,2011 Wang S, Dong H, Han J, Ho WT, Fu X, Zhao ZJ*, Identification of a variant form of tyrosine phosphatase LYP, BMC Mol Biol, 11:78,2010 Wang F, Fu X, Chen X, Chen X, Zhao Y*, Mitochondrial uncoupling inhibits p53 mitochondrial translocation in TPA-challenged skin epidermal JB6 cells, PLoS One, 5(10) ,2010 Lu L*, Wang S, Zhu M*, Liu Z, Guo M, Xing S, Fu X*, Inhibition protein tyrosine phosphatases by an oxovanadium glutamate complex, Na2[VO(Glu)2(CH3OH)](Glu = glutamate), Biometals, 23(6),1139-1147,2010 Yuan C, Lu L*, Wu Y, Liu Z, Guo M*, Xing S, Fu X*, Zhu M*,Synthesis, characterization, and protein tyrosine phosphatases inhibition activities of oxovanadium(IV) complexes with Schiff base and polypyridyl derivatives, J InorgBiochem, 104(9), 978-986, 2010 Jiang Y, Bernard D, Yu Y, Xie Y, Zhang T, Li Y, Burnett JP, Fu X*, Wang S*, Sun D*,Split Renilla luciferase protein fragment-assisted complementation (SRL-PFAC) to characterize Hsp90-Cdc37 complex and identify critical residues in protein/protein interactions, J Biol Chem, 285(27),21023-21036,2010