教育经历 1980.7 - 85.7：医学学士 白求恩医科大学 医疗系（现吉林大学医学部） 1988.9 - 91.8：医学硕士 中国医科大学第一医院 血液内科学 1994.4 - 98.3：医学博士 日本九州大学医学部 临床检查医学研究室 工作经历 1985.7 - 88.8：住院医师 延边大学附属病院 内科学 1991.9- 94.3：主治医师 延边大学附属病院 血液内科 1998.4- 00.11：外国人特别研究员 日本东京医科齿科大学难治疾病研究所 2000.12-01.5: 博士后 奥克拉荷马医学研究所 (OMRF)(Joan Conaway教授研究室) 2001.6 - 09.8：博士后-研究员 斯托瓦斯研究所（Stowers Institute）(Joan Conaway教授研究室)

1. 人染色质结构调控酶复合物的结构及其生物学功能研究; 2. 人染色质结构调控酶在肿瘤发生和发展中的调控机制研究及其肿瘤特异治疗靶向的筛选; 3. 人染色质结构调控酶在干细胞自我更新和分化中的表观遗传学机制研究; 4. 人间充质干细胞（MSC）干性维持和诱导分化的基础研究及其临床转化应用。

Wei T, Liu H, Zhu H, Chen W, Wu T, Bai Y, Zhang X, Miao Y, Wang F, Cai Y*, Jin J*. Two distinct males absent on the first (MOF)-containing histone acetyltransferases are involved in the epithelial-mesenchymal transition in different ways in human cells. Cell Mol Life Sci. 2022, 79(5):238. Liu H, Wei T, Sun L, Wu T, Li F, Zhao J, Chu J, Wang F, Cai Y*, Jin J*. The non-specific lethal (NSL) histone acetyltransferase complex transcriptionally regulates Yin Yang 1-mediated cell proliferation in human cells. Int J Mol Sci. 2022, 23(7):3801. Li Y, Li F, Feng C, Wu T, Chen Y, Shah JA, Wang F, Cai Y, Wang J and Jin Jin*. MiR-372-3p functions as a tumor suppressor in colon cancer by targeting MAP3K2. Front Genet. 2022, 13; 836256. Yang Y, Zhang L, Xiong C, Chen J, Wang L, Wen Z, Yu J, Chen P, Xu Y, Jin J, Cai Y*, Li G*. HIRA complex presets transcriptional potential through coordinating depositions of the histone variants H3.3 and H2A.Z on the poised genes in mESCs. Nucleic Acids Res. 2022, 50(1):191-206. Xiang JY, Chi YY, Han JX, Shi X, Cai Y*, Xiang H*, Xie Q*. Intestinal microbiota contributes to the improvement of alcoholic hepatitis in mice treated with schisandra chinensis extract. Front Nutr. 2022, 9:822429. Rui Y, Su J, Shen S, Hu Y, Huang D, Zheng W, Lou M, Shi Y, Wang M, Chen S, Zhao N, Dong Q, Cai Y, Xu R, Zheng S, Yu XF. Unique and complementary suppression of cGAS-STING and RNA sensing- triggered innate immune responses by SARS-CoV-2 proteins. Signal Transduct Target Ther. 2021, 6(1):123. Shah JA, Khattak S, Rauf MA, Cai Y, Jin J*. Potential Biomarkers of miR-371-373 Gene Cluster in Tumorigenesis. Life (Basel). 2021, 11(9):984. Zhu H, Wang Y, Wei T, Zhao X, Li F, Li Y, Wang F, Cai Y*, Jin J*. KAT8/MOF-Mediated Anti-Cancer Mechanism of Gemcitabine in Human Bladder Cancer Cells. Biomol Ther. 2021, 29(2):184-194. Zhu H, Wei T, Cai Y, Jin J*. Small Molecules Targeting the Specific Domains of Histone-Mark Readers in Cancer Therapy. Molecules. 2020, 25(3):578. Li Y, Wang Z, Jin J, Zhu SX, He GQ, Li SH, Wang J, Cai Y*. Quercetin pretreatment enhances the radiosensitivity of colon cancer cells by targeting Notch-1 pathway. Biochem Biophys Res Commun. 2020, 523(4):947-953. Sui Y, Wu T, Li F, Wang F, Cai Y*, Jin J*. YY1/BCCIP Coordinately Regulates P53-Responsive Element (p53RE)-Mediated Transactivation of p21Waf1/Cip1. Int J Mol Sci. 2019, 20(9):2095. Wang LY, He YX, Li M, Ding J, Sui Y, Conaway JW, Conaway RC, Wang F, Jin J*, Cai Y*. DNA-dependent protein kinase catalytic subunit (DNA-PKcs) contributes to incorporation of histone variant H2A.Z into nucleosomes. Protein Cell. 2019, 10(9):694-699. Wang L, Zhao T, Wang S, Jin J, Cai Y, Wang F*. Expression, purification, and in vitro mitochondrial interaction analysis of full-length and truncated human tumor suppresser p53. Biosci Biotechnol Biochem. 2019, 83(7):1220-1226. Zhao L, Li M, Wei T, Feng C, Wu T, Shah JA, Liu H, Wang F, Cai Y*, Jin J*. O-GlcNAc-Modification of NSL3 at Thr755 Site Maintains the Holoenzyme Activity of MOF/NSL Histone Acetyltransfease Complex. Int J Mol Sci. 2019, 21(1):173. Su J, Rui Y, Lou M, Yin L, Xiong H, Zhou Z, Shen S, Chen T, Zhang Z, Zhao N, Zhang W, Cai Y, Markham R, Zheng S, Xu R, Wei W, Yu XF. HIV-2/SIV Vpx targets a novel functional domain of STING to selectively inhibit cGAS-STING-mediated NF-κB signalling. Nat Microbiol. 2019, 4(12):2552-2564. Liu J, Lu X, Lou Y, Cai Y, Cui W, Wang J, Nie P, Chen L, Li B, Luo P. Xenogeneic Transplantation of Human Placenta-Derived Mesenchymal Stem Cells Alleviates Renal Injury and Reduces Inflammation in a Mouse Model of Lupus Nephritis. Biomed Res Int. 2019, 2019:9370919. Sui Y, Li F, Wu T, Ding J, Lu Z, Wang L, Yang Y, Wang F, Zhao L, Zhu H, Wei T, Jin J*, Cai Y*. BCCIP binds to and activates its promoter in a YY1-dependent fashion in HCT116 cells. FEBS J. 2018, 285(16):3026-3040. Zhao L, Shah JA, Cai Y, Jin J*. 'O-GlcNAc Code' Mediated Biological Functions of Downstream Proteins. Molecules. 2018 Aug 6;23(8):1967. Ding J, Yu C, Sui Y, Wang L, Yang Y, Wang F, Yao H, Xing F, Liu H, Li Y, Shah JA, Cai Y*, Jin J*. The chromatin remodeling protein INO80 contributes to the removal of H2A.Z at the p53-binding site of the p21 gene in response to doxorubicin. FEBS J. 2018, 285(17):3270-3285. Wu D, Cai Y, Jin J*. Potential coordination role between O-GlcNAcylation and epigenetics. Protein Cell. 2017, 8(10):713-723. Wu D, Zhao L, Feng Z, Yu C, Ding J, Wang L, Wang F, Liu D, Zhu H, Xing F, Conaway JW, Conaway RC, Cai Y*, Jin J*. O-Linked N-acetylglucosamine transferase 1 regulates global histone H4 acetylation via stabilization of the nonspecific lethal protein NSL3. J Biol Chem. 2017, 292(24):10014-25. Luo L, Cui J, Feng Z, Li Y, Wang M, Cai Y, Wu Y*, Jin J*. Lentiviral-mediated overexpression of KCTD12 inhibits the proliferation of human uveal melanoma OCM-1 cells. Oncol Rep. 2017, 37(2):871-878. Rui Y, Su J, Wang H, Chang J, Wang S, Zheng W, Cai Y, Wei W, Gordy JT, Markham R, Kong W, Zhang W, Yu XF. Disruption of MDA5-Mediated Innate Immune Responses by the 3C Proteins of Coxsackievirus A16, Coxsackievirus A6, and Enterovirus D68. J Virol. 2017, 91(13):e00546-17. Jiang D, Wang L, Zhao T, Zhang Z, Zhang R, Jin J, Cai Y, Wang F*. Restoration of the tumor-suppressor function to mutant p53 by Ganoderma lucidum polysaccharides in colorectal cancer cells. Oncol Rep. 2017, 37(1):594-600. Su J, Sui Y, Ding J, Li F, Shen S, Yang Y, Lu Z, Wang F, Cao L, Liu X, Jin J*, Cai Y*. Human INO80/YY1 chromatin remodeling complex transcriptionally regulates the BRCA2- and CDKN1A-interacting protein (BCCIP) in cells. Protein Cell. 2016, 7(10):749-760. Fan Z, Li D, Yu X, Zhang Y, Cai Y, Jin J, Yu J*. AIE Luminogen-Functionalized Hollow Mesoporous Silica Nanospheres for Drug Delivery and Cell Imaging. Chemistry. 2016, 22(11):3681-5. Su J, Wang F, Cai Y, Jin J*. The Functional Analysis of Histone Acetyltransferase MOF in Tumorigenesis. Int J Mol Sci. 2016, 17(1):99. Wang F, Zhao J, Liu D, Zhao T, Lu Z, Zhu L, Cao L, Yang J, Jin J*, Cai Y*. Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition. Cancer Biol Ther. 2016, 17(11):1117-1125.