曾琳琳
副教授
个人简介
教育经历 2007/09-2012/12 博士 研究生 吉林大学生命科学学院 Edmond H. Fischer实验室 微生物与生化药学专业 2002/09-2007/07 学士 吉林大学药学院 生物工程(医学)专业 工作经历: 2015/07-至今 吉林大学生命科学学院 讲师 2013/01-2015/03 美国田纳西大学兽医学院生物医学与诊断学系 博士后 2010/05-2012/12 美国田纳西大学兽医学院生物医学与诊断学系 联合培养博士研究生
研究领域
主要从事研究神经系统退行性疾病阿尔茨海默氏症(Alzheimer disease,AD)及肌萎缩性脊髓侧索硬化症(Amyotrophic lateral sclerosis,ALS)的发病机制
近期论文
1.Linlin Zeng, Chen Hu, Fuqiang Zhang, Daniel C.Xu, Mei-Zhen Cui, Xuemin Xu. Cellular FLICE-like Inhibitory Protein (c-FLIP) and PS1-associated Protein (PSAP) Mediate Presenilin 1-induced γ-Secretase-dependent and -independent Apoptosis, Respectively. Journal of Biological Chemistry, 2015, 290(30):18269-80 2.Linlin Zeng, Ting Li, Derek C. Xu, Hennifer Liu, Guozhang Mao, MeipZhen Cui , Xueqi Fu, Xuemin Xu. Death Receptor 6 Induces Apoptosis Not through Type I or Type II Pathway, but via a Unique Mitochondria-dependent Pathway by Interacting with Bax Protein. Journal of Biological Chemistry, 2012, 287(34):29125-3 3.Chen Hu, Linlin Zeng, Mei-Zhen Cui, Xuemin Xu. Nicastrin is required for APP but not Notch processing, while Aph-1 is dispensable for processing of both APP and Notch. J Neurochem. 2015 Dec 30 4.Ting Li, Linlin Zeng, Wei Gao, Mei-zhen Cui, Xueqi Fu, Xuemin Xu. PSAP Induces a Unique Apaf-1 and Smac-dependent Mitochondrial Apoptotic Pathway Independent of Bcl-2 Family Proteins. Biochimica et Biophysica Acta (BBA), 2013 Mar, 1832(3):453-74 5.Fuqiang Zhang, Feng Hao, Dong An, Linlin Zeng, Yi Wang, Xuemin Xu, and Mei-Zhen Cui.The matricellular protein Cyr61 is a key mediator of platelet-derived growth factor-induced cell migration. Journal of Biological Chemistry, 2015, 290(13):8232-42